This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this g... See more...

Aliases for TNFRSF6B Gene

Aliases for TNFRSF6B Gene

  • TNF Receptor Superfamily Member 6b 2 3 5
  • DCR3 2 3 4
  • M68 2 3 4
  • TR6 2 3 4
  • Tumor Necrosis Factor Receptor Superfamily, Member 6b, Decoy 2 3
  • Tumor Necrosis Factor Receptor Superfamily Member 6B 3 4
  • Decoy Receptor For Fas Ligand 3 4
  • DcR3 2 4
  • Decoy Receptor 3 Variant 1 3
  • Decoy Receptor 3 Variant 2 3
  • Decoy Receptor 3 4
  • DJ583P15.1.1 3
  • TNFRSF6B 5
  • M68E 3

External Ids for TNFRSF6B Gene

Previous GeneCards Identifiers for TNFRSF6B Gene

  • GC20P062166
  • GC20U900077
  • GC20P063052
  • GC20P063016
  • GC20P061761
  • GC20P062326
  • GC20P059059

Summaries for TNFRSF6B Gene

Entrez Gene Summary for TNFRSF6B Gene

  • This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011]

GeneCards Summary for TNFRSF6B Gene

TNFRSF6B (TNF Receptor Superfamily Member 6b) is a Protein Coding gene. Diseases associated with TNFRSF6B include Dyskeratosis Congenita, Autosomal Recessive 5 and Crescentic Glomerulonephritis. Among its related pathways are Apoptosis and survival Caspase cascade and TNFR1 Pathway. An important paralog of this gene is TNFRSF11B.

UniProtKB/Swiss-Prot Summary for TNFRSF6B Gene

  • Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.

Gene Wiki entry for TNFRSF6B Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TNFRSF6B Gene

Genomics for TNFRSF6B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TNFRSF6B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TNFRSF6B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TNFRSF6B

Top Transcription factor binding sites by QIAGEN in the TNFRSF6B gene promoter:
  • AP-1
  • ATF-2
  • c-Jun

Genomic Locations for TNFRSF6B Gene

Latest Assembly
chr20:63,696,652-63,698,684
(GRCh38/hg38)
Size:
2,033 bases
Orientation:
Plus strand

Previous Assembly
chr20:62,328,005-62,330,037
(GRCh37/hg19 by Entrez Gene)
Size:
2,033 bases
Orientation:
Plus strand

chr20:62,328,021-62,330,037
(GRCh37/hg19 by Ensembl)
Size:
2,017 bases
Orientation:
Plus strand

Genomic View for TNFRSF6B Gene

Genes around TNFRSF6B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFRSF6B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFRSF6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF6B Gene

Proteins for TNFRSF6B Gene

  • Protein details for TNFRSF6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95407-TNF6B_HUMAN
    Recommended name:
    Tumor necrosis factor receptor superfamily member 6B
    Protein Accession:
    O95407

    Protein attributes for TNFRSF6B Gene

    Size:
    300 amino acids
    Molecular mass:
    32680 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TNFRSF6B Gene

neXtProt entry for TNFRSF6B Gene

Post-translational modifications for TNFRSF6B Gene

  • Glycosylation at Asn173
  • Modification sites at PhosphoSitePlus

Other Protein References for TNFRSF6B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TNFRSF6B Gene

Domains & Families for TNFRSF6B Gene

Protein Domains for TNFRSF6B Gene

InterPro:
Blocks:
  • TNFR/CD27/30/40/95 cysteine-rich region

Suggested Antigen Peptide Sequences for TNFRSF6B Gene

GenScript: Design optimal peptide antigens:
  • Decoy receptor 3 variant 2 (Q6EMV3_HUMAN)
  • Decoy receptor 3 variant 1 (Q6EMV4_HUMAN)
  • M68 (TNF6B_HUMAN)
genes like me logo Genes that share domains with TNFRSF6B: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TNFRSF6B Gene

Function for TNFRSF6B Gene

Molecular function for TNFRSF6B Gene

UniProtKB/Swiss-Prot Function:
Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.
GENATLAS Biochemistry:
tumor necrosis factor receptor superfamily,member 6B,binding Fas ligand (TNFRSF6) and inhibiting FasL induced apoptosis,amplified in primary lung and colon tumors

Phenotypes From GWAS Catalog for TNFRSF6B Gene

Gene Ontology (GO) - Molecular Function for TNFRSF6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10318773
GO:0038023 signaling receptor activity TAS 9872321
genes like me logo Genes that share ontologies with TNFRSF6B: view
genes like me logo Genes that share phenotypes with TNFRSF6B: view

miRNA for TNFRSF6B Gene

miRTarBase miRNAs that target TNFRSF6B

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNFRSF6B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TNFRSF6B Gene

Localization for TNFRSF6B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF6B Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFRSF6B gene
Compartment Confidence
extracellular 5
plasma membrane 2
nucleus 2
cytosol 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TNFRSF6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space NAS 10318773
genes like me logo Genes that share ontologies with TNFRSF6B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TNFRSF6B Gene

Pathways & Interactions for TNFRSF6B Gene

genes like me logo Genes that share pathways with TNFRSF6B: view

Pathways by source for TNFRSF6B Gene

1 Sino Biological pathway for TNFRSF6B Gene
1 BioSystems pathway for TNFRSF6B Gene
1 KEGG pathway for TNFRSF6B Gene
1 GeneGo (Thomson Reuters) pathway for TNFRSF6B Gene
  • Apoptosis and survival FAS signaling cascades
3 Qiagen pathways for TNFRSF6B Gene
  • Apoptosis through Death Receptors
  • Fas Signaling
  • Molecular Mechanisms of Cancer
1 Cell Signaling Technology pathway for TNFRSF6B Gene

SIGNOR curated interactions for TNFRSF6B Gene

Inactivates:

Gene Ontology (GO) - Biological Process for TNFRSF6B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0033209 tumor necrosis factor-mediated signaling pathway TAS --
GO:0043066 negative regulation of apoptotic process TAS 9872321
genes like me logo Genes that share ontologies with TNFRSF6B: view

Drugs & Compounds for TNFRSF6B Gene

(1) Additional Compounds for TNFRSF6B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TNFRSF6B: view

Transcripts for TNFRSF6B Gene

mRNA/cDNA for TNFRSF6B Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNFRSF6B

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF6B Gene

No ASD Table

Relevant External Links for TNFRSF6B Gene

GeneLoc Exon Structure for
TNFRSF6B

Expression for TNFRSF6B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TNFRSF6B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Lymph (Hematopoietic System)
  • Stomach (Gastrointestinal Tract)

Protein differential expression in normal tissues from HIPED for TNFRSF6B Gene

This gene is overexpressed in Breast (41.3) and Cervix (27.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TNFRSF6B Gene



Protein tissue co-expression partners for TNFRSF6B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TNFRSF6B

SOURCE GeneReport for Unigene cluster for TNFRSF6B Gene:

Hs.434878

mRNA Expression by UniProt/SwissProt for TNFRSF6B Gene:

O95407-TNF6B_HUMAN
Tissue specificity: Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.

Evidence on tissue expression from TISSUES for TNFRSF6B Gene

  • Lung(4.3)
  • Skin(4.3)
  • Spleen(2.4)
  • Intestine(2.1)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with TNFRSF6B: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFRSF6B Gene

Orthologs for TNFRSF6B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF6B Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia TNFRSF6B 29 30
  • 82.57 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TNFRSF6B 29 30
  • 81.65 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TNFRSF6B 30
  • 46 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TNFRSF6B 29 30
  • 63.52 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TNFRSF6B 30
  • 54 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii tnfrsf11b 30
  • 25 (a)
OneToMany
Species where no ortholog for TNFRSF6B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TNFRSF6B Gene

ENSEMBL:
Gene Tree for TNFRSF6B (if available)
TreeFam:
Gene Tree for TNFRSF6B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TNFRSF6B: view image
Alliance of Genome Resources:
Additional Orthologs for TNFRSF6B

Paralogs for TNFRSF6B Gene

(2) SIMAP similar genes for TNFRSF6B Gene using alignment to 4 proteins:

  • TNF6B_HUMAN
  • L8EBB6_HUMAN
  • Q6EMV3_HUMAN
  • Q6EMV4_HUMAN
genes like me logo Genes that share paralogs with TNFRSF6B: view

Variants for TNFRSF6B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TNFRSF6B Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
1007122 Uncertain Significance: not provided 63,697,129(+) C/T
NM_003823.4(TNFRSF6B):c.362C>T (p.Ala121Val)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
1014937 Uncertain Significance: not provided 63,697,041(+) A/G
NM_003823.4(TNFRSF6B):c.274A>G (p.Asn92Asp)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
1017427 Uncertain Significance: not provided 63,696,994(+) G/A
NM_003823.4(TNFRSF6B):c.227G>A (p.Arg76His)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
1022344 Uncertain Significance: not provided 63,698,435(+) C/T
NM_003823.4(TNFRSF6B):c.775C>T (p.Arg259Trp)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
1023389 Uncertain Significance: not provided 63,697,423(+) T/C
NM_003823.4(TNFRSF6B):c.520T>C (p.Cys174Arg)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TNFRSF6B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF6B Gene

Variant ID Type Subtype PubMed ID
dgv7676n54 CNV loss 21841781
esv2758806 CNV gain+loss 17122850
nsv1160690 CNV deletion 26073780
nsv428381 CNV gain+loss 18775914
nsv470563 CNV loss 18288195
nsv586611 CNV loss 21841781
nsv953308 CNV deletion 24416366

Variation tolerance for TNFRSF6B Gene

Residual Variation Intolerance Score: 80.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNFRSF6B Gene

Human Gene Mutation Database (HGMD)
TNFRSF6B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNFRSF6B
Leiden Open Variation Database (LOVD)
TNFRSF6B

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFRSF6B Gene

Disorders for TNFRSF6B Gene

MalaCards: The human disease database

(11) MalaCards diseases for TNFRSF6B Gene - From: COP and GCD

Disorder Aliases PubMed IDs
dyskeratosis congenita, autosomal recessive 5
  • dkcb5
crescentic glomerulonephritis
  • idiopathic crescentic glomerulonephritis
dyskeratosis congenita autosomal recessive
  • autosomal recessive dyskeratosis congenita
silicosis
  • pneumoconiosis due to silicates
pancreatic cancer
  • pancreatic carcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TNFRSF6B

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TNFRSF6B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNFRSF6B Gene

Publications for TNFRSF6B Gene

  1. A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis. (PMID: 10318773) Yu KY … Kwon BS (The Journal of biological chemistry 1999) 2 3 4 22
  2. Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer. (PMID: 9872321) Pitti RM … Ashkenazi A (Nature 1998) 2 3 4 22
  3. Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease. (PMID: 18758464) Kugathasan S … Hakonarson H (Nature genetics 2008) 3 22 40
  4. Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster. (PMID: 10655513) Bai C … Caskey CT (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 4 22
  5. Decoy strategies: the structure of TL1A:DcR3 complex. (PMID: 21300286) Zhan C … Almo SC (Structure (London, England : 1993) 2011) 3 4

Products for TNFRSF6B Gene

Sources for TNFRSF6B Gene