The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF... See more...

Aliases for TNFSF13 Gene

Aliases for TNFSF13 Gene

  • TNF Superfamily Member 13 2 3 5
  • APRIL 2 3 4
  • Tumor Necrosis Factor (Ligand) Superfamily, Member 13 2 3
  • Tumor Necrosis Factor Ligand Superfamily Member 13 3 4
  • TNF- And APOL-Related Leukocyte Expressed Ligand 2 3 4
  • A Proliferation-Inducing Ligand 3 4
  • TALL-2 3 4
  • TRDL-1 3 4
  • CD256 2 3
  • TALL2 3 4
  • ZTNF2 3 4
  • Tumor Necrosis Factor-Related Death Ligand-1 3
  • Tumor Necrosis Factor Superfamily Member 13 3
  • Tumor Necrosis Factor-Like Protein ZTNF2 3
  • Tumor Necrosis Factor Ligand 7B 3
  • TNF-Related Death Ligand 1 4
  • UNQ383/PRO715 3
  • CD256 Antigen 4
  • TNFSF13 5
  • TNLG7B 3

External Ids for TNFSF13 Gene

Previous GeneCards Identifiers for TNFSF13 Gene

  • GC17P007876
  • GC17P008201
  • GC17P007396
  • GC17P007653
  • GC17P007654
  • GC17P007397
  • GC17P007398
  • GC17P007399
  • GC17P007402
  • GC17P007392
  • GC17P007461
  • GC17P007355

Summaries for TNFSF13 Gene

Entrez Gene Summary for TNFSF13 Gene

  • The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]

GeneCards Summary for TNFSF13 Gene

TNFSF13 (TNF Superfamily Member 13) is a Protein Coding gene. Diseases associated with TNFSF13 include Brain Glioblastoma Multiforme and Rheumatoid Arthritis. Among its related pathways are RANK Signaling in Osteoclasts and IL10 Signaling Pathway. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and tumor necrosis factor receptor binding. An important paralog of this gene is TNFSF12-TNFSF13.

UniProtKB/Swiss-Prot Summary for TNFSF13 Gene

  • Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.

Gene Wiki entry for TNFSF13 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TNFSF13 Gene

Genomics for TNFSF13 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TNFSF13 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TNFSF13 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TNFSF13

Top Transcription factor binding sites by QIAGEN in the TNFSF13 gene promoter:
  • AP-1
  • CREB
  • deltaCREB
  • MyoD
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for TNFSF13 Gene

Latest Assembly
chr17:7,558,282-7,561,608
(GRCh38/hg38)
Size:
3,327 bases
Orientation:
Plus strand

Previous Assembly
chr17:7,461,599-7,464,925
(GRCh37/hg19 by Entrez Gene)
Size:
3,327 bases
Orientation:
Plus strand

chr17:7,461,609-7,464,925
(GRCh37/hg19 by Ensembl)
Size:
3,317 bases
Orientation:
Plus strand

Genomic View for TNFSF13 Gene

Genes around TNFSF13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFSF13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFSF13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFSF13 Gene

Proteins for TNFSF13 Gene

  • Protein details for TNFSF13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75888-TNF13_HUMAN
    Recommended name:
    Tumor necrosis factor ligand superfamily member 13
    Protein Accession:
    O75888
    Secondary Accessions:
    • A8MYD5
    • B4DVT2
    • Q541E1
    • Q5U0G8
    • Q96HV6
    • Q9P1M8
    • Q9P1M9

    Protein attributes for TNFSF13 Gene

    Size:
    250 amino acids
    Molecular mass:
    27433 Da
    Quaternary structure:
    • Homotrimer.

    Three dimensional structures from OCA and Proteopedia for TNFSF13 Gene

    Alternative splice isoforms for TNFSF13 Gene

neXtProt entry for TNFSF13 Gene

Post-translational modifications for TNFSF13 Gene

Antibodies for research

  • Abcam antibodies for TNFSF13

No data available for DME Specific Peptides for TNFSF13 Gene

Domains & Families for TNFSF13 Gene

Gene Families for TNFSF13 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for TNFSF13 Gene

InterPro:
Blocks:
  • Tumor Necrosis Factor

Suggested Antigen Peptide Sequences for TNFSF13 Gene

GenScript: Design optimal peptide antigens:
  • Tumor necrosis factor ligand superfamily member 13 epsilon (A5Y848_HUMAN)
  • cDNA FLJ57090, highly similar to Tumor necrosis factor ligand superfamily member 13 (B4DVT2_HUMAN)
  • Tumor necrosis factor (Ligand) superfamily member 13 transcript variant delta (Q2QBA2_HUMAN)
  • APRIL (Q541E1_HUMAN)
  • Tumor necrosis factor (Ligand) superfamily, member 13 (Q6FGN4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75888

UniProtKB/Swiss-Prot:

TNF13_HUMAN :
  • Belongs to the tumor necrosis factor family.
Family:
  • Belongs to the tumor necrosis factor family.
genes like me logo Genes that share domains with TNFSF13: view

Function for TNFSF13 Gene

Molecular function for TNFSF13 Gene

UniProtKB/Swiss-Prot Function:
Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.
UniProtKB/Swiss-Prot Induction:
Down-regulated by phorbol myristate acetate/ionomycin treatment.
GENATLAS Biochemistry:
tumor necrosis factor,ligand,superfamily,member 13,highly expressed in transformed cell lines and in diverse human cancers putative regulator of tumor cell growth

Phenotypes From GWAS Catalog for TNFSF13 Gene

Gene Ontology (GO) - Molecular Function for TNFSF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding TAS --
GO:0005125 cytokine activity IEA --
GO:0005164 tumor necrosis factor receptor binding IEA --
GO:0005515 protein binding IPI --
GO:0048018 receptor ligand activity IBA 21873635
genes like me logo Genes that share ontologies with TNFSF13: view
genes like me logo Genes that share phenotypes with TNFSF13: view

Animal Models for TNFSF13 Gene

MGI Knock Outs for TNFSF13:

Animal Models for research

  • Taconic Biosciences Mouse Models for TNFSF13

miRNA for TNFSF13 Gene

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNFSF13

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNFSF13 Gene

Localization for TNFSF13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFSF13 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFSF13 gene
Compartment Confidence
plasma membrane 4
extracellular 4
nucleus 4
cytosol 4
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TNFSF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 19828625
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TNFSF13: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TNFSF13 Gene

Pathways & Interactions for TNFSF13 Gene

PathCards logo

SuperPathways for TNFSF13 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
.94
.94
.73
.71
.62
.61
.47
.46
2 ERK Signaling
.61
.61
.51
3 CDK-mediated phosphorylation and removal of Cdc6
4 TNF Superfamily Pathway: Human Ligand-Receptor Interactions and their Associated Functions
5 Akt Signaling
.60
.60
genes like me logo Genes that share pathways with TNFSF13: view

Pathways by source for TNFSF13 Gene

3 GeneGo (Thomson Reuters) pathways for TNFSF13 Gene
  • Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
  • Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
  • Apoptosis and survival APRIL and BAFF signaling
18 Qiagen pathways for TNFSF13 Gene
  • Akt Signaling
  • all-trans-Retinoic Acid Signaling in Brain
  • Antioxidant Action of Vitamin-C
  • APRIL Pathway
  • Endothelin-1 Signaling Pathway

SIGNOR curated interactions for TNFSF13 Gene

Activates:

Gene Ontology (GO) - Biological Process for TNFSF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006955 immune response IEA --
GO:0007165 signal transduction TAS 9743536
GO:0008284 positive regulation of cell proliferation TAS 9743536
GO:0033209 tumor necrosis factor-mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with TNFSF13: view

Drugs & Compounds for TNFSF13 Gene

(2) Drugs for TNFSF13 Gene - From: ApexBio and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pomalidomide (CC-4047) Pharma Immunomodulator,antumor/anti-angiogenic 0
TACI-IG Pharma 0

(3) Additional Compounds for TNFSF13 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for TNFSF13 Gene

Compound Action Cas Number
Pomalidomide (CC-4047) Immunomodulator,antumor/anti-angiogenic 19171-19-8
genes like me logo Genes that share compounds with TNFSF13: view

Transcripts for TNFSF13 Gene

mRNA/cDNA for TNFSF13 Gene

6 REFSEQ mRNAs :
25 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNFSF13

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for TNFSF13 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^
SP1: - - - - - - - - - - - - -
SP2: -
SP3:
SP4: - -
SP5: - -
SP6: - - -
SP7:
SP8: -
SP9: - - - - -
SP10: - - - -
SP11: - - - -
SP12: -
SP13:

ExUns: 16a · 16b ^ 17a · 17b · 17c · 17d
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for TNFSF13 Gene

GeneLoc Exon Structure for
TNFSF13

Expression for TNFSF13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TNFSF13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TNFSF13 Gene

This gene is overexpressed in Milk (27.1), Peripheral blood mononuclear cells (26.5), and Saliva (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TNFSF13 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TNFSF13

SOURCE GeneReport for Unigene cluster for TNFSF13 Gene:

Hs.54673

mRNA Expression by UniProt/SwissProt for TNFSF13 Gene:

O75888-TNF13_HUMAN
Tissue specificity: Expressed at high levels in transformed cell lines, cancers of colon, thyroid, lymphoid tissues and specifically expressed in monocytes and macrophages.

Evidence on tissue expression from TISSUES for TNFSF13 Gene

  • Spleen(4.3)
  • Nervous system(3.5)
  • Lung(3.4)
  • Intestine(3)
  • Kidney(2.9)
  • Blood(2.5)
genes like me logo Genes that share expression patterns with TNFSF13: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFSF13 Gene

Orthologs for TNFSF13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFSF13 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TNFSF13 29 30
  • 99.87 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TNFSF13 29
  • 88.67 (n)
TNFSF12 30
  • 18 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia TNFSF13 29 30
  • 86.67 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tnfsf13 29
  • 82.43 (n)
Mouse
(Mus musculus)
Mammalia Tnfsf13 29 16 30
  • 82.22 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TNFSF13 30
  • 61 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 25 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 32 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC101730941 29
  • 49.3 (n)
Zebrafish
(Danio rerio)
Actinopterygii tnfsf13 30
  • 32 (a)
OneToMany
Species where no ortholog for TNFSF13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TNFSF13 Gene

ENSEMBL:
Gene Tree for TNFSF13 (if available)
TreeFam:
Gene Tree for TNFSF13 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TNFSF13: view image
Alliance of Genome Resources:
Additional Orthologs for TNFSF13

Paralogs for TNFSF13 Gene

Paralogs for TNFSF13 Gene

(1) SIMAP similar genes for TNFSF13 Gene using alignment to 8 proteins:

  • TNF13_HUMAN
  • A5Y848_HUMAN
  • C9JF68_HUMAN
  • C9JFN2_HUMAN
  • K7EJ28_HUMAN
  • Q2QBA2_HUMAN
  • Q6FGN4_HUMAN
  • Q6FGR7_HUMAN
genes like me logo Genes that share paralogs with TNFSF13: view

Variants for TNFSF13 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TNFSF13 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs149081507 Benign: not provided 7,559,617(+) T/C
NM_003808.3(TNFSF13):c.259-7T>C
INTRON
rs376426219 Uncertain Significance: not provided 7,559,180(+) T/C
NM_172089.4(TNFSF12-TNFSF13):c.499-444T>C
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,INTRON
rs11552708 -- p.Gly67Arg
rs3803800 -- p.Asn96Ser

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TNFSF13 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TNFSF13 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV deletion 17116639
nsv457659 CNV loss 19166990
nsv574322 CNV loss 21841781

Variation tolerance for TNFSF13 Gene

Residual Variation Intolerance Score: 65.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.18; 75.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNFSF13 Gene

Human Gene Mutation Database (HGMD)
TNFSF13
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNFSF13
Leiden Open Variation Database (LOVD)
TNFSF13

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFSF13 Gene

Disorders for TNFSF13 Gene

MalaCards: The human disease database

(12) MalaCards diseases for TNFSF13 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
brain glioblastoma multiforme
  • brain glioblastoma
rheumatoid arthritis
  • ra
opsoclonus-myoclonus syndrome
  • ataxo-opso-myoclonus syndrome
b-cell growth factor
  • bcgf
autoimmune disease
  • autoimmune hypersensitivity disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TNFSF13

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TNFSF13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNFSF13 Gene

Publications for TNFSF13 Gene

  1. APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth. (PMID: 9743536) Hahne M … Tschopp J (The Journal of experimental medicine 1998) 2 3 4 22
  2. Role of APRIL (TNFSF13) polymorphisms in the susceptibility to systemic lupus erythematosus in Japanese. (PMID: 17307753) Kawasaki A … Tokunaga K (Rheumatology (Oxford, England) 2007) 3 22 40
  3. A novel polymorphism of the human APRIL gene is associated with systemic lupus erythematosus. (PMID: 12730512) Koyama T … Horiuchi T (Rheumatology (Oxford, England) 2003) 3 22 40
  4. An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK-APRIL fusion protein. (PMID: 12411489) Pradet-Balade B … Hahne M (The EMBO journal 2002) 3 4 22
  5. APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death. (PMID: 10706119) Kelly K … Jones DA (Cancer research 2000) 3 4 22

Products for TNFSF13 Gene

Sources for TNFSF13 Gene