Aliases for TNIP2 Gene
External Ids for TNIP2 Gene
Previous GeneCards Identifiers for TNIP2 Gene
This gene encodes a protein which acts as an inhibitor of NFkappaB activation. The encoded protein is also involved in MAP/ERK signaling pathway in specific cell types. It may be involved in apoptosis of endothelial cells. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the X chromosome.[provided by RefSeq, May 2014]
GeneCards Summary for TNIP2 Gene
TNIP2 (TNFAIP3 Interacting Protein 2) is a Protein Coding gene. Diseases associated with TNIP2 include Rabies. Among its related pathways are Immune response IL-23 signaling pathway and Ovarian tumor domain proteases. Gene Ontology (GO) annotations related to this gene include protein kinase binding and polyubiquitin modification-dependent protein binding. An important paralog of this gene is TNIP1.
UniProtKB/Swiss-Prot Summary for TNIP2 Gene
Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.