Aliases for TNRC6A Gene
Aliases for TNRC6A Gene
External Ids for TNRC6A Gene
- HGNC: 11969
- Entrez Gene: 27327
- Ensembl: ENSG00000090905
- OMIM: 610739
- UniProtKB: Q8NDV7
Previous HGNC Symbols for TNRC6A Gene
- TNRC6
Previous GeneCards Identifiers for TNRC6A Gene
- GC16P024741
- GC16P022832
Summaries for TNRC6A Gene
-
This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. [provided by RefSeq, Jul 2008]
GeneCards Summary for TNRC6A Gene
TNRC6A (Trinucleotide Repeat Containing 6A) is a Protein Coding gene. Among its related pathways are Gene Expression and Mitotic Prophase. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is TNRC6C.
UniProtKB/Swiss-Prot for TNRC6A Gene
-
Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes.
Additional gene information for TNRC6A Gene
- Monarch Initiative
- Search for TNRC6A at DataMed
- Search for TNRC6A at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNRC6A Gene
Genomics for TNRC6A Gene
GeneHancer (GH) Regulatory Elements for TNRC6A Gene
Promoters and enhancers for TNRC6A Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH16J024776 | Promoter/Enhancer | 1.2 | EPDnew ENCODE dbSUPER | 650.1 | +167.0 | 166953 | 2.2 | SP1 JUND HNF4A REST | GC16M024776 TNRC6A SLC5A11 LINC01567 | |
| GH16J024609 | Enhancer | 0.9 | Ensembl ENCODE | 650.7 | -0.3 | -304 | 0.2 | SIN3A ZNF335 POLR2A PATZ1 SCRT2 ZBTB20 L3MBTL2 ZNF398 ZNF518A OSR2 | TNRC6A RBBP6 | |
| GH16J024610 | Enhancer | 0.9 | Ensembl ENCODE | 650.7 | +0.3 | 271 | 0.6 | MXI1 USF1 MAX SIN3A CEBPG ZNF335 POLR2A PATZ1 PRDM10 L3MBTL2 | TNRC6A LINC01567 | |
| GH16J024699 | Enhancer | 1.1 | Ensembl ENCODE | 12.2 | +91.1 | 91119 | 3 | FOXA2 NFIB SIN3A BATF RAD21 RFX5 EGR1 SMARCC2 RCOR1 FOS | SLC5A11 TNRC6A LINC01567 GC16M024776 | |
| GH16J024838 | Enhancer | 1.4 | Ensembl ENCODE dbSUPER | 5.7 | +228.8 | 228786 | 1.5 | ATF1 FOXA2 ARNT ARID4B TCF12 GATA2 E2F8 FOS ATF7 RXRA | TNRC6A SLC5A11 ENSG00000261669 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TNRC6A on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the TNRC6A gene promoter:
Regulatory Element Products
Genomic Locations for TNRC6A Gene
Genomic Locations for TNRC6A Gene
- chr16:24,610,209-24,827,632
- (GRCh38/hg38)
- Size:
- 217,424 bases
- Orientation:
- Plus strand
- chr16:24,741,016-24,838,953
- (GRCh37/hg19)
Genomic View for TNRC6A Gene
Genes around TNRC6A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p12.1 by Entrez Gene
- 16p12.1 by HGNC
- 16p12.1 by Ensembl
TNRC6A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TNRC6A Gene
Proteins for TNRC6A Gene
-
Protein details for TNRC6A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NDV7-TNR6A_HUMAN
- Recommended name:
- Trinucleotide repeat-containing gene 6A protein
- Protein Accession:
- Q8NDV7
- C9JAR8
- O15408
- Q658L5
- Q6NVB5
- Q8NEZ0
- Q8TBT8
- Q8TCR0
- Q9NV59
- Q9P268
Protein attributes for TNRC6A Gene
- Size:
- 1962 amino acids
- Molecular mass:
- 210297 Da
- Quaternary structure:
-
- Interacts with AGO2 (PubMed:16284623, PubMed:16284622, PubMed:18690212, PubMed:19304925, PubMed:19324964, PubMed:19383768). Interacts with AGO1, AGO3 and AGO4 (PubMed:19324964, PubMed:19383768). Interacts with CNOT1; the interaction is direct and mediates the association with the CCR4-NOT complex (PubMed:21981923). Interacts with ZC3H12A (PubMed:26134560).
- Miscellaneous:
-
- Antibodies against TNRC6A are found in sera from patients with Sjoegren syndrome (SS), ataxia and sensor neuropathy diseases that developed autoantibodies against protein of the GWB structure. Autoantibodies were mapped to the GW-rich mid-part, the non-GW-rich region and the C-terminus of the protein.
- SequenceCaution:
-
- Sequence=BAA91899.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAD28525.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for TNRC6A Gene
Post-translational modifications for TNRC6A Gene
Other Protein References for TNRC6A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for TNRC6A
- Novus Biologicals Antibodies for TNRC6A
- Invitrogen Antibodies for TNRC6A
- GeneTex TNRC6A Antibody for TNRC6A
-
Boster Bio Antibodies for TNRC6A
-
Santa Cruz Biotechnology (SCBT) Antibodies for TNRC6A
- Sino Biological Antibodies for TNRC6A
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for TNRC6A
- Origene Custom Protein Services for TNRC6A
- Search GeneTex for Proteins for TNRC6A
Assay Products
No data available for DME Specific Peptides for TNRC6A Gene
Domains & Families for TNRC6A Gene
Gene Families for TNRC6A Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for TNRC6A Gene
Suggested Antigen Peptide Sequences for TNRC6A Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8NDV7- Family:
-
- Belongs to the GW182 family.
Function for TNRC6A Gene
Molecular function for TNRC6A Gene
- UniProtKB/Swiss-Prot Function:
- Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes.
- UniProtKB/Swiss-Prot Induction:
- By exogenous short interfering RNA (siRNA).
Phenotypes From GWAS Catalog for TNRC6A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003723 | RNA binding | HDA,IEA | 22681889 |
| GO:0005515 | protein binding | IPI | 19167051 |
Phenotypes for TNRC6A Gene
- MGI mutant phenotypes for TNRC6A:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for TNRC6A:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TNRC6A
-
CRISPR Products
-
OriGene CRISPR knockouts for TNRC6A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TNRC6A
- genomics-online: gRNA clones - Search results for available TNRC6A gene related products
- Applied Biological Materials CRISPR for TNRC6A
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TNRC6A
- GenScript: Design CRISPR guide RNA sequences for TNRC6A
miRNA for TNRC6A Gene
- miRTarBase miRNAs that target TNRC6A
-
- hsa-mir-30a-5p (MIRT004785)
- hsa-mir-361-5p (MIRT020089)
- hsa-mir-148a-3p (MIRT026015)
- hsa-let-7d-5p (MIRT032154)
- hsa-mir-484 (MIRT041866)
- hsa-mir-320a (MIRT044774)
- hsa-mir-30c-5p (MIRT047876)
- hsa-mir-23a-3p (MIRT050426)
- hsa-mir-520g-3p (MIRT074319)
- hsa-mir-520h (MIRT074320)
- hsa-mir-450a-2-3p (MIRT074321)
- hsa-mir-570-3p (MIRT074322)
- hsa-mir-3123 (MIRT074324)
- hsa-mir-3148 (MIRT074325)
- hsa-mir-3662 (MIRT074326)
- hsa-mir-3678-3p (MIRT074327)
- hsa-mir-3919 (MIRT074328)
- hsa-mir-3925-5p (MIRT074329)
- hsa-mir-4668-5p (MIRT074330)
- hsa-mir-4796-3p (MIRT074331)
- hsa-mir-6124 (MIRT074332)
- hsa-mir-30c-2-3p (MIRT074333)
- hsa-mir-23b-3p (MIRT074334)
- hsa-mir-30b-3p (MIRT074335)
- hsa-mir-122-5p (MIRT074336)
- hsa-mir-130a-5p (MIRT074337)
- hsa-mir-30c-1-3p (MIRT074338)
- hsa-mir-887-5p (MIRT074342)
- hsa-mir-3121-3p (MIRT074343)
- hsa-mir-23c (MIRT074344)
- hsa-mir-3689a-3p (MIRT074345)
- hsa-mir-3689b-3p (MIRT074346)
- hsa-mir-3935 (MIRT074347)
- hsa-mir-3689c (MIRT074348)
- hsa-mir-6779-5p (MIRT074351)
- hsa-mir-6780a-5p (MIRT074352)
- hsa-mir-6782-3p (MIRT074353)
- hsa-mir-6788-5p (MIRT074354)
- hsa-mir-1273h-5p (MIRT074355)
- hsa-mir-548e-5p (MIRT074362)
- hsa-mir-30d-5p (MIRT074375)
- hsa-mir-30b-5p (MIRT074376)
- hsa-mir-30e-5p (MIRT074378)
- hsa-mir-1252-3p (MIRT074381)
- hsa-mir-3646 (MIRT074382)
- hsa-mir-6077 (MIRT074383)
- hsa-mir-3122 (MIRT074388)
- hsa-mir-3913-5p (MIRT074392)
- hsa-mir-152-3p (MIRT074396)
- hsa-mir-148b-3p (MIRT074397)
- hsa-mir-193b-5p (MIRT074398)
- hsa-mir-548n (MIRT074400)
- hsa-mir-548t-5p (MIRT074401)
- hsa-mir-3170 (MIRT074402)
- hsa-mir-4259 (MIRT074403)
- hsa-mir-4260 (MIRT074404)
- hsa-mir-3668 (MIRT074405)
- hsa-mir-3942-5p (MIRT074406)
- hsa-mir-4703-5p (MIRT074408)
- hsa-mir-5094 (MIRT074409)
- hsa-mir-5572 (MIRT074410)
- hsa-mir-548az-5p (MIRT074412)
- hsa-mir-6737-5p (MIRT074413)
- hsa-mir-6812-5p (MIRT074414)
- hsa-mir-6819-5p (MIRT074415)
- hsa-mir-6855-5p (MIRT074416)
- hsa-mir-7852-3p (MIRT074417)
- hsa-mir-4252 (MIRT074425)
- hsa-mir-4482-3p (MIRT074439)
- hsa-mir-224-5p (MIRT074442)
- hsa-mir-299-5p (MIRT074443)
- hsa-mir-409-3p (MIRT074444)
- hsa-mir-652-3p (MIRT115494)
- hsa-mir-8074 (MIRT115495)
- hsa-mir-6083 (MIRT115500)
- hsa-mir-17-5p (MIRT142375)
- hsa-mir-19a-3p (MIRT142377)
- hsa-mir-19b-3p (MIRT142379)
- hsa-mir-20a-5p (MIRT142381)
- hsa-mir-93-5p (MIRT142384)
- hsa-mir-130a-3p (MIRT142395)
- hsa-mir-185-5p (MIRT142400)
- hsa-mir-106b-5p (MIRT142401)
- hsa-mir-301a-3p (MIRT142403)
- hsa-mir-130b-3p (MIRT142404)
- hsa-mir-302b-5p (MIRT142406)
- hsa-mir-302d-5p (MIRT142407)
- hsa-mir-373-5p (MIRT142408)
- hsa-mir-382-3p (MIRT142409)
- hsa-mir-20b-5p (MIRT142412)
- hsa-mir-519d-3p (MIRT142422)
- hsa-mir-518a-5p (MIRT142423)
- hsa-mir-527 (MIRT142425)
- hsa-mir-616-5p (MIRT142439)
- hsa-mir-454-3p (MIRT142443)
- hsa-mir-301b-3p (MIRT142449)
- hsa-mir-4295 (MIRT142480)
- hsa-mir-4306 (MIRT142481)
- hsa-mir-3666 (MIRT142494)
- hsa-mir-4468 (MIRT142512)
- hsa-mir-4644 (MIRT142518)
- hsa-mir-371b-5p (MIRT142532)
- hsa-mir-4756-3p (MIRT142534)
- hsa-mir-5584-5p (MIRT142544)
- hsa-mir-5739 (MIRT142547)
- hsa-mir-6501-3p (MIRT142550)
- hsa-mir-6715b-3p (MIRT142553)
- hsa-mir-7150 (MIRT142574)
- hsa-mir-4307 (MIRT194921)
- hsa-mir-369-3p (MIRT194922)
- hsa-mir-374a-5p (MIRT194923)
- hsa-mir-374b-5p (MIRT194926)
- hsa-mir-4528 (MIRT194927)
- hsa-mir-5692c (MIRT194928)
- hsa-mir-5692b (MIRT194929)
- hsa-mir-6076 (MIRT194930)
- hsa-mir-6797-3p (MIRT194931)
- hsa-mir-577 (MIRT194937)
- hsa-mir-607 (MIRT194938)
- hsa-mir-3163 (MIRT194940)
- hsa-mir-3671 (MIRT194941)
- hsa-mir-3942-3p (MIRT194942)
- hsa-mir-5000-5p (MIRT194944)
- hsa-mir-7-5p (MIRT194948)
- hsa-mir-2052 (MIRT194950)
- hsa-mir-5197-3p (MIRT194954)
- hsa-mir-26a-5p (MIRT250410)
- hsa-mir-26b-5p (MIRT250411)
- hsa-mir-190a-5p (MIRT250412)
- hsa-mir-190b (MIRT250414)
- hsa-mir-1297 (MIRT250415)
- hsa-mir-4465 (MIRT250416)
- hsa-mir-5697 (MIRT250417)
- hsa-mir-374b-3p (MIRT343320)
- hsa-mir-6748-5p (MIRT465592)
- hsa-mir-6739-3p (MIRT465593)
- hsa-mir-4677-5p (MIRT465594)
- hsa-mir-7156-5p (MIRT465595)
- hsa-mir-4273 (MIRT465596)
- hsa-mir-582-5p (MIRT465597)
- hsa-mir-2117 (MIRT465598)
- hsa-mir-6766-5p (MIRT465599)
- hsa-mir-6756-5p (MIRT465600)
- hsa-mir-5196-5p (MIRT465601)
- hsa-mir-4747-5p (MIRT465602)
- hsa-mir-4533 (MIRT465603)
- hsa-mir-3934-3p (MIRT465604)
- hsa-mir-548v (MIRT465605)
- hsa-mir-6804-5p (MIRT465606)
- hsa-mir-139-5p (MIRT465607)
- hsa-mir-6856-5p (MIRT465608)
- hsa-mir-6758-5p (MIRT465609)
- hsa-mir-8070 (MIRT465610)
- hsa-mir-3127-5p (MIRT465611)
- hsa-mir-5100 (MIRT465612)
- hsa-mir-6823-5p (MIRT465613)
- hsa-mir-205-3p (MIRT465614)
- hsa-mir-4795-3p (MIRT465615)
- hsa-mir-3200-5p (MIRT465616)
- hsa-mir-33a-3p (MIRT465617)
- hsa-mir-4276 (MIRT465618)
- hsa-mir-922 (MIRT465619)
- hsa-mir-6857-5p (MIRT465620)
- hsa-mir-6763-5p (MIRT465621)
- hsa-mir-3150a-3p (MIRT465622)
- hsa-mir-6810-5p (MIRT465623)
- hsa-mir-143-5p (MIRT465624)
- hsa-mir-3944-5p (MIRT465625)
- hsa-mir-2467-3p (MIRT465626)
- hsa-mir-4272 (MIRT465627)
- hsa-mir-8055 (MIRT500745)
- hsa-mir-138-2-3p (MIRT500746)
- hsa-mir-5096 (MIRT500747)
- hsa-mir-6735-3p (MIRT500748)
- hsa-mir-6878-3p (MIRT500749)
- hsa-mir-6513-5p (MIRT505319)
- hsa-mir-5002-5p (MIRT505320)
- hsa-mir-302c-5p (MIRT533593)
- hsa-mir-182-5p (MIRT533594)
- hsa-mir-96-5p (MIRT533595)
- hsa-mir-1271-5p (MIRT533596)
- hsa-mir-514b-5p (MIRT553462)
- hsa-mir-513c-5p (MIRT553463)
- hsa-mir-3134 (MIRT553464)
- hsa-mir-8082 (MIRT553465)
- hsa-mir-4534 (MIRT553466)
- hsa-mir-372-5p (MIRT553467)
- hsa-mir-371a-5p (MIRT553468)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TNRC6A
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNRC6A
- genomics-online: shRNA clones - Search results for available TNRC6A gene related products
Clone Products
-
OriGene ORF clones in human for TNRC6A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- VectorBuilder custom plasmid, inducible vectors for TNRC6A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TNRC6A
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TNRC6A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TNRC6A
- genomics-online: cdna clones - Search results for available TNRC6A gene related products
- orf clones - Search results for available TNRC6A gene related products
- Applied Biological Materials Clones for TNRC6A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for TNRC6A
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TNRC6A Gene
Localization for TNRC6A Gene
Subcellular locations from UniProtKB/Swiss-Prot for TNRC6A Gene
- Cytoplasm, P-body. Note=Mammalian P-bodies are also known as GW bodies (GWBs). {ECO:0000305}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| golgi apparatus | 5 |
| lysosome | 1 |
| endosome | 1 |
- Vesicles (3)
- Golgi apparatus (2)
- Nucleoplasm (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000932 | P-body | IDA | 20616046 |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005794 | Golgi apparatus | IDA | -- |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for TNRC6A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
|
| 2 | PI3K/AKT activation |
.89
|
|
| 3 | CDK-mediated phosphorylation and removal of Cdc6 |
.41
|
|
| 4 | Cellular Senescence (REACTOME) | ||
| 5 | Pre-NOTCH Expression and Processing | ||
Pathways by source for TNRC6A Gene
38 Reactome pathways for TNRC6A Gene
Interacting Proteins for TNRC6A Gene
Selected Interacting proteins:
Q8NDV7-TNR6A_HUMAN
ENSP00000379144
for TNRC6A Gene via
IID
UniProtKB
STRING
MINT
GPS-Prot Interaction Network for TNRC6A
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006417 | regulation of translation | IEA | -- |
| GO:0007223 | Wnt signaling pathway, calcium modulating pathway | TAS | -- |
| GO:0031047 | gene silencing by RNA | IEA | -- |
| GO:0035194 | posttranscriptional gene silencing by RNA | TAS | -- |
| GO:0035195 | gene silencing by miRNA | IMP | 23172285 |
No data available for SIGNOR curated interactions for TNRC6A Gene
Transcripts for TNRC6A Gene
mRNA/cDNA for TNRC6A Gene
- (281) Selected AceView cDNA sequences:
- (13) Additional mRNA sequences :
- (15) REFSEQ mRNAs :
- (18) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000315183 8303 bps (uc059sfi.1)
- ENST00000395799 8438 bps (uc002dmm.4)
- ENST00000450465 3700 bps (uc059sfl.1)
- ENST00000462400 2550 bps (uc059sfr.1)
- ENST00000464539 1853 bps (uc059sfx.1)
Unigene Clusters for TNRC6A Gene
- Trinucleotide repeat containing 6A:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for TNRC6A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TNRC6A
- genomics-online: gRNA clones - Search results for available TNRC6A gene related products
- Applied Biological Materials CRISPR for TNRC6A
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TNRC6A
- GenScript: Design CRISPR guide RNA sequences for TNRC6A
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TNRC6A
- Browse OriGene Inhibitory RNA Products For TNRC6A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNRC6A
- genomics-online: shRNA clones - Search results for available TNRC6A gene related products
Clone Products
-
OriGene ORF clones in human for TNRC6A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- VectorBuilder custom plasmid, inducible vectors for TNRC6A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TNRC6A
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TNRC6A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TNRC6A
- genomics-online: cdna clones - Search results for available TNRC6A gene related products
- orf clones - Search results for available TNRC6A gene related products
- Applied Biological Materials Clones for TNRC6A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | ^ | 16 | ^ | 17a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| SP11: |
| ExUns: | 17b | ^ | 18 | ^ | 19a | · | 19b | ^ | 20a | · | 20b | ^ | 21 | ^ | 22a | · | 22b | · | 22c | ^ | 23 | ^ | 24 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||
| SP5: | |||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||
| SP7: | - | - | - | - | - | ||||||||||||||||||
| SP8: | |||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||
| SP11: |
Expression for TNRC6A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
- Lung (Respiratory System)
-
Somite (Muscoskeletal System)
- Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
- Eye (Sensory Organs)
This gene is overexpressed in Plasma (39.5) and Monocytes (24.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TNRC6A Gene
NURSA nuclear receptor signaling pathways regulating expression of TNRC6A Gene:
TNRC6ASOURCE GeneReport for Unigene cluster for TNRC6A Gene:
Hs.655057mRNA Expression by UniProt/SwissProt for TNRC6A Gene:
Q8NDV7-TNR6A_HUMAN
Tissue specificity:
Ubiquitous.
Evidence on tissue expression from TISSUES for TNRC6A Gene
- Nervous system(4.7)
- Kidney(4.3)
- Stomach(4.3)
Primer Products
-
OriGene qPCR primer pairs for TNRC6A
- genomics-online: primer clones - Search results for available TNRC6A gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNRC6A Gene
Orthologs for TNRC6A Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TNRC6A 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | TNRC6A 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | TNRC6A 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Tnrc6a 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Tnrc6a 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | TNRC6A 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | TNRC6A 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TNRC6A 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | TNRC6A 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tnrc6a 33 |
|
||
| Str.20381 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.19158 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | TNRC6A 34 |
|
OneToOne | |
| Dr.18336 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.3119 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | gw 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for TNRC6A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for TNRC6A Gene
- ENSEMBL:
- Gene Tree for TNRC6A (if available)
- TreeFam:
- Gene Tree for TNRC6A (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TNRC6A: view image
Paralogs for TNRC6A Gene
Variants for TNRC6A Gene
| SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000004791 | -- | 24,807,686(+) | G/T | intron_variant | |
| rs1000018929 | -- | 24,739,260(+) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000023206 | -- | 24,700,246(+) | T/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000027513 | -- | 24,725,127(+) | A/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000049551 | -- | 24,660,238(+) | T/C | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3638258 | CNV | loss | 21293372 |
| nsv1113770 | CNV | deletion | 24896259 |
| nsv1144765 | CNV | deletion | 24896259 |
Residual Variation Intolerance Score:
4.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
13.94;
95.96% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TNRC6A Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNRC6A Gene
Disorders for TNRC6A Gene
Additional Disease Information for TNRC6A
No disorders were found for TNRC6A Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNRC6A Gene
Publications for TNRC6A Gene
- Disruption of GW bodies impairs mammalian RNA interference. (PMID: 16284622) Jakymiw A … Chan EK (Nature cell biology 2005) 3 4 22 58
- Clinical and serological associations of autoantibodies to GW bodies and a novel cytoplasmic autoantigen GW182. (PMID: 14598044) Eystathioy T … Fritzler MJ (Journal of molecular medicine (Berlin, Germany) 2003) 3 4 22 58
- The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies. (PMID: 13130130) Eystathioy T … Fritzler MJ (RNA (New York, N.Y.) 2003) 3 4 22 58
- cDNAs with long CAG trinucleotide repeats from human brain. (PMID: 9225980) Margolis RL … Ross CA (Human genetics 1997) 2 3 4 58
- Monocyte Chemotactic Protein-induced Protein 1 and 4 Form a Complex but Act Independently in Regulation of Interleukin-6 mRNA Degradation. (PMID: 26134560) Huang S … Fu M (The Journal of biological chemistry 2015) 3 4 58
Products for TNRC6A Gene
- Browse R&D Systems for Antibodies
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- Custom Antibody ServicesOriGene Antibodies for TNRC6A
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for TNRC6A
- Origene Custom Protein Services for TNRC6A
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TNRC6A
- Browse OriGene Inhibitory RNA Products For TNRC6A
- OriGene qPCR primer pairs for TNRC6A
- OriGene CRISPR knockouts for TNRC6A
- OriGene ORF clones in human for TNRC6A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TNRC6A
- GenScript: Next-day shipping of latest version cDNA ORF clones for TNRC6A in any vector
- GenScript Custom Purified and Recombinant Proteins Services for TNRC6A
- GenScript Custom Assay Services for TNRC6A
- GenScript Custom overexpressing Cell Line Services for TNRC6A
- GenScript: Design CRISPR guide RNA sequences for TNRC6A
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for TNRC6A
- Browse Sino Biological cDNA Clones
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- Sino Biological Antibodies for TNRC6A
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- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for TNRC6A
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
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- VectorBuilder custom plasmid, inducible vectors for TNRC6A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TNRC6A
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TNRC6A
- antibodies-online: Search results for available TNRC6A related products ranked by validation data
- antibodies-online: Search results for available TNRC6A related products ranked by validation data
- antibodies-online: Search results for available TNRC6A related products ranked by validation data
- GeneTex TNRC6A Antibody for TNRC6A
- Search GeneTex for Proteins for TNRC6A
- Santa Cruz Biotechnology (SCBT) Antibodies for TNRC6A
- Search Santa Cruz Biotechnology (SCBT) for TNRC6A siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TNRC6A
- Horizon Cell Lines for TNRC6A
- genomics-online: cdna clones - Search results for available TNRC6A gene related products
- orf clones - Search results for available TNRC6A gene related products
- genomics-online: gRNA clones - Search results for available TNRC6A gene related products
- genomics-online: primer clones - Search results for available TNRC6A gene related products
- genomics-online: shRNA clones - Search results for available TNRC6A gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TNRC6A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TNRC6A
- GeneCopoeia miRNA 3'UTR Target clone products for TNRC6A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNRC6A
- Boster Bio Antibodies for TNRC6A
- Browse Boster Bio ELISA Kits
Sources for TNRC6A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio