The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiati... See more...

Aliases for TNFSF13B Gene

Aliases for TNFSF13B Gene

  • TNF Superfamily Member 13b 2 3 5
  • B-Cell-Activating Factor 2 3 4
  • TALL-1 2 3 4
  • TALL1 2 3 4
  • BAFF 2 3 4
  • BLYS 2 3 4
  • Tumor Necrosis Factor (Ligand) Superfamily, Member 13b 2 3
  • Tumor Necrosis Factor Ligand Superfamily Member 13B 3 4
  • TNF And ApoL-Related Leukocyte Expressed Ligand 1 2 3
  • Dendritic Cell-Derived TNF-Like Molecule 3 4
  • TNF Homolog That Activates Apoptosis 2 3
  • B-Lymphocyte Stimulator 2 3
  • TNFSF20 3 4
  • CD257 2 3
  • THANK 2 3
  • ZTNF4 3 4
  • Tumor Necrosis Factor (Ligand) Superfamily, Member 20 3
  • TNF- And APOL-Related Leukocyte Expressed Ligand 1 4
  • Tumor Necrosis Factor Superfamily Member 13b 3
  • Epididymis Secretory Sperm Binding Protein 3
  • Tumor Necrosis Factor-Like Protein ZTNF4 3
  • Tumor Necrosis Factor Ligand 7A 3
  • ApoL Related Ligand TALL-1 3
  • B Lymphocyte Stimulator 4
  • CD257 Antigen 4
  • Delta4 BAFF 3
  • Delta BAFF 3
  • TNFSF13B 5
  • TNLG7A 3
  • BLyS 4
  • DTL 3

External Ids for TNFSF13B Gene

Previous HGNC Symbols for TNFSF13B Gene

  • TNFSF20

Previous GeneCards Identifiers for TNFSF13B Gene

  • GC13P107281
  • GC13P103309
  • GC13P107758
  • GC13P106619
  • GC13P107719
  • GC13P108903
  • GC13P089512

Summaries for TNFSF13B Gene

Entrez Gene Summary for TNFSF13B Gene

  • The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

GeneCards Summary for TNFSF13B Gene

TNFSF13B (TNF Superfamily Member 13b) is a Protein Coding gene. Diseases associated with TNFSF13B include Sialadenitis and Igg4-Related Disease. Among its related pathways are Rheumatoid arthritis and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and tumor necrosis factor receptor binding. An important paralog of this gene is TNFSF12-TNFSF13.

UniProtKB/Swiss-Prot Summary for TNFSF13B Gene

  • Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.
  • Isoform 2 seems to inhibit isoform 1 secretion and bioactivity.
  • [Isoform 3]: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis.

Gene Wiki entry for TNFSF13B Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TNFSF13B Gene

Genomics for TNFSF13B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TNFSF13B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J108268 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 250.4 +19.4 19361 4.8 ZNF207 CTCF CEBPB SIN3A TARDBP IRF4 EBF1 TAF1 BHLHE40 SPI1 HSALNG0099259 TNFSF13B ABHD13 LIG4 RF00001-100 RNA5SP39 MYO16
GH13J108266 Promoter/Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 19.8 +15.7 15661 1.8 GABPA SPI1 POLR2A YY1 MLLT1 ENSG00000277246 ABHD13 TNFSF13B LIG4 MYO16
GH13J108326 Enhancer 0.6 FANTOM5 9.2 +75.2 75228 0.1 CEBPA FOXA2 GABPB1 SPI1 SRF ELF1 GABPA FOXA3 LOC105370355 ABHD13 LIG4 TNFSF13B HSALNG0099261 MYO16
GH13J108277 Enhancer 0.8 Ensembl dbSUPER 0.3 +26.7 26661 0.2 ZNF592 RELA IRF9 EHMT2 RFX1 HDAC8 NR2C1 PTTG1 ZNF354B NR4A1 ABHD13 HSALNG0099259 RF00001-100 RNA5SP39 TNFSF13B MYO16
GH13J108281 Enhancer 0.6 Ensembl dbSUPER 0.3 +31.1 31061 3 TEAD4 MEIS2 CEBPB HLF CBFA2T3 HSALNG0099259 RF00001-100 RNA5SP39 TNFSF13B MYO16
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TNFSF13B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TNFSF13B

Top Transcription factor binding sites by QIAGEN in the TNFSF13B gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • c-Myc
  • C/EBPalpha
  • Evi-1
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for TNFSF13B Gene

Latest Assembly
chr13:108,251,240-108,308,484
(GRCh38/hg38)
Size:
57,245 bases
Orientation:
Plus strand

Previous Assembly
chr13:108,921,977-108,960,832
(GRCh37/hg19 by Entrez Gene)
Size:
38,856 bases
Orientation:
Plus strand

chr13:108,903,588-108,960,832
(GRCh37/hg19 by Ensembl)
Size:
57,245 bases
Orientation:
Plus strand

Genomic View for TNFSF13B Gene

Genes around TNFSF13B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFSF13B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFSF13B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFSF13B Gene

Proteins for TNFSF13B Gene

  • Protein details for TNFSF13B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y275-TN13B_HUMAN
    Recommended name:
    Tumor necrosis factor ligand superfamily member 13B
    Protein Accession:
    Q9Y275
    Secondary Accessions:
    • E0ADT7
    • Q6FHD6
    • Q7Z5J2

    Protein attributes for TNFSF13B Gene

    Size:
    285 amino acids
    Molecular mass:
    31223 Da
    Quaternary structure:
    • Homotrimer. Isoform 2 heteromultimerizes with isoform 1, probably limiting the amount of functional isoform 1 on the cell surface. Isoform 3 is unlikely form trimers or bind to BAFF receptors.

    Three dimensional structures from OCA and Proteopedia for TNFSF13B Gene

    Alternative splice isoforms for TNFSF13B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNFSF13B Gene

Post-translational modifications for TNFSF13B Gene

Other Protein References for TNFSF13B Gene

Antibodies for research

  • Abcam antibodies for TNFSF13B

No data available for DME Specific Peptides for TNFSF13B Gene

Domains & Families for TNFSF13B Gene

Gene Families for TNFSF13B Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for TNFSF13B Gene

InterPro:
Blocks:
  • Tumor Necrosis Factor

Suggested Antigen Peptide Sequences for TNFSF13B Gene

GenScript: Design optimal peptide antigens:
  • B-lymphocyte stimulator (Q8IZI4_HUMAN)
  • B-lymphocyte stimulator (Q8IZI5_HUMAN)
  • B-lymphocyte stimulator (Q8IZI6_HUMAN)
  • TNF- and APOL-related leukocyte expressed ligand 1 (TN13B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y275

UniProtKB/Swiss-Prot:

TN13B_HUMAN :
  • Belongs to the tumor necrosis factor family.
Family:
  • Belongs to the tumor necrosis factor family.
genes like me logo Genes that share domains with TNFSF13B: view

Function for TNFSF13B Gene

Molecular function for TNFSF13B Gene

UniProtKB/Swiss-Prot Function:
Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.
UniProtKB/Swiss-Prot Function:
Isoform 2 seems to inhibit isoform 1 secretion and bioactivity.
UniProtKB/Swiss-Prot Function:
[Isoform 3]: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis.
UniProtKB/Swiss-Prot Induction:
Up-regulated by exposure to IFNG/IFN-gamma. Down-regulated by phorbol myristate acetate/ionomycin treatment.
GENATLAS Biochemistry:
tumor necrosis factor (ligand) superfamily,member 13B,expressed abundantly in peripheral blood leukocytes T cell and dendritic cells and weakly in spleen,inducing the proliferation of anti IgM stimulated peripheral blood B lymphocyte

Phenotypes From GWAS Catalog for TNFSF13B Gene

Gene Ontology (GO) - Molecular Function for TNFSF13B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding TAS --
GO:0005125 cytokine activity IEA --
GO:0005164 tumor necrosis factor receptor binding IEA --
GO:0005515 protein binding IPI 10801128
GO:0048018 receptor ligand activity IBA 21873635
genes like me logo Genes that share ontologies with TNFSF13B: view
genes like me logo Genes that share phenotypes with TNFSF13B: view

Animal Models for TNFSF13B Gene

MGI Knock Outs for TNFSF13B:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNFSF13B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNFSF13B Gene

Localization for TNFSF13B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFSF13B Gene

Cell membrane. Single-pass type II membrane protein.
[Tumor necrosis factor ligand superfamily member 13b, soluble form]: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFSF13B gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 3
cytosol 3
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
lysosome 2
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Focal adhesion sites (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TNFSF13B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
GO:0005737 cytoplasm IDA 19828625
GO:0005886 plasma membrane IBA,IDA --
GO:0005925 focal adhesion IDA --
genes like me logo Genes that share ontologies with TNFSF13B: view

Pathways & Interactions for TNFSF13B Gene

PathCards logo

SuperPathways for TNFSF13B Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
.94
.94
.73
.71
.62
.61
.57
.51
.47
.46
.43
2 TGF-Beta Pathway
.60
.60
.57
.51
.43
.40
3 Akt Signaling
.60
.60
.55
4 ERK Signaling
.61
.61
.51
5 TNF Superfamily Pathway: Human Ligand-Receptor Interactions and their Associated Functions
genes like me logo Genes that share pathways with TNFSF13B: view

Pathways by source for TNFSF13B Gene

2 GeneGo (Thomson Reuters) pathways for TNFSF13B Gene
  • Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
  • Apoptosis and survival APRIL and BAFF signaling
29 Qiagen pathways for TNFSF13B Gene
  • Akt Signaling
  • all-trans-Retinoic Acid Signaling in Brain
  • Antioxidant Action of Vitamin-C
  • BAFF in B-Cell Signaling
  • Endothelin-1 Signaling Pathway
1 Cell Signaling Technology pathway for TNFSF13B Gene

SIGNOR curated interactions for TNFSF13B Gene

Activates:

Gene Ontology (GO) - Biological Process for TNFSF13B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001782 B cell homeostasis IEA --
GO:0002376 immune system process IEA --
GO:0002636 positive regulation of germinal center formation IEA --
GO:0006955 immune response IEA --
GO:0007165 signal transduction TAS 10908663
genes like me logo Genes that share ontologies with TNFSF13B: view

Drugs & Compounds for TNFSF13B Gene

(10) Drugs for TNFSF13B Gene - From: DrugBank, PharmGKB, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
belimumab Approved Pharma Target, neutralizer, antibody Therapeutic Antibodies 71
1,4-Dioxane Experimental Pharma Target 0
Blisibimod Investigational Pharma 0
LY2127399 Pharma 0
TACI-IG Pharma 0

(2) Additional Compounds for TNFSF13B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TNFSF13B: view

Transcripts for TNFSF13B Gene

mRNA/cDNA for TNFSF13B Gene

2 REFSEQ mRNAs :
25 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNFSF13B

Alternative Splicing Database (ASD) splice patterns (SP) for TNFSF13B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2: - -
SP3:
SP4: -

Relevant External Links for TNFSF13B Gene

GeneLoc Exon Structure for
TNFSF13B

Expression for TNFSF13B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TNFSF13B Gene

mRNA differential expression in normal tissues according to GTEx for TNFSF13B Gene

This gene is overexpressed in Whole Blood (x24.7).

Protein differential expression in normal tissues from HIPED for TNFSF13B Gene

This gene is overexpressed in Ovary (26.1), Esophagus (21.2), Peripheral blood mononuclear cells (14.2), and Blymphocyte (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TNFSF13B Gene



Protein tissue co-expression partners for TNFSF13B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TNFSF13B

SOURCE GeneReport for Unigene cluster for TNFSF13B Gene:

Hs.525157

mRNA Expression by UniProt/SwissProt for TNFSF13B Gene:

Q9Y275-TN13B_HUMAN
Tissue specificity: Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T-cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas. Isoform 2 is expressed in many myeloid cell lines.

Evidence on tissue expression from TISSUES for TNFSF13B Gene

  • Lymph node(4.6)
  • Spleen(4.6)
  • Blood(4.6)
  • Bone marrow(3.2)
  • Intestine(2.7)
  • Kidney(2.5)
  • Lung(2.5)
  • Nervous system(2.3)
  • Skin(2.3)
  • Heart(2.2)
  • Liver(2)
genes like me logo Genes that share expression patterns with TNFSF13B: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFSF13B Gene

Orthologs for TNFSF13B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFSF13B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TNFSF13B 29 30
  • 99.88 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TNFSF13B 29 30
  • 83.16 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TNFSF13B 29 30
  • 82.01 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tnfsf13b 29 16 30
  • 71.82 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tnfsf13b 29
  • 66.01 (n)
Oppossum
(Monodelphis domestica)
Mammalia TNFSF13B 30
  • 61 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TNFSF13B 30
  • 60 (a)
OneToOne
Chicken
(Gallus gallus)
Aves -- 30
  • 67 (a)
OneToMany
TNFSF13B 29
  • 62.63 (n)
BAFF 30
  • 51 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia TNFSF13B 30
  • 53 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tnfsf13b 29
  • 58.41 (n)
Zebrafish
(Danio rerio)
Actinopterygii tnfsf13b 29 30
  • 54.13 (n)
OneToOne
Species where no ortholog for TNFSF13B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TNFSF13B Gene

ENSEMBL:
Gene Tree for TNFSF13B (if available)
TreeFam:
Gene Tree for TNFSF13B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TNFSF13B: view image
Alliance of Genome Resources:
Additional Orthologs for TNFSF13B

Paralogs for TNFSF13B Gene

Paralogs for TNFSF13B Gene

(1) SIMAP similar genes for TNFSF13B Gene using alignment to 4 proteins:

  • TN13B_HUMAN
  • Q8IZI4_HUMAN
  • Q8IZI5_HUMAN
  • Q8IZI6_HUMAN
genes like me logo Genes that share paralogs with TNFSF13B: view

Variants for TNFSF13B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TNFSF13B Gene

SNP ID Clinical significance and condition Chr 13 pos Variation AA Info Type
rs1594535542 Likely Benign: not provided 108,303,266(+) T/C
NM_006573.4(TNFSF13B):c.495T>C (p.Phe165=)
SYNONYMOUS
rs201543678 Benign: not provided 108,270,208(+) G/Ap.Ala105Thr
NM_006573.4(TNFSF13B):c.313G>A (p.Ala105Thr)
MISSENSE
rs77273581 Benign: not provided 108,303,585(+) T/C
NM_006573.4(TNFSF13B):c.726T>C (p.Asn242=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TNFSF13B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TNFSF13B Gene

Variant ID Type Subtype PubMed ID
dgv1037n106 CNV deletion 24896259
dgv3378n54 CNV loss 21841781
dgv3379n54 CNV loss 21841781
dgv3380n54 CNV loss 21841781
dgv3381n54 CNV loss 21841781
dgv3382n54 CNV loss 21841781
dgv3383n54 CNV loss 21841781
dgv379e199 CNV deletion 23128226
esv2563318 CNV insertion 19546169
esv27365 CNV loss 19812545
esv2747975 CNV deletion 23290073
esv2747976 CNV deletion 23290073
esv3332356 CNV duplication 20981092
esv3551054 CNV deletion 23714750
esv3580887 CNV loss 25503493
esv3633502 CNV loss 21293372
nsv1050169 CNV gain 25217958
nsv1139838 CNV deletion 24896259
nsv510624 CNV deletion 20534489
nsv526850 CNV gain 19592680
nsv951917 CNV duplication 24416366

Variation tolerance for TNFSF13B Gene

Residual Variation Intolerance Score: 33.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNFSF13B Gene

Human Gene Mutation Database (HGMD)
TNFSF13B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNFSF13B
Leiden Open Variation Database (LOVD)
TNFSF13B

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFSF13B Gene

Disorders for TNFSF13B Gene

MalaCards: The human disease database

(77) MalaCards diseases for TNFSF13B Gene - From: COP and GCD

Disorder Aliases PubMed IDs
sialadenitis
  • sialoadenitis
igg4-related disease
  • hyper-igg4 disease
sjogren syndrome
  • sicca syndrome
ascaris lumbricoides infection
  • ascaris lumbricoides infection, susceptibility to
autoimmune disease
  • autoimmune hypersensitivity disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TNFSF13B

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TNFSF13B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNFSF13B Gene

Publications for TNFSF13B Gene

  1. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. (PMID: 10359578) Schneider P … Tschopp J (The Journal of experimental medicine 1999) 2 3 4 22
  2. Genetic variation in B-cell-activating factor is associated with an increased risk of developing B-cell non-Hodgkin lymphoma. (PMID: 19383901) Novak AJ … Ansell SM (Cancer research 2009) 3 22 40
  3. No evidence for an association between the -871 T/C promoter polymorphism in the B-cell-activating factor gene and primary Sjögren's syndrome. (PMID: 16507129) Gottenberg JE … Miceli-Richard C (Arthritis research & therapy 2006) 3 22 40
  4. DeltaBAFF, an alternate splice isoform that regulates receptor binding and biopresentation of the B cell survival cytokine, BAFF. (PMID: 12867412) Gavin AL … Nemazee D (The Journal of biological chemistry 2003) 3 4 22
  5. Analysis on the association of human BLYS (BAFF, TNFSF13B) polymorphisms with systemic lupus erythematosus and rheumatoid arthritis. (PMID: 12424625) Kawasaki A … Tokunaga K (Genes and immunity 2002) 3 22 40

Products for TNFSF13B Gene

Sources for TNFSF13B Gene