TNP2 Gene (Protein Coding)

Transition Protein 2

GC16M011267
GIFtS:
33
See more...

Aliases for TNP2 Gene

Aliases for TNP2 Gene

  • Transition Protein 2 2 3 5
  • TP2 2 3 4
  • Transition Protein 2 (During Histone To Protamine Replacement) 2 3
  • Nuclear Transition Protein 2 3 4
  • TP-2 3 4
  • TNP2 5

External Ids for TNP2 Gene

Previous GeneCards Identifiers for TNP2 Gene

  • GC16M011135
  • GC16M011513
  • GC16M011328
  • GC16M011269
  • GC16M011361
  • GC16M011280

Summaries for TNP2 Gene

GeneCards Summary for TNP2 Gene

TNP2 (Transition Protein 2) is a Protein Coding gene. Diseases associated with TNP2 include Male Infertility and Epididymo-Orchitis.

UniProtKB/Swiss-Prot Summary for TNP2 Gene

  • Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.

Gene Wiki entry for TNP2 Gene

Additional gene information for TNP2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TNP2 Gene

Genomics for TNP2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data

GeneHancers around TNP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TNP2

Top Transcription factor binding sites by QIAGEN in the TNP2 gene promoter:
  • AML1a
  • AP-1
  • STAT3

Genomic Locations for TNP2 Gene

Genomic Locations for TNP2 Gene
chr16:11,267,748-11,269,533
(GRCh38/hg38)
Size:
1,786 bases
Orientation:
Minus strand
chr16:11,361,605-11,363,390
(GRCh37/hg19)
Size:
1,786 bases
Orientation:
Minus strand

Genomic View for TNP2 Gene

Genes around TNP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNP2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TNP2 Gene

Proteins for TNP2 Gene

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  1. Antibody
  2. Protein
  3. Assay

  • Protein details for TNP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05952-STP2_HUMAN
    Recommended name:
    Nuclear transition protein 2
    Protein Accession:
    Q05952
    Secondary Accessions:
    • Q9NZB0

    Protein attributes for TNP2 Gene

    Size:
    138 amino acids
    Molecular mass:
    15641 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TNP2 Gene

Post-translational modifications for TNP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TNP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TNP2 Gene

Domains & Families for TNP2 Gene

Gene Families for TNP2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TNP2 Gene

InterPro:
Blocks:
  • Nuclear transition protein 2
ProtoNet:

Suggested Antigen Peptide Sequences for TNP2 Gene

GenScript: Design optimal peptide antigens:
  • Nuclear transition protein 2 (Q4VB54_HUMAN)
  • Nuclear transition protein 2 (Q4VB56_HUMAN)
  • Nuclear transition protein 2 (STP2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q05952

UniProtKB/Swiss-Prot:

STP2_HUMAN :
  • Belongs to the nuclear transition protein 2 family.
Family:
  • Belongs to the nuclear transition protein 2 family.
genes like me logo Genes that share domains with TNP2: view

Function for TNP2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for TNP2 Gene

UniProtKB/Swiss-Prot Function:
Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.
GENATLAS Biochemistry:
transition protein 2 (in haploid spermatogenic cells during transition histone-protamine)

Phenotypes From GWAS Catalog for TNP2 Gene

Gene Ontology (GO) - Molecular Function for TNP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 31515488
GO:0008270 zinc ion binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TNP2: view
genes like me logo Genes that share phenotypes with TNP2: view

Animal Model Products

CRISPR Products

miRNA for TNP2 Gene

miRTarBase miRNAs that target TNP2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TNP2 Gene

Localization for TNP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNP2 Gene

Nucleus. Chromosome. Note=Loaded onto the nucleosomes of condensing spermatids (By similarity). Nuclear import is ATP-dependent and nucleolar localization requires the protein to be phosphorylated (By similarity). {ECO:0000250 UniProtKB:P11101, ECO:0000250 UniProtKB:P11378}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNP2 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TNP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IEA --
GO:0000788 nuclear nucleosome ISS --
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with TNP2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TNP2 Gene

Pathways & Interactions for TNP2 Gene

PathCards logo

SuperPathways for TNP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TNP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IBA 21873635
GO:0007340 acrosome reaction IBA 21873635
GO:0007341 penetration of zona pellucida IBA 21873635
GO:0010954 positive regulation of protein processing ISS --
genes like me logo Genes that share ontologies with TNP2: view

No data available for Pathways by source and SIGNOR curated interactions for TNP2 Gene

Drugs & Compounds for TNP2 Gene

Products:

  1. Drug

(2) Drugs for TNP2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TNP2: view

Transcripts for TNP2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for TNP2 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNP2

Alternative Splicing Database (ASD) splice patterns (SP) for TNP2 Gene

No ASD Table

Relevant External Links for TNP2 Gene

GeneLoc Exon Structure for
TNP2

Expression for TNP2 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TNP2 Gene

mRNA expression in normal human tissues for TNP2 Gene
mRNA expression by GTEx for TNP2 GenemRNA expression by BioGPS for TNP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for TNP2 Gene

This gene is overexpressed in Testis (x52.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TNP2

SOURCE GeneReport for Unigene cluster for TNP2 Gene:

Hs.513349

mRNA Expression by UniProt/SwissProt for TNP2 Gene:

Q05952-STP2_HUMAN
Tissue specificity: Expressed by spermatids (at protein level).
genes like me logo Genes that share expression patterns with TNP2: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNP2 Gene

Orthologs for TNP2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TNP2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia TNP2 30 31
  • 97.58 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia TNP2 30 31
  • 75.45 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia TNP2 30 31
  • 66.67 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Tnp2 31
  • 44 (a)
 OneToOne
Species where no ortholog for TNP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for TNP2 Gene

ENSEMBL:
Gene Tree for TNP2 (if available)
TreeFam:
Gene Tree for TNP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TNP2: view image

Paralogs for TNP2 Gene

No data available for Paralogs for TNP2 Gene

Variants for TNP2 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TNP2 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
776977 Benign: not provided 11,269,134(-) G/T SYNONYMOUS_VARIANT
rs11640138 - p.Arg131Trp

Additional dbSNP identifiers (rs#s) for TNP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for TNP2 Gene

Variant ID Type Subtype PubMed ID
nsv1040428 CNV gain 25217958
nsv525548 CNV loss 19592680
nsv571453 CNV loss 21841781

Variation tolerance for TNP2 Gene

Residual Variation Intolerance Score: 91.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.65; 78.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNP2 Gene

Disorders for TNP2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for TNP2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
male infertility
  • infertility male
epididymo-orchitis
oligoasthenoteratozoospermia
  • oat
embryonal testis carcinoma
  • embryonal carcinoma of testis
progressive relapsing multiple sclerosis
  • prms
- elite association - COSMIC cancer census association via MalaCards
Search TNP2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TNP2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TNP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNP2 Gene

Publications for TNP2 Gene

  1. Identification of novel polymorphisms in the nuclear protein genes and their relationship with human sperm protamine deficiency and severe male infertility. (PMID: 16989827) Aoki VW … Carrell DT (Fertility and sterility 2006) 3 23 41
  2. Single-nucleotide polymorphisms and mutation analyses of the TNP1 and TNP2 genes of fertile and infertile human male populations. (PMID: 16291974) Miyagawa Y … Tanaka H (Journal of andrology 2005) 3 23 41
  3. Expression of mRNA and protein of nucleoproteins during human spermiogenesis. (PMID: 9809674) Steger K … Bergmann M (Molecular human reproduction 1998) 3 4 23
  4. Linkage of human spermatid-specific basic nuclear protein genes. Definition and evolution of the P1-->P2-->TP2 locus. (PMID: 8428967) Nelson JE … Krawetz SA (The Journal of biological chemistry 1993) 3 4 23
  5. The gene for human transition protein 2: nucleotide sequence, assignment to the protamine gene cluster, and evidence for its low expression. (PMID: 1385303) Schlüter G … Engel W (Genomics 1992) 3 4 23

ExternalLinks

View latest publications for TNP2 gene in Mastermind

Products for TNP2 Gene

  • Signalway ELISA kits for TNP2

Sources for TNP2 Gene