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Aliases for TNFSF14 Gene

Aliases for TNFSF14 Gene

  • TNF Superfamily Member 14 2 3 5
  • Tumor Necrosis Factor (Ligand) Superfamily, Member 14 2 3
  • Herpesvirus Entry Mediator Ligand 3 4
  • HVEML 3 4
  • LIGHT 3 4
  • Tumor Necrosis Factor Ligand Superfamily Member 14 3
  • Tumor Necrosis Factor Superfamily Member 14 3
  • Herpes Virus Entry Mediator Ligand 4
  • Tumor Necrosis Factor Ligand 1D 3
  • CD258 Antigen 4
  • HVEM-L 4
  • CD258 3
  • LTg 3

External Ids for TNFSF14 Gene

Previous GeneCards Identifiers for TNFSF14 Gene

  • GC19M006759
  • GC19M006604
  • GC19M006615
  • GC19M006425

Summaries for TNFSF14 Gene

Entrez Gene Summary for TNFSF14 Gene

  • The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFSF14 Gene

TNFSF14 (TNF Superfamily Member 14) is a Protein Coding gene. Diseases associated with TNFSF14 include Herpes Simplex. Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include receptor binding and tumor necrosis factor receptor binding. An important paralog of this gene is FASLG.

UniProtKB/Swiss-Prot for TNFSF14 Gene

  • Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.

Gene Wiki entry for TNFSF14 Gene

Additional gene information for TNFSF14 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFSF14 Gene

Genomics for TNFSF14 Gene

GeneHancer (GH) Regulatory Elements for TNFSF14 Gene

Promoters and enhancers for TNFSF14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I006667 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 557.2 +1.6 1598 3.9 HDGF ZFP64 IRF4 ZNF48 ZNF143 ATF7 RUNX3 PAF1 RXRA JUNB TNFSF14 ACSBG2 ZNF557 GTF2F1 VAV1 DENND1C ADGRE1 GPR108 GC19M006661
GH19I006674 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 51.6 -4.5 -4519 1.1 HDGF PKNOX1 SMAD1 YBX1 IRF4 ARID2 ZNF207 ZNF143 ZNF548 FOS TNFSF14 DENND1C C3 GPR108 TRIP10 XAB2 ZNF557 DUS3L KHSRP STXBP2
GH19I006639 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 21.9 +31.0 31030 0.7 HDAC1 ATF1 PKNOX1 BATF ZNF366 ATF7 RUNX3 JUNB ZEB2 SMARCA4 GC19P006639 TNFSF14 GTF2F1 TNFSF9 GC19M006661
GH19I006717 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 12.9 -50.6 -50570 6.4 HDGF PKNOX1 FOXA2 MLX ARID4B YBX1 DMAP1 ZNF2 YY1 SLC30A9 C3 GPR108 ZNF557 DUS3L XAB2 TNFSF14 RANBP3 ENSG00000276980
GH19I006575 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12.2 +92.1 92141 5.5 HDGF PKNOX1 SMAD1 ARNT IRF4 ZNF280A TCF12 ZNF207 ATF7 FOS GC19P006581 GC19P006580 TNFSF14 TNFSF9 CD70 DENND1C ZNF557 GC19M006573 ENSG00000199223
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TNFSF14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TNFSF14 gene promoter:

Genomic Locations for TNFSF14 Gene

Genomic Locations for TNFSF14 Gene
chr19:6,658,135-6,670,588
(GRCh38/hg38)
Size:
12,454 bases
Orientation:
Minus strand
chr19:6,663,148-6,670,599
(GRCh37/hg19)

Genomic View for TNFSF14 Gene

Genes around TNFSF14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFSF14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFSF14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFSF14 Gene

Proteins for TNFSF14 Gene

  • Protein details for TNFSF14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43557-TNF14_HUMAN
    Recommended name:
    Tumor necrosis factor ligand superfamily member 14
    Protein Accession:
    O43557
    Secondary Accessions:
    • A8K7M2
    • C9J5H4
    • O75476
    • Q6FHA1
    • Q8WVF8
    • Q96LD2

    Protein attributes for TNFSF14 Gene

    Size:
    240 amino acids
    Molecular mass:
    26350 Da
    Quaternary structure:
    • Homotrimer.

    Three dimensional structures from OCA and Proteopedia for TNFSF14 Gene

    Alternative splice isoforms for TNFSF14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNFSF14 Gene

Post-translational modifications for TNFSF14 Gene

Other Protein References for TNFSF14 Gene

No data available for DME Specific Peptides for TNFSF14 Gene

Domains & Families for TNFSF14 Gene

Gene Families for TNFSF14 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for TNFSF14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43557

UniProtKB/Swiss-Prot:

TNF14_HUMAN :
  • Belongs to the tumor necrosis factor family.
Family:
  • Belongs to the tumor necrosis factor family.
genes like me logo Genes that share domains with TNFSF14: view

Function for TNFSF14 Gene

Molecular function for TNFSF14 Gene

GENATLAS Biochemistry:
tumor necrosis factor (ligand) superfamily,member 14,highly expressed in splenocytes,activated PBL,CD8+ tumor infiltrating lymphocytes,granulocytes,monocytes,inducing apoptosis
UniProtKB/Swiss-Prot Function:
Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.
UniProtKB/Swiss-Prot Induction:
Up-regulated after T-cell activation.

Phenotypes From GWAS Catalog for TNFSF14 Gene

Gene Ontology (GO) - Molecular Function for TNFSF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 12393901
GO:0005125 cytokine activity IEA --
GO:0005164 tumor necrosis factor receptor binding IEA --
GO:0005515 protein binding IPI 9462508
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA 12393901
genes like me logo Genes that share ontologies with TNFSF14: view
genes like me logo Genes that share phenotypes with TNFSF14: view

Animal Models for TNFSF14 Gene

MGI Knock Outs for TNFSF14:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNFSF14 Gene

Localization for TNFSF14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFSF14 Gene

Tumor necrosis factor ligand superfamily member 14, membrane form: Cell membrane; Single-pass type II membrane protein.
Tumor necrosis factor ligand superfamily member 14, soluble form: Secreted.
Isoform 2: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFSF14 gene
Compartment Confidence
plasma membrane 5
extracellular 5
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TNFSF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TNFSF14: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TNFSF14 Gene

Pathways & Interactions for TNFSF14 Gene

genes like me logo Genes that share pathways with TNFSF14: view

SIGNOR curated interactions for TNFSF14 Gene

Activates:

Gene Ontology (GO) - Biological Process for TNFSF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 10799510
GO:0006955 immune response IEA --
GO:0007165 signal transduction TAS,NAS 12393901
GO:0008588 release of cytoplasmic sequestered NF-kappaB IDA 12393901
GO:0010469 regulation of receptor activity IEA --
genes like me logo Genes that share ontologies with TNFSF14: view

Drugs & Compounds for TNFSF14 Gene

(1) Drugs for TNFSF14 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
BAMINERCEPT Pharma 0

(1) Additional Compounds for TNFSF14 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TNFSF14: view

Transcripts for TNFSF14 Gene

Unigene Clusters for TNFSF14 Gene

Tumor necrosis factor (ligand) superfamily, member 14:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFSF14 Gene

No ASD Table

Relevant External Links for TNFSF14 Gene

GeneLoc Exon Structure for
TNFSF14
ECgene alternative splicing isoforms for
TNFSF14

Expression for TNFSF14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNFSF14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFSF14 Gene

This gene is overexpressed in Liver (x19.4) and Whole Blood (x11.9).

Protein differential expression in normal tissues from HIPED for TNFSF14 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (51.0), CD8 Tcells (7.3), and NK cells (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TNFSF14 Gene



Protein tissue co-expression partners for TNFSF14 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TNFSF14 Gene:

TNFSF14

SOURCE GeneReport for Unigene cluster for TNFSF14 Gene:

Hs.129708

mRNA Expression by UniProt/SwissProt for TNFSF14 Gene:

O43557-TNF14_HUMAN
Tissue specificity: Predominantly expressed in the spleen but also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumor lines.

Evidence on tissue expression from TISSUES for TNFSF14 Gene

  • Liver(4.3)
  • Spleen(4.3)
  • Blood(2)
genes like me logo Genes that share expression patterns with TNFSF14: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFSF14 Gene

Orthologs for TNFSF14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFSF14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNFSF14 33 34
  • 98.61 (n)
dog
(Canis familiaris)
Mammalia TNFSF14 33 34
  • 82.91 (n)
cow
(Bos Taurus)
Mammalia TNFSF14 33 34
  • 78.86 (n)
rat
(Rattus norvegicus)
Mammalia Tnfsf14 33
  • 77.54 (n)
mouse
(Mus musculus)
Mammalia Tnfsf14 33 16 34
  • 76.98 (n)
oppossum
(Monodelphis domestica)
Mammalia TNFSF14 34
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNFSF14 34
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TNFSF14 34
  • 42 (a)
OneToOne
Species where no ortholog for TNFSF14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TNFSF14 Gene

ENSEMBL:
Gene Tree for TNFSF14 (if available)
TreeFam:
Gene Tree for TNFSF14 (if available)

Paralogs for TNFSF14 Gene

Paralogs for TNFSF14 Gene

genes like me logo Genes that share paralogs with TNFSF14: view

Variants for TNFSF14 Gene

Sequence variations from dbSNP and Humsavar for TNFSF14 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000287634 -- 6,668,514(-) T/G intron_variant
rs1000416241 -- 6,661,795(-) A/G 3_prime_UTR_variant, intron_variant
rs1000489886 -- 6,662,014(-) G/C 3_prime_UTR_variant, intron_variant
rs1000528303 -- 6,672,333(-) G/A upstream_transcript_variant
rs1000855338 -- 6,666,552(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TNFSF14 Gene

Variant ID Type Subtype PubMed ID
nsv1134749 CNV deletion 24896259
nsv833728 CNV loss 17160897

Variation tolerance for TNFSF14 Gene

Residual Variation Intolerance Score: 61.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNFSF14 Gene

Human Gene Mutation Database (HGMD)
TNFSF14
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNFSF14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFSF14 Gene

Disorders for TNFSF14 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TNFSF14 Gene - From: HGMD, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
herpes simplex
  • herpesvirus hominis disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TNFSF14

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TNFSF14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNFSF14 Gene

Publications for TNFSF14 Gene

  1. Genomic characterization of LIGHT reveals linkage to an immune response locus on chromosome 19p13.3 and distinct isoforms generated by alternate splicing or proteolysis. (PMID: 11673523) Granger SW … Ware CF (Journal of immunology (Baltimore, Md. : 1950) 2001) 3 4 22 58
  2. LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator. (PMID: 9462508) Mauri DN … Ware CF (Immunity 1998) 2 3 4 58
  3. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) International Multiple Sclerosis Genetics Consortium … Compston A (Nature 2011) 3 44 58
  4. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K … Hosoya T (Nephron. Clinical practice 2010) 3 44 58
  5. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PMID: 20568250) Lee KM … Lan Q (American journal of hematology 2010) 3 44 58

Products for TNFSF14 Gene

Sources for TNFSF14 Gene

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