Aliases for TNRC6A Gene
External Ids for TNRC6A Gene
Previous HGNC Symbols for TNRC6A Gene
Previous GeneCards Identifiers for TNRC6A Gene
This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. [provided by RefSeq, Jul 2008]
GeneCards Summary for TNRC6A Gene
TNRC6A (Trinucleotide Repeat Containing Adaptor 6A) is a Protein Coding gene. Diseases associated with TNRC6A include Epilepsy, Familial Adult Myoclonic, 6 and Cervical Non-Keratinizing Squamous Cell Carcinoma. Among its related pathways are RET signaling and Pre-NOTCH Expression and Processing. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is TNRC6C.
UniProtKB/Swiss-Prot Summary for TNRC6A Gene
Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes.