Aliases for TNFRSF8 Gene
External Ids for TNFRSF8 Gene
Previous HGNC Symbols for TNFRSF8 Gene
Previous GeneCards Identifiers for TNFRSF8 Gene
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for TNFRSF8 Gene
TNFRSF8 (TNF Receptor Superfamily Member 8) is a Protein Coding gene. Diseases associated with TNFRSF8 include Peripheral T-Cell Lymphoma and Reticulosarcoma. Among its related pathways are Akt Signaling and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity. An important paralog of this gene is TNFRSF11A.
UniProtKB/Swiss-Prot Summary for TNFRSF8 Gene
Receptor for TNFSF8/CD30L (PubMed:8391931). May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B (PubMed:8999898).