Aliases for TNIP2 Gene
External Ids for TNIP2 Gene
Previous GeneCards Identifiers for TNIP2 Gene
This gene encodes a protein which acts as an inhibitor of NFkappaB activation. The encoded protein is also involved in MAP/ERK signaling pathway in specific cell types. It may be involved in apoptosis of endothelial cells. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the X chromosome.[provided by RefSeq, May 2014]
GeneCards Summary for TNIP2 Gene
TNIP2 (TNFAIP3 Interacting Protein 2) is a Protein Coding gene. Diseases associated with TNIP2 include Rabies. Among its related pathways are Metabolism of proteins and Activated TLR4 signalling. Gene Ontology (GO) annotations related to this gene include protein kinase binding and polyubiquitin modification-dependent protein binding. An important paralog of this gene is TNIP1.
UniProtKB/Swiss-Prot Summary for TNIP2 Gene
Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.