Aliases for TNFSF9 Gene
External Ids for TNFSF9 Gene
Previous GeneCards Identifiers for TNFSF9 Gene
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided by RefSeq, Oct 2008]
GeneCards Summary for TNFSF9 Gene
TNFSF9 (TNF Superfamily Member 9) is a Protein Coding gene. Diseases associated with TNFSF9 include Mouth Disease and Cone-Rod Dystrophy 2. Among its related pathways are ERK Signaling and Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and tumor necrosis factor receptor binding.
UniProtKB/Swiss-Prot Summary for TNFSF9 Gene
Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.