Aliases for TNKS2 Gene
- Tankyrase 2 2 3 5
- TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 2 3 4
- PARP5B 2 3 4
- ARTD6 2 3 4
- TANK2 2 3 4
- TNKL 2 3 4
- Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 2 3
- Protein Poly-ADP-Ribosyltransferase Tankyrase-2 3 4
- ADP-Ribosyltransferase Diphtheria Toxin-Like 6 3 4
- Poly [ADP-Ribose] Polymerase Tankyrase-2 3 4
- Poly [ADP-Ribose] Polymerase 5B 3 4
External Ids for TNKS2 Gene
Previous GeneCards Identifiers for TNKS2 Gene
GeneCards Summary for TNKS2 Gene
TNKS2 (Tankyrase 2) is a Protein Coding gene. Diseases associated with TNKS2 include Arthrogryposis, Renal Dysfunction, And Cholestasis 1 and Cherubism. Among its related pathways are Signaling by GPCR and Telomere Extension by Telomerase. Gene Ontology (GO) annotations related to this gene include enzyme binding and NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is TNKS.
UniProtKB/Swiss-Prot Summary for TNKS2 Gene
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:11739745, PubMed:11802774, PubMed:19759537, PubMed:21478859, PubMed:23622245, PubMed:25043379). Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation (PubMed:19759537, PubMed:21478859). Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination (PubMed:21478859). Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length (PubMed:11739745). Stimulates 26S proteasome activity (PubMed:23622245).
The Tankyrases (TNKS1/PARP5A and TNKS2/PARP5B) are poly (ADP-ribose) polymerases that catalyze the ADP-ribosylation of target proteins. TNKS' are involved in the regulation of Wnt/beta-catenin signaling and have been implicated in the pathology of various forms of cancer.