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TNN (Tenascin N) is a Protein Coding gene. Diseases associated with TNN include Cardiomyopathy, Familial Restrictive, 3 and Miliaria. Among its related pathways are Degradation of the extracellular matrix and Focal Adhesion. Gene Ontology (GO) annotations related to this gene include identical protein binding and integrin binding. An important paralog of this gene is TNR.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH01J175067 | Enhancer | 0.3 | Ensembl CraniofacialAtlas | 600.7 | -0.2 | -201 | 1.1 | TNN ENTR1P2 MRPS14 | ||
GH01J175071 | Enhancer | 0.9 | ENCODE CraniofacialAtlas | 22.9 | +4.8 | 4760 | 2.7 | CTCF KDM1A ZNF692 POLR2A ZNF600 ZNF341 CEBPA SCRT2 CEBPB MGA | TNN MN309018 KIAA0040 | |
GH01J175088 | Enhancer | 0.6 | Ensembl | 33.8 | +21.3 | 21268 | 1 | ATF7 ZNF316 ATF2 RCOR1 JUND RFX5 CHD2 GATA2 MAFK JUN | TNN MN309018 KIAA0040 | |
GH01J175090 | Enhancer | 0.5 | Ensembl | 34.6 | +23.2 | 23168 | 0.8 | ZNF501 ZXDB ZNF580 ZNF664 REST ZNF558 ZBTB21 ZNF121 ZNF680 | TNN MN309018 KIAA0040 | |
GH01J174963 | Promoter/Enhancer | 1.7 | FANTOM5 Ensembl ENCODE dbSUPER | 4.5 | -100.1 | -100085 | 9.2 | ZNF221 CEBPG SP1 LEF1 IKZF1 JUND FOXA1 RELA PKNOX1 ZNF24 | RABGAP1L RNU6-307P CACYBP TNN KIAA0040 RABGAP1L-AS1 RF00026-087 GPR52 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003674 | molecular_function | ND | -- |
GO:0005178 | integrin binding | IEA,IBA | 21873635 |
GO:0005515 | protein binding | IEA | -- |
GO:0042802 | identical protein binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005575 | cellular_component | ND | -- |
GO:0005576 | extracellular region | IEA | -- |
GO:0005615 | extracellular space | IBA | 21873635 |
GO:0009986 | cell surface | IEA | -- |
GO:0031012 | extracellular matrix | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Focal Adhesion |
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.61
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2 | PI3K-Akt signaling pathway | ||
3 | ECM-receptor interaction | ||
4 | MicroRNAs in cancer | ||
5 | ECM proteoglycans |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002076 | osteoblast development | IEA,ISS | -- |
GO:0007160 | cell-matrix adhesion | IEA,IBA | 21873635 |
GO:0007409 | axonogenesis | IEA | -- |
GO:0033689 | negative regulation of osteoblast proliferation | IEA,ISS | -- |
GO:0045668 | negative regulation of osteoblast differentiation | IEA,ISS | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TNN 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TNN 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TNN 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Tnn 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Tnn 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | TNN 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | TNN 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | TNN 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | TNN 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tnn 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | tnw 31 |
|
OneToOne | |
tenw 30 |
|
||||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
787859 | Likely Benign: not provided | 175,146,926(+) | G/T | INTRON_VARIANT | |
789154 | Benign: not provided | 175,085,490(+) | G/T | MISSENSE_VARIANT | |
rs10158841 | - | p.Asp1135Glu | |||
rs10798333 | - | p.Thr941Met | |||
rs16847812 | - | p.Asp289Asn |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv62e214 | CNV | gain | 21293372 |
dgv81e199 | CNV | deletion | 23128226 |
esv2159196 | CNV | deletion | 18987734 |
esv2566793 | CNV | deletion | 19546169 |
esv2719596 | CNV | deletion | 23290073 |
esv2719607 | CNV | deletion | 23290073 |
esv2719618 | CNV | deletion | 23290073 |
esv28085 | CNV | gain | 19812545 |
esv3587975 | CNV | loss | 21293372 |
nsv1011472 | CNV | loss | 25217958 |
nsv1113194 | CNV | deletion | 24896259 |
nsv160653 | CNV | deletion | 16902084 |
nsv3609 | CNV | deletion | 18451855 |
nsv3620 | CNV | insertion | 18451855 |
nsv498693 | CNV | loss | 21111241 |
nsv508648 | CNV | deletion | 20534489 |
nsv522101 | CNV | loss | 19592680 |
nsv821166 | CNV | deletion | 20802225 |
nsv825487 | CNV | gain | 20364138 |
Disorder | Aliases | PubMed IDs |
---|---|---|
cardiomyopathy, familial restrictive, 3 |
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miliaria |
|
|
breast cancer |
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