This gene encodes a protein that is related to chondromodulin-I, which is a cartilage-specific glycoprotein that functions to stimulate chondrocyte growth and to inhibit tube formation of endothelial cells. This protein is also an angiogenesis inhibitor. Genetic variation in this gene is associated with a risk for type 2 diabetes, central obesity and serum levels of systemic im... See more...

Aliases for TNMD Gene

Aliases for TNMD Gene

  • Tenomodulin 2 3 4 5
  • Myodulin 2 3 4
  • Tendin 2 3 4
  • Chondromodulin-1-Like Protein 3 4
  • Chondromodulin-I-Like Protein 3 4
  • BRICHOS Domain Containing 4 2 3
  • BRICD4 2 3
  • HChM1L 3 4
  • CHM1L 3 4
  • ChM1L 2 4
  • HTeM 3 4
  • TEM 2 3
  • Chondromodulin-IB 3
  • TNMD 5
  • TeM 4

External Ids for TNMD Gene

Previous GeneCards Identifiers for TNMD Gene

  • GC0XP095121
  • GC0XP096800
  • GC0XP097875
  • GC0XP098611
  • GC0XP099645
  • GC0XP099839
  • GC0XP089639

Summaries for TNMD Gene

Entrez Gene Summary for TNMD Gene

  • This gene encodes a protein that is related to chondromodulin-I, which is a cartilage-specific glycoprotein that functions to stimulate chondrocyte growth and to inhibit tube formation of endothelial cells. This protein is also an angiogenesis inhibitor. Genetic variation in this gene is associated with a risk for type 2 diabetes, central obesity and serum levels of systemic immune mediators in a body size-dependent manner. This gene is also a candidate gene for age-related macular degeneration, though a direct link has yet to be demonstrated. [provided by RefSeq, Sep 2009]

GeneCards Summary for TNMD Gene

TNMD (Tenomodulin) is a Protein Coding gene. Diseases associated with TNMD include Epicondylitis and Epileptic Encephalopathy, Early Infantile, 9. Gene Ontology (GO) annotations related to this gene include chitin binding. An important paralog of this gene is CNMD.

UniProtKB/Swiss-Prot Summary for TNMD Gene

Gene Wiki entry for TNMD Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TNMD Gene

Genomics for TNMD Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TNMD Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ100584 Promoter 0.3 EPDnew 600.7 0.0 -19 0.1 TNMD piR-56240-003 PCDH19
GH0XJ100635 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 0.2 +51.4 51365 2.6 CTCF PRDM10 GABPA PRDM1 RBFOX2 POLR2A ZNF600 CEBPA TAF1 SP1 TSPAN6 lnc-SYTL4-2 PCDH19 LOC105373298 TNMD
GH0XJ100588 Enhancer 0.5 Ensembl ENCODE 0.7 +3.3 3306 0.7 CTBP1 FOXA1 TNMD LOC105373298 TSPAN6
GH0XJ100591 Enhancer 0.5 Ensembl ENCODE 0.4 +7.8 7793 3.3 MAFF MAFK TSPAN6 SRPX2 PCDH19 DRP2 TNMD LOC105373298
GH0XJ100615 Enhancer 0.7 Ensembl ENCODE 0.3 +30.3 30297 0.3 CTCF RELA RUNX3 SMC3 ZNF610 BATF RAD21 ZFP3 FEZF1 PRDM6 PCDH19 LOC105373298 TSPAN6 TNMD
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TNMD on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TNMD

Top Transcription factor binding sites by QIAGEN in the TNMD gene promoter:
  • c-Myb
  • E47
  • GR-alpha
  • GR-beta
  • HNF-1
  • HNF-1A
  • Nkx2-5
  • Tal-1beta
  • TBP
  • TFIID

Genomic Locations for TNMD Gene

Genomic Locations for TNMD Gene
chrX:100,584,936-100,599,885
(GRCh38/hg38)
Size:
14,950 bases
Orientation:
Plus strand
chrX:99,839,790-99,854,882
(GRCh37/hg19)
Size:
15,093 bases
Orientation:
Plus strand

Genomic View for TNMD Gene

Genes around TNMD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNMD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNMD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNMD Gene

Proteins for TNMD Gene

  • Protein details for TNMD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2S6-TNMD_HUMAN
    Recommended name:
    Tenomodulin
    Protein Accession:
    Q9H2S6
    Secondary Accessions:
    • Q9HBX0
    • Q9UJG0

    Protein attributes for TNMD Gene

    Size:
    317 amino acids
    Molecular mass:
    37130 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TNMD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNMD Gene

Post-translational modifications for TNMD Gene

  • Glycosylation at Asn94 and Asn180
  • Modification sites at PhosphoSitePlus

Other Protein References for TNMD Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TNMD Gene

Domains & Families for TNMD Gene

Gene Families for TNMD Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TNMD Gene

InterPro:
Blocks:
  • BRICHOS domain
ProtoNet:

Suggested Antigen Peptide Sequences for TNMD Gene

GenScript: Design optimal peptide antigens:
  • Tendin (TNMD_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H2S6

UniProtKB/Swiss-Prot:

TNMD_HUMAN :
  • Belongs to the chondromodulin-1 family.
Family:
  • Belongs to the chondromodulin-1 family.
genes like me logo Genes that share domains with TNMD: view

Function for TNMD Gene

Molecular function for TNMD Gene

UniProtKB/Swiss-Prot Function:
May be an angiogenesis inhibitor.

Gene Ontology (GO) - Molecular Function for TNMD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TNMD: view
genes like me logo Genes that share phenotypes with TNMD: view

Animal Models for TNMD Gene

MGI Knock Outs for TNMD:

Animal Model Products

  • Taconic Biosciences Mouse Models for TNMD

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNMD

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TNMD Gene

Localization for TNMD Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNMD Gene

[Isoform 1]: Membrane. Single-pass type II membrane protein. Nucleus envelope.
[Isoform 2]: Membrane. Single-pass type II membrane protein. Nucleus envelope.
[Isoform 3]: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNMD gene
Compartment Confidence
nucleus 5
plasma membrane 3
extracellular 2
cytoskeleton 2
mitochondrion 1
endoplasmic reticulum 1
cytosol 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for TNMD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope IEA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TNMD: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TNMD Gene

Pathways & Interactions for TNMD Gene

PathCards logo

SuperPathways for TNMD Gene

No Data Available

Gene Ontology (GO) - Biological Process for TNMD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001886 endothelial cell morphogenesis IEA,IBA 21873635
GO:0001937 negative regulation of endothelial cell proliferation IEA,IBA 21873635
GO:0016525 negative regulation of angiogenesis IEA,IBA 21873635
GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway IBA 21873635
GO:0035990 tendon cell differentiation IEA --
genes like me logo Genes that share ontologies with TNMD: view

No data available for Pathways by source and SIGNOR curated interactions for TNMD Gene

Drugs & Compounds for TNMD Gene

No Compound Related Data Available

Transcripts for TNMD Gene

mRNA/cDNA for TNMD Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNMD

Alternative Splicing Database (ASD) splice patterns (SP) for TNMD Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b
SP1: -
SP2: -
SP3:

Relevant External Links for TNMD Gene

GeneLoc Exon Structure for
TNMD

Expression for TNMD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TNMD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNMD Gene

This gene is overexpressed in Adipose - Subcutaneous (x15.6), Adipose - Visceral (Omentum) (x10.5), and Breast - Mammary Tissue (x7.7).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TNMD

SOURCE GeneReport for Unigene cluster for TNMD Gene:

Hs.132957

mRNA Expression by UniProt/SwissProt for TNMD Gene:

Q9H2S6-TNMD_HUMAN
Tissue specificity: Highly expressed in hypovascular connective tissues such as tendons. Has also strong expression in adipose tissue.

Evidence on tissue expression from TISSUES for TNMD Gene

  • Muscle(4.5)
  • Bone(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with TNMD: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNMD Gene

Orthologs for TNMD Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNMD Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TNMD 30 31
  • 99.79 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TNMD 30 31
  • 94.11 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TNMD 30 31
  • 93.27 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tnmd 30 17 31
  • 91.59 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tnmd 30
  • 91.38 (n)
Oppossum
(Monodelphis domestica)
Mammalia TNMD 31
  • 73 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TNMD 31
  • 69 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TNMD 30 31
  • 62.99 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC101731375 30
  • 64.36 (n)
Zebrafish
(Danio rerio)
Actinopterygii tnmd 30 31
  • 55.17 (n)
OneToOne
Species where no ortholog for TNMD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TNMD Gene

ENSEMBL:
Gene Tree for TNMD (if available)
TreeFam:
Gene Tree for TNMD (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TNMD: view image

Paralogs for TNMD Gene

Paralogs for TNMD Gene

(1) SIMAP similar genes for TNMD Gene using alignment to 1 proteins:

  • TNMD_HUMAN
genes like me logo Genes that share paralogs with TNMD: view

Variants for TNMD Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TNMD Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
709173 Likely Benign: not provided 100,599,516(+) T/C SYNONYMOUS_VARIANT
729593 Benign: not provided 100,599,152(+) A/C SYNONYMOUS_VARIANT
773792 Likely Benign: not provided 100,585,294(+) A/G MISSENSE_VARIANT
780711 Benign: not provided 100,585,042(+) T/C SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for TNMD Gene

Variation tolerance for TNMD Gene

Residual Variation Intolerance Score: 35.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNMD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNMD

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TNMD Gene

Disorders for TNMD Gene

MalaCards: The human disease database

(5) MalaCards diseases for TNMD Gene - From: DISEASES

Disorder Aliases PubMed IDs
epicondylitis
  • andrel epicondylitis
epileptic encephalopathy, early infantile, 9
  • eiee9
shoulder impingement syndrome
  • impingement syndrome of shoulder region
tendinitis
  • tendinopathy
acrocallosal syndrome
  • acls
- elite association - COSMIC cancer census association via MalaCards
Search TNMD in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TNMD

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TNMD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNMD Gene

Publications for TNMD Gene

  1. Tenomodulin is highly expressed in adipose tissue, increased in obesity, and down-regulated during diet-induced weight loss. (PMID: 19602561) Saiki A … Carlsson LM (The Journal of clinical endocrinology and metabolism 2009) 3 4 23
  2. Single nucleotide polymorphisms of the tenomodulin gene (TNMD) in age-related macular degeneration. (PMID: 19381347) Tolppanen AM … Pulkkinen L (Molecular vision 2009) 3 23 41
  3. The genetic variation in the tenomodulin gene is associated with serum total and LDL cholesterol in a body size-dependent manner. (PMID: 18982016) Tolppanen AM … Kuusisto J (International journal of obesity (2005) 2008) 3 23 41
  4. The genetic variation of the tenomodulin gene (TNMD) is associated with serum levels of systemic immune mediators--the Finnish Diabetes Prevention Study. (PMID: 18580688) Tolppanen AM … Finnish Diabetes Prevention Study Group (Genetics in medicine : official journal of the American College of Medical Genetics 2008) 3 23 41
  5. A novel gene, tendin, is strongly expressed in tendons and ligaments and shows high homology with chondromodulin-I. (PMID: 11357195) Brandau O … Aszódi A (Developmental dynamics : an official publication of the American Association of Anatomists 2001) 3 4 23

Products for TNMD Gene

  • Signalway ELISA kits for TNMD
  • Signalway Proteins for TNMD

Sources for TNMD Gene