Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TNFSF15 Gene

Aliases for TNFSF15 Gene

  • TNF Superfamily Member 15 2 3 5
  • Vascular Endothelial Cell Growth Inhibitor 2 3 4
  • TNF Ligand-Related Molecule 1 2 3 4
  • Tumor Necrosis Factor (Ligand) Superfamily, Member 15 2 3
  • Tumor Necrosis Factor Ligand Superfamily Member 15 3 4
  • Vascular Endothelial Growth Inhibitor-192A 2 3
  • TNF Superfamily Ligand TL1A 2 3
  • VEGI 3 4
  • TL1 3 4
  • Tumor Necrosis Factor Superfamily Member 15 3
  • Tumor Necrosis Factor Ligand 1B 3
  • VEGI192A 3
  • TNLG1B 3
  • TL1A 3

External Ids for TNFSF15 Gene

Previous GeneCards Identifiers for TNFSF15 Gene

  • GC09M108349
  • GC09M109283
  • GC09M111005
  • GC09M112927
  • GC09M114632
  • GC09M116591
  • GC09M117551
  • GC09M087156

Summaries for TNFSF15 Gene

Entrez Gene Summary for TNFSF15 Gene

  • The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for TNFSF15 Gene

TNFSF15 (TNF Superfamily Member 15) is a Protein Coding gene. Diseases associated with TNFSF15 include Primary Biliary Cholangitis and Diverticulitis. Among its related pathways are Apoptosis Modulation and Signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and tumor necrosis factor receptor binding. An important paralog of this gene is FASLG.

UniProtKB/Swiss-Prot for TNFSF15 Gene

  • Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.

Gene Wiki entry for TNFSF15 Gene

Additional gene information for TNFSF15 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFSF15 Gene

Genomics for TNFSF15 Gene

GeneHancer (GH) Regulatory Elements for TNFSF15 Gene

Promoters and enhancers for TNFSF15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J114803 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 614.6 +0.8 794 4.5 IKZF1 RXRA IKZF2 RELA RXRB SP1 REST CTBP1 GABPA POLR2A TNFSF15 DEC1 WHRN ENSG00000274919
GH09J114892 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 34.9 -88.6 -88551 3.5 ZSCAN21 SP7 POLR2A RXRA ZNF600 CEBPA GATAD2A ZEB2 ATF7 ZNF629 TNFSF15 TNFSF8 ATP6V1G1 WHRN GC09P115121 DEC1
GH09J114883 Enhancer 1.4 FANTOM5 Ensembl ENCODE 34.7 -77.9 -77896 3.2 ELF3 CEBPG ELF1 SP1 HNF1A ZNF644 KAT8 RXRA CEBPA GATAD2A TNFSF15 ATP6V1G1 TNFSF8 WHRN GC09P115121 DEC1
GH09J114906 Enhancer 1.5 FANTOM5 ENCODE dbSUPER 24.6 -102.5 -102489 5 MTA3 CTCF ELF3 RERE NFIB ZSCAN21 NCOA3 TFE3 ELF1 SP1 TNFSF15 TNFSF8 ATP6V1G1 WHRN GC09P115121 DEC1
GH09J114480 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 19.8 +322.0 322027 9.4 SP1 CC2D1A CTCF NKRF MLLT1 CSDE1 ZNF687 TRIM24 RELA CREM WHRN TNFSF15 TMEM268 ENSG00000201749 TNC TNFSF8 ATP6V1G1 LOC100131877 AKNA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TNFSF15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TNFSF15 gene promoter:
  • CUTL1
  • FOXC1
  • GATA-1
  • GATA-2
  • GATA-3
  • Nkx6-1
  • RREB-1
  • STAT1
  • TBP

Genomic Locations for TNFSF15 Gene

Genomic Locations for TNFSF15 Gene
chr9:114,784,635-114,806,128
(GRCh38/hg38)
Size:
21,494 bases
Orientation:
Minus strand
chr9:117,546,915-117,568,408
(GRCh37/hg19)
Size:
21,494 bases
Orientation:
Minus strand

Genomic View for TNFSF15 Gene

Genes around TNFSF15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFSF15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFSF15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFSF15 Gene

Proteins for TNFSF15 Gene

  • Protein details for TNFSF15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95150-TNF15_HUMAN
    Recommended name:
    Tumor necrosis factor ligand superfamily member 15
    Protein Accession:
    O95150
    Secondary Accessions:
    • Q3SX69
    • Q5VJK8
    • Q5VWH1
    • Q8NFE9

    Protein attributes for TNFSF15 Gene

    Size:
    251 amino acids
    Molecular mass:
    28087 Da
    Quaternary structure:
    • Homotrimer.

    Three dimensional structures from OCA and Proteopedia for TNFSF15 Gene

    Alternative splice isoforms for TNFSF15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNFSF15 Gene

Post-translational modifications for TNFSF15 Gene

  • Glycosylation at posLast=133133 and posLast=229229

Other Protein References for TNFSF15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TNFSF15 Gene

Domains & Families for TNFSF15 Gene

Gene Families for TNFSF15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for TNFSF15 Gene

Suggested Antigen Peptide Sequences for TNFSF15 Gene

GenScript: Design optimal peptide antigens:
  • Tumor necrosis factor (Ligand) superfamily, member 15 (D9N2U0_HUMAN)
  • Vascular endothelial cell growth inhibitor (TNF15_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95150

UniProtKB/Swiss-Prot:

TNF15_HUMAN :
  • Belongs to the tumor necrosis factor family.
Family:
  • Belongs to the tumor necrosis factor family.
genes like me logo Genes that share domains with TNFSF15: view

Function for TNFSF15 Gene

Molecular function for TNFSF15 Gene

UniProtKB/Swiss-Prot Function:
Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.
UniProtKB/Swiss-Prot Induction:
Up-regulated by IL1A/interleukin-1 alpha and TNF.
GENATLAS Biochemistry:
tumor necrosis factor (ligand) superfamily,member 15,expressed in hematopoietic cells

Phenotypes From GWAS Catalog for TNFSF15 Gene

Gene Ontology (GO) - Molecular Function for TNFSF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding TAS 9434163
GO:0005125 cytokine activity IEA --
GO:0005164 tumor necrosis factor receptor binding IEA --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with TNFSF15: view
genes like me logo Genes that share phenotypes with TNFSF15: view

Human Phenotype Ontology for TNFSF15 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TNFSF15 Gene

MGI Knock Outs for TNFSF15:

Animal Model Products

  • Taconic Biosciences Mouse Models for TNFSF15

CRISPR Products

miRNA for TNFSF15 Gene

miRTarBase miRNAs that target TNFSF15

Clone Products

  • Applied Biological Materials (abm): Clones for TNFSF15 - Now 50% OFF >
  • * TNFSF15 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TNFSF15 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TNFSF15 Gene

Localization for TNFSF15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFSF15 Gene

Membrane; Single-pass type II membrane protein.
Tumor necrosis factor ligand superfamily member 15, secreted form: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFSF15 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 2
nucleus 1
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear membrane (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TNFSF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane TAS,IDA --
GO:0005887 integral component of plasma membrane TAS 9872942
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TNFSF15: view

Pathways & Interactions for TNFSF15 Gene

genes like me logo Genes that share pathways with TNFSF15: view

Pathways by source for TNFSF15 Gene

1 Sino Biological pathway for TNFSF15 Gene
1 BioSystems pathway for TNFSF15 Gene
1 KEGG pathway for TNFSF15 Gene
1 GeneGo (Thomson Reuters) pathway for TNFSF15 Gene
1 Qiagen pathway for TNFSF15 Gene
1 Cell Signaling Technology pathway for TNFSF15 Gene

SIGNOR curated interactions for TNFSF15 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for TNFSF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA 11911831
GO:0006955 immune response IEA --
GO:0007165 signal transduction IEA,NAS 9872942
GO:0007250 activation of NF-kappaB-inducing kinase activity IDA 11911831
genes like me logo Genes that share ontologies with TNFSF15: view

Drugs & Compounds for TNFSF15 Gene

(1) Drugs for TNFSF15 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pomalidomide (CC-4047) Pharma Immunomodulator,antumor/anti-angiogenic 0

(1) ApexBio Compounds for TNFSF15 Gene

Compound Action Cas Number
Pomalidomide (CC-4047) Immunomodulator,antumor/anti-angiogenic 19171-19-8
genes like me logo Genes that share compounds with TNFSF15: view

Transcripts for TNFSF15 Gene

mRNA/cDNA for TNFSF15 Gene

(2) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for TNFSF15 Gene

Tumor necrosis factor (ligand) superfamily, member 15:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for TNFSF15 - Now 50% OFF >
  • * TNFSF15 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TNFSF15 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for TNFSF15 Gene

No ASD Table

Relevant External Links for TNFSF15 Gene

GeneLoc Exon Structure for
TNFSF15
ECgene alternative splicing isoforms for
TNFSF15

Expression for TNFSF15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNFSF15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFSF15 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x5.7), Minor Salivary Gland (x5.6), Prostate (x4.8), Colon - Sigmoid (x4.7), Bladder (x4.3), and Kidney - Cortex (x4.0).

Protein differential expression in normal tissues from HIPED for TNFSF15 Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TNFSF15 Gene



Protein tissue co-expression partners for TNFSF15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TNFSF15 Gene:

TNFSF15

SOURCE GeneReport for Unigene cluster for TNFSF15 Gene:

Hs.23349

mRNA Expression by UniProt/SwissProt for TNFSF15 Gene:

O95150-TNF15_HUMAN
Tissue specificity: Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon.

Evidence on tissue expression from TISSUES for TNFSF15 Gene

  • Blood(2)
  • Intestine(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFSF15 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • lymphatic
Regions:
Abdomen:
  • biliary tract
  • liver
  • spleen
General:
  • blood
  • coagulation system
  • skin
genes like me logo Genes that share expression patterns with TNFSF15: view

Orthologs for TNFSF15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFSF15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNFSF15 35 34
  • 99.34 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TNFSF15 35 34
  • 87.33 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TNFSF15 35 34
  • 86.27 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tnfsf15 34
  • 79.35 (n)
mouse
(Mus musculus)
Mammalia Tnfsf15 35 17 34
  • 78.41 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNFSF15 35
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TNFSF15 35
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves TNFSF15 34
  • 63.92 (n)
CHTL1A 35
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TNFSF15 35
  • 30 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tnfsf15 34
  • 52.43 (n)
Species where no ortholog for TNFSF15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TNFSF15 Gene

ENSEMBL:
Gene Tree for TNFSF15 (if available)
TreeFam:
Gene Tree for TNFSF15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TNFSF15: view image

Paralogs for TNFSF15 Gene

Paralogs for TNFSF15 Gene

genes like me logo Genes that share paralogs with TNFSF15: view

Variants for TNFSF15 Gene

Sequence variations from dbSNP and Humsavar for TNFSF15 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000085413 -- 114,788,000(-) C/T 3_prime_UTR_variant
rs1000105084 -- 114,793,350(-) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000136502 -- 114,792,999(-) TCTATTAGTTCT/TCT genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000313447 -- 114,805,129(-) A/C genic_upstream_transcript_variant, intron_variant
rs1000470964 -- 114,804,383(-) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TNFSF15 Gene

Variant ID Type Subtype PubMed ID
nsv831695 CNV gain 17160897

Variation tolerance for TNFSF15 Gene

Residual Variation Intolerance Score: 50.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.24; 40.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNFSF15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNFSF15
Human Gene Mutation Database (HGMD)
TNFSF15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFSF15 Gene

Disorders for TNFSF15 Gene

MalaCards: The human disease database

(5) MalaCards diseases for TNFSF15 Gene - From: HGMD, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
primary biliary cholangitis
  • pbc
diverticulitis
keshan disease
  • caused by deficiency of selenium in the diet
inflammatory bowel disease
  • inflammatory bowel diseases
crohn's disease
  • ileitis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TNFSF15

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TNFSF15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNFSF15 Gene

Publications for TNFSF15 Gene

  1. IBD-associated TL1A gene (TNFSF15) haplotypes determine increased expression of TL1A protein. (PMID: 19262684) Michelsen KS … Targan SR (PloS one 2009) 3 23 45 58
  2. TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator. (PMID: 11911831) Migone TS … Wei P (Immunity 2002) 3 4 23 58
  3. Characterization of a novel TNF-like ligand and recently described TNF ligand and TNF receptor superfamily genes and their constitutive and inducible expression in hematopoietic and non-hematopoietic cells. (PMID: 9434163) Tan KB … Truneh A (Gene 1997) 2 3 4 58
  4. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PMID: 21297633) Anderson CA … Rioux JD (Nature genetics 2011) 3 45 58
  5. Decoy strategies: the structure of TL1A:DcR3 complex. (PMID: 21300286) Zhan C … Almo SC (Structure (London, England : 1993) 2011) 3 4 58

Products for TNFSF15 Gene

Sources for TNFSF15 Gene

Content
Loading form....