Aliases for TNPO2 Gene

Aliases for TNPO2 Gene

  • Transportin 2 2 3 5
  • Karyopherin Beta-2b 3 4
  • Transportin-2 3 4
  • Importin 3 2 3
  • Transportin 2 (Importin 3, Karyopherin Beta 2b) 3
  • Karyopherin Beta 2b, Transportin 3
  • Karyopherin Beta 2b 2
  • KPNB2B 3
  • IPO3 3
  • TRN2 3

External Ids for TNPO2 Gene

Previous GeneCards Identifiers for TNPO2 Gene

  • GC19M012672
  • GC19M012673
  • GC19M012674
  • GC19M012810
  • GC19M012383

Summaries for TNPO2 Gene

GeneCards Summary for TNPO2 Gene

TNPO2 (Transportin 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding and nuclear localization sequence binding. An important paralog of this gene is TNPO1.

UniProtKB/Swiss-Prot Summary for TNPO2 Gene

  • Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).

Gene Wiki entry for TNPO2 Gene

Additional gene information for TNPO2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TNPO2 Gene

Genomics for TNPO2 Gene

GeneHancer (GH) Regulatory Elements for TNPO2 Gene

Promoters and enhancers for TNPO2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TNPO2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TNPO2

Top Transcription factor binding sites by QIAGEN in the TNPO2 gene promoter:
  • Arnt
  • Nkx2-5
  • Pax-6
  • Sp1

Genomic Locations for TNPO2 Gene

Genomic Locations for TNPO2 Gene
chr19:12,699,194-12,724,011
(GRCh38/hg38)
Size:
24,818 bases
Orientation:
Minus strand
chr19:12,810,008-12,834,825
(GRCh37/hg19)
Size:
24,818 bases
Orientation:
Minus strand

Genomic View for TNPO2 Gene

Genes around TNPO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNPO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNPO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNPO2 Gene

Proteins for TNPO2 Gene

  • Protein details for TNPO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14787-TNPO2_HUMAN
    Recommended name:
    Transportin-2
    Protein Accession:
    O14787
    Secondary Accessions:
    • O14655
    • Q6IN77

    Protein attributes for TNPO2 Gene

    Size:
    897 amino acids
    Molecular mass:
    101388 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TNPO2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNPO2 Gene

Post-translational modifications for TNPO2 Gene

  • Ubiquitination at Lys862
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TNPO2 Gene

Domains & Families for TNPO2 Gene

Gene Families for TNPO2 Gene

Protein Domains for TNPO2 Gene

Blocks:
  • HEAT repeat
  • Importin-beta, N-terminal
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TNPO2 Gene

GenScript: Design optimal peptide antigens:
  • TNPO2 protein (Q05D48_HUMAN)
  • Karyopherin beta-2b (TNPO2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O14787

UniProtKB/Swiss-Prot:

TNPO2_HUMAN :
  • Belongs to the importin beta family. Importin beta-2 subfamily.
Family:
  • Belongs to the importin beta family. Importin beta-2 subfamily.
genes like me logo Genes that share domains with TNPO2: view

Function for TNPO2 Gene

Molecular function for TNPO2 Gene

UniProtKB/Swiss-Prot Function:
Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).

Phenotypes From GWAS Catalog for TNPO2 Gene

Gene Ontology (GO) - Molecular Function for TNPO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12896982
GO:0008139 nuclear localization sequence binding IBA,TAS 21873635
GO:0008536 Ran GTPase binding IEA --
GO:0061608 nuclear import signal receptor activity IBA 21873635
genes like me logo Genes that share ontologies with TNPO2: view
genes like me logo Genes that share phenotypes with TNPO2: view

Animal Models for TNPO2 Gene

MGI Knock Outs for TNPO2:
  • Tnpo2 Tnpo2<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

miRNA for TNPO2 Gene

miRTarBase miRNAs that target TNPO2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNPO2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNPO2 Gene

Localization for TNPO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNPO2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNPO2 gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TNPO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005634 nucleus IBA,TAS 21873635
GO:0005737 cytoplasm IBA,TAS 21873635
genes like me logo Genes that share ontologies with TNPO2: view

Pathways & Interactions for TNPO2 Gene

PathCards logo

SuperPathways for TNPO2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TNPO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006606 protein import into nucleus IBA 21873635
GO:0006886 intracellular protein transport IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with TNPO2: view

No data available for Pathways by source and SIGNOR curated interactions for TNPO2 Gene

Drugs & Compounds for TNPO2 Gene

(1) Drugs for TNPO2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with TNPO2: view

Transcripts for TNPO2 Gene

mRNA/cDNA for TNPO2 Gene

3 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
18 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNPO2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNPO2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - - - - -
SP5: -
SP6: -
SP7: - - -
SP8:

ExUns: 21a · 21b · 21c ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29a · 29b
SP1: -
SP2: - -
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8: -

Relevant External Links for TNPO2 Gene

GeneLoc Exon Structure for
TNPO2

Expression for TNPO2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TNPO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TNPO2 Gene

This gene is overexpressed in Bone (40.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TNPO2 Gene



Protein tissue co-expression partners for TNPO2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TNPO2

SOURCE GeneReport for Unigene cluster for TNPO2 Gene:

Hs.416049

Evidence on tissue expression from TISSUES for TNPO2 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with TNPO2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNPO2 Gene

Orthologs for TNPO2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TNPO2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNPO2 31 30
  • 99.52 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TNPO2 31
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNPO2 31
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TNPO2 31 30
  • 93.05 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TNPO2 31 30
  • 92.72 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tnpo2 30
  • 91.92 (n)
mouse
(Mus musculus)
Mammalia Tnpo2 17 31 30
  • 91.75 (n)
lizard
(Anolis carolinensis)
Reptilia TNPO2 31
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tnpo2 30
  • 81.77 (n)
zebrafish
(Danio rerio)
Actinopterygii TNPO2 (2 of 2) 31
  • 95 (a)
OneToMany
tnpo2 31 30
  • 79.52 (n)
OneToMany
iktdsubc_2a7 30
fruit fly
(Drosophila melanogaster)
Insecta Trn 31
  • 72 (a)
ManyToMany
CG8219 31
  • 58 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea imb-2 31
  • 51 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KAP104 31
  • 31 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.12801 30
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5618 31
  • 70 (a)
OneToMany
Species where no ortholog for TNPO2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TNPO2 Gene

ENSEMBL:
Gene Tree for TNPO2 (if available)
TreeFam:
Gene Tree for TNPO2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TNPO2: view image

Paralogs for TNPO2 Gene

Paralogs for TNPO2 Gene

(2) SIMAP similar genes for TNPO2 Gene using alignment to 9 proteins:

  • TNPO2_HUMAN
  • K7ELC3_HUMAN
  • K7EMA3_HUMAN
  • K7ENW1_HUMAN
  • K7ESC1_HUMAN
  • K7ESG1_HUMAN
  • K7ESJ3_HUMAN
  • L8ECE4_HUMAN
  • Q05D48_HUMAN
genes like me logo Genes that share paralogs with TNPO2: view

Variants for TNPO2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TNPO2 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
712233 Benign: not provided 12,702,168(-) G/A MISSENSE_VARIANT,INTRON_VARIANT
723854 Benign: not provided 12,715,306(-) G/A SYNONYMOUS_VARIANT
775408 Benign: not provided 12,703,730(-) A/G SYNONYMOUS_VARIANT
777899 Benign: not provided 12,701,448(-) G/A SYNONYMOUS_VARIANT
778810 Benign: not provided 12,715,037(-) CCAT/C INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for TNPO2 Gene

Structural Variations from Database of Genomic Variants (DGV) for TNPO2 Gene

Variant ID Type Subtype PubMed ID
dgv138n111 CNV deletion 26073780
esv3308736 CNV mobile element insertion 20981092
esv3346704 CNV insertion 20981092
nsv1113977 CNV deletion 24896259
nsv1160586 CNV duplication 26073780
nsv953977 CNV deletion 24416366

Variation tolerance for TNPO2 Gene

Residual Variation Intolerance Score: 6.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNPO2 Gene

Human Gene Mutation Database (HGMD)
TNPO2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNPO2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNPO2 Gene

Disorders for TNPO2 Gene

Additional Disease Information for TNPO2

No disorders were found for TNPO2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNPO2 Gene

Publications for TNPO2 Gene

  1. Karyopherin beta 2B participates in mRNA export from the nucleus. (PMID: 12384575) Shamsher MK … Radu A (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 23 54
  2. Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins. (PMID: 9298975) Siomi MC … Dreyfuss G (The Journal of cell biology 1997) 2 3 4 54
  3. Transportins 1 and 2 are redundant nuclear import factors for hnRNP A1 and HuR. (PMID: 15037768) Rebane A … Steitz JA (RNA (New York, N.Y.) 2004) 3 23 54
  4. Transportin2 functions as importin and mediates nuclear import of HuR. (PMID: 14981248) Güttinger S … Kutay U (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 23 54
  5. A novel nuclear localization signal in the auxiliary domain of apobec-1 complementation factor regulates nucleocytoplasmic import and shuttling. (PMID: 12896982) Blanc V … Davidson NO (The Journal of biological chemistry 2003) 3 23 54

Products for TNPO2 Gene

Sources for TNPO2 Gene