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Aliases for TNRC6A Gene

Aliases for TNRC6A Gene

  • Trinucleotide Repeat Containing 6A 2 3 5
  • Glycine-Tryptophan Protein Of 182 KDa 3 4
  • EMSY Interactor Protein 3 4
  • CAG Repeat Protein 26 3 4
  • GW182 Autoantigen 3 4
  • CAGH26 3 4
  • TNRC6 3 4
  • Trinucleotide Repeat-Containing Gene 6A Protein 3
  • Trinucleotide Repeat Containing 6 2
  • CTD-2540M10.1 3
  • Protein GW1 4
  • KIAA1460 4
  • GW182 3
  • EDIE 3
  • GW1 3

External Ids for TNRC6A Gene

Previous HGNC Symbols for TNRC6A Gene

  • TNRC6

Previous GeneCards Identifiers for TNRC6A Gene

  • GC16P024741
  • GC16P022832

Summaries for TNRC6A Gene

Entrez Gene Summary for TNRC6A Gene

  • This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNRC6A Gene

TNRC6A (Trinucleotide Repeat Containing 6A) is a Protein Coding gene. Among its related pathways are RET signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is TNRC6C.

UniProtKB/Swiss-Prot for TNRC6A Gene

  • Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.

Gene Wiki entry for TNRC6A Gene

Additional gene information for TNRC6A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNRC6A Gene

Genomics for TNRC6A Gene

GeneHancer (GH) Regulatory Elements for TNRC6A Gene

Promoters and enhancers for TNRC6A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I024728 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.1 +120.5 120466 4 PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF207 TNRC6A SLC5A11 RBBP6 SCML2P2 GC16M024776 LINC01567
GH16I024610 Enhancer 0.9 Ensembl ENCODE 550.8 +0.3 271 0.6 MXI1 MAZ USF1 L3MBTL2 CEBPB MAX SIN3A USF2 ZNF518A ZNF335 TNRC6A LINC01567
GH16I024609 Enhancer 0.9 Ensembl ENCODE 550.8 -0.3 -304 0.2 ZNF449 SIN3A ZNF335 POLR2A PATZ1 SCRT2 ZBTB20 EZH2 MAZ L3MBTL2 TNRC6A RBBP6
GH16I024699 Enhancer 1.1 Ensembl ENCODE 12.2 +91.1 91119 3 FOXA2 NFIB SIN3A BATF RAD21 RFX5 YY1 SMARCC2 RCOR1 FOS SLC5A11 TNRC6A LINC01567 GC16M024776
GH16I024838 Enhancer 1.4 Ensembl ENCODE dbSUPER 5.7 +228.8 228786 1.5 ATF1 FOXA2 ARNT ARID4B TCF12 GATA2 E2F8 FOS ATF7 NCOA1 TNRC6A SLC5A11 ENSG00000261669
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TNRC6A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TNRC6A gene promoter:

Genomic Locations for TNRC6A Gene

Genomic Locations for TNRC6A Gene
chr16:24,610,209-24,827,632
(GRCh38/hg38)
Size:
217,424 bases
Orientation:
Plus strand
chr16:24,741,016-24,838,953
(GRCh37/hg19)

Genomic View for TNRC6A Gene

Genes around TNRC6A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNRC6A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNRC6A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNRC6A Gene

Proteins for TNRC6A Gene

  • Protein details for TNRC6A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NDV7-TNR6A_HUMAN
    Recommended name:
    Trinucleotide repeat-containing gene 6A protein
    Protein Accession:
    Q8NDV7
    Secondary Accessions:
    • C9JAR8
    • O15408
    • Q658L5
    • Q6NVB5
    • Q8NEZ0
    • Q8TBT8
    • Q8TCR0
    • Q9NV59
    • Q9P268

    Protein attributes for TNRC6A Gene

    Size:
    1962 amino acids
    Molecular mass:
    210297 Da
    Quaternary structure:
    • Interacts with AGO2 (PubMed:16284623, PubMed:16284622, PubMed:18690212, PubMed:19304925, PubMed:19324964, PubMed:19383768). Interacts with AGO1, AGO3 and AGO4 (PubMed:19324964, PubMed:19383768). Interacts with CNOT1; the interaction is direct and mediates the association with the CCR4-NOT complex (PubMed:21981923). Interacts with ZC3H12A (PubMed:26134560).
    Miscellaneous:
    • Antibodies against TNRC6A are found in sera from patients with Sjoegren syndrome (SS), ataxia and sensor neuropathy diseases that developed autoantibodies against protein of the GWB structure. Autoantibodies were mapped to the GW-rich mid-part, the non-GW-rich region and the C-terminus of the protein.
    SequenceCaution:
    • Sequence=BAA91899.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAD28525.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TNRC6A Gene

    Alternative splice isoforms for TNRC6A Gene

neXtProt entry for TNRC6A Gene

Post-translational modifications for TNRC6A Gene

No Post-translational modifications

Antibody Products

  • Abcam antibodies for TNRC6A
  • Cloud-Clone Corp. Antibodies for TNRC6A

No data available for DME Specific Peptides for TNRC6A Gene

Domains & Families for TNRC6A Gene

Gene Families for TNRC6A Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TNRC6A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NDV7

UniProtKB/Swiss-Prot:

TNR6A_HUMAN :
  • Belongs to the GW182 family.
Family:
  • Belongs to the GW182 family.
genes like me logo Genes that share domains with TNRC6A: view

Function for TNRC6A Gene

Molecular function for TNRC6A Gene

UniProtKB/Swiss-Prot Function:
Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.
UniProtKB/Swiss-Prot Induction:
By exogenous short interfering RNA (siRNA).

Phenotypes From GWAS Catalog for TNRC6A Gene

Gene Ontology (GO) - Molecular Function for TNRC6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,HDA 22681889
GO:0005515 protein binding IPI 19167051
genes like me logo Genes that share ontologies with TNRC6A: view
genes like me logo Genes that share phenotypes with TNRC6A: view

Animal Model Products

miRNA for TNRC6A Gene

miRTarBase miRNAs that target TNRC6A

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TNRC6A Gene

Localization for TNRC6A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNRC6A Gene

Cytoplasm, P-body. Note=Mammalian P-bodies are also known as GW bodies (GWBs).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNRC6A gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 5
lysosome 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (3)
  • Golgi apparatus (2)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TNRC6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IDA 20616046
GO:0005654 nucleoplasm IDA,TAS --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TNRC6A: view

Pathways & Interactions for TNRC6A Gene

genes like me logo Genes that share pathways with TNRC6A: view

Gene Ontology (GO) - Biological Process for TNRC6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0007223 Wnt signaling pathway, calcium modulating pathway TAS --
GO:0031047 gene silencing by RNA IEA --
GO:0035194 posttranscriptional gene silencing by RNA TAS --
GO:0035195 gene silencing by miRNA IMP 23172285
genes like me logo Genes that share ontologies with TNRC6A: view

No data available for SIGNOR curated interactions for TNRC6A Gene

Drugs & Compounds for TNRC6A Gene

No Compound Related Data Available

Transcripts for TNRC6A Gene

Unigene Clusters for TNRC6A Gene

Trinucleotide repeat containing 6A:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNRC6A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a ·
SP1: - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: -
SP5: -
SP6: -
SP7:
SP8: -
SP9:
SP10:
SP11:

ExUns: 17b ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22a · 22b · 22c ^ 23 ^ 24
SP1: -
SP2: -
SP3: -
SP4: - -
SP5:
SP6:
SP7: - - - - -
SP8:
SP9:
SP10:
SP11:

Relevant External Links for TNRC6A Gene

GeneLoc Exon Structure for
TNRC6A
ECgene alternative splicing isoforms for
TNRC6A

Expression for TNRC6A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNRC6A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TNRC6A Gene

This gene is overexpressed in Plasma (39.5) and Monocytes (24.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TNRC6A Gene



Protein tissue co-expression partners for TNRC6A Gene

NURSA nuclear receptor signaling pathways regulating expression of TNRC6A Gene:

TNRC6A

SOURCE GeneReport for Unigene cluster for TNRC6A Gene:

Hs.655057

mRNA Expression by UniProt/SwissProt for TNRC6A Gene:

Q8NDV7-TNR6A_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for TNRC6A Gene

  • Nervous system(4.7)
  • Kidney(4.3)
  • Stomach(4.3)
genes like me logo Genes that share expression patterns with TNRC6A: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNRC6A Gene

Orthologs for TNRC6A Gene

This gene was present in the common ancestor of animals.

Orthologs for TNRC6A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNRC6A 33 34
  • 96.56 (n)
dog
(Canis familiaris)
Mammalia TNRC6A 33 34
  • 95.72 (n)
cow
(Bos Taurus)
Mammalia TNRC6A 33 34
  • 95.55 (n)
mouse
(Mus musculus)
Mammalia Tnrc6a 33 16 34
  • 93.92 (n)
rat
(Rattus norvegicus)
Mammalia Tnrc6a 33
  • 93.86 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TNRC6A 34
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TNRC6A 34
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves TNRC6A 33 34
  • 86.31 (n)
lizard
(Anolis carolinensis)
Reptilia TNRC6A 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tnrc6a 33
  • 74.27 (n)
Str.20381 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.19158 33
zebrafish
(Danio rerio)
Actinopterygii TNRC6A 34
  • 60 (a)
OneToOne
Dr.18336 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3119 33
fruit fly
(Drosophila melanogaster)
Insecta gw 34
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 30 (a)
OneToMany
Species where no ortholog for TNRC6A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNRC6A Gene

ENSEMBL:
Gene Tree for TNRC6A (if available)
TreeFam:
Gene Tree for TNRC6A (if available)

Paralogs for TNRC6A Gene

Paralogs for TNRC6A Gene

(2) SIMAP similar genes for TNRC6A Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with TNRC6A: view

Variants for TNRC6A Gene

Sequence variations from dbSNP and Humsavar for TNRC6A Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000004791 -- 24,807,686(+) G/T intron_variant
rs1000018929 -- 24,739,260(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000023206 -- 24,700,246(+) T/G genic_upstream_transcript_variant, intron_variant
rs1000027513 -- 24,725,127(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000049551 -- 24,660,238(+) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TNRC6A Gene

Variant ID Type Subtype PubMed ID
nsv1144765 CNV deletion 24896259
nsv1113770 CNV deletion 24896259
esv3638258 CNV loss 21293372

Variation tolerance for TNRC6A Gene

Residual Variation Intolerance Score: 4.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.94; 95.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNRC6A Gene

Human Gene Mutation Database (HGMD)
TNRC6A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNRC6A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNRC6A Gene

Disorders for TNRC6A Gene

Additional Disease Information for TNRC6A

No disorders were found for TNRC6A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNRC6A Gene

Publications for TNRC6A Gene

  1. Disruption of GW bodies impairs mammalian RNA interference. (PMID: 16284622) Jakymiw A … Chan EK (Nature cell biology 2005) 3 4 22 58
  2. Clinical and serological associations of autoantibodies to GW bodies and a novel cytoplasmic autoantigen GW182. (PMID: 14598044) Eystathioy T … Fritzler MJ (Journal of molecular medicine (Berlin, Germany) 2003) 3 4 22 58
  3. The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies. (PMID: 13130130) Eystathioy T … Fritzler MJ (RNA (New York, N.Y.) 2003) 3 4 22 58
  4. cDNAs with long CAG trinucleotide repeats from human brain. (PMID: 9225980) Margolis RL … Ross CA (Human genetics 1997) 2 3 4 58
  5. Monocyte Chemotactic Protein-induced Protein 1 and 4 Form a Complex but Act Independently in Regulation of Interleukin-6 mRNA Degradation. (PMID: 26134560) Huang S … Fu M (The Journal of biological chemistry 2015) 3 4 58

Products for TNRC6A Gene

Sources for TNRC6A Gene

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