Aliases for TNPO3 Gene
External Ids for TNPO3 Gene
Previous HGNC Symbols for TNPO3 Gene
Previous GeneCards Identifiers for TNPO3 Gene
The protein encoded by this gene is a nuclear import receptor for serine/arginine-rich (SR) proteins such as the splicing factors SFRS1 and SFRS2. The encoded protein has also been shown to be involved in HIV-1 infection, apparently through interaction with the HIV-1 capsid protein. Two transcript variants encoding different isoforms as well as a noncoding transcript have been found for this gene.[provided by RefSeq, Jul 2010]
GeneCards Summary for TNPO3 Gene
TNPO3 (Transportin 3) is a Protein Coding gene. Diseases associated with TNPO3 include Muscular Dystrophy, Limb-Girdle, Autosomal Dominant 2 and Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2Q. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is IPO13.
UniProtKB/Swiss-Prot Summary for TNPO3 Gene
Seems to function in nuclear protein import as nuclear transport receptor. In vitro, mediates the nuclear import of splicing factor SR proteins RBM4, SFRS1 and SFRS2, by recognizing phosphorylated RS domains.