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Aliases for TNFSF4 Gene

Aliases for TNFSF4 Gene

  • TNF Superfamily Member 4 2 3 5
  • Glycoprotein Gp34 3 4
  • TXGP1 3 4
  • Tax-Transcriptionally Activated Glycoprotein 1 (34kD) 3
  • Tax-Transcriptionally Activated Glycoprotein 1, 34kD 2
  • Tumor Necrosis Factor (Ligand) Superfamily, Member 4 2
  • Tumor Necrosis Factor (Ligand) Superfamily Member 4 3
  • Tumor Necrosis Factor Ligand Superfamily Member 4 3
  • TAX Transcriptionally-Activated Glycoprotein 1 4
  • Tumor Necrosis Factor Superfamily Member 4 3
  • Tumor Necrosis Factor Ligand 2B 3
  • OX40 Antigen Ligand 3
  • CD252 Antigen 4
  • CD134 Ligand 3
  • OX40 Ligand 4
  • CD134L 3
  • OX-40L 3
  • TNLG2B 3
  • CD252 3
  • OX4OL 3
  • OX40L 4
  • GP34 3

External Ids for TNFSF4 Gene

Previous HGNC Symbols for TNFSF4 Gene

  • TXGP1

Previous GeneCards Identifiers for TNFSF4 Gene

  • GC01M170716
  • GC01M168781
  • GC01M169733
  • GC01M170392
  • GC01M169884
  • GC01M171419
  • GC01M144377

Summaries for TNFSF4 Gene

Entrez Gene Summary for TNFSF4 Gene

  • This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for TNFSF4 Gene

TNFSF4 (TNF Superfamily Member 4) is a Protein Coding gene. Diseases associated with TNFSF4 include Myocardial Infarction and Sjogren Syndrome. Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include receptor binding and tumor necrosis factor receptor binding.

UniProtKB/Swiss-Prot for TNFSF4 Gene

  • Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.

Additional gene information for TNFSF4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFSF4 Gene

Genomics for TNFSF4 Gene

GeneHancer (GH) Regulatory Elements for TNFSF4 Gene

Promoters and enhancers for TNFSF4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I173200 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 550.8 +3.2 3196 7.9 HDGF PKNOX1 FOXA2 MLX ARID4B FEZF1 ZNF143 ATF7 RUNX3 RXRA TNFSF4 ENSG00000224228 TNFSF18 ENSG00000226375
GH01I172892 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 11.7 +311.8 311803 7.3 PKNOX1 FEZF1 BATF IRF4 RAD21 BRCA1 ZNF335 EGR1 SCRT2 RCOR1 FASLG TNFSF4 ENSG00000224228 SUCO AIMP1P2 ENSG00000224000
GH01I172845 Enhancer 0.8 FANTOM5 Ensembl 13.4 +362.5 362471 0.4 ATF1 EBF1 BATF FOSL1 ZNF316 EGR1 IKZF1 CREM MAFK ENSG00000224228 TNFSF4 LOC105371618 AIMP1P2
GH01I172754 Enhancer 0.4 FANTOM5 12.6 +453.9 453861 0.4 BCL11A BATF RUNX3 ENSG00000279061 TNFSF4 ENSG00000224228
GH01I172931 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 2.2 +273.9 273909 5.3 PKNOX1 SMAD1 ARNT ZNF766 FOS ZNF592 MEF2D SMARCA4 GLIS1 KDM1A ENSG00000224228 TNFSF18 TNFSF4 ENSG00000224000
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TNFSF4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TNFSF4 gene promoter:

Genomic Locations for TNFSF4 Gene

Genomic Locations for TNFSF4 Gene
24,342 bases
Minus strand

Genomic View for TNFSF4 Gene

Genes around TNFSF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFSF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFSF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFSF4 Gene

Proteins for TNFSF4 Gene

  • Protein details for TNFSF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor necrosis factor ligand superfamily member 4
    Protein Accession:
    Secondary Accessions:
    • Q5JZA5
    • Q8IV74
    • Q9HCN9

    Protein attributes for TNFSF4 Gene

    183 amino acids
    Molecular mass:
    21050 Da
    Quaternary structure:
    • Homotrimer.
    • Sequence=CAA18438.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TNFSF4 Gene

    Alternative splice isoforms for TNFSF4 Gene


neXtProt entry for TNFSF4 Gene

Post-translational modifications for TNFSF4 Gene

  • Glycosylation at posLast=9090, isoforms=2114, isoforms=2152, and isoforms=2157
  • Modification sites at PhosphoSitePlus

Other Protein References for TNFSF4 Gene

No data available for DME Specific Peptides for TNFSF4 Gene

Domains & Families for TNFSF4 Gene

Gene Families for TNFSF4 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for TNFSF4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tumor necrosis factor family.
  • Belongs to the tumor necrosis factor family.
genes like me logo Genes that share domains with TNFSF4: view

Function for TNFSF4 Gene

Molecular function for TNFSF4 Gene

GENATLAS Biochemistry:
tumor necrosis factor (ligand) superfamily,member 4,tax-transcriptionally activated glycoprotein1,human OX-40 ligand,expressed in T cell infected by HTLV1
UniProtKB/Swiss-Prot Function:
Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.
UniProtKB/Swiss-Prot Induction:
By HTLV-1 transactivator p40-Tax.

Phenotypes From GWAS Catalog for TNFSF4 Gene

Gene Ontology (GO) - Molecular Function for TNFSF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 7913952
GO:0005125 cytokine activity IEA --
GO:0005164 tumor necrosis factor receptor binding IEA --
GO:0005515 protein binding IPI 16905106
GO:0032813 tumor necrosis factor receptor superfamily binding IBA,ISS --
genes like me logo Genes that share ontologies with TNFSF4: view
genes like me logo Genes that share phenotypes with TNFSF4: view

Human Phenotype Ontology for TNFSF4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TNFSF4 Gene

MGI Knock Outs for TNFSF4:

Animal Model Products

Clone Products

  • R&D Systems cDNA Clones for TNFSF4 (OX40 Ligand/TNFSF4)

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TNFSF4 Gene

Localization for TNFSF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFSF4 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFSF4 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TNFSF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA,IEA 17166734
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 18397322
GO:0009986 cell surface IDA 18397322
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TNFSF4: view

Pathways & Interactions for TNFSF4 Gene

genes like me logo Genes that share pathways with TNFSF4: view

Pathways by source for TNFSF4 Gene

SIGNOR curated interactions for TNFSF4 Gene


Gene Ontology (GO) - Biological Process for TNFSF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002215 defense response to nematode ISS --
GO:0002526 acute inflammatory response ISS --
GO:0002726 positive regulation of T cell cytokine production ISS --
GO:0002819 regulation of adaptive immune response ISS --
GO:0002830 positive regulation of type 2 immune response ISS --
genes like me logo Genes that share ontologies with TNFSF4: view

Drugs & Compounds for TNFSF4 Gene

No Compound Related Data Available

Transcripts for TNFSF4 Gene

Unigene Clusters for TNFSF4 Gene

Tumor necrosis factor (ligand) superfamily, member 4:
Representative Sequences:

Clone Products

  • R&D Systems cDNA Clones for TNFSF4 (OX40 Ligand/TNFSF4)

Alternative Splicing Database (ASD) splice patterns (SP) for TNFSF4 Gene

No ASD Table

Relevant External Links for TNFSF4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNFSF4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNFSF4 Gene

NURSA nuclear receptor signaling pathways regulating expression of TNFSF4 Gene:


SOURCE GeneReport for Unigene cluster for TNFSF4 Gene:


Evidence on tissue expression from TISSUES for TNFSF4 Gene

  • Heart(3)
  • Intestine(3)
  • Liver(2.8)
  • Stomach(2.8)
  • Lymph node(2.7)
  • Spleen(2.7)
  • Muscle(2.6)
  • Blood(2.5)
  • Nervous system(2.5)
  • Kidney(2.2)
  • Skin(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFSF4 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • nervous
  • respiratory
  • skeletal muscle
Head and neck:
  • brain
  • cranial nerve
  • ear
  • eye
  • head
  • mouth
  • pharynx
  • heart
  • blood vessel
  • peripheral nervous system
genes like me logo Genes that share expression patterns with TNFSF4: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TNFSF4 Gene

Orthologs for TNFSF4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TNFSF4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TNFSF4 33 34
  • 99.64 (n)
(Canis familiaris)
Mammalia TNFSF4 33 34
  • 81.68 (n)
(Bos Taurus)
Mammalia TNFSF4 33 34
  • 81.4 (n)
(Rattus norvegicus)
Mammalia Tnfsf4 33
  • 69.65 (n)
(Mus musculus)
Mammalia Tnfsf4 33 16 34
  • 68.54 (n)
(Monodelphis domestica)
Mammalia TNFSF4 34
  • 36 (a)
(Ornithorhynchus anatinus)
Mammalia TNFSF4 34
  • 35 (a)
Species where no ortholog for TNFSF4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TNFSF4 Gene

Gene Tree for TNFSF4 (if available)
Gene Tree for TNFSF4 (if available)

Paralogs for TNFSF4 Gene

No data available for Paralogs for TNFSF4 Gene

Variants for TNFSF4 Gene

Sequence variations from dbSNP and Humsavar for TNFSF4 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000004849 -- 173,305,067(-) T/C genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000012315 -- 173,246,786(-) A/C genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000023583 -- 173,443,049(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, non_coding_transcript_variant
rs1000038766 -- 173,357,247(-) T/C genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000049540 -- 173,271,060(-) G/A/C genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant

Variation tolerance for TNFSF4 Gene

Residual Variation Intolerance Score: 46.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.49; 10.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNFSF4 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TNFSF4 Gene

Disorders for TNFSF4 Gene

MalaCards: The human disease database

(8) MalaCards diseases for TNFSF4 Gene - From: HGMD, OMIM, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
myocardial infarction
  • myocardial infarction, susceptibility to
sjogren syndrome
  • sicca syndrome
systemic lupus erythematosus
  • sle
lupus erythematosus
  • systemic lupus erythematosus
  • narcolepsy, without cataplexy
- elite association - COSMIC cancer census association via MalaCards


  • Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269 PubMed:18059267}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. The upstream region of TNFSF4 contains a single risk haplotype for SLE, which is correlated with increased expression of both cell-surface TNFSF4 and TNFSF4 transcripts. Increased levels of TNFSF4 are thought to augment T-cell-APC interaction and the functional consequences of T-cell activation, thereby destabilizing peripheral tolerance.

Additional Disease Information for TNFSF4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TNFSF4: view

No data available for Genatlas for TNFSF4 Gene

Publications for TNFSF4 Gene

  1. New variations in human OX40 ligand (CD134L) gene. (PMID: 11197696) Hikami K … Tokunaga K (Genes and immunity 2000) 3 4 22 44 58
  2. Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34. (PMID: 8076595) Baum PR … Clifford KN (The EMBO journal 1994) 2 3 4 22 58
  3. Molecular cloning and characterization of a novel glycoprotein, gp34, that is specifically induced by the human T-cell leukemia virus type I transactivator p40tax. (PMID: 1996093) Miura S … Nakamura M (Molecular and cellular biology 1991) 2 3 4 22 58
  4. Association of TNFSF4 (OX40L) polymorphisms with susceptibility to systemic sclerosis. (PMID: 19778912) Gourh P … Agarwal SK (Annals of the rheumatic diseases 2010) 3 22 44 58
  5. Genetic variants of TNFSF4 and risk for carotid artery disease and stroke. (PMID: 18998106) Olofsson PS … Hansson GK (Journal of molecular medicine (Berlin, Germany) 2009) 3 22 44 58

Products for TNFSF4 Gene

Sources for TNFSF4 Gene

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