The protein encoded by this gene is a nuclear import receptor for serine/arginine-rich (SR) proteins such as the splicing factors SFRS1 and SFRS2. The encoded protein has also been shown to be involved in HIV-1 infection, apparently through interaction with the HIV-1 capsid protein. Several protein-coding and non-coding transcript variants have been found for this gene. [provid... See more...

Aliases for TNPO3 Gene

Aliases for TNPO3 Gene

  • Transportin 3 2 3 5
  • TRN-SR 2 3 4
  • IPO12 2 3 4
  • Limb Girdle Muscular Dystrophy 1F (Autosomal Dominant) 2 3
  • Transportin-SR 3 4
  • Transportin-3 3 4
  • Importin 12 2 3
  • TRN-SR2 2 3
  • MTR10A 2 3
  • Imp12 3 4
  • Importin-12 4
  • LGMD1F 3
  • LGMDD2 3
  • TRNSR 3
  • TNPO3 5

External Ids for TNPO3 Gene

Previous HGNC Symbols for TNPO3 Gene

  • LGMD1F

Previous GeneCards Identifiers for TNPO3 Gene

  • GC07M128149
  • GC07M128148
  • GC07M128188
  • GC07M128382
  • GC07M128594
  • GC07M122955

Summaries for TNPO3 Gene

Entrez Gene Summary for TNPO3 Gene

  • The protein encoded by this gene is a nuclear import receptor for serine/arginine-rich (SR) proteins such as the splicing factors SFRS1 and SFRS2. The encoded protein has also been shown to be involved in HIV-1 infection, apparently through interaction with the HIV-1 capsid protein. Several protein-coding and non-coding transcript variants have been found for this gene. [provided by RefSeq, Apr 2020]

GeneCards Summary for TNPO3 Gene

TNPO3 (Transportin 3) is a Protein Coding gene. Diseases associated with TNPO3 include Muscular Dystrophy, Limb-Girdle, Autosomal Dominant 2 and Muscular Dystrophy. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is IPO13.

UniProtKB/Swiss-Prot Summary for TNPO3 Gene

  • Importin, which transports target proteins into the nucleus (PubMed:10366588, PubMed:10713112, PubMed:11517331, PubMed:12628928, PubMed:24449914). Specifically mediates the nuclear import of splicing factor serine/arginine (SR) proteins, such as RBM4, SFRS1 and SFRS2, by recognizing phosphorylated SR domains (PubMed:10366588, PubMed:10713112, PubMed:11517331, PubMed:12628928, PubMed:24449914). Also mediates the nuclear import of serine/arginine (SR) protein CPSF6, independently of CPSF6 phosphorylation (PubMed:30916345, PubMed:31465518). The nuclear import process is regulated by the small GTPase Ran that partitions between cytoplasm and nucleus in the predominantly GDP- and GTP-bound form, respectively (PubMed:23878195, PubMed:24449914). Importin associates with target cargo proteins in the cytoplasm, and the competitive binding of GTP-bound Ran induces the release of cargos in the nucleus (PubMed:23878195, PubMed:24449914).
  • (Microbial infection) Involved in immunodeficiency virus (HIV-1) infection by importing the pre-integration complex (PIC) into the nucleus (PubMed:18722123, PubMed:21901095, PubMed:22398280, PubMed:29329553). Required for a nuclear maturation step of HIV-1 prior to integration (PubMed:21901095, PubMed:22398280).

Gene Wiki entry for TNPO3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TNPO3 Gene

Genomics for TNPO3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TNPO3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TNPO3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TNPO3

Top Transcription factor binding sites by QIAGEN in the TNPO3 gene promoter:
  • AP-1
  • CREB
  • deltaCREB
  • ISGF-3
  • MAZR
  • Pax-5
  • SRF
  • SRF (504 AA)
  • USF-1
  • USF1

Genomic Locations for TNPO3 Gene

Genomic Locations for TNPO3 Gene
chr7:128,954,180-129,055,173
(GRCh38/hg38)
Size:
100,994 bases
Orientation:
Minus strand
chr7:128,594,234-128,695,227
(GRCh37/hg19)
Size:
100,994 bases
Orientation:
Minus strand

Genomic View for TNPO3 Gene

Genes around TNPO3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNPO3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNPO3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNPO3 Gene

Proteins for TNPO3 Gene

  • Protein details for TNPO3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5L0-TNPO3_HUMAN
    Recommended name:
    Transportin-3
    Protein Accession:
    Q9Y5L0
    Secondary Accessions:
    • A4D1K9
    • C9IZM0
    • Q6NUM1
    • Q96G71
    • Q96GU9
    • Q9Y3R2

    Protein attributes for TNPO3 Gene

    Size:
    923 amino acids
    Molecular mass:
    104203 Da
    Quaternary structure:
    • Interacts with (GTP-bound) Ran (PubMed:23878195, PubMed:24915079, PubMed:24449914). Interacts with (phosphorylated) SFRS1 and SFRS2; leading to their nuclear import (PubMed:10366588, PubMed:10713112, PubMed:11517331). Interacts with NUP62 (PubMed:11517331, PubMed:24449914). Interacts with RBM4 (PubMed:12628928). Interacts with CPSF6, promoting its nuclear import (PubMed:24449914).
    • (Microbial infection) Interacts with the HIV-1 pre-integration complex (PIC), which is composed of viral genome, matrix protein, Vpr and integrase (PubMed:18722123, PubMed:29329553). Interacts with HIV-1 integrase protein; the interaction is direct (PubMed:29329553).
    SequenceCaution:
    • Sequence=AAD38537.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TNPO3 Gene

    Alternative splice isoforms for TNPO3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNPO3 Gene

Post-translational modifications for TNPO3 Gene

  • Ubiquitination at Lys594
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TNPO3 Gene

Domains & Families for TNPO3 Gene

Gene Families for TNPO3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for TNPO3 Gene

InterPro:
Blocks:
  • Exportin 1-like
ProtoNet:

Suggested Antigen Peptide Sequences for TNPO3 Gene

GenScript: Design optimal peptide antigens:
  • Transportin-SR (TNPO3_HUMAN)
genes like me logo Genes that share domains with TNPO3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TNPO3 Gene

Function for TNPO3 Gene

Molecular function for TNPO3 Gene

UniProtKB/Swiss-Prot Function:
Importin, which transports target proteins into the nucleus (PubMed:10366588, PubMed:10713112, PubMed:11517331, PubMed:12628928, PubMed:24449914). Specifically mediates the nuclear import of splicing factor serine/arginine (SR) proteins, such as RBM4, SFRS1 and SFRS2, by recognizing phosphorylated SR domains (PubMed:10366588, PubMed:10713112, PubMed:11517331, PubMed:12628928, PubMed:24449914). Also mediates the nuclear import of serine/arginine (SR) protein CPSF6, independently of CPSF6 phosphorylation (PubMed:30916345, PubMed:31465518). The nuclear import process is regulated by the small GTPase Ran that partitions between cytoplasm and nucleus in the predominantly GDP- and GTP-bound form, respectively (PubMed:23878195, PubMed:24449914). Importin associates with target cargo proteins in the cytoplasm, and the competitive binding of GTP-bound Ran induces the release of cargos in the nucleus (PubMed:23878195, PubMed:24449914).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Involved in immunodeficiency virus (HIV-1) infection by importing the pre-integration complex (PIC) into the nucleus (PubMed:18722123, PubMed:21901095, PubMed:22398280, PubMed:29329553). Required for a nuclear maturation step of HIV-1 prior to integration (PubMed:21901095, PubMed:22398280).

Phenotypes From GWAS Catalog for TNPO3 Gene

Gene Ontology (GO) - Molecular Function for TNPO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12628928
GO:0008536 Ran GTPase binding IDA 23878195
GO:0042802 identical protein binding IPI 22872640
GO:0061608 nuclear import signal receptor activity TAS 10366588
genes like me logo Genes that share ontologies with TNPO3: view
genes like me logo Genes that share phenotypes with TNPO3: view

Human Phenotype Ontology for TNPO3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for TNPO3 Gene

miRTarBase miRNAs that target TNPO3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNPO3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TNPO3 Gene

Localization for TNPO3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNPO3 Gene

Nucleus envelope. Cytoplasm. Note=Localizes to the nuclear envelope and annulate lamellae, which consists in stacks of endoplasmic reticulum membranes containing a high density of nuclear pores. {ECO:0000269 PubMed:31192305}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNPO3 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TNPO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope IEA,IDA 31192305
GO:0005642 annulate lamellae IDA 31192305
GO:0005737 cytoplasm IBA 21873635
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with TNPO3: view

Pathways & Interactions for TNPO3 Gene

PathCards logo

SuperPathways for TNPO3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TNPO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006606 protein import into nucleus IDA 12628928
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with TNPO3: view

No data available for Pathways by source and SIGNOR curated interactions for TNPO3 Gene

Drugs & Compounds for TNPO3 Gene

No Compound Related Data Available

Transcripts for TNPO3 Gene

mRNA/cDNA for TNPO3 Gene

10 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNPO3

Alternative Splicing Database (ASD) splice patterns (SP) for TNPO3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: -
SP2:
SP3: - -
SP4: - - - -
SP5:

ExUns: 23 ^ 24 ^ 25
SP1:
SP2: -
SP3:
SP4:
SP5:

Relevant External Links for TNPO3 Gene

GeneLoc Exon Structure for
TNPO3

Expression for TNPO3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TNPO3 Gene

Protein differential expression in normal tissues from HIPED for TNPO3 Gene

This gene is overexpressed in Bone (50.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TNPO3 Gene



Protein tissue co-expression partners for TNPO3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TNPO3

SOURCE GeneReport for Unigene cluster for TNPO3 Gene:

Hs.193613

mRNA Expression by UniProt/SwissProt for TNPO3 Gene:

Q9Y5L0-TNPO3_HUMAN
Tissue specificity: Expressed in skeletal muscle.

Evidence on tissue expression from TISSUES for TNPO3 Gene

  • Nervous system(4.6)
  • Intestine(4.6)
  • Liver(4.4)
  • Kidney(2.5)
  • Blood(2.4)
  • Skin(2.3)
  • Spleen(2.2)
  • Lymph node(2.1)
  • Muscle(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TNPO3 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • immune
  • lymphatic
  • skeletal muscle
  • skeleton
Regions:
Thorax:
  • clavicle
  • scapula
Abdomen:
  • biliary tract
  • liver
  • spleen
Pelvis:
  • pelvis
Limb:
  • arm
  • forearm
  • humerus
  • lower limb
  • shin
  • shoulder
  • thigh
  • upper limb
General:
  • blood
  • coagulation system
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with TNPO3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TNPO3 Gene

Orthologs for TNPO3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TNPO3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TNPO3 30 31
  • 99.71 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TNPO3 31
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia TNPO3 30 31
  • 94.9 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TNPO3 30 31
  • 94.66 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TNPO3 31
  • 93 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tnpo3 30
  • 90.9 (n)
Mouse
(Mus musculus)
Mammalia Tnpo3 30 17 31
  • 90.79 (n)
OneToOne
Chicken
(Gallus gallus)
Aves TNPO3 30 31
  • 77.27 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TNPO3 31
  • 89 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tnpo3 30
  • 76.25 (n)
Str.15240 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.29508 30
Zebrafish
(Danio rerio)
Actinopterygii tnpo3 30 31
  • 73.06 (n)
OneToOne
zgc55409 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6715 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003576 30
  • 50.83 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Trn-SR 30 31
  • 50.62 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea tsr-1 30 31
  • 43.91 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MTR10 30 31 33
  • 40.93 (n)
OneToMany
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AAR115C 30
  • 39.59 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A02321g 30
  • 39.02 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT5G62600 30
  • 40.77 (n)
Rice
(Oryza sativa)
Liliopsida Os10g0477800 30
  • 42.33 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10940 31
  • 47 (a)
OneToOne
Bread mold
(Neurospora crassa)
Ascomycetes NCU06355 30
  • 41.85 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mtr10 30
  • 40.98 (n)
Species where no ortholog for TNPO3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TNPO3 Gene

ENSEMBL:
Gene Tree for TNPO3 (if available)
TreeFam:
Gene Tree for TNPO3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TNPO3: view image

Paralogs for TNPO3 Gene

Paralogs for TNPO3 Gene

Pseudogenes.org Pseudogenes for TNPO3 Gene

genes like me logo Genes that share paralogs with TNPO3: view

Variants for TNPO3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TNPO3 Gene

TNPO3_HUMAN-Q9Y5L0
Variations in TNPO3 are associated with resistance or susceptibility to immunodeficiency virus type 1 (resistance or susceptibility to HIV-1) [MIM:609423] (PubMed:31465518). A variation that causes LGMDD2 muscular dystrophy induces protection against HIV-1 infection (PubMed:31465518).

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TNPO3 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
642252 Uncertain Significance: Limb-girdle muscular dystrophy, type 1F 128,984,238(-) C/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
647236 Uncertain Significance: Limb-girdle muscular dystrophy, type 1F 129,005,104(-) C/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
648298 Uncertain Significance: Limb-girdle muscular dystrophy, type 1F 128,993,857(-) G/C MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
661107 Uncertain Significance: Limb-girdle muscular dystrophy, type 1F 129,000,476(-) G/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
661166 Uncertain Significance: Limb-girdle muscular dystrophy, type 1F 129,017,961(-) G/A MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT

Additional dbSNP identifiers (rs#s) for TNPO3 Gene

Structural Variations from Database of Genomic Variants (DGV) for TNPO3 Gene

Variant ID Type Subtype PubMed ID
esv2670312 CNV deletion 23128226
esv2735137 CNV deletion 23290073
esv2761368 CNV gain 21179565
esv3572135 CNV loss 25503493
nsv1025216 CNV loss 25217958
nsv507416 OTHER sequence alteration 20534489
nsv831125 CNV loss 17160897

Variation tolerance for TNPO3 Gene

Residual Variation Intolerance Score: 2.57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.16; 23.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNPO3 Gene

Human Gene Mutation Database (HGMD)
TNPO3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNPO3

SNP Genotyping and Copy Number Assay Products

Disorders for TNPO3 Gene

MalaCards: The human disease database

(14) MalaCards diseases for TNPO3 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
muscular dystrophy, limb-girdle, autosomal dominant 2
  • lgmdd2
muscular dystrophy
  • muscular dystrophies
autosomal dominant limb-girdle muscular dystrophy
  • limb-girdle muscular dystrophy autosomal dominant
primary biliary cirrhosis
  • pbc
limb-girdle muscular dystrophy
  • lgmd
- elite association - COSMIC cancer census association via MalaCards
Search TNPO3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TNPO3_HUMAN
  • Muscular dystrophy, limb-girdle, autosomal dominant 2 (LGMDD2) [MIM:608423]: An autosomal dominant myopathy characterized by proximal muscle weakness primarily affecting the lower limbs, but also affecting the upper limbs in most patients. Affected individuals also have distal muscle weakness of the hands and lower leg muscles. The disease has generally a benign clinical course but some individuals with childhood or juvenile onset manifest severe widespread myopathy, leading to wheelchair dependency and respiratory insufficiency. Muscle biopsy shows dystrophic changes with abnormal nuclei, rimmed vacuoles, and filamentous inclusions. {ECO:0000269 PubMed:23543484, ECO:0000269 PubMed:23667635, ECO:0000269 PubMed:31071488, ECO:0000269 PubMed:31192305, ECO:0000269 PubMed:31465518}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for TNPO3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TNPO3: view

No data available for Genatlas for TNPO3 Gene

Publications for TNPO3 Gene

  1. A human importin-beta family protein, transportin-SR2, interacts with the phosphorylated RS domain of SR proteins. (PMID: 10713112) Lai MC … Tarn WY (The Journal of biological chemistry 2000) 2 3 4 23
  2. Transportin-SR, a nuclear import receptor for SR proteins. (PMID: 10366588) Kataoka N … Dreyfuss G (The Journal of cell biology 1999) 2 3 4 23
  3. Next-generation sequencing identifies transportin 3 as the causative gene for LGMD1F. (PMID: 23667635) Torella A … Nigro V (PloS one 2013) 2 3 4
  4. Limb-girdle muscular dystrophy 1F is caused by a microdeletion in the transportin 3 gene. (PMID: 23543484) Melià MJ … Martí R (Brain : a journal of neurology 2013) 2 3 4
  5. Association of a functional polymorphism in the IRF5 region with systemic sclerosis in a Japanese population. (PMID: 19479858) Ito I … Tsuchiya N (Arthritis and rheumatism 2009) 3 23 41

Products for TNPO3 Gene

  • Signalway ELISA kits for TNPO3

Sources for TNPO3 Gene