Aliases for TNKS1BP1 Gene

Aliases for TNKS1BP1 Gene

  • Tankyrase 1 Binding Protein 1 2 3 5
  • Tankyrase 1 Binding Protein 1, 182kDa 2 3
  • 182 KDa Tankyrase-1-Binding Protein 3 4
  • TAB182 3 4
  • Testis Secretory Sperm-Binding Protein Li 206a 3
  • Tankyrase 1-Binding Protein Of 182 KDa 3
  • KIAA1741 4

External Ids for TNKS1BP1 Gene

Previous GeneCards Identifiers for TNKS1BP1 Gene

  • GC11M059460
  • GC11M058580
  • GC11M057318
  • GC11M056842
  • GC11M056823
  • GC11M057067
  • GC11M053415
  • GC11M057521
  • GC11M058186

Summaries for TNKS1BP1 Gene

GeneCards Summary for TNKS1BP1 Gene

TNKS1BP1 (Tankyrase 1 Binding Protein 1) is a Protein Coding gene. Among its related pathways are Regulation of TP53 Activity and TP53 Regulates Transcription of Cell Cycle Genes. Gene Ontology (GO) annotations related to this gene include enzyme binding and ankyrin binding. An important paralog of this gene is KIAA1671.

Gene Wiki entry for TNKS1BP1 Gene

Additional gene information for TNKS1BP1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TNKS1BP1 Gene

Genomics for TNKS1BP1 Gene

GeneHancer (GH) Regulatory Elements for TNKS1BP1 Gene

Promoters and enhancers for TNKS1BP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TNKS1BP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TNKS1BP1 gene promoter:
  • E47
  • Egr-4
  • GATA-1
  • Hand1
  • HFH-1
  • Lmo2
  • Pax-4a
  • Pax-5
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for TNKS1BP1 Gene

Genomic Locations for TNKS1BP1 Gene
chr11:57,299,629-57,324,952
(GRCh38/hg38)
Size:
25,324 bases
Orientation:
Minus strand
chr11:57,067,103-57,092,426
(GRCh37/hg19)
Size:
25,324 bases
Orientation:
Minus strand

Genomic View for TNKS1BP1 Gene

Genes around TNKS1BP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNKS1BP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNKS1BP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNKS1BP1 Gene

Proteins for TNKS1BP1 Gene

  • Protein details for TNKS1BP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0C2-TB182_HUMAN
    Recommended name:
    182 kDa tankyrase-1-binding protein
    Protein Accession:
    Q9C0C2
    Secondary Accessions:
    • A7E2F8
    • Q6PJ35
    • Q6ZV74

    Protein attributes for TNKS1BP1 Gene

    Size:
    1729 amino acids
    Molecular mass:
    181796 Da
    Quaternary structure:
    • Binds to the ANK repeat domain of TNKS1 and TNKS2.
    SequenceCaution:
    • Sequence=BAB21832.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB84939.1; Type=Frameshift; Positions=1070, 1098, 1466; Evidence={ECO:0000305}; Sequence=BAB84939.1; Type=Frameshift; Positions=1071, 1097, 1467; Evidence={ECO:0000305};

    Alternative splice isoforms for TNKS1BP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNKS1BP1 Gene

Post-translational modifications for TNKS1BP1 Gene

Other Protein References for TNKS1BP1 Gene

Antibody Products

No data available for DME Specific Peptides for TNKS1BP1 Gene

Domains & Families for TNKS1BP1 Gene

Gene Families for TNKS1BP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TNKS1BP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TNKS1BP1 Gene

GenScript: Design optimal peptide antigens:
  • TNKS1BP1 protein (Q86TK2_HUMAN)
  • 182 kDa tankyrase-1-binding protein (TB182_HUMAN)
genes like me logo Genes that share domains with TNKS1BP1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TNKS1BP1 Gene

Function for TNKS1BP1 Gene

Phenotypes From GWAS Catalog for TNKS1BP1 Gene

Gene Ontology (GO) - Molecular Function for TNKS1BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11854288
GO:0019899 enzyme binding IDA 11854288
GO:0044877 protein-containing complex binding IPI 25749521
GO:0045296 cadherin binding HDA 25468996
GO:0071532 ankyrin repeat binding IPI,IMP 11854288
genes like me logo Genes that share ontologies with TNKS1BP1: view
genes like me logo Genes that share phenotypes with TNKS1BP1: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TNKS1BP1 Gene

Localization for TNKS1BP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNKS1BP1 Gene

Nucleus. Cytoplasm, cytoskeleton. Chromosome. Note=Colocalizes with chromosomes during mitosis, and in the cytoplasm with cortical actin.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNKS1BP1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for TNKS1BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 11854288
GO:0005694 chromosome IEA --
GO:0005720 nuclear heterochromatin IDA 11854288
GO:0005737 cytoplasm IDA,IEA 11854288
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TNKS1BP1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TNKS1BP1 Gene

Pathways & Interactions for TNKS1BP1 Gene

genes like me logo Genes that share pathways with TNKS1BP1: view

Gene Ontology (GO) - Biological Process for TNKS1BP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0006302 double-strand break repair IMP 25749521
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS --
GO:0007004 telomere maintenance via telomerase NAS 11854288
GO:0010800 positive regulation of peptidyl-threonine phosphorylation IMP 25749521
genes like me logo Genes that share ontologies with TNKS1BP1: view

No data available for SIGNOR curated interactions for TNKS1BP1 Gene

Drugs & Compounds for TNKS1BP1 Gene

No Compound Related Data Available

Transcripts for TNKS1BP1 Gene

mRNA/cDNA for TNKS1BP1 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNKS1BP1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - - -
SP2: - -
SP3:
SP4: - -
SP5: -

Relevant External Links for TNKS1BP1 Gene

GeneLoc Exon Structure for
TNKS1BP1
ECgene alternative splicing isoforms for
TNKS1BP1

Expression for TNKS1BP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNKS1BP1 Gene

Protein differential expression in normal tissues from HIPED for TNKS1BP1 Gene

This gene is overexpressed in Cervix (15.9) and Pancreas (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TNKS1BP1 Gene



Protein tissue co-expression partners for TNKS1BP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TNKS1BP1 Gene:

TNKS1BP1

SOURCE GeneReport for Unigene cluster for TNKS1BP1 Gene:

Hs.530730

mRNA Expression by UniProt/SwissProt for TNKS1BP1 Gene:

Q9C0C2-TB182_HUMAN
Tissue specificity: Detected in testis, ovary, lung, skeletal muscle, heart, prostate and pancreas, and at very low levels in brain and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for TNKS1BP1 Gene

  • Liver(4.5)
  • Skin(4.4)
  • Spleen(4.3)
  • Nervous system(4.3)
  • Pancreas(2.3)
genes like me logo Genes that share expression patterns with TNKS1BP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNKS1BP1 Gene

Orthologs for TNKS1BP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNKS1BP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNKS1BP1 33 32
  • 97.98 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TNKS1BP1 33 32
  • 83.01 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tnks1bp1 17 33 32
  • 77.51 (n)
rat
(Rattus norvegicus)
Mammalia Tnks1bp1 32
  • 77.5 (n)
cow
(Bos Taurus)
Mammalia TNKS1BP1 33 32
  • 73.32 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TNKS1BP1 33
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNKS1BP1 33
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves TNKS1BP1 33
  • 33 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TNKS1BP1 33
  • 29 (a)
OneToOne
Species where no ortholog for TNKS1BP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TNKS1BP1 Gene

ENSEMBL:
Gene Tree for TNKS1BP1 (if available)
TreeFam:
Gene Tree for TNKS1BP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TNKS1BP1: view image

Paralogs for TNKS1BP1 Gene

Paralogs for TNKS1BP1 Gene

genes like me logo Genes that share paralogs with TNKS1BP1: view

Variants for TNKS1BP1 Gene

Sequence variations from dbSNP and Humsavar for TNKS1BP1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000116445 -- 57,311,623(-) C/T intron_variant
rs1000123600 -- 57,316,132(-) A/T intron_variant
rs1000226550 -- 57,314,871(-) T/C intron_variant
rs1000252545 -- 57,311,442(-) C/T intron_variant
rs1000368828 -- 57,299,475(-) T/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TNKS1BP1 Gene

Variant ID Type Subtype PubMed ID
esv3547831 CNV deletion 23714750
nsv1070036 CNV deletion 25765185

Variation tolerance for TNKS1BP1 Gene

Residual Variation Intolerance Score: 89.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.64; 82.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNKS1BP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNKS1BP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNKS1BP1 Gene

Disorders for TNKS1BP1 Gene

Additional Disease Information for TNKS1BP1

No disorders were found for TNKS1BP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNKS1BP1 Gene

Publications for TNKS1BP1 Gene

  1. The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182). (PMID: 11854288) Seimiya H … Smith S (The Journal of biological chemistry 2002) 2 3 4 23 56
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 56
  3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 56
  4. Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones. (PMID: 12693554) Jikuya H … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2003) 3 4 56
  5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D … Nagase T (DNA research : an international journal for rapid publication of reports on genes and genomes 2002) 3 4 56

Products for TNKS1BP1 Gene

Sources for TNKS1BP1 Gene