Aliases for TNFSF8 Gene
External Ids for TNFSF8 Gene
Previous HGNC Symbols for TNFSF8 Gene
Previous GeneCards Identifiers for TNFSF8 Gene
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
GeneCards Summary for TNFSF8 Gene
TNFSF8 (TNF Superfamily Member 8) is a Protein Coding gene. Diseases associated with TNFSF8 include Anaplastic Large Cell Lymphoma and Lymphoma, Hodgkin, Classic. Among its related pathways are TRAF Pathway and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and tumor necrosis factor receptor binding.
UniProtKB/Swiss-Prot Summary for TNFSF8 Gene
Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.