Aliases for TNFSF10 Gene
Aliases for TNFSF10 Gene
- TNF Superfamily Member 10 2 3 5
- Tumor Necrosis Factor (Ligand) Superfamily, Member 10 2 3
- Apo-2 Ligand 3 4
- Apo-2L 3 4
- APO2L 3 4
- TRAIL 3 4
- Tumor Necrosis Factor Apoptosis-Inducing Ligand Splice Variant Delta 3
- Chemokine Tumor Necrosis Factor Ligand Superfamily Member 10 3
- Tumor Necrosis Factor Ligand Superfamily Member 10 3
- Tumor Necrosis Factor (Ligand) Family, Member 10 3
External Ids for TNFSF10 Gene
- HGNC: 11925
- Entrez Gene: 8743
- Ensembl: ENSG00000121858
- OMIM: 603598
- UniProtKB: P50591
Previous GeneCards Identifiers for TNFSF10 Gene
- GC03M169274
- GC03M173180
- GC03M173625
- GC03M173544
- GC03M173706
- GC03M172223
- GC03M169593
Summaries for TNFSF10 Gene
-
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
GeneCards Summary for TNFSF10 Gene
TNFSF10 (TNF Superfamily Member 10) is a Protein Coding gene. Diseases associated with TNFSF10 include Malignant Glioma and Ulceroglandular Tularemia. Among its related pathways are PEDF Induced Signaling and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include receptor binding and tumor necrosis factor receptor binding. An important paralog of this gene is TNFSF11.
UniProtKB/Swiss-Prot for TNFSF10 Gene
-
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:26457518, PubMed:10549288). Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
Additional gene information for TNFSF10 Gene
- Monarch Initiative
- Search for TNFSF10 at DataMed
- Search for TNFSF10 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFSF10 Gene
Genomics for TNFSF10 Gene
GeneHancer (GH) Regulatory Elements for TNFSF10 Gene
Promoters and enhancers for TNFSF10 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH03I172519 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE dbSUPER | 550.8 | +1.1 | 1058 | 5.5 | HDGF ARID4B BATF IRF4 ZNF48 RAD21 YY1 ZNF366 FOS IKZF2 | TNFSF10 LOC100856791 GC03P172523 | |
| GH03I172590 | Promoter/Enhancer | 1.9 | Ensembl ENCODE dbSUPER | 12.7 | -70.3 | -70341 | 6.4 | HDGF PKNOX1 FOXA2 MLX DMAP1 IRF4 YY1 ZNF766 ZNF207 ZNF143 | LINC02068 TNFSF10 GHSR | |
| GH03I172552 | Enhancer | 1.1 | ENCODE dbSUPER | 21.7 | -30.3 | -30267 | 3.4 | FOXA2 MLX ZFP64 ARID4B DMAP1 YY1 SLC30A9 RXRA SP5 ZHX2 | TNFSF10 LINC02068 | |
| GH03I172579 | Enhancer | 1.3 | FANTOM5 Ensembl ENCODE dbSUPER | 13.4 | -56.9 | -56906 | 2 | JUNB ELF1 BATF ZNF217 JUND IKZF1 ATF7 HNF4A ETV6 RUNX3 | TNFSF10 LINC02068 | |
| GH03I172606 | Enhancer | 1.3 | FANTOM5 Ensembl ENCODE dbSUPER | 11.7 | -84.3 | -84347 | 1.9 | JUN JUNB DPF2 ATF2 ZFP69B SP1 PRDM6 ZNF692 IKZF1 PRDM10 | TNFSF10 GHSR SLC31A1P1 PIR41392 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TNFSF10 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the TNFSF10 gene promoter:
Regulatory Element Products
Genomic Locations for TNFSF10 Gene
Genomic Locations for TNFSF10 Gene
- chr3:172,505,508-172,523,507
- (GRCh38/hg38)
- Size:
- 18,000 bases
- Orientation:
- Minus strand
- chr3:172,223,298-172,241,297
- (GRCh37/hg19)
Genomic View for TNFSF10 Gene
Genes around TNFSF10 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q26.31 by Ensembl
- 3q26.31 by Entrez Gene
- 3q26 by HGNC
TNFSF10 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TNFSF10 Gene
Proteins for TNFSF10 Gene
-
Protein details for TNFSF10 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P50591-TNF10_HUMAN
- Recommended name:
- Tumor necrosis factor ligand superfamily member 10
- Protein Accession:
- P50591
- A1Y9B3
Protein attributes for TNFSF10 Gene
- Size:
- 281 amino acids
- Molecular mass:
- 32509 Da
- Quaternary structure:
-
- Homotrimer (PubMed:26457518). One TNFSF10 homotrimer interacts with three TNFSF10A mononers (PubMed:26457518). One TNFSF10 homotrimer interacts with three TNFSF10B mononers (PubMed:10549288).
Three dimensional structures from OCA and Proteopedia for TNFSF10 Gene
Protein Expression for TNFSF10 Gene
Post-translational modifications for TNFSF10 Gene
- Tyrosine phosphorylated by PKDCC/VLK.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for TNFSF10 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for TNFSF10 (TRAIL/TNFSF10)
-
Custom Antibody ServicesOriGene Antibodies for TNFSF10
- Novus Biologicals Antibodies for TNFSF10
-
Abcam antibodies for TNFSF10
- Invitrogen Antibodies for TNFSF10
- antibodies-online: Search results for 388 available TNFSF10 Antibodies ranked by validation data
- Compare Top TNFSF10 Antibodies
-
Recommended
- 221 WB Antibodies (anti-human)
- 49 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 8 Func Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 2 Neut Antibodies (anti-human)
- 1 ELISPOT (Capture) Antibody (anti-human)
- 1 ELISPOT (Detection) Antibody (anti-human)
- 12 IF (p) Antibodies (anti-rat)
- 23 WB Antibodies (anti-rat)
- 2 IHC Antibodies (anti-mouse)
- 3 IP Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 16 FACS Antibodies (anti-mouse)
- 44 WB Antibodies (anti-mouse)
- 1 IF Antibody (anti-human)
- 1 ELISPOT (Detection) Antibody (anti-human)
- 1 ELISPOT (Capture) Antibody (anti-human)
- 2 Neut Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 8 Func Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 49 FACS Antibodies (anti-human)
- 221 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-rat)
- 23 WB Antibodies (anti-rat)
- 2 IHC Antibodies (anti-mouse)
- 3 IP Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 16 FACS Antibodies (anti-mouse)
- 44 WB Antibodies (anti-mouse)
- 1 IF Antibody (anti-human)
- GeneTex TNFSF10 antibody for TNFSF10
-
Santa Cruz Biotechnology (SCBT) Antibodies for TNFSF10
- Sino Biological Antibodies for TNFSF10
Protein Products
- R&D Systems Proteins and Enzymes for TNFSF10 (TRAIL/TNFSF10)
- Search Origene for MassSpec and Protein Over-expression Lysates for TNFSF10
- Origene Custom Protein Services for TNFSF10
- Sino Biological Recombinant Proteins for TNFSF10
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for TNFSF10
- GeneTex Proteins for TNFSF10
-
ProSci Proteins for TNFSF10
- tumor necrosis factor (ligand) superfamily, member 10 [40-297]
- tumor necrosis factor (ligand) superfamily, member 10 [40-103]
- tumor necrosis factor (ligand) superfamily, member 10 [90-336]
- tumor necrosis factor (ligand) superfamily, member 10 [90-335]
- tumor necrosis factor (ligand) superfamily, member 10 [90-217]
- tumor necrosis factor (ligand) superfamily, member 10 [90-257]
- tumor necrosis factor superfamily member 10 [91-016]
- tumor necrosis factor superfamily member 10 [92-218]
- tumor necrosis factor (ligand) superfamily, member 10 [40-167]
-
Abcam proteins for TNFSF10
Assay Products
- R&D Systems Luminex Assays, ELISAs, and other biochemical assays for TNFSF10 (TRAIL/TNFSF10)
- Novus Biologicals ELISA Kits for TNFSF10
- antibodies-online: Search results for 82 available TNFSF10 Elisa Kits ranked by validation data
- Compare Top TNFSF10 Elisa Kits
-
Recommended
- 2 Chicken ELISA Kits
- 2 Cow (Bovine) ELISA Kits
- 6 Dog (Canine) ELISA Kits
- 2 Guinea Pig ELISA Kits
- 33 Human ELISA Kits
- 15 Mouse (Murine) ELISA Kits
- 3 Pig (Porcine) ELISA Kits
- 3 Rabbit ELISA Kits
- 11 Rat (Rattus) ELISA Kits
- 2 Sheep (Ovine) ELISA Kits
- 2 Chicken ELISA Kits
- 2 Cow (Bovine) ELISA Kits
- 6 Dog (Canine) ELISA Kits
- 2 Guinea Pig ELISA Kits
- 33 Human ELISA Kits
- 15 Mouse (Murine) ELISA Kits
- 3 Pig (Porcine) ELISA Kits
- 3 Rabbit ELISA Kits
- 11 Rat (Rattus) ELISA Kits
- 2 Sheep (Ovine) ELISA Kits
-
Abcam assays for TNFSF10
- Sino Biological Assays for TNFSF10
No data available for DME Specific Peptides for TNFSF10 Gene
Domains & Families for TNFSF10 Gene
Gene Families for TNFSF10 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- CD markers
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for TNFSF10 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for TNFSF10 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ51976, moderately similar to Tumor necrosis factor ligand superfamily member 10 (A1Y9B3_HUMAN)
- cDNA, FLJ93150, Homo sapiens tumor necrosis factor (ligand) superfamily, member 10(TNFSF10), mRNA (Q6IBA9_HUMAN)
- Chemokine tumor necrosis factor ligand superfamily member 10 (Q6JSD9_HUMAN)
- TNF-related apoptosis-inducing ligand (TNF10_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P50591- Family:
-
- Belongs to the tumor necrosis factor family.
Function for TNFSF10 Gene
Molecular function for TNFSF10 Gene
- GENATLAS Biochemistry:
- tumor necrosis factor (ligand) superfamily,member 10,TNF-related apoptosis inducing ligand (TRAIL),predominantly expressed in spleen,lung,prostate
- UniProtKB/Swiss-Prot Function:
- Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:26457518, PubMed:10549288). Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
Phenotypes From GWAS Catalog for TNFSF10 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | receptor binding | TAS | 8663110 |
| GO:0005125 | cytokine activity | IEA | -- |
| GO:0005164 | tumor necrosis factor receptor binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 10549288 |
| GO:0008270 | zinc ion binding | IDA | 26457518 |
Phenotypes for TNFSF10 Gene
- MGI mutant phenotypes for TNFSF10:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for TNFSF10:
Animal Models for TNFSF10 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TNFSF10
-
-
ViGene Biosciences lentiviral particle packaged cDNA for TNFSF10 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TNFSF10 gene
- Search ViGene Biosciences for TNFSF10
CRISPR Products
-
OriGene CRISPR knockouts for TNFSF10
- genomics-online: gRNA clones - Search results for 162 available TNFSF10 gene related products
- Overview of 162 available TNFSF10 gene related products
- Applied Biological Materials CRISPR for TNFSF10
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TNFSF10
- GenScript: Design CRISPR guide RNA sequences for TNFSF10
miRNA for TNFSF10 Gene
- miRTarBase miRNAs that target TNFSF10
-
- hsa-mir-222-3p (MIRT003756)
- hsa-mir-221-3p (MIRT003757)
- hsa-mir-98-5p (MIRT027770)
- hsa-mir-25-3p (MIRT732909)
- hsa-mir-1297 (MIRT783652)
- hsa-mir-26a-5p (MIRT784362)
- hsa-mir-26b-5p (MIRT784365)
- hsa-mir-3152-5p (MIRT784684)
- hsa-mir-3199 (MIRT784837)
- hsa-mir-365a-5p (MIRT785054)
- hsa-mir-365b-5p (MIRT785058)
- hsa-mir-4465 (MIRT785951)
- hsa-mir-513c-5p (MIRT787157)
- hsa-mir-514b-5p (MIRT787177)
- hsa-mir-562 (MIRT787711)
- hsa-mir-5697 (MIRT787810)
- hsa-mir-6819-3p (MIRT788951)
- hsa-mir-6836-3p (MIRT789029)
- hsa-mir-6877-3p (MIRT789260)
- hsa-mir-8052 (MIRT789641)
miRNA Products
- Search ViGene Biosciences for TNFSF10
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TNFSF10
- Browse OriGene Inhibitory RNA Products For TNFSF10
- genomics-online: shRNA clones - Search results for 162 available TNFSF10 gene related products
- Overview of 162 available TNFSF10 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TNFSF10 gene
Clone Products
-
OriGene ORF clones in human for TNFSF10
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TNFSF10
- VectorBuilder custom plasmid, inducible vectors for TNFSF10
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TNFSF10
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TNFSF10
- Applied Biological Materials Clones for TNFSF10
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
- ESI BIO PureStem ES-209, Meso-prx/latp Progenitor for TNFSF10
-
Horizon Cell Lines for TNFSF10
-
ViGene Biosciences adenoviral particle packaged cDNA for TNFSF10 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TNFSF10 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TNFSF10 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNFSF10 Gene
Localization for TNFSF10 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TNFSF10 Gene
- Membrane; Single-pass type II membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytosol | 3 |
| mitochondrion | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| peroxisome | 1 |
| lysosome | 1 |
- Microtubules (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IEA | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 8663110 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for TNFSF10 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling |
.61
|
.47
|
| 2 | Regulation by c-FLIP |
.01
|
|
| 3 | Apoptosis Modulation and Signaling |
.41
|
.33
|
| 4 | TGF-Beta Pathway |
.60
.57
|
.51
.40
|
| 5 | Akt Signaling |
.60
.60
|
|
Pathways by source for TNFSF10 Gene
2 Sino Biological pathways for TNFSF10 Gene
1 GeneTex pathway for TNFSF10 Gene
5 BioSystems pathways for TNFSF10 Gene
13 Reactome pathways for TNFSF10 Gene
7 KEGG pathways for TNFSF10 Gene
1 GeneGo (Thomson Reuters) pathway for TNFSF10 Gene
1 R&D Systems pathway for TNFSF10 Gene
31 Qiagen pathways for TNFSF10 Gene
1 Cell Signaling Technology pathway for TNFSF10 Gene
Interacting Proteins for TNFSF10 Gene
Selected Interacting proteins:
P50591-TNF10_HUMAN
ENSP00000241261
for TNFSF10 Gene via
IID
UniProtKB
STRING
MINT
SIGNOR curated interactions for TNFSF10 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006915 | apoptotic process | IEA,TAS | -- |
| GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | TAS | -- |
| GO:0006955 | immune response | IEA | -- |
| GO:0007165 | signal transduction | TAS | 8663110 |
| GO:0007166 | cell surface receptor signaling pathway | TAS | -- |
Drugs & Compounds for TNFSF10 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| CCCP | Pharma | uncoupler of oxidative phosphorylation | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(1) ApexBio Compounds for TNFSF10 Gene
| Compound | Action | Cas Number |
|---|---|---|
| CCCP | uncoupler of oxidative phosphorylation | 555-60-2 |
Transcripts for TNFSF10 Gene
mRNA/cDNA for TNFSF10 Gene
- (3) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (277) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TNFSF10 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TNFSF10
- genomics-online: gRNA clones - Search results for 162 available TNFSF10 gene related products
- Overview of 162 available TNFSF10 gene related products
- Applied Biological Materials CRISPR for TNFSF10
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TNFSF10
- GenScript: Design CRISPR guide RNA sequences for TNFSF10
miRNA Products
- Search ViGene Biosciences for TNFSF10
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TNFSF10
- Browse OriGene Inhibitory RNA Products For TNFSF10
- genomics-online: shRNA clones - Search results for 162 available TNFSF10 gene related products
- Overview of 162 available TNFSF10 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TNFSF10 gene
Clone Products
-
OriGene ORF clones in human for TNFSF10
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TNFSF10
- VectorBuilder custom plasmid, inducible vectors for TNFSF10
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TNFSF10
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TNFSF10
- Applied Biological Materials Clones for TNFSF10
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||
| SP8: | - | - |
Expression for TNFSF10 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Monocytes Peripheral Blood
- T Helper Cells Thymus
- Hematopoietic Stem Cells Liver Bud
- Natural killer-like cells(Woll PS et. al. 2009)
-
Endothelium (Cardiovascular System)
- Endothelial Cells Blood Brain Barrier
- Adult Endothelial Cells Blood Brain Barrier
- Endothelial-like cells(James D et. al. 2010)
-
Brain (Nervous System)
- Endothelial Cells Blood Brain Barrier
- Adult Endothelial Cells Blood Brain Barrier
-
Thymus (Hematopoietic System)
- T Helper Cells Thymus
-
Liver (Hepatobiliary System)
- Hematopoietic Stem Cells Liver Bud
- Intestine (Gastrointestinal Tract)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Gall Bladder (Hepatobiliary System)
-
Kidney (Urinary System)
mRNA differential expression in normal tissues according to GTEx for TNFSF10 Gene
This gene is overexpressed in Whole Blood (x7.2) and Minor Salivary Gland (x4.5).
This gene is overexpressed in Milk (45.1) and Islet of Langerhans (18.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TNFSF10 Gene
NURSA nuclear receptor signaling pathways regulating expression of TNFSF10 Gene:
TNFSF10SOURCE GeneReport for Unigene cluster for TNFSF10 Gene:
Hs.478275mRNA Expression by UniProt/SwissProt for TNFSF10 Gene:
P50591-TNF10_HUMAN
Tissue specificity:
Widespread; most predominant in spleen, lung and prostate.
Evidence on tissue expression from TISSUES for TNFSF10 Gene
- Nervous system(4.4)
- Blood(3.2)
- Liver(3.2)
- Lung(3.1)
- Kidney(3)
- Intestine(2.7)
- Spleen(2.7)
- Lymph node(2.5)
- Skin(2.3)
Primer Products
-
OriGene qPCR primer pairs for TNFSF10
-
OriGene qPCR primer pairs and template standards for TNFSF10
- genomics-online: primer clones - Search results for 162 available TNFSF10 gene related products
- Overview of 162 available TNFSF10 gene related products
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFSF10 Gene
Orthologs for TNFSF10 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TNFSF10 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | TNFSF10 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | TNFSF10 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Tnfsf10 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Tnfsf10 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | TNFSF10 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | TNFSF10 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TNFSF10 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | TNFSF10 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tnfsf10 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tnfsf10 33 34 |
|
- Species where no ortholog for TNFSF10 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for TNFSF10 Gene
Variants for TNFSF10 Gene
| SNP ID | Clin | Chr 03 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000042287 | -- | 172,515,667(-) | C/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000074747 | -- | 172,505,606(-) | T/A | 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant | |
| rs1000110807 | -- | 172,516,105(-) | A/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000176735 | -- | 172,524,376(-) | C/T | upstream_transcript_variant | |
| rs1000437116 | -- | 172,518,678(-) | C/G | intron_variant |
Residual Variation Intolerance Score:
62.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.74;
33.00% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TNFSF10 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFSF10 Gene
Disorders for TNFSF10 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| malignant glioma |
|
|
| ulceroglandular tularemia |
|
|
| primary effusion lymphoma |
|
|
| dystrophinopathies |
|
|
| ameloblastoma |
|
Search TNFSF10 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TNFSF10
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for TNFSF10 Gene
Publications for TNFSF10 Gene
- Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. (PMID: 8663110) Pitti RM … Ashkenazi A (The Journal of biological chemistry 1996) 2 3 4 58
- Identification and characterization of a new member of the TNF family that induces apoptosis. (PMID: 8777713) Wiley SR … Smith CA (Immunity 1995) 2 3 4 58
- The structure of the death receptor 4-TNF-related apoptosis-inducing ligand (DR4-TRAIL) complex. (PMID: 26457518) Ramamurthy V … Sheriff S (Acta crystallographica. Section F, Structural biology communications 2015) 3 4 58
- Isolation of a TRAIL antagonist from the serum of HIV-infected patients. (PMID: 21859711) Schnepple DJ … Badley AD (The Journal of biological chemistry 2011) 3 4 58
- Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1-independent sensitization to TRAIL-induced apoptosis. (PMID: 20097879) Mader I … Fulda S (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010) 3 22 58
Products for TNFSF10 Gene
- R&D Systems Antibodies for TNFSF10 (TRAIL/TNFSF10)
- R&D Systems Proteins and Enzymes for TNFSF10 (TRAIL/TNFSF10)
- R&D Systems ELISAs, Luminex Assays, and other biochemical assays for TNFSF10 (TRAIL/TNFSF10)
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- Abcam antibodies for TNFSF10
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- Browse Antibodies at Cloud-Clone Corp.
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- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- ApexBio compounds for TNFSF10
- Cyagen custom Knockout/knockin (KOKI) mouse models for TNFSF10
- VectorBuilder custom plasmid, inducible vectors for TNFSF10
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TNFSF10
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TNFSF10
- antibodies-online: Search results for 388 available TNFSF10 Antibodies ranked by validation data
- Compare Top TNFSF10 Antibodies
- Recommended
- 221 WB Antibodies (anti-human)
- 49 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
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- 5 IHC (p) Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 2 Neut Antibodies (anti-human)
- 1 ELISPOT (Capture) Antibody (anti-human)
- 1 ELISPOT (Detection) Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 44 WB Antibodies (anti-mouse)
- 16 FACS Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 IP Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 23 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 221 WB Antibodies (anti-human)
- 49 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 8 Func Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 2 Neut Antibodies (anti-human)
- 1 ELISPOT (Capture) Antibody (anti-human)
- 1 ELISPOT (Detection) Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 44 WB Antibodies (anti-mouse)
- 16 FACS Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 IP Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 23 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- antibodies-online: Search results for 82 available TNFSF10 Elisa Kits ranked by validation data
- Compare Top TNFSF10 Elisa Kits
- Recommended
- 2 Chicken ELISA Kits
- 2 Cow (Bovine) ELISA Kits
- 6 Dog (Canine) ELISA Kits
- 2 Guinea Pig ELISA Kits
- 33 Human ELISA Kits
- 15 Mouse (Murine) ELISA Kits
- 3 Pig (Porcine) ELISA Kits
- 3 Rabbit ELISA Kits
- 11 Rat (Rattus) ELISA Kits
- 2 Sheep (Ovine) ELISA Kits
- 2 Chicken ELISA Kits
- 2 Cow (Bovine) ELISA Kits
- 6 Dog (Canine) ELISA Kits
- 2 Guinea Pig ELISA Kits
- 33 Human ELISA Kits
- 15 Mouse (Murine) ELISA Kits
- 3 Pig (Porcine) ELISA Kits
- 3 Rabbit ELISA Kits
- 11 Rat (Rattus) ELISA Kits
- 2 Sheep (Ovine) ELISA Kits
- antibodies-online: Search results for 80 available TNFSF10 Proteins ranked by validation data
- Compare Top TNFSF10 Proteins
- GeneTex TNFSF10 antibody for TNFSF10
- GeneTex Proteins for TNFSF10
- ViGene Biosciences adenoviral particle packaged cDNA for TNFSF10 gene
- ViGene Biosciences lentiviral particle packaged cDNA for TNFSF10 gene
- ViGene Biosciences ready-to-package AAV shRNAs for TNFSF10 gene
- Search ViGene Biosciences for TNFSF10
- Santa Cruz Biotechnology (SCBT) Antibodies for TNFSF10
- Search Santa Cruz Biotechnology (SCBT) for TNFSF10 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TNFSF10
- Custom Antibody ServicesProSci Antibodies for TNFSF10
- ProSci Proteins for TNFSF10
- tumor necrosis factor (ligand) superfamily, member 10 [90-217]
- tumor necrosis factor (ligand) superfamily, member 10 [90-257]
- tumor necrosis factor (ligand) superfamily, member 10 [90-335]
- tumor necrosis factor (ligand) superfamily, member 10 [90-336]
- tumor necrosis factor superfamily member 10 [91-016]
- tumor necrosis factor superfamily member 10 [92-218]
- tumor necrosis factor (ligand) superfamily, member 10 [40-103]
- tumor necrosis factor (ligand) superfamily, member 10 [40-167]
- tumor necrosis factor (ligand) superfamily, member 10 [40-297]
- Horizon Cell Lines for TNFSF10
- genomics-online: cdna clones - Search results for 162 available TNFSF10 gene related products
- Overview of 162 available TNFSF10 gene related products
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- genomics-online: primer clones - Search results for 162 available TNFSF10 gene related products
- Overview of 162 available TNFSF10 gene related products
- genomics-online: shRNA clones - Search results for 162 available TNFSF10 gene related products
- Overview of 162 available TNFSF10 gene related products
Sources for TNFSF10 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
