Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. [provided by RefSeq, Jul 2008]
TNRC6A (Trinucleotide Repeat Containing Adaptor 6A) is a Protein Coding gene. Diseases associated with TNRC6A include Epilepsy, Familial Adult Myoclonic, 6 and Cervical Non-Keratinizing Squamous Cell Carcinoma. Among its related pathways are Downstream signaling events of B Cell Receptor (BCR) and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is TNRC6C.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003723 | RNA binding | IEA,HDA | 22681889 |
GO:0005515 | protein binding | IPI | 19167051 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000932 | P-body | IBA,IDA | 20616046 |
GO:0005654 | nucleoplasm | IDA,TAS | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005794 | Golgi apparatus | IDA | -- |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling |
.92
|
|
2 | GAB1 signalosome |
.89
|
|
3 | CDK-mediated phosphorylation and removal of Cdc6 |
.41
|
|
4 | Cellular Senescence (REACTOME) | ||
5 | Pre-NOTCH Expression and Processing |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006417 | regulation of translation | IEA | -- |
GO:0007223 | Wnt signaling pathway, calcium modulating pathway | TAS | -- |
GO:0009267 | cellular response to starvation | IEA | -- |
GO:0010628 | positive regulation of gene expression | TAS | -- |
GO:0010629 | negative regulation of gene expression | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Ethanol | Approved | Pharma | 3481 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | ^ | 16 | ^ | 17a | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: |
ExUns: | 17b | ^ | 18 | ^ | 19a | · | 19b | ^ | 20a | · | 20b | ^ | 21 | ^ | 22a | · | 22b | · | 22c | ^ | 23 | ^ | 24 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||
SP5: | |||||||||||||||||||||||
SP6: | |||||||||||||||||||||||
SP7: | - | - | - | - | - | ||||||||||||||||||
SP8: | |||||||||||||||||||||||
SP9: | |||||||||||||||||||||||
SP10: | |||||||||||||||||||||||
SP11: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TNRC6A 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TNRC6A 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TNRC6A 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Tnrc6a 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Tnrc6a 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | TNRC6A 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | TNRC6A 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | TNRC6A 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | TNRC6A 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tnrc6a 30 |
|
||
Str.20381 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.19158 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | TNRC6A 31 |
|
OneToOne | |
Dr.18336 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.3119 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | gw 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs117821015 | Benign: not provided | 24,777,228(+) |
G/A NM_014494.4(TNRC6A):c.459G>A (p.Gln153=) |
SYNONYMOUS | |
rs11859919 | Benign: not provided | 24,806,293(+) |
G/A NM_014494.4(TNRC6A):c.4329+10G>A |
INTRON | |
rs138756937 | Likely Benign: not provided | 24,823,629(+) |
G/A NM_014494.4(TNRC6A):c.5711G>A (p.Gly1904Glu) |
MISSENSE | |
rs139212478 | Benign: not provided | 24,791,045(+) |
G/A NM_014494.4(TNRC6A):c.2403G>A (p.Gln801=) |
SYNONYMOUS | |
rs139403173 | Benign: not provided | 24,791,651(+) |
T/C NM_014494.4(TNRC6A):c.3009T>C (p.Asp1003=) |
SYNONYMOUS |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3638258 | CNV | loss | 21293372 |
nsv1113770 | CNV | deletion | 24896259 |
nsv1144765 | CNV | deletion | 24896259 |
Disorder | Aliases | PubMed IDs |
---|---|---|
epilepsy, familial adult myoclonic, 6 |
|
|
cervical non-keratinizing squamous cell carcinoma |
|
|
familial adult myoclonic epilepsy |
|
|
granulomatous disease, chronic, autosomal recessive, 3 |
|
|
epilepsy |
|
|