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Aliases for TNMD Gene

Aliases for TNMD Gene

  • Tenomodulin 2 3 3 5
  • Chondromodulin-1-Like Protein 3 4
  • Chondromodulin-I-Like Protein 3 4
  • BRICHOS Domain Containing 4 2 3
  • Myodulin 3 4
  • Tendin 3 4
  • HChM1L 3 4
  • CHM1L 3 4
  • HTeM 3 4
  • TEM 3 4
  • Chondromodulin-IB 3
  • BRICD4 3

External Ids for TNMD Gene

Previous GeneCards Identifiers for TNMD Gene

  • GC0XP095121
  • GC0XP096800
  • GC0XP097875
  • GC0XP098611
  • GC0XP099645
  • GC0XP099839
  • GC0XP089639

Summaries for TNMD Gene

Entrez Gene Summary for TNMD Gene

  • This gene encodes a protein that is related to chondromodulin-I, which is a cartilage-specific glycoprotein that functions to stimulate chondrocyte growth and to inhibit tube formation of endothelial cells. This protein is also an angiogenesis inhibitor. Genetic variation in this gene is associated with a risk for type 2 diabetes, central obesity and serum levels of systemic immune mediators in a body size-dependent manner. This gene is also a candidate gene for age-related macular degeneration, though a direct link has yet to be demonstrated. [provided by RefSeq, Sep 2009]

GeneCards Summary for TNMD Gene

TNMD (Tenomodulin) is a Protein Coding gene. Diseases associated with TNMD include Epileptic Encephalopathy, Early Infantile, 9. Gene Ontology (GO) annotations related to this gene include chitin binding. An important paralog of this gene is CNMD.

UniProtKB/Swiss-Prot for TNMD Gene

  • May be an angiogenesis inhibitor.

Gene Wiki entry for TNMD Gene

Additional gene information for TNMD Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNMD Gene

Genomics for TNMD Gene

GeneHancer (GH) Regulatory Elements for TNMD Gene

Promoters and enhancers for TNMD Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI100588 Enhancer 0.4 ENCODE 0.8 +3.3 3306 0.2 CTBP1 FOXA1 TNMD LOC105373298
GH0XI100615 Enhancer 0.6 ENCODE 0.3 +30.3 30346 0.2 CTCF NFIA ZNF384 FEZF1 BATF RAD21 RELA PRDM6 ZNF610 ZFP3 PCDH19 LOC105373298 TNMD
GH0XI100591 Enhancer 0.3 ENCODE 0.4 +6.8 6792 1.1 MAFK TSPAN6 SRPX2 DRP2 TNMD LOC105373298
GH0XI100593 Enhancer 0.2 ENCODE 0.4 +8.7 8715 0.8 TNMD LOC105373298
GH0XI100493 Enhancer 0.3 ENCODE 0.2 -89.8 -89825 2.2 PKNOX1 PIR46293 TNMD
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TNMD on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TNMD gene promoter:

Genomic Locations for TNMD Gene

Genomic Locations for TNMD Gene
16,191 bases
Plus strand

Genomic View for TNMD Gene

Genes around TNMD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNMD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNMD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNMD Gene

Proteins for TNMD Gene

  • Protein details for TNMD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q9HBX0
    • Q9UJG0

    Protein attributes for TNMD Gene

    317 amino acids
    Molecular mass:
    37130 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TNMD Gene


neXtProt entry for TNMD Gene

Post-translational modifications for TNMD Gene

  • Glycosylation at isoforms=2, 394 and isoforms=2, 3180

Other Protein References for TNMD Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TNMD Gene

Domains & Families for TNMD Gene

Gene Families for TNMD Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TNMD Gene


Suggested Antigen Peptide Sequences for TNMD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the chondromodulin-1 family.
  • Belongs to the chondromodulin-1 family.
genes like me logo Genes that share domains with TNMD: view

Function for TNMD Gene

Molecular function for TNMD Gene

UniProtKB/Swiss-Prot Function:
May be an angiogenesis inhibitor.

Gene Ontology (GO) - Molecular Function for TNMD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TNMD: view
genes like me logo Genes that share phenotypes with TNMD: view

Animal Models for TNMD Gene

MGI Knock Outs for TNMD:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TNMD Gene

Localization for TNMD Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNMD Gene

Isoform 1: Membrane; Single-pass type II membrane protein. Nucleus envelope.
Isoform 2: Membrane; Single-pass type II membrane protein. Nucleus envelope.
Isoform 3: Cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNMD gene
Compartment Confidence
nucleus 5
plasma membrane 3
extracellular 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TNMD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope IEA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TNMD: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TNMD Gene

Pathways & Interactions for TNMD Gene

No Data Available

Interacting Proteins for TNMD Gene

Gene Ontology (GO) - Biological Process for TNMD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001886 endothelial cell morphogenesis IEA --
GO:0001937 negative regulation of endothelial cell proliferation IEA --
GO:0016525 negative regulation of angiogenesis IEA --
GO:0035990 tendon cell differentiation IEA --
GO:0071773 cellular response to BMP stimulus IEA --
genes like me logo Genes that share ontologies with TNMD: view

No data available for Pathways by source and SIGNOR curated interactions for TNMD Gene

Drugs & Compounds for TNMD Gene

No Compound Related Data Available

Transcripts for TNMD Gene

mRNA/cDNA for TNMD Gene

Unigene Clusters for TNMD Gene

Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNMD Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b
SP1: -
SP2: -

Relevant External Links for TNMD Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNMD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNMD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNMD Gene

This gene is overexpressed in Adipose - Subcutaneous (x15.6), Adipose - Visceral (Omentum) (x10.5), and Breast - Mammary Tissue (x7.7).

NURSA nuclear receptor signaling pathways regulating expression of TNMD Gene:


SOURCE GeneReport for Unigene cluster for TNMD Gene:


mRNA Expression by UniProt/SwissProt for TNMD Gene:

Tissue specificity: Highly expressed in hypovascular connective tissues such as tendons. Has also strong expression in adipose tissue.

Evidence on tissue expression from TISSUES for TNMD Gene

  • Muscle(4.4)
genes like me logo Genes that share expression patterns with TNMD: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNMD Gene

Orthologs for TNMD Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNMD Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TNMD 33 34
  • 99.79 (n)
(Canis familiaris)
Mammalia TNMD 33 34
  • 94.11 (n)
(Bos Taurus)
Mammalia TNMD 33 34
  • 93.27 (n)
(Mus musculus)
Mammalia Tnmd 33 16 34
  • 91.59 (n)
(Rattus norvegicus)
Mammalia Tnmd 33
  • 91.38 (n)
(Monodelphis domestica)
Mammalia TNMD 34
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia TNMD 34
  • 69 (a)
(Gallus gallus)
Aves TNMD 33 34
  • 62.99 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731375 33
  • 64.36 (n)
(Danio rerio)
Actinopterygii tnmd 33 34
  • 55.17 (n)
Species where no ortholog for TNMD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNMD Gene

Gene Tree for TNMD (if available)
Gene Tree for TNMD (if available)

Paralogs for TNMD Gene

Paralogs for TNMD Gene

(1) SIMAP similar genes for TNMD Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TNMD: view

Variants for TNMD Gene

Sequence variations from dbSNP and Humsavar for TNMD Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000845035 -- 100,600,101(+) G/A downstream_transcript_variant
rs1001128180 -- 100,591,039(+) C/T intron_variant
rs1001321793 -- 100,590,546(+) T/G intron_variant
rs1001418981 -- 100,591,181(+) A/G intron_variant
rs1002762127 -- 100,599,352(+) C/T intron_variant

Variation tolerance for TNMD Gene

Residual Variation Intolerance Score: 35.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNMD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TNMD Gene

Disorders for TNMD Gene

MalaCards: The human disease database

(1) MalaCards diseases for TNMD Gene - From: DISEASES

Disorder Aliases PubMed IDs
epileptic encephalopathy, early infantile, 9
  • eiee9
- elite association - COSMIC cancer census association via MalaCards
Search TNMD in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TNMD

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TNMD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNMD Gene

Publications for TNMD Gene

  1. Tenomodulin is highly expressed in adipose tissue, increased in obesity, and down-regulated during diet-induced weight loss. (PMID: 19602561) Saiki A … Carlsson LM (The Journal of clinical endocrinology and metabolism 2009) 3 4 22 58
  2. Single nucleotide polymorphisms of the tenomodulin gene (TNMD) in age-related macular degeneration. (PMID: 19381347) Tolppanen AM … Pulkkinen L (Molecular vision 2009) 3 22 44 58
  3. The genetic variation in the tenomodulin gene is associated with serum total and LDL cholesterol in a body size-dependent manner. (PMID: 18982016) Tolppanen AM … Kuusisto J (International journal of obesity (2005) 2008) 3 22 44 58
  4. The genetic variation of the tenomodulin gene (TNMD) is associated with serum levels of systemic immune mediators--the Finnish Diabetes Prevention Study. (PMID: 18580688) Tolppanen AM … Finnish Diabetes Prevention Study Group (Genetics in medicine : official journal of the American College of Medical Genetics 2008) 3 22 44 58
  5. A novel gene, tendin, is strongly expressed in tendons and ligaments and shows high homology with chondromodulin-I. (PMID: 11357195) Brandau O … Aszódi A (Developmental dynamics : an official publication of the American Association of Anatomists 2001) 3 4 22 58

Products for TNMD Gene

Sources for TNMD Gene

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