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This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-... See more...
Aliases for TNRC6A Gene
Aliases for TNRC6A Gene
External Ids for TNRC6A Gene
- HGNC: 11969
- NCBI Entrez Gene: 27327
- Ensembl: ENSG00000090905
- OMIM®: 610739
- UniProtKB/Swiss-Prot: Q8NDV7
Previous HGNC Symbols for TNRC6A Gene
- TNRC6
Previous GeneCards Identifiers for TNRC6A Gene
- GC16P024651
- GC16P024741
- GC16P022832
Summaries for TNRC6A Gene
-
This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. [provided by RefSeq, Jul 2008]
GeneCards Summary for TNRC6A Gene
TNRC6A (Trinucleotide Repeat Containing Adaptor 6A) is a Protein Coding gene. Diseases associated with TNRC6A include Epilepsy, Familial Adult Myoclonic, 6 and Cervical Non-Keratinizing Squamous Cell Carcinoma. Among its related pathways are RET signaling and Pre-NOTCH Expression and Processing. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is TNRC6C.
UniProtKB/Swiss-Prot Summary for TNRC6A Gene
-
Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes.
Additional gene information for TNRC6A Gene
- HGNC (11969)
- NCBI Entrez Gene (27327)
- Ensembl (ENSG00000090905)
- OMIM® (610739)
- UniProtKB/Swiss-Prot (Q8NDV7)
- Open Targets Platform(ENSG00000090905)
- Monarch Initiative
- Alliance of Genome Resources
- Search for TNRC6A at DataMed
- Search for TNRC6A at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TNRC6A Gene
Genomics for TNRC6A Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TNRC6A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TNRC6A on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TNRC6A
- Top Transcription factor binding sites by QIAGEN in the TNRC6A gene promoter:
-
- AML1a
- c-Myb
- LCR-F1
- NF-AT
- NF-AT1
- POU3F2
- POU3F2 (N-Oct-5a)
- POU3F2 (N-Oct-5b)
- POU6F1 (c2)
- S8
Genomic Locations for TNRC6A Gene
Latest Assembly
- chr16:24,610,205-24,827,632
- (GRCh38/hg38)
- Size:
- 217,428 bases
- Orientation:
- Plus strand
Previous Assembly
- chr16:24,621,526-24,837,539
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 216,014 bases
- Orientation:
- Plus strand
Alternative Locations (GRCh38/hg38)
- chr16(PATCHES):1,423-76,918 (+)
Genomic View for TNRC6A Gene
Genes around TNRC6A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p12.1 by HGNC
- 16p12.1 by Entrez Gene
- 16p12.1 by Ensembl
TNRC6A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TNRC6A Gene
Proteins for TNRC6A Gene
-
Protein details for TNRC6A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NDV7-TNR6A_HUMAN
- Recommended name:
- Trinucleotide repeat-containing gene 6A protein
- Protein Accession:
- Q8NDV7
- C9JAR8
- O15408
- Q658L5
- Q6NVB5
- Q8NEZ0
- Q8TBT8
- Q8TCR0
- Q9NV59
- Q9P268
Protein attributes for TNRC6A Gene
- Size:
- 1962 amino acids
- Molecular mass:
- 210297 Da
- Quaternary structure:
-
- Interacts with AGO2 (PubMed:16284623, PubMed:16284622, PubMed:18690212, PubMed:19304925, PubMed:19324964, PubMed:19383768). Interacts with AGO1, AGO3 and AGO4 (PubMed:19324964, PubMed:19383768). Interacts with CNOT1; the interaction is direct and mediates the association with the CCR4-NOT complex (PubMed:21981923). Interacts with ZC3H12A (PubMed:26134560). Interacts with SND1 (PubMed:28546213). Interacts with GARRE1 (PubMed:29395067).
- SequenceCaution:
-
- Sequence=BAA91899.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAD28525.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
- Miscellaneous:
-
- Antibodies against TNRC6A are found in sera from patients with Sjoegren syndrome (SS), ataxia and sensor neuropathy diseases that developed autoantibodies against protein of the GWB structure. Autoantibodies were mapped to the GW-rich mid-part, the non-GW-rich region and the C-terminus of the protein.
Protein Expression for TNRC6A Gene
Post-translational modifications for TNRC6A Gene
Other Protein References for TNRC6A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
-
Custom Antibody ServicesOriGene Antibodies for TNRC6A
- Novus Biologicals Antibodies for TNRC6A
-
Abcam antibodies for TNRC6A
- Invitrogen Antibodies for TNRC6A (AFLGC-TNRC6A)
-
Boster Bio Antibodies for TNRC6A
-
Custom Antibody ServicesProSci Antibodies for TNRC6A
-
Santa Cruz Biotechnology (SCBT) Antibodies for TNRC6A
- Sino Biological Antibodies for TNRC6A
Protein products for research
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for TNRC6A
- Origene Custom Protein Services for TNRC6A
- Novus Biologicals proteins for TNRC6A
-
Abcam proteins for TNRC6A
Assay products for research
No data available for DME Specific Peptides for TNRC6A Gene
Domains & Families for TNRC6A Gene
Gene Families for TNRC6A Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for TNRC6A Gene
- InterPro:
- Blocks:
-
- RNA-binding region RNP-1 (RNA recognition motif)
Suggested Antigen Peptide Sequences for TNRC6A Gene
- GenScript: Design optimal peptide antigens:
-
- Glycine-tryptophan protein of 182 kDa (TNR6A_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q8NDV7- Family:
-
- Belongs to the GW182 family.
Function for TNRC6A Gene
Molecular function for TNRC6A Gene
- UniProtKB/Swiss-Prot Function:
- Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes.
- UniProtKB/Swiss-Prot Induction:
- By exogenous short interfering RNA (siRNA).
Phenotypes From GWAS Catalog for TNRC6A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003723 | RNA binding | IEA,HDA | 22681889 |
| GO:0005515 | protein binding | IPI | 19167051 |
Phenotypes for TNRC6A Gene
- MGI mutant phenotypes for TNRC6A:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for TNRC6A:
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for TNRC6A - Starting at $85 >
- * TNRC6A CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for TNRC6A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TNRC6A
-
Santa Cruz Biotechnology (SCBT) CRISPR for TNRC6A
miRNA for TNRC6A Gene
- miRTarBase miRNAs that target TNRC6A
-
- mmu-miR-30a-5p (MIRT003715)
- hsa-miR-30a-5p (MIRT004785)
- mmu-miR-26a-5p (MIRT011485)
- mmu-miR-190a-5p (MIRT013702)
- mmu-miR-149-5p (MIRT014798)
- hsa-miR-361-5p (MIRT020089)
- hsa-miR-148a-3p (MIRT026015)
- hsa-let-7d-5p (MIRT032154)
- hsa-miR-484 (MIRT041866)
- hsa-miR-320a (MIRT044774)
- hsa-miR-30c-5p (MIRT047876)
- hsa-miR-23a-3p (MIRT050426)
- hsa-miR-520g-3p (MIRT074319)
- hsa-miR-520h (MIRT074320)
- hsa-miR-450a-2-3p (MIRT074321)
- hsa-miR-570-3p (MIRT074322)
- hsa-miR-3123 (MIRT074324)
- hsa-miR-3148 (MIRT074325)
- hsa-miR-3662 (MIRT074326)
- hsa-miR-3678-3p (MIRT074327)
- hsa-miR-3919 (MIRT074328)
- hsa-miR-3925-5p (MIRT074329)
- hsa-miR-4668-5p (MIRT074330)
- hsa-miR-4796-3p (MIRT074331)
- hsa-miR-6124 (MIRT074332)
- hsa-miR-30c-2-3p (MIRT074333)
- hsa-miR-23b-3p (MIRT074334)
- hsa-miR-30b-3p (MIRT074335)
- hsa-miR-122-5p (MIRT074336)
- hsa-miR-130a-5p (MIRT074337)
- hsa-miR-30c-1-3p (MIRT074338)
- hsa-miR-887-5p (MIRT074342)
- hsa-miR-3121-3p (MIRT074343)
- hsa-miR-23c (MIRT074344)
- hsa-miR-3689a-3p (MIRT074345)
- hsa-miR-3689b-3p (MIRT074346)
- hsa-miR-3935 (MIRT074347)
- hsa-miR-3689c (MIRT074348)
- hsa-miR-6779-5p (MIRT074351)
- hsa-miR-6780a-5p (MIRT074352)
- hsa-miR-6782-3p (MIRT074353)
- hsa-miR-6788-5p (MIRT074354)
- hsa-miR-1273h-5p (MIRT074355)
- hsa-miR-548e-5p (MIRT074362)
- hsa-miR-30d-5p (MIRT074375)
- hsa-miR-30b-5p (MIRT074376)
- hsa-miR-30e-5p (MIRT074378)
- hsa-miR-1252-3p (MIRT074381)
- hsa-miR-3646 (MIRT074382)
- hsa-miR-6077 (MIRT074383)
- hsa-miR-3122 (MIRT074388)
- hsa-miR-3913-5p (MIRT074392)
- hsa-miR-152-3p (MIRT074396)
- hsa-miR-148b-3p (MIRT074397)
- hsa-miR-193b-5p (MIRT074398)
- hsa-miR-548n (MIRT074400)
- hsa-miR-548t-5p (MIRT074401)
- hsa-miR-3170 (MIRT074402)
- hsa-miR-4259 (MIRT074403)
- hsa-miR-4260 (MIRT074404)
- hsa-miR-3668 (MIRT074405)
- hsa-miR-3942-5p (MIRT074406)
- hsa-miR-4703-5p (MIRT074408)
- hsa-miR-5094 (MIRT074409)
- hsa-miR-5572 (MIRT074410)
- hsa-miR-548az-5p (MIRT074412)
- hsa-miR-6737-5p (MIRT074413)
- hsa-miR-6812-5p (MIRT074414)
- hsa-miR-6819-5p (MIRT074415)
- hsa-miR-6855-5p (MIRT074416)
- hsa-miR-7852-3p (MIRT074417)
- hsa-miR-4252 (MIRT074425)
- hsa-miR-4482-3p (MIRT074439)
- hsa-miR-224-5p (MIRT074442)
- hsa-miR-299-5p (MIRT074443)
- hsa-miR-409-3p (MIRT074444)
- hsa-miR-652-3p (MIRT115494)
- hsa-miR-8074 (MIRT115495)
- hsa-miR-6083 (MIRT115500)
- hsa-miR-17-5p (MIRT142375)
- hsa-miR-19a-3p (MIRT142377)
- hsa-miR-19b-3p (MIRT142379)
- hsa-miR-20a-5p (MIRT142381)
- hsa-miR-93-5p (MIRT142384)
- hsa-miR-130a-3p (MIRT142395)
- hsa-miR-185-5p (MIRT142400)
- hsa-miR-106b-5p (MIRT142401)
- hsa-miR-301a-3p (MIRT142403)
- hsa-miR-130b-3p (MIRT142404)
- hsa-miR-302b-5p (MIRT142406)
- hsa-miR-302d-5p (MIRT142407)
- hsa-miR-373-5p (MIRT142408)
- hsa-miR-382-3p (MIRT142409)
- hsa-miR-20b-5p (MIRT142412)
- hsa-miR-519d-3p (MIRT142422)
- hsa-miR-518a-5p (MIRT142423)
- hsa-miR-527 (MIRT142425)
- hsa-miR-616-5p (MIRT142439)
- hsa-miR-454-3p (MIRT142443)
- hsa-miR-301b-3p (MIRT142449)
- hsa-miR-4295 (MIRT142480)
- hsa-miR-4306 (MIRT142481)
- hsa-miR-3666 (MIRT142494)
- hsa-miR-4468 (MIRT142512)
- hsa-miR-4644 (MIRT142518)
- hsa-miR-371b-5p (MIRT142532)
- hsa-miR-4756-3p (MIRT142534)
- hsa-miR-5584-5p (MIRT142544)
- hsa-miR-5739 (MIRT142547)
- hsa-miR-6501-3p (MIRT142550)
- hsa-miR-6715b-3p (MIRT142553)
- hsa-miR-7150 (MIRT142574)
- hsa-miR-4307 (MIRT194921)
- hsa-miR-369-3p (MIRT194922)
- hsa-miR-374a-5p (MIRT194923)
- hsa-miR-374b-5p (MIRT194926)
- hsa-miR-4528 (MIRT194927)
- hsa-miR-5692c (MIRT194928)
- hsa-miR-5692b (MIRT194929)
- hsa-miR-6076 (MIRT194930)
- hsa-miR-6797-3p (MIRT194931)
- hsa-miR-577 (MIRT194937)
- hsa-miR-607 (MIRT194938)
- hsa-miR-3163 (MIRT194940)
- hsa-miR-3671 (MIRT194941)
- hsa-miR-3942-3p (MIRT194942)
- hsa-miR-5000-5p (MIRT194944)
- hsa-miR-7-5p (MIRT194948)
- hsa-miR-2052 (MIRT194950)
- hsa-miR-5197-3p (MIRT194954)
- hsa-miR-26a-5p (MIRT250410)
- hsa-miR-26b-5p (MIRT250411)
- hsa-miR-190a-5p (MIRT250412)
- hsa-miR-190b (MIRT250414)
- hsa-miR-1297 (MIRT250415)
- hsa-miR-4465 (MIRT250416)
- hsa-miR-5697 (MIRT250417)
- hsa-miR-374b-3p (MIRT343320)
- hsa-miR-6748-5p (MIRT465592)
- hsa-miR-6739-3p (MIRT465593)
- hsa-miR-4677-5p (MIRT465594)
- hsa-miR-7156-5p (MIRT465595)
- hsa-miR-4273 (MIRT465596)
- hsa-miR-582-5p (MIRT465597)
- hsa-miR-2117 (MIRT465598)
- hsa-miR-6766-5p (MIRT465599)
- hsa-miR-6756-5p (MIRT465600)
- hsa-miR-5196-5p (MIRT465601)
- hsa-miR-4747-5p (MIRT465602)
- hsa-miR-4533 (MIRT465603)
- hsa-miR-3934-3p (MIRT465604)
- hsa-miR-548v (MIRT465605)
- hsa-miR-6804-5p (MIRT465606)
- hsa-miR-139-5p (MIRT465607)
- hsa-miR-6856-5p (MIRT465608)
- hsa-miR-6758-5p (MIRT465609)
- hsa-miR-8070 (MIRT465610)
- hsa-miR-3127-5p (MIRT465611)
- hsa-miR-5100 (MIRT465612)
- hsa-miR-6823-5p (MIRT465613)
- hsa-miR-205-3p (MIRT465614)
- hsa-miR-4795-3p (MIRT465615)
- hsa-miR-3200-5p (MIRT465616)
- hsa-miR-33a-3p (MIRT465617)
- hsa-miR-4276 (MIRT465618)
- hsa-miR-922 (MIRT465619)
- hsa-miR-6857-5p (MIRT465620)
- hsa-miR-6763-5p (MIRT465621)
- hsa-miR-3150a-3p (MIRT465622)
- hsa-miR-6810-5p (MIRT465623)
- hsa-miR-143-5p (MIRT465624)
- hsa-miR-3944-5p (MIRT465625)
- hsa-miR-2467-3p (MIRT465626)
- hsa-miR-4272 (MIRT465627)
- hsa-miR-8055 (MIRT500745)
- hsa-miR-138-2-3p (MIRT500746)
- hsa-miR-5096 (MIRT500747)
- hsa-miR-6735-3p (MIRT500748)
- hsa-miR-6878-3p (MIRT500749)
- hsa-miR-6513-5p (MIRT505319)
- hsa-miR-5002-5p (MIRT505320)
- hsa-miR-302c-5p (MIRT533593)
- hsa-miR-182-5p (MIRT533594)
- hsa-miR-96-5p (MIRT533595)
- hsa-miR-1271-5p (MIRT533596)
- hsa-miR-514b-5p (MIRT553462)
- hsa-miR-513c-5p (MIRT553463)
- hsa-miR-3134 (MIRT553464)
- hsa-miR-8082 (MIRT553465)
- hsa-miR-4534 (MIRT553466)
- hsa-miR-372-5p (MIRT553467)
- hsa-miR-371a-5p (MIRT553468)
- mmu-miR-1843a-5p (MIRT580325)
- mmu-miR-1940 (MIRT580326)
- mmu-miR-1958 (MIRT580327)
- mmu-miR-690 (MIRT580328)
- mmu-miR-129-5p (MIRT596936)
- mmu-miR-30a-3p (MIRT734945)
- mmu-miR-30b-3p (MIRT734946)
- mmu-miR-30c-1-3p (MIRT734947)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TNRC6A
- Browse OriGene Inhibitory RNA Products For TNRC6A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNRC6A
Clone products for research
- Applied Biological Materials (abm): Clones for TNRC6A - Starting at $45 >
- * TNRC6A as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Addgene plasmids for TNRC6A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TNRC6A
Cell Lines for research
-
Horizon Cell Lines for TNRC6A
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TNRC6A Gene
Localization for TNRC6A Gene
Subcellular locations from UniProtKB/Swiss-Prot for TNRC6A Gene
- Cytoplasm, P-body. Note=Mammalian P-bodies are also known as GW bodies (GWBs). {ECO:0000305}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| golgi apparatus | 4 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endosome | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
- Vesicles (3)
- Golgi apparatus (2)
- Nucleoplasm (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000932 | P-body | IBA,IDA | 20616046 |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005794 | Golgi apparatus | IDA | -- |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for TNRC6A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
|
| 2 | PI3K/AKT activation |
.89
|
|
| 3 | CDK-mediated phosphorylation and removal of Cdc6 |
.41
|
|
| 4 | Cellular Senescence (REACTOME) | ||
| 5 | Pre-NOTCH Expression and Processing | ||
Pathways by source for TNRC6A Gene
38 Reactome pathways for TNRC6A Gene
Interacting Proteins for TNRC6A Gene
Selected Interacting proteins:
Q8NDV7-TNR6A_HUMAN
ENSP00000379144
for TNRC6A Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for TNRC6A
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006417 | regulation of translation | IEA | -- |
| GO:0007223 | Wnt signaling pathway, calcium modulating pathway | TAS | -- |
| GO:0009267 | cellular response to starvation | IEA | -- |
| GO:0010628 | positive regulation of gene expression | TAS | -- |
| GO:0010629 | negative regulation of gene expression | TAS | -- |
No data available for SIGNOR curated interactions for TNRC6A Gene
Drugs & Compounds for TNRC6A Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Ethanol | Approved | Pharma | 3544 |
Transcripts for TNRC6A Gene
mRNA/cDNA for TNRC6A Gene
- 3 REFSEQ mRNAs :
- 16 NCBI additional mRNA sequence :
- 18 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000315183 8303 nts (view in UCSC)
- ENST00000395799 8491 nts (view in UCSC)
- ENST00000450465 3700 nts (view in UCSC)
- ENST00000462400 2550 nts (view in UCSC)
- ENST00000464539 1853 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for TNRC6A - Starting at $85 >
- * TNRC6A CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for TNRC6A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TNRC6A
-
Santa Cruz Biotechnology (SCBT) CRISPR for TNRC6A
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TNRC6A
- Browse OriGene Inhibitory RNA Products For TNRC6A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNRC6A
Clone products for research
- Applied Biological Materials (abm): Clones for TNRC6A - Starting at $45 >
- * TNRC6A as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Addgene plasmids for TNRC6A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TNRC6A
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | ^ | 16 | ^ | 17a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: |
| ExUns: | 17b | ^ | 18 | ^ | 19a | · | 19b | ^ | 20a | · | 20b | ^ | 21 | ^ | 22a | · | 22b | · | 22c | ^ | 23 | ^ | 24 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||
| SP5: | |||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||
| SP7: | - | - | - | - | - | ||||||||||||||||||
| SP8: | |||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||
| SP11: |
Relevant External Links for TNRC6A Gene
- GeneLoc Exon Structure for
- TNRC6A
Expression for TNRC6A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
- Lung (Respiratory System)
-
Somite (Muscoskeletal System)
- Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
- Eye (Sensory Organs)
This gene is overexpressed in Plasma (39.5) and Monocytes (24.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TNRC6A Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TNRC6A
SOURCE GeneReport for Unigene cluster for TNRC6A Gene:
Hs.655057mRNA Expression by UniProt/SwissProt for TNRC6A Gene:
Q8NDV7-TNR6A_HUMAN
Tissue specificity:
Ubiquitous.
Evidence on tissue expression from TISSUES for TNRC6A Gene
- Nervous system(4.8)
- Kidney(4.5)
- Stomach(4.4)
- Liver(2.6)
- Skin(2.5)
- Lung(2.3)
- Intestine(2.3)
- Muscle(2.2)
- Heart(2.2)
- Spleen(2.1)
- Lymph node(2)
Primer products for research
-
OriGene qPCR primer pairs for TNRC6A
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNRC6A Gene
Orthologs for TNRC6A Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TNRC6A 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | TNRC6A 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | TNRC6A 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Tnrc6a 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Tnrc6a 29 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | TNRC6A 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | TNRC6A 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | TNRC6A 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | TNRC6A 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tnrc6a 29 |
|
||
| Str.20381 29 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.19158 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | TNRC6A 30 |
|
OneToOne | |
| Dr.18336 29 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.3119 29 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | gw 30 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 30 |
|
OneToMany |
- Species where no ortholog for TNRC6A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for TNRC6A Gene
- ENSEMBL:
- Gene Tree for TNRC6A (if available)
- TreeFam:
- Gene Tree for TNRC6A (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TNRC6A: view image
- Alliance of Genome Resources:
- Additional Orthologs for TNRC6A
Paralogs for TNRC6A Gene
Variants for TNRC6A Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TNRC6A Gene
| SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs117821015 | Benign: not provided | 24,777,228(+) |
G/A NM_014494.4(TNRC6A):c.459G>A (p.Gln153=) |
SYNONYMOUS | |
| rs11859919 | Benign: not provided | 24,806,293(+) |
G/A NM_014494.4(TNRC6A):c.4329+10G>A |
INTRON | |
| rs138756937 | Likely Benign: not provided | 24,823,629(+) |
G/A NM_014494.4(TNRC6A):c.5711G>A (p.Gly1904Glu) |
MISSENSE | |
| rs139212478 | Benign: not provided | 24,791,045(+) |
G/A NM_014494.4(TNRC6A):c.2403G>A (p.Gln801=) |
SYNONYMOUS | |
| rs139403173 | Benign: not provided | 24,791,651(+) |
T/C NM_014494.4(TNRC6A):c.3009T>C (p.Asp1003=) |
SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3638258 | CNV | loss | 21293372 |
| nsv1113770 | CNV | deletion | 24896259 |
| nsv1144765 | CNV | deletion | 24896259 |
Residual Variation Intolerance Score:
4.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
13.94;
95.96% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TNRC6A Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNRC6A Gene
Disorders for TNRC6A Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| epilepsy, familial adult myoclonic, 6 |
|
|
| cervical non-keratinizing squamous cell carcinoma |
|
|
| familial adult myoclonic epilepsy |
|
|
| epilepsy, familial adult myoclonic, 2 |
|
|
| granulomatous disease, chronic, autosomal recessive, 3 |
|
|
Search TNRC6A in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
TNR6A_HUMAN- Epilepsy, familial adult myoclonic, 6 (FAME6) [MIM:618074]: A form of familial myoclonic epilepsy, a neurologic disorder characterized by cortical hand tremors, myoclonic jerks and occasional generalized or focal seizures with a non-progressive or very slowly progressive disease course. Usually, myoclonic tremor is the presenting symptom, characterized by tremulous finger movements and myoclonic jerks of the limbs increased by action and posture. In a minority of patients, seizures are the presenting symptom. Some patients exhibit mild cognitive impairment. FAME6 inheritance is autosomal dominant. {ECO:0000269 PubMed:29507423}. Note=The disease is caused by variants affecting the gene represented in this entry.
Additional Disease Information for TNRC6A
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for Genatlas for TNRC6A Gene
Publications for TNRC6A Gene
- Disruption of GW bodies impairs mammalian RNA interference. (PMID: 16284622) Jakymiw A … Chan EK (Nature cell biology 2005) 3 4 22
- Clinical and serological associations of autoantibodies to GW bodies and a novel cytoplasmic autoantigen GW182. (PMID: 14598044) Eystathioy T … Fritzler MJ (Journal of molecular medicine (Berlin, Germany) 2003) 3 4 22
- The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies. (PMID: 13130130) Eystathioy T … Fritzler MJ (RNA (New York, N.Y.) 2003) 3 4 22
- cDNAs with long CAG trinucleotide repeats from human brain. (PMID: 9225980) Margolis RL … Ross CA (Human genetics 1997) 2 3 4
- High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies. (PMID: 29395067) Youn JY … Gingras AC (Molecular cell 2018) 3 4
ExternalLinks
Products for TNRC6A Gene
- Custom Antibody ServicesOriGene Antibodies for TNRC6A
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for TNRC6A
- Origene Custom Protein Services for TNRC6A
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TNRC6A
- Browse OriGene Inhibitory RNA Products For TNRC6A
- OriGene qPCR primer pairs for TNRC6A
- OriGene CRISPR knockouts for TNRC6A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TNRC6A
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- Browse Sino Biological Assays
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- Novus Biologicals proteins for TNRC6A
- Browse Antibodies
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- Invitrogen Antibodies for TNRC6A (AFLGC-TNRC6A)
- VectorBuilder Custom and pre-made DNA vectors for TNRC6A (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for TNRC6A (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for TNRC6A (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for TNRC6A CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for TNRC6A
- Addgene plasmids for TNRC6A
- antibodies-online: Search results for available TNRC6A related products ranked by validation data
- antibodies-online: Search results for available TNRC6A related products ranked by validation data
- antibodies-online: Search results for available TNRC6A related products ranked by validation data
- Santa Cruz Biotechnology (SCBT) Antibodies for TNRC6A
- Search Santa Cruz Biotechnology (SCBT) for TNRC6A siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TNRC6A
- Horizon Cell Lines for TNRC6A
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TNRC6A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TNRC6A
- Search GeneCopoeia for miRNA 3'UTR Target clone products for TNRC6A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNRC6A
- Boster Bio Antibodies for TNRC6A
- Browse Boster Bio ELISA Kits
Sources for TNRC6A Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources