The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This c... See more...

Aliases for TNFSF8 Gene

Aliases for TNFSF8 Gene

  • TNF Superfamily Member 8 2 3 5
  • Tumor Necrosis Factor (Ligand) Superfamily, Member 8 2 3
  • Tumor Necrosis Factor Ligand Superfamily Member 8 3 4
  • CD153 Antigen 3 4
  • CD30 Ligand 3 4
  • CD30LG 3 4
  • CD30-L 3 4
  • CD153 2 3
  • CD30L 3 4
  • Tumor Necrosis Factor Superfamily Member 8 3
  • Tumor Necrosis Factor Ligand 3A 3
  • CD30 Antigen Ligand 3
  • TNLG3A 3
  • TNFSF8 5

External Ids for TNFSF8 Gene

Previous HGNC Symbols for TNFSF8 Gene

  • CD30LG

Previous GeneCards Identifiers for TNFSF8 Gene

  • GC09M108463
  • GC09M109397
  • GC09M111118
  • GC09M113041
  • GC09M114744
  • GC09M116704
  • GC09M117656
  • GC09M087269

Summaries for TNFSF8 Gene

Entrez Gene Summary for TNFSF8 Gene

  • The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for TNFSF8 Gene

TNFSF8 (TNF Superfamily Member 8) is a Protein Coding gene. Diseases associated with TNFSF8 include Anaplastic Large Cell Lymphoma and Lymphoma, Hodgkin, Classic. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and tumor necrosis factor receptor binding.

UniProtKB/Swiss-Prot Summary for TNFSF8 Gene

  • Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TNFSF8 Gene

Genomics for TNFSF8 Gene

GeneHancer (GH) Regulatory Elements Pubs


GeneHancers around TNFSF8 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TNFSF8

Top Transcription factor binding sites by QIAGEN in the TNFSF8 gene promoter:
  • NF-kappaB
  • NF-kappaB1

Genomic Locations for TNFSF8 Gene

Latest Assembly
chr9:114,893,343-114,930,674
(GRCh38/hg38)
Size:
37,332 bases
Orientation:
Minus strand

Previous Assembly
chr9:117,655,623-117,692,875
(GRCh37/hg19 by Entrez Gene)
Size:
37,253 bases
Orientation:
Minus strand

chr9:117,656,003-117,692,697
(GRCh37/hg19 by Ensembl)
Size:
36,695 bases
Orientation:
Minus strand

Genomic View for TNFSF8 Gene

Genes around TNFSF8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFSF8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFSF8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFSF8 Gene

Proteins for TNFSF8 Gene

  • Protein details for TNFSF8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32971-TNFL8_HUMAN
    Recommended name:
    Tumor necrosis factor ligand superfamily member 8
    Protein Accession:
    P32971
    Secondary Accessions:
    • O43404

    Protein attributes for TNFSF8 Gene

    Size:
    234 amino acids
    Molecular mass:
    26017 Da
    Quaternary structure:
    • Homotrimer.

neXtProt entry for TNFSF8 Gene

Post-translational modifications for TNFSF8 Gene

  • Glycosylation at Asn81, Asn109, Asn153, Asn189, and Asn201
  • Modification sites at PhosphoSitePlus

Other Protein References for TNFSF8 Gene

No data available for DME Specific Peptides for TNFSF8 Gene

Domains & Families for TNFSF8 Gene

Gene Families for TNFSF8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Predicted membrane proteins

Protein Domains for TNFSF8 Gene

InterPro:
Blocks:
  • Tumor Necrosis Factor

Suggested Antigen Peptide Sequences for TNFSF8 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ94189, Homo sapiens tumor necrosis factor (ligand) superfamily, member 8(TNFSF8), mRNA (Q52M88_HUMAN)
  • CD30 ligand (TNFL8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P32971

UniProtKB/Swiss-Prot:

TNFL8_HUMAN :
  • Belongs to the tumor necrosis factor family.
Family:
  • Belongs to the tumor necrosis factor family.
genes like me logo Genes that share domains with TNFSF8: view

Function for TNFSF8 Gene

Molecular function for TNFSF8 Gene

UniProtKB/Swiss-Prot Function:
Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.
GENATLAS Biochemistry:
tumor necrosis factor (ligand) superfamily,member 8,CD30 ligand on surface of T cells

Phenotypes From GWAS Catalog for TNFSF8 Gene

Gene Ontology (GO) - Molecular Function for TNFSF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding TAS 8391931
GO:0005125 cytokine activity IEA --
GO:0005164 tumor necrosis factor receptor binding IEA --
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with TNFSF8: view
genes like me logo Genes that share phenotypes with TNFSF8: view

Animal Models for TNFSF8 Gene

MGI Knock Outs for TNFSF8:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNFSF8

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNFSF8 Gene

Localization for TNFSF8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFSF8 Gene

Membrane. Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFSF8 gene
Compartment Confidence
plasma membrane 5
extracellular 4
mitochondrion 2
nucleus 2
cytosol 2
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TNFSF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8391931
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TNFSF8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TNFSF8 Gene

Pathways & Interactions for TNFSF8 Gene

PathCards logo

SuperPathways for TNFSF8 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
.94
.94
.73
.71
.62
.61
.47
.46
2 ERK Signaling
.61
.61
.51
3 TNF Superfamily Pathway: Human Ligand-Receptor Interactions and their Associated Functions
4 Akt Signaling
.60
.60
5 PAK Pathway
.56
.56
genes like me logo Genes that share pathways with TNFSF8: view

Pathways by source for TNFSF8 Gene

1 Sino Biological pathway for TNFSF8 Gene
1 KEGG pathway for TNFSF8 Gene
1 GeneGo (Thomson Reuters) pathway for TNFSF8 Gene
  • Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
16 Qiagen pathways for TNFSF8 Gene
  • Akt Signaling
  • all-trans-Retinoic Acid Signaling in Brain
  • Antioxidant Action of Vitamin-C
  • Endothelin-1 Signaling Pathway
  • ERK Signaling

Gene Ontology (GO) - Biological Process for TNFSF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IEA --
GO:0007165 signal transduction IEA --
GO:0007267 cell-cell signaling TAS 8391931
GO:0033209 tumor necrosis factor-mediated signaling pathway TAS --
GO:0042129 regulation of T cell proliferation TAS 8391931
genes like me logo Genes that share ontologies with TNFSF8: view

No data available for SIGNOR curated interactions for TNFSF8 Gene

Drugs & Compounds for TNFSF8 Gene

No Compound Related Data Available

Transcripts for TNFSF8 Gene

mRNA/cDNA for TNFSF8 Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNFSF8

Alternative Splicing Database (ASD) splice patterns (SP) for TNFSF8 Gene

No ASD Table

Relevant External Links for TNFSF8 Gene

GeneLoc Exon Structure for
TNFSF8

Expression for TNFSF8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TNFSF8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Heart (Cardiovascular System)
  • Thymus (Hematopoietic System)

mRNA differential expression in normal tissues according to GTEx for TNFSF8 Gene

This gene is overexpressed in Whole Blood (x20.8) and Spleen (x5.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TNFSF8

SOURCE GeneReport for Unigene cluster for TNFSF8 Gene:

Hs.494901

Evidence on tissue expression from TISSUES for TNFSF8 Gene

  • Lymph node(2.7)
  • Spleen(2.4)
  • Bone marrow(2.2)
  • Intestine(2.1)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with TNFSF8: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFSF8 Gene

Orthologs for TNFSF8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFSF8 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TNFSF8 29 30
  • 99.57 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TNFSF8 29 30
  • 86.18 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TNFSF8 29 30
  • 85.47 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tnfsf8 29 16 30
  • 78.83 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tnfsf8 29
  • 77.54 (n)
Oppossum
(Monodelphis domestica)
Mammalia TNFSF8 30
  • 56 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TNFSF8 30
  • 55 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TNFSF8 29 30
  • 50.58 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TNFSF8 30
  • 32 (a)
OneToOne
Species where no ortholog for TNFSF8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for TNFSF8 Gene

ENSEMBL:
Gene Tree for TNFSF8 (if available)
TreeFam:
Gene Tree for TNFSF8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TNFSF8: view image
Alliance of Genome Resources:
Additional Orthologs for TNFSF8

Paralogs for TNFSF8 Gene

No data available for Paralogs for TNFSF8 Gene

Variants for TNFSF8 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TNFSF8 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TNFSF8 Gene

Variant ID Type Subtype PubMed ID
nsv6680 CNV deletion 18451855
nsv7434 OTHER inversion 18451855
nsv831695 CNV gain 17160897
nsv950931 CNV duplication 24416366

Variation tolerance for TNFSF8 Gene

Residual Variation Intolerance Score: 41% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNFSF8 Gene

Human Gene Mutation Database (HGMD)
TNFSF8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNFSF8
Leiden Open Variation Database (LOVD)
TNFSF8

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TNFSF8 Gene

Disorders for TNFSF8 Gene

MalaCards: The human disease database

(5) MalaCards diseases for TNFSF8 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
anaplastic large cell lymphoma
  • alcl
lymphoma, hodgkin, classic
  • chl
lymphoma
  • lymphoid cancer
lymphoma, non-hodgkin, familial
  • non-hodgkin lymphoma; nhl
leukemia, acute lymphoblastic
  • all
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TNFSF8

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TNFSF8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNFSF8 Gene

Publications for TNFSF8 Gene

  1. Characterisation of the human CD30 ligand gene structure. (PMID: 9349718) Croager EJ … Abraham LJ (Biochimica et biophysica acta 1997) 2 3 4 22
  2. Association study between CD30 and CD30 ligand genes and type 1 diabetes in the Japanese population. (PMID: 11960307) Ahmed S … Hara T (Genes and immunity 2002) 3 22 40
  3. CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF. (PMID: 8391931) Smith CA … Jenkins NA (Cell 1993) 2 3 4
  4. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PMID: 20568250) Lee KM … Lan Q (American journal of hematology 2010) 3 40
  5. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood HD … Lan Q (Occupational and environmental medicine 2009) 3 40

Products for TNFSF8 Gene

Sources for TNFSF8 Gene