Aliases for TNFRSF1B Gene
External Ids for TNFRSF1B Gene
Previous HGNC Symbols for TNFRSF1B Gene
Previous GeneCards Identifiers for TNFRSF1B Gene
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]
GeneCards Summary for TNFRSF1B Gene
TNFRSF1B (TNF Receptor Superfamily Member 1B) is a Protein Coding gene. Diseases associated with TNFRSF1B include Mycosis Fungoides and Sezary's Disease. Among its related pathways are Apoptosis Modulation and Signaling and NF-KappaB Family Pathway. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and tumor necrosis factor-activated receptor activity. An important paralog of this gene is TNFRSF11A.
UniProtKB/Swiss-Prot Summary for TNFRSF1B Gene
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.