Aliases for TNIP3 Gene
External Ids for TNIP3 Gene
Previous GeneCards Identifiers for TNIP3 Gene
GeneCards Summary for TNIP3 Gene
TNIP3 (TNFAIP3 Interacting Protein 3) is a Protein Coding gene. Diseases associated with TNIP3 include Inflammatory Bowel Disease 2. Among its related pathways are Immune response IL-23 signaling pathway and Deubiquitination. Gene Ontology (GO) annotations related to this gene include polyubiquitin modification-dependent protein binding. An important paralog of this gene is TNIP1.
UniProtKB/Swiss-Prot Summary for TNIP3 Gene
Binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding.