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Aliases for TNPO2 Gene

Aliases for TNPO2 Gene

  • Transportin 2 2 3 5
  • Karyopherin Beta-2b 3 4
  • Importin 3 2 3
  • Transportin 2 (Importin 3, Karyopherin Beta 2b) 3
  • Karyopherin Beta 2b, Transportin 3
  • Karyopherin Beta 2b 2
  • Transportin-2 3
  • KPNB2B 3
  • IPO3 3
  • TRN2 3

External Ids for TNPO2 Gene

Previous GeneCards Identifiers for TNPO2 Gene

  • GC19M012672
  • GC19M012673
  • GC19M012674
  • GC19M012810
  • GC19M012383

Summaries for TNPO2 Gene

GeneCards Summary for TNPO2 Gene

TNPO2 (Transportin 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding and nuclear localization sequence binding. An important paralog of this gene is TNPO1.

UniProtKB/Swiss-Prot for TNPO2 Gene

  • Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).

Gene Wiki entry for TNPO2 Gene

Additional gene information for TNPO2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNPO2 Gene

Genomics for TNPO2 Gene

GeneHancer (GH) Regulatory Elements for TNPO2 Gene

Promoters and enhancers for TNPO2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I012720 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 555.4 +1.6 1635 4.2 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC TNPO2 ZNF136 TRMT1 ZNF44 ZNF700 ZNF564 ZNF799 WDR83OS ZNF763 ZNF791
GH19I013148 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 28.5 -429.7 -429684 10.2 MLX DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 STX10 IER2 ENSG00000267598 CCDC130 ZNF136 ZNF44 TRMT1 ZNF709 ZNF564 ZNF791
GH19I013011 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10 -296.2 -296184 17.2 HDGF FOXA2 MLX ARNT ARID4B FEZF1 DMAP1 ZNF2 YY1 ZNF213 NFIX ZNF136 ZNF709 ZNF791 TRMT1 CCDC130 MRI1 ZNF44 ZNF564 ZNF625
GH19I013115 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.1 -394.9 -394925 7.7 DMAP1 YBX1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D ZNF610 TRMT1 NACC1 ZNF791 ZNF136 ZNF442 CCDC130 MRI1 ZNF564 WDR83OS ZNF44
GH19I013632 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.8 -909.2 -909235 1.7 PKNOX1 ZFP64 ZNF133 FEZF1 ZNF48 ETS1 GLIS2 ZNF213 KLF7 YY2 CACNA1A CCDC130 MRI1 WDR83OS TRMT1 TRIR RPS6P25 RFX1 DCAF15 DDX39A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TNPO2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TNPO2 gene promoter:

Genomic Locations for TNPO2 Gene

Genomic Locations for TNPO2 Gene
chr19:12,699,194-12,724,011
(GRCh38/hg38)
Size:
24,818 bases
Orientation:
Minus strand
chr19:12,810,008-12,834,825
(GRCh37/hg19)

Genomic View for TNPO2 Gene

Genes around TNPO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNPO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNPO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNPO2 Gene

Proteins for TNPO2 Gene

  • Protein details for TNPO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14787-TNPO2_HUMAN
    Recommended name:
    Transportin-2
    Protein Accession:
    O14787
    Secondary Accessions:
    • O14655
    • Q6IN77

    Protein attributes for TNPO2 Gene

    Size:
    897 amino acids
    Molecular mass:
    101388 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TNPO2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNPO2 Gene

Post-translational modifications for TNPO2 Gene

No data available for DME Specific Peptides for TNPO2 Gene

Domains & Families for TNPO2 Gene

Gene Families for TNPO2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for TNPO2 Gene

Suggested Antigen Peptide Sequences for TNPO2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14787

UniProtKB/Swiss-Prot:

TNPO2_HUMAN :
  • Belongs to the importin beta family. Importin beta-2 subfamily.
Family:
  • Belongs to the importin beta family. Importin beta-2 subfamily.
genes like me logo Genes that share domains with TNPO2: view

Function for TNPO2 Gene

Molecular function for TNPO2 Gene

UniProtKB/Swiss-Prot Function:
Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).

Phenotypes From GWAS Catalog for TNPO2 Gene

Gene Ontology (GO) - Molecular Function for TNPO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12896982
GO:0008139 nuclear localization sequence binding TAS 9298975
GO:0008536 Ran GTPase binding IEA --
GO:0008565 protein transporter activity IBA --
genes like me logo Genes that share ontologies with TNPO2: view
genes like me logo Genes that share phenotypes with TNPO2: view

Animal Model Products

CRISPR Products

miRNA for TNPO2 Gene

miRTarBase miRNAs that target TNPO2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TNPO2 Gene

Localization for TNPO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNPO2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNPO2 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TNPO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus TAS 9298975
GO:0005737 cytoplasm IBA,TAS --
GO:0031965 nuclear membrane IBA --
GO:0034399 nuclear periphery IBA --
genes like me logo Genes that share ontologies with TNPO2: view

Pathways & Interactions for TNPO2 Gene

SuperPathways for TNPO2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TNPO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000060 protein import into nucleus, translocation IBA --
GO:0006607 NLS-bearing protein import into nucleus IBA --
GO:0006610 ribosomal protein import into nucleus IBA --
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IEA --
genes like me logo Genes that share ontologies with TNPO2: view

No data available for Pathways by source and SIGNOR curated interactions for TNPO2 Gene

Drugs & Compounds for TNPO2 Gene

(1) Drugs for TNPO2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with TNPO2: view

Transcripts for TNPO2 Gene

Unigene Clusters for TNPO2 Gene

Transportin 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNPO2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - - - - -
SP5: -
SP6: -
SP7: - - -
SP8:

ExUns: 21a · 21b · 21c ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29a · 29b
SP1: -
SP2: - -
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8: -

Relevant External Links for TNPO2 Gene

GeneLoc Exon Structure for
TNPO2
ECgene alternative splicing isoforms for
TNPO2

Expression for TNPO2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNPO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TNPO2 Gene

This gene is overexpressed in Bone (40.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TNPO2 Gene



Protein tissue co-expression partners for TNPO2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TNPO2 Gene:

TNPO2

SOURCE GeneReport for Unigene cluster for TNPO2 Gene:

Hs.416049

Evidence on tissue expression from TISSUES for TNPO2 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with TNPO2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNPO2 Gene

Orthologs for TNPO2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TNPO2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNPO2 33 34
  • 99.52 (n)
oppossum
(Monodelphis domestica)
Mammalia TNPO2 34
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNPO2 34
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TNPO2 33 34
  • 93.05 (n)
dog
(Canis familiaris)
Mammalia TNPO2 33 34
  • 92.72 (n)
rat
(Rattus norvegicus)
Mammalia Tnpo2 33
  • 91.92 (n)
mouse
(Mus musculus)
Mammalia Tnpo2 33 16 34
  • 91.75 (n)
lizard
(Anolis carolinensis)
Reptilia TNPO2 34
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tnpo2 33
  • 81.77 (n)
zebrafish
(Danio rerio)
Actinopterygii TNPO2 (2 of 2) 34
  • 95 (a)
OneToMany
tnpo2 33 34
  • 79.52 (n)
iktdsubc_2a7 33
fruit fly
(Drosophila melanogaster)
Insecta Trn 34
  • 72 (a)
ManyToMany
CG8219 34
  • 58 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea imb-2 34
  • 51 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KAP104 34
  • 31 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.12801 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5618 34
  • 70 (a)
OneToMany
Species where no ortholog for TNPO2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TNPO2 Gene

ENSEMBL:
Gene Tree for TNPO2 (if available)
TreeFam:
Gene Tree for TNPO2 (if available)

Paralogs for TNPO2 Gene

Paralogs for TNPO2 Gene

genes like me logo Genes that share paralogs with TNPO2: view

Variants for TNPO2 Gene

Sequence variations from dbSNP and Humsavar for TNPO2 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000007871 -- 12,717,540(-) G/A/C intron_variant
rs1000018073 -- 12,699,254(-) G/A 3_prime_UTR_variant
rs1000292235 -- 12,720,208(-) G/A intron_variant
rs1000509369 -- 12,703,176(-) A/T intron_variant
rs1000683253 -- 12,713,826(-) G/A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TNPO2 Gene

Variant ID Type Subtype PubMed ID
nsv953977 CNV deletion 24416366
nsv1160586 CNV duplication 26073780
nsv1113977 CNV deletion 24896259
esv3346704 CNV insertion 20981092
esv3308736 CNV mobile element insertion 20981092
dgv138n111 CNV deletion 26073780

Variation tolerance for TNPO2 Gene

Residual Variation Intolerance Score: 6.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNPO2 Gene

Human Gene Mutation Database (HGMD)
TNPO2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNPO2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNPO2 Gene

Disorders for TNPO2 Gene

Additional Disease Information for TNPO2

No disorders were found for TNPO2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNPO2 Gene

Publications for TNPO2 Gene

  1. Karyopherin beta 2B participates in mRNA export from the nucleus. (PMID: 12384575) Shamsher MK … Radu A (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 22 58
  2. Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins. (PMID: 9298975) Siomi MC … Dreyfuss G (The Journal of cell biology 1997) 2 3 4 58
  3. Transportin2 functions as importin and mediates nuclear import of HuR. (PMID: 14981248) Güttinger S … Kutay U (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 22 58
  4. Transportins 1 and 2 are redundant nuclear import factors for hnRNP A1 and HuR. (PMID: 15037768) Rebane A … Steitz JA (RNA (New York, N.Y.) 2004) 3 22 58
  5. A novel nuclear localization signal in the auxiliary domain of apobec-1 complementation factor regulates nucleocytoplasmic import and shuttling. (PMID: 12896982) Blanc V … Davidson NO (The Journal of biological chemistry 2003) 3 22 58

Products for TNPO2 Gene

Sources for TNPO2 Gene

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