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Aliases for TNFRSF8 Gene

Aliases for TNFRSF8 Gene

  • TNF Receptor Superfamily Member 8 2 3 5
  • Lymphocyte Activation Antigen CD30 3 4
  • CD30L Receptor 3 4
  • Ki-1 Antigen 3 4
  • D1S166E 3 4
  • CD30 3 4
  • Tumor Necrosis Factor Receptor Superfamily, Member 8 2
  • Tumor Necrosis Factor Receptor Superfamily Member 8 3
  • Cytokine Receptor CD30 3
  • CD30 Antigen 4
  • Ki-1 3

External Ids for TNFRSF8 Gene

Previous HGNC Symbols for TNFRSF8 Gene

  • CD30
  • D1S166E

Previous GeneCards Identifiers for TNFRSF8 Gene

  • GC01P012187
  • GC01P011968
  • GC01P011732
  • GC01P011832
  • GC01P012057
  • GC01P011277

Summaries for TNFRSF8 Gene

Entrez Gene Summary for TNFRSF8 Gene

  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFRSF8 Gene

TNFRSF8 (TNF Receptor Superfamily Member 8) is a Protein Coding gene. Diseases associated with TNFRSF8 include Anaplastic Large Cell Lymphoma and Malignant Histiocytosis. Among its related pathways are Cytokine Signaling in Immune system and Akt Signaling. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity.

UniProtKB/Swiss-Prot for TNFRSF8 Gene

  • Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B.

Gene Wiki entry for TNFRSF8 Gene

Additional gene information for TNFRSF8 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF8 Gene

Genomics for TNFRSF8 Gene

GeneHancer (GH) Regulatory Elements for TNFRSF8 Gene

Promoters and enhancers for TNFRSF8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I012063 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 577.7 +0.8 797 1.9 HDAC1 ATF1 RB1 NFRKB SIN3A ZBTB40 ZNF335 EGR1 ATF7 IKZF2 TNFRSF8 MIIP GC01M012075 GC01P012045
GH01I012166 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 16.2 +111.1 111085 15.6 HDGF FOXA2 PKNOX1 SMAD1 ARNT IRF4 YY1 ZNF766 ZNF207 ZNF143 TNFRSF1B MTHFR TNFRSF8 CLCN6 VPS13D AGTRAP MIIP MFN2 MIR7846 MIR4632
GH01I012054 Enhancer 0.8 FANTOM5 dbSUPER 32.6 -8.9 -8908 0.2 ZNF687 JUNB EBF1 ZNF592 ATF4 IKZF1 ATF7 RUNX3 IKZF2 TNFRSF8 RNU6-777P RPL23AP89 MFN2 MIIP GC01P012045
GH01I012067 Enhancer 0.9 FANTOM5 dbSUPER 28.6 +2.9 2870 0.3 HDAC1 RNF2 ETV1 EBF1 EP300 ATF4 ZNF316 ZNF766 CTBP1 POLR2A TNFRSF8 MIIP GC01M012075 GC01P012045
GH01I012018 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 12.1 -43.5 -43460 2.4 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B ZNF143 FOS MIIP UBIAD1 TNFRSF8 RNU6-777P RPL23AP89 PLOD1 KIAA2013 LINC01647 NPPA-AS1 ENSG00000202461
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TNFRSF8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TNFRSF8 gene promoter:

Genomic Locations for TNFRSF8 Gene

Genomic Locations for TNFRSF8 Gene
80,878 bases
Plus strand

Genomic View for TNFRSF8 Gene

Genes around TNFRSF8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFRSF8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFRSF8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF8 Gene

Proteins for TNFRSF8 Gene

  • Protein details for TNFRSF8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor necrosis factor receptor superfamily member 8
    Protein Accession:
    Secondary Accessions:
    • B1AN79
    • B9EGD9
    • D3YTD8
    • Q6P4D9

    Protein attributes for TNFRSF8 Gene

    595 amino acids
    Molecular mass:
    63747 Da
    Quaternary structure:
    • Interacts with TRAF1, TRAF2, TRAF3 and TRAF5.
    • Most specific Hodgkin disease associated antigen.

    Three dimensional structures from OCA and Proteopedia for TNFRSF8 Gene

    Alternative splice isoforms for TNFRSF8 Gene


neXtProt entry for TNFRSF8 Gene

Post-translational modifications for TNFRSF8 Gene

  • Phosphorylated on serine and tyrosine residues.
  • Glycosylation at isoforms=101, isoforms=3209, and isoforms=3276
  • Modification sites at PhosphoSitePlus

Other Protein References for TNFRSF8 Gene

No data available for DME Specific Peptides for TNFRSF8 Gene

Domains & Families for TNFRSF8 Gene

Gene Families for TNFRSF8 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TNFRSF8 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TNFRSF8: view

No data available for UniProtKB/Swiss-Prot for TNFRSF8 Gene

Function for TNFRSF8 Gene

Molecular function for TNFRSF8 Gene

GENATLAS Biochemistry:
tumor necrosis factor receptor superfamily,member 8,cell differentiation antigen CD30 (Ki-1),lymphoid activating,identified by monoclonal antibodies HRS-1,Ki-1
UniProtKB/Swiss-Prot Function:
Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B.

Phenotypes From GWAS Catalog for TNFRSF8 Gene

Gene Ontology (GO) - Molecular Function for TNFRSF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 1310894
GO:0005031 tumor necrosis factor-activated receptor activity IBA --
GO:0048406 nerve growth factor binding IBA --
genes like me logo Genes that share ontologies with TNFRSF8: view
genes like me logo Genes that share phenotypes with TNFRSF8: view

Animal Models for TNFRSF8 Gene

MGI Knock Outs for TNFRSF8:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNFRSF8 Gene

Localization for TNFRSF8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF8 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFRSF8 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 4
cytoskeleton 2
cytosol 2
lysosome 2

Gene Ontology (GO) - Cellular Components for TNFRSF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TNFRSF8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TNFRSF8 Gene

Pathways & Interactions for TNFRSF8 Gene

genes like me logo Genes that share pathways with TNFRSF8: view

Pathways by source for TNFRSF8 Gene

Gene Ontology (GO) - Biological Process for TNFRSF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IBA --
GO:0006955 immune response IBA --
GO:0007165 signal transduction TAS 10192335
GO:0007411 axon guidance IBA --
GO:0008285 negative regulation of cell proliferation TAS 10192335
genes like me logo Genes that share ontologies with TNFRSF8: view

No data available for SIGNOR curated interactions for TNFRSF8 Gene

Drugs & Compounds for TNFRSF8 Gene

(16) Drugs for TNFRSF8 Gene - From: DrugBank, PharmGKB, DGIdb, FDA Approved Drugs, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
brentuximab vedotin Approved Pharma Target, binder 0
Adcetris Approved August 2011 Pharma 0
CD30 ligand Pharma 0
AFM13 Pharma 0
brentuximab Pharma antibody, inhibitor Therapeutic Antibodies 0

(6) Additional Compounds for TNFRSF8 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TNFRSF8: view

Transcripts for TNFRSF8 Gene

Unigene Clusters for TNFRSF8 Gene

Tumor necrosis factor receptor superfamily, member 8:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF8 Gene

No ASD Table

Relevant External Links for TNFRSF8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNFRSF8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNFRSF8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFRSF8 Gene

This gene is overexpressed in Whole Blood (x6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TNFRSF8 Gene

NURSA nuclear receptor signaling pathways regulating expression of TNFRSF8 Gene:


SOURCE GeneReport for Unigene cluster for TNFRSF8 Gene:


Evidence on tissue expression from TISSUES for TNFRSF8 Gene

  • Blood(4.7)
  • Lymph node(2.9)
  • Skin(2.7)
  • Bone marrow(2.4)
genes like me logo Genes that share expression patterns with TNFRSF8: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFRSF8 Gene

Orthologs for TNFRSF8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TNFRSF8 33 34
  • 98.83 (n)
(Bos Taurus)
Mammalia TNFRSF8 33 34
  • 77.39 (n)
(Canis familiaris)
Mammalia TNFRSF8 33 34
  • 76.9 (n)
(Mus musculus)
Mammalia Tnfrsf8 33 16 34
  • 71 (n)
(Rattus norvegicus)
Mammalia Tnfrsf8 33
  • 67.16 (n)
(Gallus gallus)
Aves TNFRSF8 33 34
  • 54.05 (n)
Species where no ortholog for TNFRSF8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TNFRSF8 Gene

Gene Tree for TNFRSF8 (if available)
Gene Tree for TNFRSF8 (if available)

Paralogs for TNFRSF8 Gene

No data available for Paralogs for TNFRSF8 Gene

Variants for TNFRSF8 Gene

Sequence variations from dbSNP and Humsavar for TNFRSF8 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs193921033 uncertain-significance, Malignant tumor of prostate 12,104,381(+) G/A/T 5_prime_UTR_variant, coding_sequence_variant, missense_variant
rs138595447 uncertain-significance, not specified 12,123,717(+) C/A/T coding_sequence_variant, missense_variant
rs1000017817 -- 12,091,497(+) T/A genic_upstream_transcript_variant, intron_variant
rs1000023885 -- 12,117,563(+) C/T intron_variant
rs1000080422 -- 12,132,796(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF8 Gene

Variant ID Type Subtype PubMed ID
esv1290308 CNV deletion 17803354
esv2662914 CNV deletion 23128226
esv2670946 CNV deletion 23128226
esv2743796 CNV deletion 23290073
esv3350116 CNV insertion 20981092
esv3439333 CNV insertion 20981092
esv3584475 CNV gain 24956385
esv3585230 CNV loss 21293372
esv3585231 CNV loss 21293372
nsv1133810 CNV deletion 24896259
nsv466060 CNV loss 19166990
nsv469830 CNV loss 16826518
nsv476183 CNV novel sequence insertion 20440878
nsv508891 CNV insertion 20534489
nsv525898 CNV loss 19592680
nsv545436 CNV loss 21841781
nsv820293 CNV loss 19587683
nsv945772 CNV duplication 23825009
nsv945773 CNV duplication 23825009

Variation tolerance for TNFRSF8 Gene

Residual Variation Intolerance Score: 42.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.25; 40.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNFRSF8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFRSF8 Gene

Disorders for TNFRSF8 Gene

MalaCards: The human disease database

(56) MalaCards diseases for TNFRSF8 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
anaplastic large cell lymphoma
  • alcl
malignant histiocytosis
  • histiocytic medullary reticulosis [obs]
embryonal carcinoma
  • primary extragonadal embryonal carcinoma
  • lymphoma, non-hodgkin
  • lymphoid cancer
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TNFRSF8

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TNFRSF8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNFRSF8 Gene

Publications for TNFRSF8 Gene

  1. Association study between CD30 and CD30 ligand genes and type 1 diabetes in the Japanese population. (PMID: 11960307) Ahmed S … Hara T (Genes and immunity 2002) 3 22 44 58
  2. Opposite effects of the CD30 ligand are not due to CD30 mutations: results from cDNA cloning and sequence comparison of the CD30 antigen from different sources. (PMID: 7527901) Jung W … Pfreundschuh M (Molecular immunology 1994) 3 4 22 58
  3. Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's disease. (PMID: 1310894) Dürkop H … Stein H (Cell 1992) 2 3 4 58
  4. Altered expression of the lymphocyte activation antigen CD30 in active celiac disease. (PMID: 20166880) Periolo N … Cherñavsky AC (Autoimmunity 2010) 3 22 58
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58

Products for TNFRSF8 Gene

Sources for TNFRSF8 Gene

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