Aliases for TNKS Gene

Aliases for TNKS Gene

  • Tankyrase 2 3 5
  • PARP5A 2 3 4
  • ARTD5 2 3 4
  • TINF1 2 3 4
  • TNKS1 2 3 4
  • TIN1 2 3 4
  • Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 3
  • TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 1 2 3
  • Protein Poly-ADP-Ribosyltransferase Tankyrase-1 3 4
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 5 3 4
  • Poly [ADP-Ribose] Polymerase Tankyrase-1 3 4
  • Poly [ADP-Ribose] Polymerase 5A 3 4
  • Tankyrase I 3 4
  • Tankyrase-1 3 4
  • PARP-5a 2 3
  • TNKS-1 3 4
  • PARPL 3 4
  • PART5 2 3
  • TANK1 3 4
  • TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 4
  • EC 2.4.2.30 4
  • EC 2.4.2.- 4
  • TNKS 5

External Ids for TNKS Gene

Previous GeneCards Identifiers for TNKS Gene

  • GC08P009330
  • GC08P009450
  • GC08P008339
  • GC08P009413

Summaries for TNKS Gene

GeneCards Summary for TNKS Gene

TNKS (Tankyrase) is a Protein Coding gene. Diseases associated with TNKS include Cherubism and Lung Acinar Adenocarcinoma. Among its related pathways are Signaling by GPCR and Deubiquitination. Gene Ontology (GO) annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is TNKS2.

UniProtKB/Swiss-Prot Summary for TNKS Gene

  • Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:10988299, PubMed:11739745, PubMed:16076287, PubMed:19759537, PubMed:21478859, PubMed:22864114, PubMed:23622245, PubMed:25043379). Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation (PubMed:19759537, PubMed:21478859). Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination (PubMed:21478859). Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length (PubMed:11739745). Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI (PubMed:22864114). May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles (PubMed:10988299). May be involved in spindle pole assembly through PARsylation of NUMA1 (PubMed:16076287). Stimulates 26S proteasome activity (PubMed:23622245).

Tocris Summary for TNKS Gene

  • The Tankyrases (TNKS1/PARP5A and TNKS2/PARP5B) are poly (ADP-ribose) polymerases that catalyze the ADP-ribosylation of target proteins. TNKS' are involved in the regulation of Wnt/beta-catenin signaling and have been implicated in the pathology of various forms of cancer.

Gene Wiki entry for TNKS Gene

No data available for Entrez Gene Summary , CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TNKS Gene

Genomics for TNKS Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TNKS Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J009554 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 256.4 +1.8 1816 5.1 SP1 ZNF207 ZNF600 IKZF1 ZNF592 KLF9 POLR2A ZNF223 BRCA1 YY1 ENSG00000272267 TNKS ERI1 RPL10P19 lnc-ERI1-7 MK280269-061 MSRA
GH08J008624 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.8 -928.6 -928626 4 JUND NFIC BCL11A CEBPB DEK TRIM22 ZEB1 MAX EP300 SMC3 FAM86B3P TNKS CLDN23 ALG1L13P RPL10P19 HSALNG0063283 HSALNG0063281 HSALNG0063275 RF00017-6286 PRAG1
GH08J009608 Enhancer 0.7 Ensembl 18.3 +53.2 53170 3.2 ZNF600 CEBPA MAFF FOXA2 ZNF316 EBF1 ZBTB48 MAFK ATF4 PRDM4 TNKS ENSG00000272267 RPL10P19 lnc-PPP1R3B-12 piR-59297-625 MK280269-061 MSRA
GH08J009614 Promoter/Enhancer 1 Ensembl ENCODE 12.1 +59.9 59866 0.2 ZNF580 FEZF1 BHLHE40 SPI1 POLR2A SCRT1 ZNF362 ZNF664 ZNF18 PRDM4 TNKS lnc-PPP1R3B-12 piR-59297-625 MK280269-061 MSRA
GH08J009679 Promoter 0.7 Ensembl 11.1 +124.5 124471 0.2 FEZF1 SP2 ZBTB21 ZNF366 PKNOX1 ZNF629 ZBTB6 RAD21 POLR2A PRDM1 TNKS HSALNG0063344 HSALNG0063345 MSRA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TNKS on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TNKS

Top Transcription factor binding sites by QIAGEN in the TNKS gene promoter:
  • c-Myb
  • CREB
  • deltaCREB
  • Gfi-1
  • Max
  • p300
  • Sp1
  • TBP

Genomic Locations for TNKS Gene

Latest Assembly
chr8:9,555,230-9,782,346
(GRCh38/hg38)
Size:
227,117 bases
Orientation:
Plus strand

Previous Assembly
chr8:9,413,422-9,639,856
(GRCh37/hg19 by Entrez Gene)
Size:
226,435 bases
Orientation:
Plus strand

chr8:9,413,424-9,639,856
(GRCh37/hg19 by Ensembl)
Size:
226,433 bases
Orientation:
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr8(PATCHES):3,566,718-3,795,557 (-)

Genomic View for TNKS Gene

Genes around TNKS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNKS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNKS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNKS Gene

Proteins for TNKS Gene

  • Protein details for TNKS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95271-TNKS1_HUMAN
    Recommended name:
    Poly [ADP-ribose] polymerase tankyrase-1
    Protein Accession:
    O95271
    Secondary Accessions:
    • O95272
    • Q4G0F2

    Protein attributes for TNKS Gene

    Size:
    1327 amino acids
    Molecular mass:
    142039 Da
    Quaternary structure:
    • Oligomerizes and associates with TNKS2. Interacts with the cytoplasmic domain of LNPEP/Otase in SLC2A4/GLUT4-vesicles. Binds to the N-terminus of telomeric TERF1 via the ANK repeats. Found in a complex with POT1; TERF1 and TINF2 (PubMed:12768206). Interacts with AXIN1 (PubMed:19759537, PubMed:21478859, PubMed:21799911). Interacts with AXIN2 (PubMed:19759537, PubMed:21478859). Interacts with BLZF1 and CASC3 (PubMed:21478859). Interacts with NUMA1 (PubMed:12080061).

    Three dimensional structures from OCA and Proteopedia for TNKS Gene

    Alternative splice isoforms for TNKS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNKS Gene

Post-translational modifications for TNKS Gene

  • Phosphorylated on serine residues by MAPK kinases upon insulin stimulation. Phosphorylated during mitosis.
  • Ubiquitinated by RNF146 when auto-poly-ADP-ribosylated, leading to its degradation.
  • ADP-ribosylated (-auto). Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination.
  • Ubiquitination at Lys210 and Lys767
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TNKS Gene

Domains & Families for TNKS Gene

Protein Domains for TNKS Gene

InterPro:
Blocks:
  • Ankyrin repeat signature
  • Sterile alpha motif SAM
  • Sterile alpha motif homology 2

Suggested Antigen Peptide Sequences for TNKS Gene

GenScript: Design optimal peptide antigens:
  • Tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase (Q4G0F2_HUMAN)
  • Tankyrase I (TNKS1_HUMAN)
genes like me logo Genes that share domains with TNKS: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TNKS Gene

Function for TNKS Gene

Molecular function for TNKS Gene

UniProtKB/Swiss-Prot Function:
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:10988299, PubMed:11739745, PubMed:16076287, PubMed:19759537, PubMed:21478859, PubMed:22864114, PubMed:23622245, PubMed:25043379). Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation (PubMed:19759537, PubMed:21478859). Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination (PubMed:21478859). Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length (PubMed:11739745). Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI (PubMed:22864114). May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles (PubMed:10988299). May be involved in spindle pole assembly through PARsylation of NUMA1 (PubMed:16076287). Stimulates 26S proteasome activity (PubMed:23622245).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.; EC=2.4.2.30; Evidence={ECO:0000269|PubMed:19759537};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide; Xref=Rhea:RHEA:54424, Rhea:RHEA-COMP:9867, Rhea:RHEA-COMP:13832, ChEBI:CHEBI:17154, ChEBI:CHEBI:29961, ChEBI:CHEBI:57540, ChEBI:CHEBI:138102; Evidence={ECO:0000305};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide; Xref=Rhea:RHEA:58224, Rhea:RHEA-COMP:10208, Rhea:RHEA-COMP:15089, ChEBI:CHEBI:17154, ChEBI:CHEBI:29973, ChEBI:CHEBI:57540, ChEBI:CHEBI:142540; Evidence={ECO:0000305};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Specifically inhibited by XAV939, a small molecule, leading to inhibit the Wnt signaling pathway by stabilizing AXIN1 and AXIN2.
GENATLAS Biochemistry:
tankyrase,a poly (ADP ribose) polymerase located at telomeres,centromeres and nuclear pore complexes,binding the telomere-specific DNA binding protein TERF1 potential modulator of telomere length

Enzyme Numbers (IUBMB) for TNKS Gene

Phenotypes From GWAS Catalog for TNKS Gene

Gene Ontology (GO) - Molecular Function for TNKS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003950 NAD+ ADP-ribosyltransferase activity IEA,TAS --
GO:0005515 protein binding IEA,IPI 9822378
GO:0008270 zinc ion binding IDA 18436240
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with TNKS: view
genes like me logo Genes that share phenotypes with TNKS: view

Animal Models for TNKS Gene

MGI Knock Outs for TNKS:
  • Tnks Tnks<tm1.1Yjc>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNKS

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNKS Gene

Localization for TNKS Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNKS Gene

Cytoplasm. Golgi apparatus membrane. Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus, nuclear pore complex. Chromosome, telomere. Cytoplasm, cytoskeleton, spindle pole. Note=Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles (PubMed:22864114). A minor proportion is also found at nuclear pore complexes and around the pericentriolar matrix of mitotic centromeres (PubMed:10523501). During interphase, a small fraction of TNKS is found in the nucleus, associated with TERF1 (PubMed:12768206). Localizes to spindle poles at mitosis onset via interaction with NUMA1 (PubMed:12080061). {ECO:0000269 PubMed:10523501, ECO:0000269 PubMed:12080061, ECO:0000269 PubMed:12768206, ECO:0000269 PubMed:22864114}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNKS gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
golgi apparatus 5
plasma membrane 3
extracellular 2
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nuclear membrane (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TNKS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0000242 pericentriolar material TAS 11454873
GO:0000781 chromosome, telomeric region IEA,IDA 9822378
GO:0000922 spindle pole IEA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with TNKS: view

Pathways & Interactions for TNKS Gene

genes like me logo Genes that share pathways with TNKS: view

Pathways by source for TNKS Gene

1 GeneGo (Thomson Reuters) pathway for TNKS Gene
  • NAD metabolism
2 Qiagen pathways for TNKS Gene
  • Telomerase Components in Cell Signaling
  • Telomere Extension by Telomerase

SIGNOR curated interactions for TNKS Gene

Activates:
Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for TNKS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IDA 19759537
GO:0006471 protein ADP-ribosylation IBA,IDA 9822378
GO:0007049 cell cycle IEA --
GO:0007052 mitotic spindle organization TAS 17026964
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with TNKS: view

Drugs & Compounds for TNKS Gene

(11) Drugs for TNKS Gene - From: ApexBio, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Approved, Investigational Pharma 474,474
NADH Approved Nutra 0
NAD Experimental Pharma 0
JW 55 Pharma PARP domain inhibitor, Tankyrase inhibitor 0
MN 64 Pharma tankyrase inhibitor, Potent and selective tankyrase inhibitor 0

(3) Additional Compounds for TNKS Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) Tocris Compounds for TNKS Gene

Compound Action Cas Number
JW 55 Tankyrase inhibitor 664993-53-7
MN 64 Potent and selective tankyrase inhibitor 92831-11-3
TC-E 5001 Potent tankyrase inhibitor 865565-29-3
WIKI4 Potent tankyrase inhibitor 838818-26-1
XAV 939 Potent tankyrase inhibitor 284028-89-3

(7) ApexBio Compounds for TNKS Gene

Compound Action Cas Number
G007-LK tankyrase 1/2 inhibitor 1380672-07-0
JW 55 PARP domain inhibitor 664993-53-7
MN 64 tankyrase inhibitor 92831-11-3
Tankyrase Inhibitors (TNKS) 22 Tankyrase inhibitor
Tankyrase Inhibitors (TNKS) 49 Tankyrase inhibitor
TC-E 5001 865565-29-3
XAV-939 Tankyrase 1/2 inhibitor 284028-89-3
genes like me logo Genes that share compounds with TNKS: view

Drug products for research

Transcripts for TNKS Gene

mRNA/cDNA for TNKS Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNKS

Alternative Splicing Database (ASD) splice patterns (SP) for TNKS Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^
SP1:
SP2:

ExUns: 26 ^ 27a · 27b
SP1: -
SP2:

Relevant External Links for TNKS Gene

GeneLoc Exon Structure for
TNKS

Expression for TNKS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TNKS Gene

Protein differential expression in normal tissues from HIPED for TNKS Gene

This gene is overexpressed in Platelet (39.3), Heart (16.2), and Spinal cord (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TNKS Gene



Protein tissue co-expression partners for TNKS Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TNKS

SOURCE GeneReport for Unigene cluster for TNKS Gene:

Hs.370267

mRNA Expression by UniProt/SwissProt for TNKS Gene:

O95271-TNKS1_HUMAN
Tissue specificity: Ubiquitous; highest levels in testis.

Evidence on tissue expression from TISSUES for TNKS Gene

  • Nervous system(4.4)
  • Intestine(2.3)
  • Skin(2.2)
  • Kidney(2.2)
  • Muscle(2.2)
  • Blood(2.1)
  • Liver(2)
genes like me logo Genes that share expression patterns with TNKS: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNKS Gene

Orthologs for TNKS Gene

This gene was present in the common ancestor of animals.

Orthologs for TNKS Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TNKS 29 30
  • 99.45 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TNKS 30
  • 97 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia TNKS 29 30
  • 93.52 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TNKS 29 30
  • 92.34 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TNKS 30
  • 89 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Tnks 29 16 30
  • 88.51 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tnks 29
  • 88.26 (n)
Chicken
(Gallus gallus)
Aves TNKS 29 30
  • 82.9 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TNKS 30
  • 92 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tnks 29
  • 79.93 (n)
Str.10012 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.3525 29
Zebrafish
(Danio rerio)
Actinopterygii TNKS (1 of 2) 30
  • 86 (a)
OneToMany
tnks 29 30
  • 76.99 (n)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta BcDNA:LD22548 31
  • 64 (a)
tankyrase 29 30
  • 62.38 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001947 29
  • 62.47 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 74 (a)
OneToMany
Species where no ortholog for TNKS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TNKS Gene

ENSEMBL:
Gene Tree for TNKS (if available)
TreeFam:
Gene Tree for TNKS (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TNKS: view image
Alliance of Genome Resources:
Additional Orthologs for TNKS

Paralogs for TNKS Gene

Paralogs for TNKS Gene

(21) SIMAP similar genes for TNKS Gene using alignment to 5 proteins:

  • TNKS1_HUMAN
  • E5RHD2_HUMAN
  • E7EQ52_HUMAN
  • E7EWY6_HUMAN
  • H0YAW5_HUMAN
genes like me logo Genes that share paralogs with TNKS: view

Variants for TNKS Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TNKS Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs114570088 Benign: not provided 9,751,725(+) C/T
NM_003747.3(TNKS):c.2949C>T (p.Pro983=)
SYNONYMOUS
rs139926450 Benign: not provided 9,556,224(+) A/T
NM_003747.3(TNKS):c.285A>T (p.Thr95=)
SYNONYMOUS
rs35433754 Benign: not provided 9,556,383(+) G/A
NM_003747.3(TNKS):c.444G>A (p.Ser148=)
SYNONYMOUS
rs35809238 Benign: not provided 9,707,001(+) C/T
NM_003747.3(TNKS):c.1456+4C>T
INTRON
rs59517107 Benign: not provided 9,580,154(+) T/C
NM_003747.3(TNKS):c.674-5T>C
INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TNKS Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TNKS Gene

Variant ID Type Subtype PubMed ID
dgv11946n54 CNV loss 21841781
dgv11947n54 CNV loss 21841781
dgv11948n54 CNV loss 21841781
dgv11949n54 CNV loss 21841781
dgv11950n54 CNV loss 21841781
dgv11951n54 CNV loss 21841781
dgv207n73 CNV deletion 24416366
dgv3769n106 CNV deletion 24896259
esv2147282 CNV deletion 18987734
esv2454645 CNV insertion 19546169
esv2509921 CNV deletion 19546169
esv25806 CNV loss 19812545
esv2661157 CNV deletion 23128226
esv2673959 CNV deletion 23128226
esv2678826 CNV deletion 23128226
esv29852 CNV loss 19812545
esv3273607 CNV deletion 24192839
esv3305059 CNV mobile element insertion 20981092
esv3308311 CNV mobile element insertion 20981092
esv3323508 CNV insertion 20981092
esv3379710 CNV insertion 20981092
esv3389459 CNV insertion 20981092
esv3430426 CNV insertion 20981092
esv3543037 CNV deletion 23714750
esv3543040 CNV deletion 23714750
esv3616189 CNV loss 21293372
esv3616191 CNV loss 21293372
esv3616192 CNV loss 21293372
esv3616193 CNV loss 21293372
esv3616194 CNV loss 21293372
esv3616195 CNV loss 21293372
esv3616196 CNV loss 21293372
esv3616197 CNV loss 21293372
esv3891335 CNV loss 25118596
esv3891336 CNV loss 25118596
esv995663 CNV deletion 20482838
nsv1033031 CNV gain 25217958
nsv1077012 CNV deletion 25765185
nsv1109949 CNV deletion 24896259
nsv1151510 CNV deletion 26484159
nsv435864 CNV deletion 17901297
nsv437043 CNV loss 16327808
nsv438035 CNV loss 16468122
nsv473494 CNV novel sequence insertion 20440878
nsv474997 CNV novel sequence insertion 20440878
nsv509251 CNV insertion 20534489
nsv512942 CNV insertion 21212237
nsv515114 CNV loss 21397061
nsv6074 CNV insertion 18451855
nsv6075 CNV insertion 18451855
nsv610225 CNV loss 21841781
nsv610233 CNV loss 21841781
nsv610258 CNV gain 21841781
nsv610262 CNV loss 21841781
nsv819378 CNV loss 19587683
nsv824530 CNV loss 20364138
nsv982121 CNV deletion 23825009

Variation tolerance for TNKS Gene

Residual Variation Intolerance Score: 0.398% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNKS Gene

Human Gene Mutation Database (HGMD)
TNKS
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNKS
Leiden Open Variation Database (LOVD)
TNKS

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNKS Gene

Disorders for TNKS Gene

MalaCards: The human disease database

(7) MalaCards diseases for TNKS Gene - From: COP and GCD

Disorder Aliases PubMed IDs
cherubism
  • crbm
lung acinar adenocarcinoma
  • acinar adenocarcinoma of the lung
arthrogryposis, renal dysfunction, and cholestasis 1
  • arcs1
arthrogryposis, renal dysfunction, and cholestasis 2
  • arcs2
cornelia de lange syndrome
  • brachmann de lange syndrome
- elite association - COSMIC cancer census association via MalaCards
Search TNKS in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TNKS

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TNKS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNKS Gene

Publications for TNKS Gene

  1. Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups. (PMID: 20421936) Scherag A … Meyre D (PLoS genetics 2010) 3 22 40
  2. Polymorphisms in telomere-associated genes, breast cancer susceptibility and prognosis. (PMID: 19766477) Varadi V … Försti A (European journal of cancer (Oxford, England : 1990) 2009) 3 22 40
  3. Polymorphisms in telomere maintenance genes and risk of lung cancer. (PMID: 19773453) Choi JE … Park JY (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009) 3 22 40
  4. Zinc binding catalytic domain of human tankyrase 1. (PMID: 18436240) Lehtiö L … Weigelt J (Journal of molecular biology 2008) 3 4 22
  5. NuMA is a major acceptor of poly(ADP-ribosyl)ation by tankyrase 1 in mitosis. (PMID: 16076287) Chang W … Smith S (The Biochemical journal 2005) 3 4 22

Products for TNKS Gene

Sources for TNKS Gene