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The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
TNFSF10 (TNF Superfamily Member 10) is a Protein Coding gene. Diseases associated with TNFSF10 include Thoracic Cancer and Ameloblastoma. Among its related pathways are Apoptosis Modulation and Signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and tumor necrosis factor receptor binding. An important paralog of this gene is TNFSF11.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005102 | signaling receptor binding | TAS | 8663110 |
GO:0005125 | cytokine activity | IEA | -- |
GO:0005164 | tumor necrosis factor receptor binding | IEA | -- |
GO:0005515 | protein binding | IPI | 10549288 |
GO:0008270 | zinc ion binding | IDA | 26457518 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IEA | -- |
GO:0005886 | plasma membrane | IEA | -- |
GO:0005887 | integral component of plasma membrane | TAS | 8663110 |
GO:0016020 | membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
|
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
Glucocorticoid Receptor Signaling
.43
|
2 | CASP8 activity is inhibited |
.01
|
|
3 | TGF-Beta Pathway |
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
|
JNK Pathway
.51
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.41
|
4 | Apoptosis Modulation and Signaling |
.41
|
Apoptosis and survival Apoptotic TNF-family pathways
.35
.31
|
5 | TNFR1 Pathway |
Apoptosis through Death Receptors
.42
TRAIL Pathway
.40
|
.34
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006915 | apoptotic process | TAS,IEA | -- |
GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | TAS | -- |
GO:0006955 | immune response | IEA | -- |
GO:0007165 | signal transduction | TAS | 8663110 |
GO:0007166 | cell surface receptor signaling pathway | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
CCCP | Pharma | uncoupler of oxidative phosphorylation | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Compound | Action | Cas Number |
---|---|---|
CCCP | uncoupler of oxidative phosphorylation | 555-60-2 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||
SP8: | - | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TNFSF10 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TNFSF10 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TNFSF10 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Tnfsf10 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Tnfsf10 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | TNFSF10 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | TNFSF10 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | TNFSF10 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | TNFSF10 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tnfsf10 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | tnfsf10 30 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 03 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
759867 | Likely Benign: not provided | 172,514,870(-) | G/A | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
769617 | Benign: not provided | 172,523,280(-) | G/A | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
788974 | Benign: not provided | 172,523,288(-) | C/T | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT | |
rs16845759 | - | p.Asp47Glu | |||
rs6763816 | - | p.Val33Ile |
Disorder | Aliases | PubMed IDs |
---|---|---|
thoracic cancer |
|
|
ameloblastoma |
|
|
colon adenocarcinoma |
|
|
pancreatic cancer |
|
|
malignant glioma |
|