Aliases for TNFRSF4 Gene
External Ids for TNFRSF4 Gene
Previous HGNC Symbols for TNFRSF4 Gene
Previous GeneCards Identifiers for TNFRSF4 Gene
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]
GeneCards Summary for TNFRSF4 Gene
TNFRSF4 (TNF Receptor Superfamily Member 4) is a Protein Coding gene. Diseases associated with TNFRSF4 include Immunodeficiency 16 and Acute Graft Versus Host Disease. Among its related pathways are TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions and Akt Signaling. Gene Ontology (GO) annotations related to this gene include tumor necrosis factor-activated receptor activity. An important paralog of this gene is TNFRSF1B.