Aliases for TNFSF13 Gene
External Ids for TNFSF13 Gene
Previous GeneCards Identifiers for TNFSF13 Gene
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]
GeneCards Summary for TNFSF13 Gene
TNFSF13 (TNF Superfamily Member 13) is a Protein Coding gene. Diseases associated with TNFSF13 include Brain Glioblastoma Multiforme and Rheumatoid Arthritis. Among its related pathways are RANK Signaling in Osteoclasts and IL10 Signaling Pathway. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and tumor necrosis factor receptor binding. An important paralog of this gene is TNFSF12-TNFSF13.
UniProtKB/Swiss-Prot Summary for TNFSF13 Gene
Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.