Aliases for TNRC6A Gene
External Ids for TNRC6A Gene
Previous HGNC Symbols for TNRC6A Gene
Previous GeneCards Identifiers for TNRC6A Gene
This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. [provided by RefSeq, Jul 2008]
GeneCards Summary for TNRC6A Gene
TNRC6A (Trinucleotide Repeat Containing Adaptor 6A) is a Protein Coding gene. Diseases associated with TNRC6A include Epilepsy, Familial Adult Myoclonic, 6 and Cervical Non-Keratinizing Squamous Cell Carcinoma. Among its related pathways are Downstream signaling events of B Cell Receptor (BCR) and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is TNRC6C.
UniProtKB/Swiss-Prot Summary for TNRC6A Gene
Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes.