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Aliases for TNP1 Gene

Aliases for TNP1 Gene

  • Transition Protein 1 2 3 5
  • Transition Protein 1 (During Histone To Protamine Replacement) 2 3
  • Spermatid Nuclear Transition Protein 1 2 3
  • STP-1 3 4
  • TP-1 3 4
  • TP1 3

External Ids for TNP1 Gene

Previous GeneCards Identifiers for TNP1 Gene

  • GC02M215821
  • GC02M216445
  • GC02M217688
  • GC02M217926
  • GC02M217549
  • GC02M217432
  • GC02M217724
  • GC02M209578

Summaries for TNP1 Gene

Entrez Gene Summary for TNP1 Gene

  • Transition protein-1 is a spermatid-specific product of the haploid genome which replaces histone and is itself replaced in the mature sperm by the protamines (see PRM1, MIM 182880; PRM2, MIM 182890) (Luerssen et al., 1990 [PubMed 2249851]).[supplied by OMIM, Mar 2008]

GeneCards Summary for TNP1 Gene

TNP1 (Transition Protein 1) is a Protein Coding gene. Diseases associated with TNP1 include Epididymo-Orchitis and Aggressive Systemic Mastocytosis. Among its related pathways are Transcription_CREM signaling in testis.

UniProtKB/Swiss-Prot for TNP1 Gene

  • Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.

Gene Wiki entry for TNP1 Gene

Additional gene information for TNP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNP1 Gene

Genomics for TNP1 Gene

GeneHancer (GH) Regulatory Elements for TNP1 Gene

Promoters and enhancers for TNP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I216860 Promoter 0.6 EPDnew 550.8 0.0 -18 0.1 PKNOX1 TNP1 LOC105373876 LOC101928278 ENSG00000236886
GH02I216003 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.1 +854.6 854567 3.8 HDGF PKNOX1 SMAD1 RB1 ZFP64 SIN3A ZBTB40 BATF IRF4 RFX5 XRCC5 TNP1 LINC01963 MREG GC02M216014 ENSG00000226276 PECR
GH02I216772 Enhancer 1.4 FANTOM5 Ensembl ENCODE 10.6 +85.2 85192 4.1 PKNOX1 SMAD1 ATF1 FOXA2 FEZF1 NCOA2 TCF12 ZNF766 GATA2 FOS ENSG00000227021 ENSG00000236295 LINC01921 ENSG00000231597 TNP1 LOC105373876 ENSG00000229352 GC02M216786 GC02M216703 ENSG00000236886
GH02I217651 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -793.5 -793484 3.6 NCOA3 CTCF ESRRA CLOCK MAX RFX5 CTBP1 GATA3 FOSL2 FOS LINC01921 ENSG00000231597 TNP1 ENSG00000227021 LOC105373876 LOC100533848 DIRC3 GC02P217430
GH02I216791 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.4 +67.6 67581 2.3 CTCF KLF1 TEAD4 CEBPG E4F1 FOSL1 TCF12 ZFHX2 CTBP1 GATA3 RNA5SP120 ENSG00000227021 ENSG00000231597 TNP1 LOC105373876 LINC01921 IGFBP5 ENSG00000236886 ENSG00000236295 ENSG00000229352
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TNP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TNP1 gene promoter:

Genomic Locations for TNP1 Gene

Genomic Locations for TNP1 Gene
chr2:216,859,458-216,860,064
(GRCh38/hg38)
Size:
607 bases
Orientation:
Minus strand
chr2:217,724,181-217,724,787
(GRCh37/hg19)

Genomic View for TNP1 Gene

Genes around TNP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNP1 Gene

Proteins for TNP1 Gene

  • Protein details for TNP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09430-STP1_HUMAN
    Recommended name:
    Spermatid nuclear transition protein 1
    Protein Accession:
    P09430

    Protein attributes for TNP1 Gene

    Size:
    55 amino acids
    Molecular mass:
    6424 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TNP1 Gene

Post-translational modifications for TNP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TNP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TNP1 Gene

Domains & Families for TNP1 Gene

Gene Families for TNP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TNP1 Gene

Suggested Antigen Peptide Sequences for TNP1 Gene

Graphical View of Domain Structure for InterPro Entry

P09430

UniProtKB/Swiss-Prot:

STP1_HUMAN :
  • Belongs to the nuclear transition protein 1 family.
Family:
  • Belongs to the nuclear transition protein 1 family.
genes like me logo Genes that share domains with TNP1: view

Function for TNP1 Gene

Molecular function for TNP1 Gene

GENATLAS Biochemistry:
transition protein 1 (in haploid spermatogenic cells during transition histone-protamine)
UniProtKB/Swiss-Prot Function:
Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.

Phenotypes From GWAS Catalog for TNP1 Gene

Gene Ontology (GO) - Molecular Function for TNP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IMP 12743712
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TNP1: view
genes like me logo Genes that share phenotypes with TNP1: view

miRNA for TNP1 Gene

miRTarBase miRNAs that target TNP1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TNP1 Gene

Localization for TNP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNP1 Gene

Nucleus. Chromosome. Note=Loaded onto the nucleosomes of condensing spermatids. {ECO:0000250 UniProtKB:P10856}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNP1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for TNP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IDA 12743712
GO:0000788 nuclear nucleosome IEA,ISS --
GO:0001673 male germ cell nucleus IEA,IBA --
GO:0005634 nucleus ISS --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with TNP1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TNP1 Gene

Pathways & Interactions for TNP1 Gene

genes like me logo Genes that share pathways with TNP1: view

Pathways by source for TNP1 Gene

1 GeneGo (Thomson Reuters) pathway for TNP1 Gene

Gene Ontology (GO) - Biological Process for TNP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000012 single strand break repair IDA 12743712
GO:0006337 nucleosome disassembly IMP 10781074
GO:0006338 chromatin remodeling IDA 12743712
GO:0006342 chromatin silencing IEP 11315969
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with TNP1: view

No data available for SIGNOR curated interactions for TNP1 Gene

Drugs & Compounds for TNP1 Gene

(1) Drugs for TNP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for TNP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TNP1: view

Transcripts for TNP1 Gene

mRNA/cDNA for TNP1 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(70) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TNP1 Gene

Transition protein 1 (during histone to protamine replacement):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b
SP1:
SP2: -

Relevant External Links for TNP1 Gene

GeneLoc Exon Structure for
TNP1
ECgene alternative splicing isoforms for
TNP1

Expression for TNP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNP1 Gene

This gene is overexpressed in Testis (x52.6).

NURSA nuclear receptor signaling pathways regulating expression of TNP1 Gene:

TNP1

SOURCE GeneReport for Unigene cluster for TNP1 Gene:

Hs.3017

mRNA Expression by UniProt/SwissProt for TNP1 Gene:

P09430-STP1_HUMAN
Tissue specificity: Expressed by spermatids (at protein level).
genes like me logo Genes that share expression patterns with TNP1: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNP1 Gene

Orthologs for TNP1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TNP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNP1 33 34
  • 98.79 (n)
dog
(Canis familiaris)
Mammalia TNP1 34
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tnp1 34
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TNP1 34
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TNP1 34
  • 74 (a)
OneToOne
Species where no ortholog for TNP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TNP1 Gene

ENSEMBL:
Gene Tree for TNP1 (if available)
TreeFam:
Gene Tree for TNP1 (if available)

Paralogs for TNP1 Gene

No data available for Paralogs for TNP1 Gene

Variants for TNP1 Gene

Sequence variations from dbSNP and Humsavar for TNP1 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000538377 -- 216,861,338(-) A/G upstream_transcript_variant
rs1000833661 -- 216,861,014(-) C/T upstream_transcript_variant
rs1000926993 -- 216,861,070(-) G/C upstream_transcript_variant
rs1001809463 -- 216,860,088(-) G/C upstream_transcript_variant
rs1003315001 -- 216,859,384(-) T/C downstream_transcript_variant

Variation tolerance for TNP1 Gene

Residual Variation Intolerance Score: 57.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.24; 5.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNP1 Gene

Human Gene Mutation Database (HGMD)
TNP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNP1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TNP1 Gene

Disorders for TNP1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TNP1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
epididymo-orchitis
aggressive systemic mastocytosis
  • asm
male infertility
  • infertility male
male reproductive system disease
  • genital diseases, male
- elite association - COSMIC cancer census association via MalaCards
Search TNP1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TNP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TNP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNP1 Gene

Publications for TNP1 Gene

  1. Nucleotide sequence of the gene for human transition protein 1 and its chromosomal localization on chromosome 2. (PMID: 2249851) Luerssen H … Engel W (Genomics 1990) 2 3 4 22 58
  2. Identification of novel polymorphisms in the nuclear protein genes and their relationship with human sperm protamine deficiency and severe male infertility. (PMID: 16989827) Aoki VW … Carrell DT (Fertility and sterility 2006) 3 22 44 58
  3. Single-nucleotide polymorphisms and mutation analyses of the TNP1 and TNP2 genes of fertile and infertile human male populations. (PMID: 16291974) Miyagawa Y … Tanaka H (Journal of andrology 2005) 3 22 44 58
  4. Expression of mRNA and protein of nucleoproteins during human spermiogenesis. (PMID: 9809674) Steger K … Bergmann M (Molecular human reproduction 1998) 3 4 22 58
  5. Genome-wide association study identifies four loci associated with eruption of permanent teeth. (PMID: 21931568) Geller F … Melbye M (PLoS genetics 2011) 3 44 58

Products for TNP1 Gene

Sources for TNP1 Gene

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