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Aliases for TNFSF14 Gene

Aliases for TNFSF14 Gene

  • TNF Superfamily Member 14 2 3 5
  • Tumor Necrosis Factor (Ligand) Superfamily, Member 14 2 3
  • Tumor Necrosis Factor Ligand Superfamily Member 14 3 4
  • Herpesvirus Entry Mediator Ligand 3 4
  • HVEML 3 4
  • LIGHT 3 4
  • Tumor Necrosis Factor Superfamily Member 14 3
  • Herpes Virus Entry Mediator Ligand 4
  • Tumor Necrosis Factor Ligand 1D 3
  • CD258 Antigen 4
  • HVEM-L 4
  • CD258 3
  • LTg 3

External Ids for TNFSF14 Gene

Previous GeneCards Identifiers for TNFSF14 Gene

  • GC19M006759
  • GC19M006604
  • GC19M006615
  • GC19M006425

Summaries for TNFSF14 Gene

Entrez Gene Summary for TNFSF14 Gene

  • The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFSF14 Gene

TNFSF14 (TNF Superfamily Member 14) is a Protein Coding gene. Among its related pathways are Innate Immune System and ERK Signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and tumor necrosis factor receptor binding. An important paralog of this gene is LTB.

UniProtKB/Swiss-Prot for TNFSF14 Gene

  • Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Acts as a ligand for TNFRSF14/HVEM (PubMed:9462508, PubMed:10754304). Upon binding to TNFRSF14/HVEM, delivers costimulatory signals to T cells, leading to T cell proliferation and IFNG production (PubMed:10754304).

Gene Wiki entry for TNFSF14 Gene

Additional gene information for TNFSF14 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFSF14 Gene

Genomics for TNFSF14 Gene

GeneHancer (GH) Regulatory Elements for TNFSF14 Gene

Promoters and enhancers for TNFSF14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J006667 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 607.1 +1.7 1726 4.1 ZNF473 ZNF148 NKRF CEBPG ZNF687 RELA SP1 CREM MLLT1 ZNF404 TNFSF14 ZNF557 XAB2 KHSRP ACSBG2 DUS3L GTF2F1 VAV1 DENND1C ADGRE1
GH19J006674 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 51.4 -4.5 -4519 1.1 SP1 NKRF MLLT1 GTF2F1 BACH1 MAFK RELA ZNF548 CREM EGR1 TNFSF14 XAB2 ZNF557 KHSRP DUS3L DENND1C C3 TRIP10 GPR108 RANBP3
GH19J006718 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.9 -50.4 -50359 6.8 ZNF652 CC2D1A SP1 ELF3 POLR2A MLLT1 CEBPG RERE GTF2F1 CSDE1 C3 XAB2 ZNF557 DUS3L KHSRP ENSG00000267571 RANBP3 VMAC GPR108 TRIP10
GH19J006639 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 21.9 +31.0 31030 0.7 CBFA2T2 ZSCAN21 CREM SMARCA4 PKNOX1 ZNF629 HDAC1 ZNF316 MGA EED GC19P006639 TNFSF14 GTF2F1 TNFSF9 GC19M006661
GH19J006572 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12.2 +94.2 94190 9.6 SP1 ZKSCAN8 CBFA2T2 ZNF148 NKRF MLLT1 ZNF687 ZSCAN21 TRIM24 RELA KHSRP SNRPEP4 TNFSF14 TNFSF9 CD70 DENND1C ZNF557 GC19P006581 GC19P006580 GC19P006571
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TNFSF14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TNFSF14 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • STAT3

Genomic Locations for TNFSF14 Gene

Genomic Locations for TNFSF14 Gene
chr19:6,658,135-6,670,588
(GRCh38/hg38)
Size:
12,454 bases
Orientation:
Minus strand
chr19:6,663,148-6,670,599
(GRCh37/hg19)
Size:
7,452 bases
Orientation:
Minus strand

Genomic View for TNFSF14 Gene

Genes around TNFSF14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFSF14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFSF14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFSF14 Gene

Proteins for TNFSF14 Gene

  • Protein details for TNFSF14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43557-TNF14_HUMAN
    Recommended name:
    Tumor necrosis factor ligand superfamily member 14
    Protein Accession:
    O43557
    Secondary Accessions:
    • A8K7M2
    • C9J5H4
    • O75476
    • Q6FHA1
    • Q8WVF8
    • Q96LD2

    Protein attributes for TNFSF14 Gene

    Size:
    240 amino acids
    Molecular mass:
    26350 Da
    Quaternary structure:
    • Homotrimer. Interacts with TNFRSF14.

    Three dimensional structures from OCA and Proteopedia for TNFSF14 Gene

    Alternative splice isoforms for TNFSF14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNFSF14 Gene

Post-translational modifications for TNFSF14 Gene

Other Protein References for TNFSF14 Gene

No data available for DME Specific Peptides for TNFSF14 Gene

Domains & Families for TNFSF14 Gene

Gene Families for TNFSF14 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for TNFSF14 Gene

GenScript: Design optimal peptide antigens:
  • Herpes virus entry mediator ligand (TNF14_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O43557

UniProtKB/Swiss-Prot:

TNF14_HUMAN :
  • Belongs to the tumor necrosis factor family.
Family:
  • Belongs to the tumor necrosis factor family.
genes like me logo Genes that share domains with TNFSF14: view

Function for TNFSF14 Gene

Molecular function for TNFSF14 Gene

UniProtKB/Swiss-Prot Function:
Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Acts as a ligand for TNFRSF14/HVEM (PubMed:9462508, PubMed:10754304). Upon binding to TNFRSF14/HVEM, delivers costimulatory signals to T cells, leading to T cell proliferation and IFNG production (PubMed:10754304).
UniProtKB/Swiss-Prot Induction:
Up-regulated after T-cell activation.
GENATLAS Biochemistry:
tumor necrosis factor (ligand) superfamily,member 14,highly expressed in splenocytes,activated PBL,CD8+ tumor infiltrating lymphocytes,granulocytes,monocytes,inducing apoptosis

Phenotypes From GWAS Catalog for TNFSF14 Gene

Gene Ontology (GO) - Molecular Function for TNFSF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IPI 12393901
GO:0005125 cytokine activity IEA --
GO:0005164 tumor necrosis factor receptor binding IEA --
GO:0005515 protein binding IPI 9462508
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA 12393901
genes like me logo Genes that share ontologies with TNFSF14: view
genes like me logo Genes that share phenotypes with TNFSF14: view

Animal Models for TNFSF14 Gene

MGI Knock Outs for TNFSF14:

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for TNFSF14 - Now 50% OFF >
  • * TNFSF14 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TNFSF14 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNFSF14 Gene

Localization for TNFSF14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFSF14 Gene

Tumor necrosis factor ligand superfamily member 14, membrane form: Cell membrane; Single-pass type II membrane protein.
Tumor necrosis factor ligand superfamily member 14, soluble form: Secreted.
Isoform 2: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFSF14 gene
Compartment Confidence
plasma membrane 5
extracellular 5
mitochondrion 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TNFSF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TNFSF14: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TNFSF14 Gene

Pathways & Interactions for TNFSF14 Gene

genes like me logo Genes that share pathways with TNFSF14: view

SIGNOR curated interactions for TNFSF14 Gene

Activates:

Gene Ontology (GO) - Biological Process for TNFSF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 10799510
GO:0006955 immune response IEA --
GO:0007165 signal transduction TAS,NAS 12393901
GO:0010469 regulation of signaling receptor activity IEA --
GO:0010820 positive regulation of T cell chemotaxis IEA --
genes like me logo Genes that share ontologies with TNFSF14: view

Drugs & Compounds for TNFSF14 Gene

(1) Drugs for TNFSF14 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Baminercept Investigational Pharma 0

(1) Additional Compounds for TNFSF14 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TNFSF14: view

Transcripts for TNFSF14 Gene

mRNA/cDNA for TNFSF14 Gene

(2) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(731) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for TNFSF14 Gene

Tumor necrosis factor (ligand) superfamily, member 14:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for TNFSF14 - Now 50% OFF >
  • * TNFSF14 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TNFSF14 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for TNFSF14 Gene

No ASD Table

Relevant External Links for TNFSF14 Gene

GeneLoc Exon Structure for
TNFSF14
ECgene alternative splicing isoforms for
TNFSF14

Expression for TNFSF14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNFSF14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFSF14 Gene

This gene is overexpressed in Liver (x19.4) and Whole Blood (x11.9).

Protein differential expression in normal tissues from HIPED for TNFSF14 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (51.0), CD8 Tcells (7.3), and NK cells (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TNFSF14 Gene



Protein tissue co-expression partners for TNFSF14 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TNFSF14 Gene:

TNFSF14

SOURCE GeneReport for Unigene cluster for TNFSF14 Gene:

Hs.129708

mRNA Expression by UniProt/SwissProt for TNFSF14 Gene:

O43557-TNF14_HUMAN
Tissue specificity: Predominantly expressed in the spleen but also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumor lines.

Evidence on tissue expression from TISSUES for TNFSF14 Gene

  • Spleen(4.3)
  • Liver(4.2)
  • Blood(2)
genes like me logo Genes that share expression patterns with TNFSF14: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFSF14 Gene

Orthologs for TNFSF14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFSF14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNFSF14 35 34
  • 98.61 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TNFSF14 35 34
  • 82.91 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TNFSF14 35 34
  • 78.86 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tnfsf14 34
  • 77.54 (n)
mouse
(Mus musculus)
Mammalia Tnfsf14 17 35 34
  • 76.98 (n)
oppossum
(Monodelphis domestica)
Mammalia TNFSF14 35
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNFSF14 35
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TNFSF14 35
  • 42 (a)
OneToOne
Species where no ortholog for TNFSF14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TNFSF14 Gene

ENSEMBL:
Gene Tree for TNFSF14 (if available)
TreeFam:
Gene Tree for TNFSF14 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TNFSF14: view image

Paralogs for TNFSF14 Gene

Paralogs for TNFSF14 Gene

genes like me logo Genes that share paralogs with TNFSF14: view

Variants for TNFSF14 Gene

Sequence variations from dbSNP and Humsavar for TNFSF14 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000287634 -- 6,668,514(-) T/G intron_variant
rs1000416241 -- 6,661,795(-) A/G 3_prime_UTR_variant, intron_variant
rs1000489886 -- 6,662,014(-) G/C 3_prime_UTR_variant, intron_variant
rs1000528303 -- 6,672,333(-) G/A upstream_transcript_variant
rs1000855338 -- 6,666,552(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TNFSF14 Gene

Variant ID Type Subtype PubMed ID
nsv1134749 CNV deletion 24896259
nsv833728 CNV loss 17160897

Variation tolerance for TNFSF14 Gene

Residual Variation Intolerance Score: 61.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNFSF14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNFSF14
Human Gene Mutation Database (HGMD)
TNFSF14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFSF14 Gene

Disorders for TNFSF14 Gene

Additional Disease Information for TNFSF14

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TNFSF14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNFSF14 Gene

Publications for TNFSF14 Gene

  1. Genomic characterization of LIGHT reveals linkage to an immune response locus on chromosome 19p13.3 and distinct isoforms generated by alternate splicing or proteolysis. (PMID: 11673523) Granger SW … Ware CF (Journal of immunology (Baltimore, Md. : 1950) 2001) 3 4 23 58
  2. LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator. (PMID: 9462508) Mauri DN … Ware CF (Immunity 1998) 2 3 4 58
  3. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) International Multiple Sclerosis Genetics Consortium … Compston A (Nature 2011) 3 45 58
  4. CXCR3 binding chemokine and TNFSF14 over expression in bladder urothelium of patients with ulcerative interstitial cystitis. (PMID: 20096889) Ogawa T … Nishizawa O (The Journal of urology 2010) 3 23 58
  5. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K … Hosoya T (Nephron. Clinical practice 2010) 3 45 58

Products for TNFSF14 Gene

  • Biorbyt antibodies for TNFSF14

Sources for TNFSF14 Gene

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