Aliases for TNKS2 Gene
- Tankyrase 2 2 3 5
- TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 2 3 4
- Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 2 3
- Protein Poly-ADP-Ribosyltransferase Tankyrase-2 3 4
- ADP-Ribosyltransferase Diphtheria Toxin-Like 6 3 4
- Poly [ADP-Ribose] Polymerase Tankyrase-2 3 4
- Poly [ADP-Ribose] Polymerase 5B 3 4
- Tankyrase-Related Protein 3 4
- Tankyrase-Like Protein 3 4
- Tankyrase II 3 4
- PARP5B 3 4
External Ids for TNKS2 Gene
Previous GeneCards Identifiers for TNKS2 Gene
GeneCards Summary for TNKS2 Gene
TNKS2 (Tankyrase 2) is a Protein Coding gene. Diseases associated with TNKS2 include Acrocallosal Syndrome. Among its related pathways are Telomere Extension by Telomerase and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include enzyme binding and NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is TNKS.
UniProtKB/Swiss-Prot Summary for TNKS2 Gene
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:11739745, PubMed:11802774, PubMed:19759537, PubMed:21478859, PubMed:23622245, PubMed:25043379). Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation (PubMed:19759537, PubMed:21478859). Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination (PubMed:21478859). Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length (PubMed:11739745). Stimulates 26S proteasome activity (PubMed:23622245).
The Tankyrases (TNKS1/PARP5A and TNKS2/PARP5B) are poly (ADP-ribose) polymerases that catalyze the ADP-ribosylation of target proteins. TNKS' are involved in the regulation of Wnt/beta-catenin signaling and have been implicated in the pathology of various forms of cancer.