Aliases for TNFRSF9 Gene
External Ids for TNFRSF9 Gene
Previous HGNC Symbols for TNFRSF9 Gene
Previous GeneCards Identifiers for TNFRSF9 Gene
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008]
GeneCards Summary for TNFRSF9 Gene
TNFRSF9 (TNF Receptor Superfamily Member 9) is a Protein Coding gene. Diseases associated with TNFRSF9 include Retroperitoneal Hemangiopericytoma and Nodular Goiter. Among its related pathways are TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions and Akt Signaling. Gene Ontology (GO) annotations related to this gene include cytokine binding. An important paralog of this gene is CD27.
UniProtKB/Swiss-Prot Summary for TNFRSF9 Gene
Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.