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Aliases for TNFSF9 Gene

Aliases for TNFSF9 Gene

  • TNF Superfamily Member 9 2 3 5
  • Tumor Necrosis Factor (Ligand) Superfamily, Member 9 2 3
  • Homolog Of Mouse 4-1BB-L 2 3
  • Receptor 4-1BB Ligand 2 3
  • 4-1BB Ligand 3 4
  • 4-1BBL 3 4
  • Tumor Necrosis Factor Ligand Superfamily Member 9 3
  • Tumor Necrosis Factor Superfamily Member 9 3
  • Tumor Necrosis Factor Ligand 5A 3
  • 4-1BB-L 3
  • CD137L 3
  • TNLG5A 3

External Ids for TNFSF9 Gene

Previous GeneCards Identifiers for TNFSF9 Gene

  • GC19P006625
  • GC19P006471
  • GC19P006482
  • GC19P006293

Summaries for TNFSF9 Gene

Entrez Gene Summary for TNFSF9 Gene

  • The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided by RefSeq, Oct 2008]

GeneCards Summary for TNFSF9 Gene

TNFSF9 (TNF Superfamily Member 9) is a Protein Coding gene. Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include receptor binding and tumor necrosis factor receptor binding.

UniProtKB/Swiss-Prot for TNFSF9 Gene

  • Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.

Additional gene information for TNFSF9 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFSF9 Gene

Genomics for TNFSF9 Gene

GeneHancer (GH) Regulatory Elements for TNFSF9 Gene

Promoters and enhancers for TNFSF9 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I006527 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +2.1 2082 6.2 YBX1 IRF4 E2F8 ZNF143 ZNF548 MCM3 SP3 MEF2D ZNF610 GLIS1 TNFSF9 ZNF557 KHSRP DUS3L SAFB2 SAFB SNRPEP4 ENSG00000267571 GTF2F1 RANBP3
GH19I006575 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 8.3 +49.9 49885 5.5 HDGF PKNOX1 SMAD1 ARNT IRF4 ZNF280A TCF12 ZNF207 ATF7 FOS GC19P006580 GC19P006581 TNFSF14 TNFSF9 CD70 DENND1C ZNF557 GC19M006573 ENSG00000199223
GH19I006587 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 4.8 +59.2 59205 1.5 HDGF PKNOX1 SMAD1 ARNT SIN3A YBX1 ZNF48 ZNF143 ZNF207 ATF7 DUS3L ZNF557 VMAC DENND1C ARHGEF18 SAFB TRIP10 GPR108 CD70 TNFSF9
GH19I006517 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 3.7 -10.3 -10286 1.1 HDGF SMAD1 YBX1 BATF IRF4 ATF7 ETV6 IKZF2 RUNX3 SMARCA5 CD70 TNFSF9 RFX2 TUBB4A
GH19I006592 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 4.1 +64.0 64007 0.7 HDGF SMAD1 IRF3 RELA ZNF335 CTBP1 ZNF143 ATF7 ETV6 BCLAF1 GC19P006595 RPL7P50 CD70 TNFSF9 DENND1C ZNF557 GC19P006581
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TNFSF9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TNFSF9 gene promoter:

Genomic Locations for TNFSF9 Gene

Genomic Locations for TNFSF9 Gene
7,367 bases
Plus strand

Genomic View for TNFSF9 Gene

Genes around TNFSF9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFSF9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFSF9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFSF9 Gene

Proteins for TNFSF9 Gene

  • Protein details for TNFSF9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor necrosis factor ligand superfamily member 9
    Protein Accession:
    Secondary Accessions:
    • Q2M3S2

    Protein attributes for TNFSF9 Gene

    254 amino acids
    Molecular mass:
    26625 Da
    Quaternary structure:
    • Homotrimer.

    Three dimensional structures from OCA and Proteopedia for TNFSF9 Gene

neXtProt entry for TNFSF9 Gene

Post-translational modifications for TNFSF9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TNFSF9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TNFSF9 Gene

Domains & Families for TNFSF9 Gene

Gene Families for TNFSF9 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for TNFSF9 Gene

Suggested Antigen Peptide Sequences for TNFSF9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tumor necrosis factor family.
  • Belongs to the tumor necrosis factor family.
genes like me logo Genes that share domains with TNFSF9: view

Function for TNFSF9 Gene

Molecular function for TNFSF9 Gene

GENATLAS Biochemistry:
,tumor necrosis factor (ligand) superfamily,member 9,inducible T cell antigen 4-1BB ligand
UniProtKB/Swiss-Prot Function:
Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.

Phenotypes From GWAS Catalog for TNFSF9 Gene

Gene Ontology (GO) - Molecular Function for TNFSF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 8088337
GO:0005125 cytokine activity IEA --
GO:0005164 tumor necrosis factor receptor binding IEA --
GO:0032813 tumor necrosis factor receptor superfamily binding IBA --
genes like me logo Genes that share ontologies with TNFSF9: view
genes like me logo Genes that share phenotypes with TNFSF9: view

miRNA for TNFSF9 Gene

miRTarBase miRNAs that target TNFSF9

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TNFSF9 Gene

Localization for TNFSF9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFSF9 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFSF9 gene
Compartment Confidence
plasma membrane 5
extracellular 4
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TNFSF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane IBA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TNFSF9: view

Pathways & Interactions for TNFSF9 Gene

genes like me logo Genes that share pathways with TNFSF9: view

Gene Ontology (GO) - Biological Process for TNFSF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 8088337
GO:0006955 immune response IEA --
GO:0007165 signal transduction TAS 8088337
GO:0007267 cell-cell signaling TAS 8088337
GO:0008283 cell proliferation TAS 8088337
genes like me logo Genes that share ontologies with TNFSF9: view

No data available for SIGNOR curated interactions for TNFSF9 Gene

Drugs & Compounds for TNFSF9 Gene

No Compound Related Data Available

Transcripts for TNFSF9 Gene

mRNA/cDNA for TNFSF9 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(32) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TNFSF9 Gene

Tumor necrosis factor (ligand) superfamily, member 9:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFSF9 Gene

No ASD Table

Relevant External Links for TNFSF9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNFSF9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNFSF9 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TNFSF9 Gene

NURSA nuclear receptor signaling pathways regulating expression of TNFSF9 Gene:


SOURCE GeneReport for Unigene cluster for TNFSF9 Gene:


mRNA Expression by UniProt/SwissProt for TNFSF9 Gene:

Tissue specificity: Expressed in brain, placenta, lung, skeletal muscle and kidney.

Evidence on tissue expression from TISSUES for TNFSF9 Gene

  • Lung(4.2)
  • Blood(2.5)
  • Spleen(2.2)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with TNFSF9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFSF9 Gene

Orthologs for TNFSF9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TNFSF9 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia TNFSF9 33 34
  • 69.92 (n)
(Bos Taurus)
Mammalia TNFSF9 33 34
  • 63.62 (n)
(Ornithorhynchus anatinus)
Mammalia TNFSF9 34
  • 35 (a)
(Monodelphis domestica)
Mammalia TNFSF9 34
  • 34 (a)
(Mus musculus)
Mammalia Tnfsf9 34
  • 27 (a)
Species where no ortholog for TNFSF9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TNFSF9 Gene

Gene Tree for TNFSF9 (if available)
Gene Tree for TNFSF9 (if available)

Paralogs for TNFSF9 Gene

No data available for Paralogs for TNFSF9 Gene

Variants for TNFSF9 Gene

Sequence variations from dbSNP and Humsavar for TNFSF9 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000491087 -- 6,532,534(+) TGTT/ intron_variant
rs1000586506 -- 6,536,122(+) A/C downstream_transcript_variant
rs1000799869 -- 6,531,655(+) G/A intron_variant
rs1001166752 -- 6,531,917(+) G/A intron_variant
rs1001753441 -- 6,530,891(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TNFSF9 Gene

Variant ID Type Subtype PubMed ID
dgv1700n106 CNV deletion 24896259
esv22875 CNV loss 19812545
esv2668569 CNV deletion 23128226
nsv1072314 CNV deletion 25765185
nsv138022 CNV insertion 16902084
nsv833727 CNV loss 17160897
nsv833728 CNV loss 17160897

Variation tolerance for TNFSF9 Gene

Residual Variation Intolerance Score: 71.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.31; 41.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNFSF9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFSF9 Gene

Disorders for TNFSF9 Gene

Additional Disease Information for TNFSF9

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TNFSF9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNFSF9 Gene

Publications for TNFSF9 Gene

  1. The structure of the trimer of human 4-1BB ligand is unique among members of the tumor necrosis factor superfamily. (PMID: 20032458) Won EY … Cho HS (The Journal of biological chemistry 2010) 3 4 22 58
  2. Molecular and biological characterization of human 4-1BB and its ligand. (PMID: 8088337) Alderson MR … Din WS (European journal of immunology 1994) 2 3 4 58
  3. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 44 58
  4. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S … Kang D (Human immunology 2010) 3 44 58
  5. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PMID: 20568250) Lee KM … Lan Q (American journal of hematology 2010) 3 44 58

Products for TNFSF9 Gene

Sources for TNFSF9 Gene

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