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The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNF... See more...
Aliases for TNFSF10 Gene
Aliases for TNFSF10 Gene
- Chemokine Tumor Necrosis Factor Ligand Superfamily Member 10 3
- Tumor Necrosis Factor (Ligand) Family, Member 10 3
- TNF-Related Apoptosis Inducing Ligand TRAIL 3
- Tumor Necrosis Factor Superfamily Member 10 3
- TNF-Related Apoptosis-Inducing Ligand 4
- Tumor Necrosis Factor Ligand 6A 3
- Protein TRAIL 4
- CD253 Antigen 4
- TNFSF10 5
- TNLG6A 3
External Ids for TNFSF10 Gene
- HGNC: 11925
- Entrez Gene: 8743
- Ensembl: ENSG00000121858
- OMIM: 603598
- UniProtKB: P50591
Previous GeneCards Identifiers for TNFSF10 Gene
- GC03M169274
- GC03M173180
- GC03M173625
- GC03M173544
- GC03M173706
- GC03M172223
- GC03M169593
Summaries for TNFSF10 Gene
-
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
GeneCards Summary for TNFSF10 Gene
TNFSF10 (TNF Superfamily Member 10) is a Protein Coding gene. Diseases associated with TNFSF10 include Thoracic Cancer and Ameloblastoma. Among its related pathways are Apoptosis Modulation and Signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and tumor necrosis factor receptor binding. An important paralog of this gene is TNFSF11.
UniProtKB/Swiss-Prot Summary for TNFSF10 Gene
-
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:26457518, PubMed:10549288). Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
Additional gene information for TNFSF10 Gene
- HGNC(11925)
- Entrez Gene(8743)
- Ensembl(ENSG00000121858)
- OMIM(603598)
- UniProtKB(P50591)
- Open Targets Platform(ENSG00000121858)
- Monarch Initiative
- Search for TNFSF10 at DataMed
- Search for TNFSF10 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TNFSF10 Gene
Genomics for TNFSF10 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TNFSF10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TNFSF10 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TNFSF10
- Top Transcription factor binding sites by QIAGEN in the TNFSF10 gene promoter:
-
- GR
- GR-alpha
- HSF1 (long)
- HSF1short
- IRF-7A
- PPAR-gamma1
- PPAR-gamma2
- Sp1
- STAT1
- STAT5A
Genomic Locations for TNFSF10 Gene
Genomic Locations for TNFSF10 Gene
- chr3:172,505,508-172,523,475
- (GRCh38/hg38)
- Size:
- 17,968 bases
- Orientation:
- Minus strand
- chr3:172,223,298-172,241,297
- (GRCh37/hg19)
- Size:
- 18,000 bases
- Orientation:
- Minus strand
Genomic View for TNFSF10 Gene
Genes around TNFSF10 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q26 by HGNC
- 3q26.31 by Entrez Gene
- 3q26.31 by Ensembl
TNFSF10 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TNFSF10 Gene
Proteins for TNFSF10 Gene
-
Protein details for TNFSF10 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P50591-TNF10_HUMAN
- Recommended name:
- Tumor necrosis factor ligand superfamily member 10
- Protein Accession:
- P50591
- A1Y9B3
Protein attributes for TNFSF10 Gene
- Size:
- 281 amino acids
- Molecular mass:
- 32509 Da
- Quaternary structure:
-
- Homotrimer (PubMed:26457518). One TNFSF10 homotrimer interacts with three TNFSF10A mononers (PubMed:26457518). One TNFSF10 homotrimer interacts with three TNFSF10B mononers (PubMed:10549288).
- Miscellaneous:
-
- [Isoform 2]: Induced upon HIV infection, antagonizes signaling via TRAIL receptor R2 (TNFRSF10B).
Three dimensional structures from OCA and Proteopedia for TNFSF10 Gene
Protein Expression for TNFSF10 Gene
Post-translational modifications for TNFSF10 Gene
- Tyrosine phosphorylated by PKDCC/VLK.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for TNFSF10 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for TNFSF10
- AM31199AF-N
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- AP00024PU-N
- AP06701PU-N
- AP31097BT-N
- AP31097BT-S
- AP31097PU-N
- AP31097PU-S
- PM1214P
- PP1084B1
- PP1084B2
- PP1084P1
- PP1084P2
- SM1847LE
- SM1847P
- SM1847RP
- SP1177P
- TA305942
- TA312997
- TA320500
- TA320501
- TA328462
- TA330336
- TA336381
- TA347955
- TA354552
- TA354553
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- TA811775S
- Novus Biologicals Antibodies for TNFSF10
-
Abcam antibodies for TNFSF10
- Invitrogen Antibodies for TNFSF10 (AFLGC-TNFSF10)
- antibodies-online: Show 115 available TNFSF10 Antibodies ranked by validation data
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Recommended
- 239 WB Antibodies (anti-human)
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- 5 IHC Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 1 ELISPOT (Capture) Antibody (anti-human)
- 1 ELISPOT (Detection) Antibody (anti-human)
- 1 IF Antibody (anti-human)
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- 52 WB Antibodies (anti-mouse)
- 13 FACS Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
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- 28 WB Antibodies (anti-rat)
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-
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Protein Products
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-
ProSci Proteins for TNFSF10
- tumor necrosis factor (ligand) superfamily, member 10 [40-297]
- tumor necrosis factor (ligand) superfamily, member 10 [40-459]
- tumor necrosis factor superfamily member 10 [92-218]
- tumor necrosis factor (ligand) superfamily, member 10 [40-103]
- tumor necrosis factor (ligand) superfamily, member 10 [90-217]
- tumor necrosis factor (ligand) superfamily, member 10 [40-167]
- tumor necrosis factor (ligand) superfamily, member 10 [90-257]
- tumor necrosis factor (ligand) superfamily, member 10 [90-335]
- tumor necrosis factor (ligand) superfamily, member 10 [90-336]
- tumor necrosis factor (ligand) superfamily, member 10 [90-338]
- tumor necrosis factor superfamily member 10 [91-016]
-
Abcam proteins for TNFSF10
Assay Products
- RayBiotech Human TRAIL ELISA
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- antibodies-online: Show 102 available TNFSF10 Elisa Kits ranked by validation data
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-
Quality Products:
- ABIN1117664
- ABIN921077
- ABIN415276
- ABIN4884871
- ABIN2685737
- ABIN4993228
- ABIN491832
- ABIN1029845
- ABIN924801
- ABIN5525407
- ABIN1117195
- ABIN415807
- ABIN2703528
- ABIN4993229
- ABIN1029846
- ABIN4948109
- ABIN1117544
- ABIN5525408
- ABIN2708457
- ABIN5670286
- ABIN1117671
- ABIN416536
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- ABIN2952200
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- ABIN1572895
- ABIN627392
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-
Abcam assays for TNFSF10
- Sino Biological Assays for TNFSF10
No data available for DME Specific Peptides for TNFSF10 Gene
Domains & Families for TNFSF10 Gene
Gene Families for TNFSF10 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- CD markers
- Predicted intracellular proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for TNFSF10 Gene
- InterPro:
- Blocks:
-
- Tumor Necrosis Factor
- ProtoNet:
Suggested Antigen Peptide Sequences for TNFSF10 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ51976, moderately similar to Tumor necrosis factor ligand superfamily member 10 (A1Y9B3_HUMAN)
- cDNA, FLJ93150, Homo sapiens tumor necrosis factor (ligand) superfamily, member 10(TNFSF10), mRNA (Q6IBA9_HUMAN)
- Chemokine tumor necrosis factor ligand superfamily member 10 (Q6JSD9_HUMAN)
- TNF-related apoptosis-inducing ligand (TNF10_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P50591- Family:
-
- Belongs to the tumor necrosis factor family.
Function for TNFSF10 Gene
Molecular function for TNFSF10 Gene
- UniProtKB/Swiss-Prot Function:
- Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:26457518, PubMed:10549288). Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
- GENATLAS Biochemistry:
- tumor necrosis factor (ligand) superfamily,member 10,TNF-related apoptosis inducing ligand (TRAIL),predominantly expressed in spleen,lung,prostate
Phenotypes From GWAS Catalog for TNFSF10 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | signaling receptor binding | TAS | 8663110 |
| GO:0005125 | cytokine activity | IEA | -- |
| GO:0005164 | tumor necrosis factor receptor binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 10549288 |
| GO:0008270 | zinc ion binding | IDA | 26457518 |
Phenotypes for TNFSF10 Gene
- MGI mutant phenotypes for TNFSF10:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for TNFSF10:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Decreased vaccinia virus (VACV) infection
- Reduced mammosphere formation
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Polylobed nuclei
- Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)
- Decreased viability (cell death)
Animal Models for TNFSF10 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TNFSF10 - Select products 50% OFF >
- * TNFSF10 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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OriGene CRISPR knockouts for TNFSF10
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TNFSF10
-
Santa Cruz Biotechnology (SCBT) CRISPR for TNFSF10
miRNA for TNFSF10 Gene
- miRTarBase miRNAs that target TNFSF10
-
- hsa-miR-222-3p (MIRT003756)
- hsa-miR-221-3p (MIRT003757)
- hsa-miR-98-5p (MIRT027770)
- rno-miR-672-5p (MIRT438466)
- rno-miR-151-5p (MIRT438467)
- mmu-miR-3089-5p (MIRT601454)
- mmu-miR-1194 (MIRT601455)
- mmu-miR-546 (MIRT601456)
- mmu-miR-3471 (MIRT601457)
- mmu-miR-212-3p (MIRT603207)
- mmu-miR-132-3p (MIRT603208)
- mmu-miR-377-3p (MIRT603209)
- mmu-miR-466m-3p (MIRT603210)
- mmu-miR-466o-3p (MIRT603211)
- mmu-miR-466n-3p (MIRT603212)
- mmu-miR-24-3p (MIRT605392)
- mmu-miR-3106-5p (MIRT605393)
- mmu-miR-1199-5p (MIRT606121)
- mmu-miR-1195 (MIRT606122)
- mmu-miR-1249-3p (MIRT606123)
- mmu-miR-466q (MIRT606124)
- hsa-miR-25-3p (MIRT732909)
- hsa-miR-1297 (MIRT783652)
- hsa-miR-26a-5p (MIRT784362)
- hsa-miR-26b-5p (MIRT784365)
- hsa-miR-3152-5p (MIRT784684)
- hsa-miR-3199 (MIRT784837)
- hsa-miR-365a-5p (MIRT785054)
- hsa-miR-365b-5p (MIRT785058)
- hsa-miR-4465 (MIRT785951)
- hsa-miR-513c-5p (MIRT787157)
- hsa-miR-514b-5p (MIRT787177)
- hsa-miR-562 (MIRT787711)
- hsa-miR-5697 (MIRT787810)
- hsa-miR-6819-3p (MIRT788951)
- hsa-miR-6836-3p (MIRT789029)
- hsa-miR-6877-3p (MIRT789260)
- hsa-miR-8052 (MIRT789641)
miRNA Products
Inhibitory RNA Products
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Clone Products
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- MG226180
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- RC207596L2
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- RC207596L4
- RC230918
- RC230918L3
- RC230918L4
- RC230941
- RC230941L3
- RC230941L4
- RG207596
- RG230918
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- RR214556
- RR214556L3
- RR214556L4
- MR226180L3V
- MR226180L4V
- RC207596L1V
- RC207596L2V
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TNFSF10
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Cell Line Products
- ESI BIO PureStem ES-209, Meso-prx/latp Progenitor for TNFSF10
-
Horizon Cell Lines for TNFSF10
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNFSF10 Gene
Localization for TNFSF10 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TNFSF10 Gene
- Cell membrane. Single-pass type II membrane protein. Secreted. Note=Exists both as membrane-bound and soluble form. {ECO:0000269 PubMed:14609566}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| mitochondrion | 3 |
| nucleus | 3 |
| endoplasmic reticulum | 3 |
| cytosol | 3 |
| cytoskeleton | 2 |
| endosome | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| golgi apparatus | 1 |
- Microtubules (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IEA | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 8663110 |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for TNFSF10 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
|
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
Glucocorticoid Receptor Signaling
.43
|
| 2 | CASP8 activity is inhibited |
.01
|
|
| 3 | TGF-Beta Pathway |
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
|
JNK Pathway
.51
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.41
|
| 4 | Apoptosis Modulation and Signaling |
.41
|
Apoptosis and survival Apoptotic TNF-family pathways
.35
.31
|
| 5 | TNFR1 Pathway |
Apoptosis through Death Receptors
.42
TRAIL Pathway
.40
|
.34
|
Pathways by source for TNFSF10 Gene
3 Sino Biological pathways for TNFSF10 Gene
5 BioSystems pathways for TNFSF10 Gene
13 Reactome pathways for TNFSF10 Gene
9 KEGG pathways for TNFSF10 Gene
1 GeneGo (Thomson Reuters) pathway for TNFSF10 Gene
- Apoptosis and survival Apoptotic TNF-family pathways
2 R&D Systems pathways for TNFSF10 Gene
31 Qiagen pathways for TNFSF10 Gene
- Akt Signaling
- all-trans-Retinoic Acid Mediated Apoptosis
- all-trans-Retinoic Acid Signaling in Brain
- Antioxidant Action of Vitamin-C
- Apoptosis through Death Receptors
1 Cell Signaling Technology pathway for TNFSF10 Gene
1 GeneTex pathway for TNFSF10 Gene
Interacting Proteins for TNFSF10 Gene
Selected Interacting proteins:
P50591-TNF10_HUMAN
ENSP00000241261
for TNFSF10 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for TNFSF10
SIGNOR curated interactions for TNFSF10 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006915 | apoptotic process | TAS,IEA | -- |
| GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | TAS | -- |
| GO:0006955 | immune response | IEA | -- |
| GO:0007165 | signal transduction | TAS | 8663110 |
| GO:0007166 | cell surface receptor signaling pathway | TAS | -- |
Drugs & Compounds for TNFSF10 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| CCCP | Pharma | uncoupler of oxidative phosphorylation | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(1) ApexBio Compounds for TNFSF10 Gene
| Compound | Action | Cas Number |
|---|---|---|
| CCCP | uncoupler of oxidative phosphorylation | 555-60-2 |
Transcripts for TNFSF10 Gene
mRNA/cDNA for TNFSF10 Gene
- 3 REFSEQ mRNAs :
- 16 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000241261 1876 nts (view in UCSC)
- ENST00000420541 1619 nts (view in UCSC)
- ENST00000430881 467 nts (view in UCSC)
- ENST00000466777 1326 nts (view in UCSC)
- ENST00000472804 566 nts (view in UCSC)
CRISPR Products
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-
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miRNA Products
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Clone Products
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-
- MG226180
- MR226180
- MR226180L3
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- RC207596
- RC207596L1
- RC207596L2
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- RC207596L4
- RC230918
- RC230918L3
- RC230918L4
- RC230941
- RC230941L3
- RC230941L4
- RG207596
- RG230918
- RG230941
- RR214556
- RR214556L3
- RR214556L4
- MR226180L3V
- MR226180L4V
- RC207596L1V
- RC207596L2V
- RC207596L3V
- RC207596L4V
- RC230918L3V
- RC230918L4V
- RC230941L3V
- RC230941L4V
- RR214556L3V
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Addgene plasmids for TNFSF10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TNFSF10
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||
| SP8: | - | - |
Relevant External Links for TNFSF10 Gene
- GeneLoc Exon Structure for
- TNFSF10
Expression for TNFSF10 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Monocytes Peripheral Blood
- T Helper Cells Thymus
- Hematopoietic Stem Cells Liver Bud
- Natural killer-like cells(Woll PS et. al. 2009)
-
Endothelium (Cardiovascular System)
- Endothelial Cells Blood Brain Barrier
- Adult Endothelial Cells Blood Brain Barrier
- Endothelial-like cells(James D et. al. 2010)
-
Brain (Nervous System)
- Endothelial Cells Blood Brain Barrier
- Adult Endothelial Cells Blood Brain Barrier
-
Thymus (Hematopoietic System)
- T Helper Cells Thymus
-
Liver (Hepatobiliary System)
- Hematopoietic Stem Cells Liver Bud
- Intestine (Gastrointestinal Tract)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Gall Bladder (Hepatobiliary System)
-
Kidney (Urinary System)
mRNA differential expression in normal tissues according to GTEx for TNFSF10 Gene
This gene is overexpressed in Whole Blood (x7.2) and Minor Salivary Gland (x4.5).
This gene is overexpressed in Milk (45.1) and Islet of Langerhans (18.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TNFSF10 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TNFSF10
SOURCE GeneReport for Unigene cluster for TNFSF10 Gene:
Hs.478275mRNA Expression by UniProt/SwissProt for TNFSF10 Gene:
P50591-TNF10_HUMAN
Tissue specificity:
Widespread; most predominant in spleen, lung and prostate.
Evidence on tissue expression from TISSUES for TNFSF10 Gene
- Nervous system(4.6)
- Liver(3.6)
- Kidney(3.6)
- Blood(3.6)
- Lung(3.5)
- Spleen(3.4)
- Lymph node(3.3)
- Intestine(3.3)
- Skin(3.1)
- Heart(3)
- Muscle(2.8)
- Stomach(2.7)
- Bone marrow(2.7)
- Pancreas(2.4)
- Thyroid gland(2.3)
- Adrenal gland(2.3)
- Bone(2.1)
Primer Products
-
OriGene qPCR primer pairs for TNFSF10
-
OriGene qPCR primer pairs and template standards for TNFSF10
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFSF10 Gene
Orthologs for TNFSF10 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TNFSF10 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | TNFSF10 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | TNFSF10 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Tnfsf10 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Tnfsf10 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | TNFSF10 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | TNFSF10 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | TNFSF10 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | TNFSF10 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tnfsf10 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | tnfsf10 30 31 |
|
OneToOne |
- Species where no ortholog for TNFSF10 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for TNFSF10 Gene
- ENSEMBL:
- Gene Tree for TNFSF10 (if available)
- TreeFam:
- Gene Tree for TNFSF10 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TNFSF10: view image
Paralogs for TNFSF10 Gene
Variants for TNFSF10 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TNFSF10 Gene
| SNP ID | Clinical significance and condition | Chr 03 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 759867 | Likely Benign: not provided | 172,514,870(-) | G/A | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
| 769617 | Benign: not provided | 172,523,280(-) | G/A | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
| 788974 | Benign: not provided | 172,523,288(-) | C/T | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT | |
| rs16845759 | - | p.Asp47Glu | |||
| rs6763816 | - | p.Val33Ile |
Residual Variation Intolerance Score:
62.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.74;
33.00% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TNFSF10 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFSF10 Gene
Disorders for TNFSF10 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| thoracic cancer |
|
|
| ameloblastoma |
|
|
| colon adenocarcinoma |
|
|
| pancreatic cancer |
|
|
| malignant glioma |
|
Search TNFSF10 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TNFSF10
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for TNFSF10 Gene
Publications for TNFSF10 Gene
- Identification and characterization of a new member of the TNF family that induces apoptosis. (PMID: 8777713) Wiley SR … Smith CA (Immunity 1995) 2 3 4 23
- Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. (PMID: 8663110) Pitti RM … Ashkenazi A (The Journal of biological chemistry 1996) 2 3 4
- The structure of the death receptor 4-TNF-related apoptosis-inducing ligand (DR4-TRAIL) complex. (PMID: 26457518) Ramamurthy V … Sheriff S (Acta crystallographica. Section F, Structural biology communications 2015) 3 4
- Isolation of a TRAIL antagonist from the serum of HIV-infected patients. (PMID: 21859711) Schnepple DJ … Badley AD (The Journal of biological chemistry 2011) 3 4
- Endogenous Bak inhibitors Mcl-1 and Bcl-xL: differential impact on TRAIL resistance in Bax-deficient carcinoma. (PMID: 20308427) Gillissen B … Daniel PT (The Journal of cell biology 2010) 3 23
ExternalLinks
Products for TNFSF10 Gene
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- 1 ELISPOT (Capture) Antibody (anti-human)
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- tumor necrosis factor (ligand) superfamily, member 10 [40-297]
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Sources for TNFSF10 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
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- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
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- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
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- (38) dbSNP
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- (40) HGMD
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- (44) Atlas
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- (50) miRBase
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- (53) PubMed
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- (62) Qiagen
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- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
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- (104) diseasecard
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