TNFSF10 Gene (Protein Coding)

TNF Superfamily Member 10

GC03M172505
GIFtS:
47
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNF... See more...

Aliases for TNFSF10 Gene

Aliases for TNFSF10 Gene

  • TNF Superfamily Member 10 2 3 5
  • Apo-2L 2 3 4
  • TRAIL 2 3 4
  • Tumor Necrosis Factor (Ligand) Superfamily, Member 10 2 3
  • Tumor Necrosis Factor Ligand Superfamily Member 10 3 4
  • Apo-2 Ligand 3 4
  • APO2L 3 4
  • CD253 2 3
  • TL2 2 3
  • Tumor Necrosis Factor Apoptosis-Inducing Ligand Splice Variant Delta 3
  • Chemokine Tumor Necrosis Factor Ligand Superfamily Member 10 3
  • Tumor Necrosis Factor (Ligand) Family, Member 10 3
  • TNF-Related Apoptosis Inducing Ligand TRAIL 3
  • Tumor Necrosis Factor Superfamily Member 10 3
  • TNF-Related Apoptosis-Inducing Ligand 4
  • Tumor Necrosis Factor Ligand 6A 3
  • Protein TRAIL 4
  • CD253 Antigen 4
  • TNFSF10 5
  • TNLG6A 3

External Ids for TNFSF10 Gene

Previous GeneCards Identifiers for TNFSF10 Gene

  • GC03M169274
  • GC03M173180
  • GC03M173625
  • GC03M173544
  • GC03M173706
  • GC03M172223
  • GC03M169593

Summaries for TNFSF10 Gene

Entrez Gene Summary for TNFSF10 Gene

  • The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for TNFSF10 Gene

TNFSF10 (TNF Superfamily Member 10) is a Protein Coding gene. Diseases associated with TNFSF10 include Thoracic Cancer and Pancreatic Cancer. Among its related pathways are Apoptosis Modulation and Signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and tumor necrosis factor receptor binding. An important paralog of this gene is TNFSF11.

UniProtKB/Swiss-Prot Summary for TNFSF10 Gene

  • Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:26457518, PubMed:10549288). Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.

Gene Wiki entry for TNFSF10 Gene

Additional gene information for TNFSF10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TNFSF10 Gene

Genomics for TNFSF10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for TNFSF10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TNFSF10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TNFSF10

Top Transcription factor binding sites by QIAGEN in the TNFSF10 gene promoter:
  • GR
  • GR-alpha
  • HSF1 (long)
  • HSF1short
  • IRF-7A
  • PPAR-gamma1
  • PPAR-gamma2
  • Sp1
  • STAT1
  • STAT5A

Genomic Locations for TNFSF10 Gene

Latest Assembly
chr3:172,505,508-172,523,475
(GRCh38/hg38)
Size:
17,968 bases
Orientation:
Minus strand

Previous Assembly
chr3:172,223,298-172,241,220
(GRCh37/hg19 by Entrez Gene)
Size:
17,923 bases
Orientation:
Minus strand

chr3:172,223,298-172,241,297
(GRCh37/hg19 by Ensembl)
Size:
18,000 bases
Orientation:
Minus strand

Genomic View for TNFSF10 Gene

Genes around TNFSF10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFSF10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFSF10 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TNFSF10 Gene

Proteins for TNFSF10 Gene

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  • Protein details for TNFSF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50591-TNF10_HUMAN
    Recommended name:
    Tumor necrosis factor ligand superfamily member 10
    Protein Accession:
    P50591
    Secondary Accessions:
    • A1Y9B3

    Protein attributes for TNFSF10 Gene

    Size:
    281 amino acids
    Molecular mass:
    32509 Da
    Quaternary structure:
    • Homotrimer (PubMed:26457518). One TNFSF10 homotrimer interacts with three TNFSF10A mononers (PubMed:26457518). One TNFSF10 homotrimer interacts with three TNFSF10B mononers (PubMed:10549288).
    Miscellaneous:
    • [Isoform 2]: Induced upon HIV infection, antagonizes signaling via TRAIL receptor R2 (TNFRSF10B).

    Three dimensional structures from OCA and Proteopedia for TNFSF10 Gene

    Alternative splice isoforms for TNFSF10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNFSF10 Gene

Protein Expression for TNFSF10 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for TNFSF10 Gene

Other Protein References for TNFSF10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for TNFSF10

Protein products for research

  • Abcam proteins for TNFSF10

No data available for DME Specific Peptides for TNFSF10 Gene

Domains & Families for TNFSF10 Gene

Gene Families for TNFSF10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for TNFSF10 Gene

InterPro:
Blocks:
  • Tumor Necrosis Factor

Suggested Antigen Peptide Sequences for TNFSF10 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ51976, moderately similar to Tumor necrosis factor ligand superfamily member 10 (A1Y9B3_HUMAN)
  • cDNA, FLJ93150, Homo sapiens tumor necrosis factor (ligand) superfamily, member 10(TNFSF10), mRNA (Q6IBA9_HUMAN)
  • Chemokine tumor necrosis factor ligand superfamily member 10 (Q6JSD9_HUMAN)
  • TNF-related apoptosis-inducing ligand (TNF10_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P50591

UniProtKB/Swiss-Prot:

TNF10_HUMAN :
  • Belongs to the tumor necrosis factor family.
Family:
  • Belongs to the tumor necrosis factor family.
genes like me logo Genes that share domains with TNFSF10: view

Function for TNFSF10 Gene

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Molecular function for TNFSF10 Gene

UniProtKB/Swiss-Prot Function:
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:26457518, PubMed:10549288). Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
GENATLAS Biochemistry:
tumor necrosis factor (ligand) superfamily,member 10,TNF-related apoptosis inducing ligand (TRAIL),predominantly expressed in spleen,lung,prostate

Phenotypes From GWAS Catalog for TNFSF10 Gene

Gene Ontology (GO) - Molecular Function for TNFSF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding TAS 8663110
GO:0005125 cytokine activity IEA --
GO:0005164 tumor necrosis factor receptor binding IEA --
GO:0005515 protein binding IPI 10549288
GO:0008270 zinc ion binding IDA 26457518
genes like me logo Genes that share ontologies with TNFSF10: view
genes like me logo Genes that share phenotypes with TNFSF10: view

Animal Models for TNFSF10 Gene

MGI Knock Outs for TNFSF10:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNFSF10

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNFSF10 Gene

Localization for TNFSF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFSF10 Gene

Cell membrane. Single-pass type II membrane protein. Secreted. Note=Exists both as membrane-bound and soluble form. {ECO:0000269 PubMed:14609566}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFSF10 gene
Compartment Confidence
plasma membrane 5
extracellular 5
mitochondrion 3
nucleus 3
endoplasmic reticulum 3
cytosol 3
cytoskeleton 2
endosome 2
lysosome 2
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TNFSF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane TAS 8663110
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TNFSF10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TNFSF10 Gene

Pathways & Interactions for TNFSF10 Gene

PathCards logo

SuperPathways for TNFSF10 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
Glucocorticoid Receptor Signaling
.43
Cytokine-cytokine receptor interaction
.43
2 Dimerization of procaspase-8
Dimerization of procaspase-8
.69
RIPK1-mediated regulated necrosis
.69
Caspase activation via extrinsic apoptotic signalling pathway
.39
TRAIL signaling pathway
.33
CASP8 activity is inhibited
.01
Ligand-dependent caspase activation
.01
Regulated Necrosis
.01
Regulation by c-FLIP
.01
Regulation of necroptotic cell death
.01
TRAIL signaling
.01
3 TGF-Beta Pathway
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
JNK Pathway
.51
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.40
4 Apoptosis Modulation and Signaling
Apoptosis
.41
Apoptosis Modulation and Signaling
.41
Apoptosis Signaling Pathways
.36
Apoptosis and survival Apoptotic TNF-family pathways
.35
Apoptosis
.31
5 TNFR1 Pathway
Apoptosis through Death Receptors
.42
TRAIL Pathway
.40
Death Receptor Signaling
.36
TNF Signaling
.34
genes like me logo Genes that share pathways with TNFSF10: view

Pathways by source for TNFSF10 Gene

3 Sino Biological pathways for TNFSF10 Gene
1 GeneGo (Thomson Reuters) pathway for TNFSF10 Gene
  • Apoptosis and survival Apoptotic TNF-family pathways
31 Qiagen pathways for TNFSF10 Gene
  • Akt Signaling
  • all-trans-Retinoic Acid Mediated Apoptosis
  • all-trans-Retinoic Acid Signaling in Brain
  • Antioxidant Action of Vitamin-C
  • Apoptosis through Death Receptors
1 Cell Signaling Technology pathway for TNFSF10 Gene
1 GeneTex pathway for TNFSF10 Gene

SIGNOR curated interactions for TNFSF10 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for TNFSF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS,IEA --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process TAS --
GO:0006955 immune response IEA --
GO:0007165 signal transduction TAS 8663110
GO:0007166 cell surface receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with TNFSF10: view

Drugs & Compounds for TNFSF10 Gene

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(100) Drugs for TNFSF10 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
CCCP Pharma uncoupler of oxidative phosphorylation 0

(52) Additional Compounds for TNFSF10 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for TNFSF10 Gene

Compound Action Cas Number
CCCP uncoupler of oxidative phosphorylation 555-60-2
genes like me logo Genes that share compounds with TNFSF10: view

Transcripts for TNFSF10 Gene

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mRNA/cDNA for TNFSF10 Gene

3 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNFSF10

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for TNFSF10 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: -
SP5: - - - - - -
SP6:
SP7: - - - - - - - -
SP8: - -

Relevant External Links for TNFSF10 Gene

GeneLoc Exon Structure for
TNFSF10

Expression for TNFSF10 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TNFSF10 Gene

mRNA expression in normal human tissues for TNFSF10 Gene
mRNA expression by BioGPS for TNFSF10 GenemRNA expression by GTEx for TNFSF10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFSF10 Gene

This gene is overexpressed in Whole Blood (x7.2) and Minor Salivary Gland (x4.5).

Protein differential expression in normal tissues from HIPED for TNFSF10 Gene

This gene is overexpressed in Milk (45.1) and Islet of Langerhans (18.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TNFSF10 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TNFSF10

SOURCE GeneReport for Unigene cluster for TNFSF10 Gene:

Hs.478275

mRNA Expression by UniProt/SwissProt for TNFSF10 Gene:

P50591-TNF10_HUMAN
Tissue specificity: Widespread; most predominant in spleen, lung and prostate.

Evidence on tissue expression from TISSUES for TNFSF10 Gene

  • Nervous system(4.6)
  • Kidney(3.5)
  • Liver(3.5)
  • Blood(3.4)
  • Lung(3.3)
  • Spleen(3.2)
  • Intestine(3.1)
  • Lymph node(3.1)
  • Skin(2.9)
  • Heart(2.8)
  • Muscle(2.7)
  • Stomach(2.6)
  • Bone marrow(2.5)
  • Adrenal gland(2.2)
  • Thyroid gland(2.2)
  • Pancreas(2.2)
genes like me logo Genes that share expression patterns with TNFSF10: view

Primer products for research

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFSF10 Gene

Orthologs for TNFSF10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFSF10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia TNFSF10 29 30
  • 99.17 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia TNFSF10 29 30
  • 85.56 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia TNFSF10 29 30
  • 80.76 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Tnfsf10 29 16 30
  • 74.84 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Tnfsf10 29
  • 74.47 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia TNFSF10 30
  • 58 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia TNFSF10 30
  • 48 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves TNFSF10 29 30
  • 64.11 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia TNFSF10 30
  • 49 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia tnfsf10 29
  • 58.4 (n)
Zebrafish
(Danio rerio)
 Actinopterygii tnfsf10 29 30
  • 54.2 (n)
 OneToOne
Species where no ortholog for TNFSF10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TNFSF10 Gene

ENSEMBL:
Gene Tree for TNFSF10 (if available)
TreeFam:
Gene Tree for TNFSF10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TNFSF10: view image
Alliance of Genome Resources:
Additional Orthologs for TNFSF10

Paralogs for TNFSF10 Gene

Paralogs for TNFSF10 Gene

genes like me logo Genes that share paralogs with TNFSF10: view

Variants for TNFSF10 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TNFSF10 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs1291288240 Likely Benign: not provided 172,514,870(-) G/A
NM_003810.4(TNFSF10):c.261C>T (p.Leu87=) 		NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS
rs41308132 Benign: not provided 172,523,280(-) G/A
NM_003810.4(TNFSF10):c.105C>T (p.Tyr35=) 		NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS
rs6763816 Benign: not provided 172,523,288(-) C/Tp.Val33Ile
NM_003810.4(TNFSF10):c.97G>A (p.Val33Ile) 		MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
rs16845759 -- p.Asp47Glu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TNFSF10 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TNFSF10 Gene

Variant ID Type Subtype PubMed ID
nsv1114452 CNV deletion 24896259
nsv7356 OTHER inversion 18451855
nsv829794 CNV gain 17160897
nsv954508 CNV duplication 24416366

Variation tolerance for TNFSF10 Gene

Residual Variation Intolerance Score: 62.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.74; 33.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNFSF10 Gene

Human Gene Mutation Database (HGMD)
TNFSF10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNFSF10
Leiden Open Variation Database (LOVD)
TNFSF10

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFSF10 Gene

Disorders for TNFSF10 Gene

MalaCards: The human disease database

(49) MalaCards diseases for TNFSF10 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
thoracic cancer
  • thoracic tumor
pancreatic cancer
  • pancreatic carcinoma
colorectal cancer
  • crc
colon adenocarcinoma
  • adenocarcinoma of colon
epilepsy, familial temporal lobe, 2
  • etl2
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TNFSF10

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TNFSF10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNFSF10 Gene

Publications for TNFSF10 Gene

  1. Identification and characterization of a new member of the TNF family that induces apoptosis. (PMID: 8777713) Wiley SR … Smith CA (Immunity 1995) 2 3 4 22
  2. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. (PMID: 8663110) Pitti RM … Ashkenazi A (The Journal of biological chemistry 1996) 2 3 4
  3. The structure of the death receptor 4-TNF-related apoptosis-inducing ligand (DR4-TRAIL) complex. (PMID: 26457518) Ramamurthy V … Sheriff S (Acta crystallographica. Section F, Structural biology communications 2015) 3 4
  4. Isolation of a TRAIL antagonist from the serum of HIV-infected patients. (PMID: 21859711) Schnepple DJ … Badley AD (The Journal of biological chemistry 2011) 3 4
  5. Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1-independent sensitization to TRAIL-induced apoptosis. (PMID: 20097879) Mader I … Fulda S (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010) 3 22

ExternalLinks

View latest publications for TNFSF10 gene in Mastermind

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