This gene encodes a member of the tumor necrosis factor superfamily. It encodes a hybrid protein composed of the cytoplasmic and transmembrane domains of family member 12 fused to the C-terminal domain of family member 13. The hybrid protein is membrane anchored and presents the receptor-binding domain of family member 13 at the cell surface. It stimulates cycling in T- and B-l... See more...

Aliases for TNFSF12-TNFSF13 Gene

Aliases for TNFSF12-TNFSF13 Gene

  • TNFSF12-TNFSF13 Readthrough 2 3 5
  • Tumor Necrosis Factor (Ligand) Superfamily, Member 12-Member 13 3
  • TNFSF12-TNFSF13 Protein 3
  • Protein TNFSF12-TNFSF13 13
  • TWE-PRIL 3

External Ids for TNFSF12-TNFSF13 Gene

Previous GeneCards Identifiers for TNFSF12-TNFSF13 Gene

  • GC17U900475
  • GC17P007393
  • GC17P007347
  • GC17P007453
  • GC17P007552
  • GC17P007555
  • GC17P007798
  • GC17P007830
  • GC17P007853
  • GC17P007571
  • GC17P007622
  • GC17P007677
  • GC17P007714
  • GC17P007741
  • GC17P007774

Summaries for TNFSF12-TNFSF13 Gene

Entrez Gene Summary for TNFSF12-TNFSF13 Gene

  • This gene encodes a member of the tumor necrosis factor superfamily. It encodes a hybrid protein composed of the cytoplasmic and transmembrane domains of family member 12 fused to the C-terminal domain of family member 13. The hybrid protein is membrane anchored and presents the receptor-binding domain of family member 13 at the cell surface. It stimulates cycling in T- and B-lymphoma cell lines. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFSF12-TNFSF13 Gene

TNFSF12-TNFSF13 (TNFSF12-TNFSF13 Readthrough) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include cytokine activity and tumor necrosis factor receptor binding. An important paralog of this gene is TNFSF13.

Gene Wiki entry for TNFSF12-TNFSF13 Gene

Additional gene information for TNFSF12-TNFSF13 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TNFSF12-TNFSF13 Gene

Genomics for TNFSF12-TNFSF13 Gene

GeneHancer (GH) Regulatory Elements for TNFSF12-TNFSF13 Gene

Promoters and enhancers for TNFSF12-TNFSF13 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TNFSF12-TNFSF13 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TNFSF12-TNFSF13

Top Transcription factor binding sites by QIAGEN in the TNFSF12-TNFSF13 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • FOXO1
  • FOXO1a
  • MyoD
  • NF-kappaB
  • NF-kappaB1

Genomic Locations for TNFSF12-TNFSF13 Gene

Genomic Locations for TNFSF12-TNFSF13 Gene
chr17:7,549,058-7,561,608
(GRCh38/hg38)
Size:
12,551 bases
Orientation:
Plus strand
chr17:7,452,375-7,464,925
(GRCh37/hg19)
Size:
12,551 bases
Orientation:
Plus strand

Genomic View for TNFSF12-TNFSF13 Gene

Genes around TNFSF12-TNFSF13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFSF12-TNFSF13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFSF12-TNFSF13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFSF12-TNFSF13 Gene

Proteins for TNFSF12-TNFSF13 Gene

  • Protein details for TNFSF12-TNFSF13 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0A6YY99-A0A0A6YY99_HUMAN
    Recommended name:
    Protein TNFSF12-TNFSF13
    Protein Accession:
    A0A0A6YY99

    Protein attributes for TNFSF12-TNFSF13 Gene

    Size:
    330 amino acids
    Molecular mass:
    36589 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TNFSF12-TNFSF13 Gene

Post-translational modifications for TNFSF12-TNFSF13 Gene

No Post-translational modifications

Other Protein References for TNFSF12-TNFSF13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TNFSF12-TNFSF13 Gene

Domains & Families for TNFSF12-TNFSF13 Gene

Gene Families for TNFSF12-TNFSF13 Gene

Unknown:
  • Belongs to the tumor necrosis factor family.
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TNFSF12-TNFSF13 Gene

genes like me logo Genes that share domains with TNFSF12-TNFSF13: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TNFSF12-TNFSF13 Gene

Function for TNFSF12-TNFSF13 Gene

Phenotypes From GWAS Catalog for TNFSF12-TNFSF13 Gene

Gene Ontology (GO) - Molecular Function for TNFSF12-TNFSF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005164 tumor necrosis factor receptor binding IEA --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with TNFSF12-TNFSF13: view
genes like me logo Genes that share phenotypes with TNFSF12-TNFSF13: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNFSF12-TNFSF13

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TNFSF12-TNFSF13 Gene

Localization for TNFSF12-TNFSF13 Gene

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TNFSF12-TNFSF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TNFSF12-TNFSF13: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for TNFSF12-TNFSF13 Gene

Pathways & Interactions for TNFSF12-TNFSF13 Gene

PathCards logo

SuperPathways for TNFSF12-TNFSF13 Gene

No Data Available

Interacting Proteins for TNFSF12-TNFSF13 Gene

;

Gene Ontology (GO) - Biological Process for TNFSF12-TNFSF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IEA --
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with TNFSF12-TNFSF13: view

No data available for Pathways by source and SIGNOR curated interactions for TNFSF12-TNFSF13 Gene

Drugs & Compounds for TNFSF12-TNFSF13 Gene

No Compound Related Data Available

Transcripts for TNFSF12-TNFSF13 Gene

mRNA/cDNA for TNFSF12-TNFSF13 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNFSF12-TNFSF13

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFSF12-TNFSF13 Gene

No ASD Table

Relevant External Links for TNFSF12-TNFSF13 Gene

GeneLoc Exon Structure for
TNFSF12-TNFSF13

Expression for TNFSF12-TNFSF13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TNFSF12-TNFSF13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TNFSF12-TNFSF13

genes like me logo Genes that share expression patterns with TNFSF12-TNFSF13: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFSF12-TNFSF13 Gene

Orthologs for TNFSF12-TNFSF13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFSF12-TNFSF13 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Tnfsf12Tnfsf13 30
  • 85.03 (n)
Tnfsf12 31
  • 68 (a)
ManyToMany
BC096441 31
  • 68 (a)
ManyToMany
Tnfsfm13 17
chimpanzee
(Pan troglodytes)
Mammalia TNFSF12 31
  • 69 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia TNFSF12 31
  • 61 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 31
  • 57 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia TNFSF13 31
  • 48 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 23 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 33 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii tnfsf13 31 30
  • 51.75 (n)
OneToMany
Species where no ortholog for TNFSF12-TNFSF13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFSF12-TNFSF13 Gene

ENSEMBL:
Gene Tree for TNFSF12-TNFSF13 (if available)
TreeFam:
Gene Tree for TNFSF12-TNFSF13 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TNFSF12-TNFSF13: view image

Paralogs for TNFSF12-TNFSF13 Gene

Paralogs for TNFSF12-TNFSF13 Gene

genes like me logo Genes that share paralogs with TNFSF12-TNFSF13: view

Variants for TNFSF12-TNFSF13 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TNFSF12-TNFSF13 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
567668 Uncertain Significance: Common variable immunodeficiency 7,549,491(+) G/C MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
638913 Uncertain Significance: Common variable immunodeficiency 7,557,316(+) T/C MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT
640807 Uncertain Significance: Common variable immunodeficiency 7,556,847(+) G/A MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
649356 Uncertain Significance: Common variable immunodeficiency 7,557,273(+) C/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT
654786 Uncertain Significance: Common variable immunodeficiency 7,550,181(+) G/A MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT

Additional dbSNP identifiers (rs#s) for TNFSF12-TNFSF13 Gene

Structural Variations from Database of Genomic Variants (DGV) for TNFSF12-TNFSF13 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV deletion 17116639
nsv457659 CNV loss 19166990
nsv523672 CNV loss 19592680
nsv574322 CNV loss 21841781

Variation tolerance for TNFSF12-TNFSF13 Gene

Residual Variation Intolerance Score: 41.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.29; 6.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNFSF12-TNFSF13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNFSF12-TNFSF13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFSF12-TNFSF13 Gene

Disorders for TNFSF12-TNFSF13 Gene

Additional Disease Information for TNFSF12-TNFSF13

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TNFSF12-TNFSF13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNFSF12-TNFSF13 Gene

Publications for TNFSF12-TNFSF13 Gene

  1. An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK-APRIL fusion protein. (PMID: 12411489) Pradet-Balade B … Hahne M (The EMBO journal 2002) 2 3 23 54
  2. Association of common variants in TNFRSF13B, TNFSF13, and ANXA3 with serum levels of non-albumin protein and immunoglobulin isotypes in Japanese. (PMID: 22558069) Osman W … Nakamura Y (PloS one 2012) 3 41 54
  3. A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy. (PMID: 22197929) Yu XQ … Liu JJ (Nature genetics 2011) 3 41 54
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41 54
  5. Role of APRIL (TNFSF13) polymorphisms in the susceptibility to systemic lupus erythematosus in Japanese. (PMID: 17307753) Kawasaki A … Tokunaga K (Rheumatology (Oxford, England) 2007) 3 23 54

Products for TNFSF12-TNFSF13 Gene

Sources for TNFSF12-TNFSF13 Gene