This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-... See more...

Aliases for TNRC6A Gene

Aliases for TNRC6A Gene

  • Trinucleotide Repeat Containing Adaptor 6A 2 3 5
  • Trinucleotide Repeat-Containing Gene 6A Protein 3 4
  • Glycine-Tryptophan Protein Of 182 KDa 3 4
  • Trinucleotide Repeat Containing 6A 2 3
  • EMSY Interactor Protein 3 4
  • CAG Repeat Protein 26 3 4
  • GW182 Autoantigen 3 4
  • CAGH26 3 4
  • TNRC6 3 4
  • Trinucleotide Repeat Containing 6 2
  • CTD-2540M10.1 3
  • Protein GW1 4
  • KIAA1460 4
  • FAME6 3
  • GW182 3
  • EDIE 3
  • GW1 3

External Ids for TNRC6A Gene

Previous HGNC Symbols for TNRC6A Gene

  • TNRC6

Previous GeneCards Identifiers for TNRC6A Gene

  • GC16P024651
  • GC16P024741
  • GC16P022832

Summaries for TNRC6A Gene

Entrez Gene Summary for TNRC6A Gene

  • This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNRC6A Gene

TNRC6A (Trinucleotide Repeat Containing Adaptor 6A) is a Protein Coding gene. Diseases associated with TNRC6A include Epilepsy, Familial Adult Myoclonic, 6 and Benign Adult Familial Myoclonic Epilepsy. Among its related pathways are Downstream signaling events of B Cell Receptor (BCR) and RET signaling. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is TNRC6C.

UniProtKB/Swiss-Prot Summary for TNRC6A Gene

  • Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes.

Gene Wiki entry for TNRC6A Gene

Additional gene information for TNRC6A Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TNRC6A Gene

Genomics for TNRC6A Gene

GeneHancer (GH) Regulatory Elements for TNRC6A Gene

Promoters and enhancers for TNRC6A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J024609 Promoter/Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas 500.7 +0.2 191 1.6 USF1 TRIM28 SAP30 ZNF274 HDAC2 ZNF341 POLR2A OSR2 ZNF491 NFIC TNRC6A lnc-RBBP6-4 ENSG00000261669 RBBP6 PALB2 RF00017-2019
GH16J024775 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE dbSUPER 500.1 +166.2 166214 3.6 ZNF316 MAFF MAFK RBM22 JUND GATA3 FOXA1 MAFG ZBTB40 HNF4A lnc-ARHGAP17-11 TNRC6A SLC5A11 RF00017-2021
GH16J024611 Promoter 0.5 Ensembl 500.7 -0.9 -908 0.2 ZNF491 ZNF514 TNRC6A lnc-RBBP6-4 ENSG00000261669 RBBP6 PALB2 piR-36393-197
GH16J024612 Enhancer 0.2 Ensembl 500.7 +1.5 1492 0.2 TNRC6A lnc-RBBP6-4 RF00017-2019
GH16J024699 Enhancer 0.8 ENCODE 12.2 +91.1 91119 3 ZNF217 CTCF TCF12 JUND FOS EP300 CTBP1 FOXA2 OSR2 NR2F2 SLC5A11 TNRC6A lnc-RBBP6-1 HSALNG0110303 lnc-RBBP6-4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TNRC6A on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TNRC6A

Top Transcription factor binding sites by QIAGEN in the TNRC6A gene promoter:
  • AML1a
  • c-Myb
  • LCR-F1
  • NF-AT
  • NF-AT1
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • POU6F1 (c2)
  • S8

Genomic Locations for TNRC6A Gene

Genomic Locations for TNRC6A Gene
chr16:24,610,209-24,827,632
(GRCh38/hg38)
Size:
217,424 bases
Orientation:
Plus strand
chr16:24,741,016-24,838,953
(GRCh37/hg19)
Size:
97,938 bases
Orientation:
Plus strand

Genomic View for TNRC6A Gene

Genes around TNRC6A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNRC6A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNRC6A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNRC6A Gene

Proteins for TNRC6A Gene

  • Protein details for TNRC6A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NDV7-TNR6A_HUMAN
    Recommended name:
    Trinucleotide repeat-containing gene 6A protein
    Protein Accession:
    Q8NDV7
    Secondary Accessions:
    • C9JAR8
    • O15408
    • Q658L5
    • Q6NVB5
    • Q8NEZ0
    • Q8TBT8
    • Q8TCR0
    • Q9NV59
    • Q9P268

    Protein attributes for TNRC6A Gene

    Size:
    1962 amino acids
    Molecular mass:
    210297 Da
    Quaternary structure:
    • Interacts with AGO2 (PubMed:16284623, PubMed:16284622, PubMed:18690212, PubMed:19304925, PubMed:19324964, PubMed:19383768). Interacts with AGO1, AGO3 and AGO4 (PubMed:19324964, PubMed:19383768). Interacts with CNOT1; the interaction is direct and mediates the association with the CCR4-NOT complex (PubMed:21981923). Interacts with ZC3H12A (PubMed:26134560). Interacts with SND1 (PubMed:28546213).
    Miscellaneous:
    • Antibodies against TNRC6A are found in sera from patients with Sjoegren syndrome (SS), ataxia and sensor neuropathy diseases that developed autoantibodies against protein of the GWB structure. Autoantibodies were mapped to the GW-rich mid-part, the non-GW-rich region and the C-terminus of the protein.
    SequenceCaution:
    • Sequence=BAA91899.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAD28525.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TNRC6A Gene

    Alternative splice isoforms for TNRC6A Gene

neXtProt entry for TNRC6A Gene

Post-translational modifications for TNRC6A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for TNRC6A

No data available for DME Specific Peptides for TNRC6A Gene

Domains & Families for TNRC6A Gene

Gene Families for TNRC6A Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for TNRC6A Gene

Blocks:
  • RNA-binding region RNP-1 (RNA recognition motif)
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TNRC6A Gene

GenScript: Design optimal peptide antigens:
  • Glycine-tryptophan protein of 182 kDa (TNR6A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NDV7

UniProtKB/Swiss-Prot:

TNR6A_HUMAN :
  • Belongs to the GW182 family.
Family:
  • Belongs to the GW182 family.
genes like me logo Genes that share domains with TNRC6A: view

Function for TNRC6A Gene

Molecular function for TNRC6A Gene

UniProtKB/Swiss-Prot Function:
Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes.
UniProtKB/Swiss-Prot Induction:
By exogenous short interfering RNA (siRNA).

Phenotypes From GWAS Catalog for TNRC6A Gene

Gene Ontology (GO) - Molecular Function for TNRC6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,HDA 22681889
GO:0005515 protein binding IPI 19167051
genes like me logo Genes that share ontologies with TNRC6A: view
genes like me logo Genes that share phenotypes with TNRC6A: view

Animal Model Products

CRISPR Products

miRNA for TNRC6A Gene

miRTarBase miRNAs that target TNRC6A

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNRC6A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TNRC6A Gene

Localization for TNRC6A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNRC6A Gene

Cytoplasm, P-body. Note=Mammalian P-bodies are also known as GW bodies (GWBs). {ECO:0000305}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNRC6A gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 4
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
peroxisome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (3)
  • Golgi apparatus (2)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TNRC6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IDA 20616046
GO:0005654 nucleoplasm TAS,IDA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TNRC6A: view

Pathways & Interactions for TNRC6A Gene

genes like me logo Genes that share pathways with TNRC6A: view

Gene Ontology (GO) - Biological Process for TNRC6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0007223 Wnt signaling pathway, calcium modulating pathway TAS --
GO:0009267 cellular response to starvation IEA --
GO:0010628 positive regulation of gene expression TAS --
GO:0010629 negative regulation of gene expression TAS --
genes like me logo Genes that share ontologies with TNRC6A: view

No data available for SIGNOR curated interactions for TNRC6A Gene

Drugs & Compounds for TNRC6A Gene

No Compound Related Data Available

Transcripts for TNRC6A Gene

mRNA/cDNA for TNRC6A Gene

3 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
18 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNRC6A

Alternative Splicing Database (ASD) splice patterns (SP) for TNRC6A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a ·
SP1: - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: -
SP5: -
SP6: -
SP7:
SP8: -
SP9:
SP10:
SP11:

ExUns: 17b ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22a · 22b · 22c ^ 23 ^ 24
SP1: -
SP2: -
SP3: -
SP4: - -
SP5:
SP6:
SP7: - - - - -
SP8:
SP9:
SP10:
SP11:

Relevant External Links for TNRC6A Gene

GeneLoc Exon Structure for
TNRC6A

Expression for TNRC6A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TNRC6A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TNRC6A Gene

This gene is overexpressed in Plasma (39.5) and Monocytes (24.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TNRC6A Gene



Protein tissue co-expression partners for TNRC6A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TNRC6A

SOURCE GeneReport for Unigene cluster for TNRC6A Gene:

Hs.655057

mRNA Expression by UniProt/SwissProt for TNRC6A Gene:

Q8NDV7-TNR6A_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for TNRC6A Gene

  • Nervous system(4.7)
  • Kidney(4.3)
  • Stomach(4.3)
genes like me logo Genes that share expression patterns with TNRC6A: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNRC6A Gene

Orthologs for TNRC6A Gene

This gene was present in the common ancestor of animals.

Orthologs for TNRC6A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNRC6A 31 30
  • 96.56 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TNRC6A 31 30
  • 95.72 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TNRC6A 31 30
  • 95.55 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tnrc6a 17 31 30
  • 93.92 (n)
rat
(Rattus norvegicus)
Mammalia Tnrc6a 30
  • 93.86 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TNRC6A 31
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TNRC6A 31
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves TNRC6A 31 30
  • 86.31 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TNRC6A 31
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tnrc6a 30
  • 74.27 (n)
Str.20381 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.19158 30
zebrafish
(Danio rerio)
Actinopterygii TNRC6A 31
  • 60 (a)
OneToOne
Dr.18336 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3119 30
fruit fly
(Drosophila melanogaster)
Insecta gw 31
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 30 (a)
OneToMany
Species where no ortholog for TNRC6A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNRC6A Gene

ENSEMBL:
Gene Tree for TNRC6A (if available)
TreeFam:
Gene Tree for TNRC6A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TNRC6A: view image

Paralogs for TNRC6A Gene

Paralogs for TNRC6A Gene

(2) SIMAP similar genes for TNRC6A Gene using alignment to 7 proteins:

  • TNR6A_HUMAN
  • G8JLL8_HUMAN
  • H3BRT3_HUMAN
  • H3BTQ1_HUMAN
  • H7C269_HUMAN
  • I3L218_HUMAN
  • I3L3S5_HUMAN
genes like me logo Genes that share paralogs with TNRC6A: view

Variants for TNRC6A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TNRC6A Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
708973 Benign: not provided 24,791,045(+) G/A SYNONYMOUS_VARIANT
717234 Benign: not provided 24,791,651(+) T/C SYNONYMOUS_VARIANT
724787 Likely Benign: not provided 24,823,629(+) G/A MISSENSE_VARIANT
769896 Benign: not provided 24,777,101(+) AGCAGCCACAGCC/A INFRAME_DELETION
769897 Benign: not provided 24,790,317(+) A/G MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for TNRC6A Gene

Structural Variations from Database of Genomic Variants (DGV) for TNRC6A Gene

Variant ID Type Subtype PubMed ID
esv3638258 CNV loss 21293372
nsv1113770 CNV deletion 24896259
nsv1144765 CNV deletion 24896259

Variation tolerance for TNRC6A Gene

Residual Variation Intolerance Score: 4.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.94; 95.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNRC6A Gene

Human Gene Mutation Database (HGMD)
TNRC6A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNRC6A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNRC6A Gene

Disorders for TNRC6A Gene

MalaCards: The human disease database

(5) MalaCards diseases for TNRC6A Gene - From: OMIM, ClinVar, GTR, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
epilepsy, familial adult myoclonic, 6
  • fame6
benign adult familial myoclonic epilepsy
  • adcme
griscelli syndrome, type 3
  • gs3
hermansky-pudlak syndrome 4
  • albinism with hemorrhagic diathesis and pigmented reticuloendothelial cells
sensory peripheral neuropathy
  • peripheral sensory neuropathy
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

TNR6A_HUMAN
  • Epilepsy, familial adult myoclonic, 6 (FAME6) [MIM:618074]: A form of familial myoclonic epilepsy, a neurologic disorder characterized by cortical hand tremors, myoclonic jerks and occasional generalized or focal seizures with a non-progressive or very slowly progressive disease course. Usually, myoclonic tremor is the presenting symptom, characterized by tremulous finger movements and myoclonic jerks of the limbs increased by action and posture. In a minority of patients, seizures are the presenting symptom. Some patients exhibit mild cognitive impairment. FAME6 inheritance is autosomal dominant. {ECO:0000269 PubMed:29507423}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for TNRC6A

genes like me logo Genes that share disorders with TNRC6A: view

No data available for Genatlas for TNRC6A Gene

Publications for TNRC6A Gene

  1. Disruption of GW bodies impairs mammalian RNA interference. (PMID: 16284622) Jakymiw A … Chan EK (Nature cell biology 2005) 3 4 23 54
  2. The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies. (PMID: 13130130) Eystathioy T … Fritzler MJ (RNA (New York, N.Y.) 2003) 3 4 23 54
  3. Clinical and serological associations of autoantibodies to GW bodies and a novel cytoplasmic autoantigen GW182. (PMID: 14598044) Eystathioy T … Fritzler MJ (Journal of molecular medicine (Berlin, Germany) 2003) 3 4 23 54
  4. cDNAs with long CAG trinucleotide repeats from human brain. (PMID: 9225980) Margolis RL … Ross CA (Human genetics 1997) 2 3 4 54
  5. Tudor-SN-mediated endonucleolytic decay of human cell microRNAs promotes G1/S phase transition. (PMID: 28546213) Elbarbary RA … Maquat LE (Science (New York, N.Y.) 2017) 3 4 54

Products for TNRC6A Gene

Sources for TNRC6A Gene