Aliases for TNFRSF6B Gene
External Ids for TNFRSF6B Gene
Previous GeneCards Identifiers for TNFRSF6B Gene
This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011]
GeneCards Summary for TNFRSF6B Gene
TNFRSF6B (TNF Receptor Superfamily Member 6b) is a Protein Coding gene. Diseases associated with TNFRSF6B include Dyskeratosis Congenita, Autosomal Recessive 5 and Crescentic Glomerulonephritis. Among its related pathways are Apoptosis and survival Caspase cascade and TNFR1 Pathway. An important paralog of this gene is TNFRSF11B.
UniProtKB/Swiss-Prot Summary for TNFRSF6B Gene
Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.