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This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation,... See more...
Aliases for TNFRSF1A Gene
Aliases for TNFRSF1A Gene
- P60 3 4
- Tumor Necrosis Factor Receptor Superfamily, Member 1A 2
- Tumor Necrosis Factor Receptor 1A Isoform Beta 3
- Tumor Necrosis Factor Binding Protein 1 3
- Tumor Necrosis Factor Receptor Type 1 3
- Tumor Necrosis Factor Receptor Type I 4
- Tumor Necrosis Factor-Alpha Receptor 3
- Tumor Necrosis Factor Receptor 1 4
- CD120a Antigen 4
- TNFRSF1A 5
- TNFR55 3
- P55-R 3
- TBP1 3
- FPF 3
External Ids for TNFRSF1A Gene
- HGNC: 11916
- Entrez Gene: 7132
- Ensembl: ENSG00000067182
- OMIM: 191190
- UniProtKB: P19438
Previous HGNC Symbols for TNFRSF1A Gene
- TNFR1
Previous GeneCards Identifiers for TNFRSF1A Gene
- GC12M006292
- GC12M006412
- GC12M006308
Summaries for TNFRSF1A Gene
-
This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mutations in this gene underlie tumor necrosis factor receptor-associated periodic syndrome (TRAPS), characterized by fever, abdominal pain and other features. Mutations in this gene may also be associated with multiple sclerosis in human patients. [provided by RefSeq, Sep 2016]
GeneCards Summary for TNFRSF1A Gene
TNFRSF1A (TNF Receptor Superfamily Member 1A) is a Protein Coding gene. Diseases associated with TNFRSF1A include Periodic Fever, Familial, Autosomal Dominant and Multiple Sclerosis 5. Among its related pathways are Apoptosis Modulation and Signaling and Signal transduction_JNK pathway. Gene Ontology (GO) annotations related to this gene include tumor necrosis factor-activated receptor activity. An important paralog of this gene is TNFRSF25.
UniProtKB/Swiss-Prot Summary for TNFRSF1A Gene
-
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
Additional gene information for TNFRSF1A Gene
- HGNC(11916)
- Entrez Gene(7132)
- Ensembl(ENSG00000067182)
- OMIM(191190)
- UniProtKB(P19438)
- Open Targets Platform(ENSG00000067182)
- Monarch Initiative
- Search for TNFRSF1A at DataMed
- Search for TNFRSF1A at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TNFRSF1A Gene
Genomics for TNFRSF1A Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TNFRSF1A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TNFRSF1A on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TNFRSF1A
- Top Transcription factor binding sites by QIAGEN in the TNFRSF1A gene promoter:
-
- AP-1
- CREB
- deltaCREB
- STAT1
- STAT1alpha
- STAT1beta
- STAT3
- STAT5A
Genomic Locations for TNFRSF1A Gene
Genomic Locations for TNFRSF1A Gene
- chr12:6,328,757-6,342,114
- (GRCh38/hg38)
- Size:
- 13,358 bases
- Orientation:
- Minus strand
- chr12:6,437,923-6,451,283
- (GRCh37/hg19)
- Size:
- 13,361 bases
- Orientation:
- Minus strand
Genomic View for TNFRSF1A Gene
Genes around TNFRSF1A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p13.31 by HGNC
- 12p13.31 by Entrez Gene
- 12p13.31 by Ensembl
TNFRSF1A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TNFRSF1A Gene
Proteins for TNFRSF1A Gene
-
Protein details for TNFRSF1A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P19438-TNR1A_HUMAN
- Recommended name:
- Tumor necrosis factor receptor superfamily member 1A
- Protein Accession:
- P19438
- A8K4X3
- B2RDE4
- B3KPQ1
- B4DQB7
- B4E309
- B5M0B5
- D3DUR1
- Q9UCA4
Protein attributes for TNFRSF1A Gene
- Size:
- 455 amino acids
- Molecular mass:
- 50495 Da
- Quaternary structure:
-
- Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4, BABAM2, FEM1B, GRB2, SQSTM1 and TRPC4AP (PubMed:10356400, PubMed:10359574, PubMed:10542291, PubMed:15465831, PubMed:8387891, PubMed:9915703). Interacts directly with NOL3 (via CARD domain); inhibits TNF-signaling pathway (By similarity). Interacts with SH3RF2, TRADD and RIPK1. SH3RF2 facilitates the recruitment of RIPK1 and TRADD to TNFRSF1A in a TNF-alpha-dependent process (PubMed:24130170).
- (Microbial infection) Interacts with mumps virus protein SH; this interaction inhibits downstream NF-kappa-B pathway activation.
- (Microbial infection) Interacts with HCV core protein.
- (Microbial infection) Interacts with human cytomegalovirus/HHV-5 protein UL138.
- (Microbial infection) Interacts with host TNFRSF1A; this interaction leads to the stimulation of both surface expression and shedding of TNFRSF1A.
- Miscellaneous:
-
- [Isoform 4]: Disease-associated isoform. Isoform 4 splicing pattern is driven by a variation in the exon 6/intron 6 boundary region that alters exon 6 splicing. Exon 6 skipping introduces a frameshift and the translation of a protein lacking the intracellular, the transmembrane and part of the extracellular domain.
Three dimensional structures from OCA and Proteopedia for TNFRSF1A Gene
Protein Expression for TNFRSF1A Gene
Post-translational modifications for TNFRSF1A Gene
- The soluble form is produced from the membrane form by proteolytic processing.
-
Glycosylation at Asn145, Asn151, and Asn54
- NX_P19438 (NX_P19438-1)
- Modification sites at PhosphoSitePlus
Other Protein References for TNFRSF1A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ TNF-R1 Antibody and Immunotag™ TNFR1 Antibody
- NSJ Bioreagents TNFR1 Antibody
- Creative Diagnostics Anti-TNF Receptor I polyclonal antibody
-
Creative Biolabs
- Recombinant Anti-human TNFRSF1A VHH Single Domain Antibody
- Anti-Human TNFRSF1A Therapeutic Antibody Fab Fragment (H398)
- Recombinant Camel Anti-TNFRSF1A Single Domain Antibody (DOM1h-574-188)
- Hi-Affi™ Recombinant Rabbit Anti-TNFRSF1A Monoclonal Antibody (DS3613AB)
- Recombinant Mouse Anti-TNFRSF1A Antibody (CBL948)
- Mouse Anti-TNFRSF1A Recombinant Antibody (MABTNFR1-A1)
- Mouse Anti-TNFRSF1A Recombinant Antibody (CBYJT-3797)
- Mouse Anti-TNFRSF1A Recombinant Antibody (CBYJT-3803)
- Recombinant Humanized Anti-TNFRSF1A Antibody scFv Fragment (L4h4)
-
Custom Antibody ServicesOriGene Antibodies for TNFRSF1A
- AM26301BT-N
- AM26312FC-N
- AM26312PU-N
- AM32020BT-N
- AM32020PU-N
- AP00043PU-N
- AP06465PU-N
- AP08528PU-N
- AP12726PU-N
- AP23346PU-N
- AP26365PU-N
- AP26379PU-N
- AP33326SU-N
- AP33326SU-S
- AP33393PU-N
- AP54307PU-N
- AP54311PU-N
- BM4053
- BM4053B
- BM4053X
- CL044F
- CL044PS
- CL044R
- CL044R1
- CL044RT
- PP1085B1
- PP1085B2
- PP1085P1
- PP1085P2
- R1137
- R1137P
- SM1185AF
- SM1185B
- SM1185F
- SM1185LE
- SM1185P
- SM1185R
- TA311173
- TA311833
- TA326458
- TA327070
- TA328457
- TA328458
- TA330321
- TA600021
- TA700021
- Novus Biologicals Antibodies for TNFRSF1A
-
Abcam antibodies for TNFRSF1A
- Invitrogen Antibodies for TNFRSF1A (AFLGC-Tnfrsf1a)
- antibodies-online: "Show 1523 available Tumor Necrosis Factor Soluble Receptor I,TNFsR I Antibodies ranked by validation data"
- "Compare Top Tumor Necrosis Factor Soluble Receptor I,TNFsR I Antibodies"
-
Recommended
- 249 WB Antibodies (anti-human)
- 38 FACS Antibodies (anti-human)
- 23 IHC (p) Antibodies (anti-human)
- 13 IP Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 8 IHC Antibodies (anti-human)
- 4 IHC (fro) Antibodies (anti-human)
- 3 Neut Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 145 WB Antibodies (anti-mouse)
- 21 FACS Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 8 IHC Antibodies (anti-mouse)
- 8 IP Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 1 ICFC Antibody (anti-mouse)
- 111 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 5 IHC Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for TNFRSF1A
- Sino Biological Antibodies for TNFRSF1A
Protein Products
-
BioLegend
- Recombinant Human sTNF-RII (TNFRSF1B) (carrier-free) (591602)
- Recombinant Human sTNF-RII (TNFRSF1B) (carrier-free) (591606)
- Recombinant Human sTNF-RI (TNFRSF1A) (carrier-free) (591504)
- Recombinant Human sTNF-RII (TNFRSF1B) (carrier-free) (591604)
- Recombinant Human sTNF-RI (TNFRSF1A) (carrier-free) (591502)
- Recombinant Human sTNF-RII (TNFRSF1B) (carrier-free) (591608)
- Recombinant Human sTNF-RI (TNFRSF1A) (carrier-free) (591508)
- Recombinant Human sTNF-RI (TNFRSF1A) (carrier-free) (591506)
- Search Origene for MassSpec and Protein Over-expression Lysates for TNFRSF1A
- Origene Custom Protein Services for TNFRSF1A
- Sino Biological Cell Lysates for TNFRSF1A
- Sino Biological Recombinant Proteins for TNFRSF1A
- ProSpec Recombinant Proteins for TNFRSF1A
-
ProSci Proteins for TNFRSF1A
- tumor necrosis factor receptor superfamily, member 1A [40-299]
- tumor necrosis factor receptor superfamily, member 1a [92-179]
- tumor necrosis factor receptor superfamily, member 1A [96-727]
- tumor necrosis factor receptor superfamily, member 1A [96-729]
- tumor necrosis factor receptor superfamily member 1A [91-574]
- tumor necrosis factor receptor superfamily member 1A [92-693]
- tumor necrosis factor receptor superfamily, member 1A [90-260]
-
Abcam proteins for TNFRSF1A
Assay Products
- RayBiotech Human sTNFRI ELISA
- Novus Biologicals ELISA Kits for TNFRSF1A
- antibodies-online: "Show 81 available Tumor Necrosis Factor Soluble Receptor I,TNFsR I Elisa Kits ranked by validation data"
- "Compare Top Tumor Necrosis Factor Soluble Receptor I,TNFsR I Elisa Kits"
-
Quality Products:
- ABIN625089
- ABIN1117662
- ABIN2691150
- ABIN417656
- ABIN1117193
- ABIN3198617
- ABIN5520097
- ABIN2708115
- ABIN2685722
- ABIN456707
- ABIN1567756
- ABIN5499339
- ABIN625426
- ABIN424877
- ABIN2859279
- ABIN5520099
- ABIN6719840
- ABIN5669722
- ABIN6384326
- ABIN5659669
- ABIN1117676
- ABIN1572805
- ABIN2703513
- ABIN5520100
- ABIN5670386
- ABIN432159
- ABIN6384327
- ABIN5659671
- ABIN4973400
- ABIN2540117
- ABIN1567759
- ABIN6202426
-
Abcam assays for TNFRSF1A
- Sino Biological Assays for TNFRSF1A
No data available for DME Specific Peptides for TNFRSF1A Gene
Domains & Families for TNFRSF1A Gene
Gene Families for TNFRSF1A Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Candidate cardiovascular disease genes
- CD markers
- Disease related genes
- FDA approved drug targets
- Plasma proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for TNFRSF1A Gene
- InterPro:
- Blocks:
-
- TNFR/CD27/30/40/95 cysteine-rich region
- Death domain
- ProtoNet:
Suggested Antigen Peptide Sequences for TNFRSF1A Gene
- GenScript: Design optimal peptide antigens:
-
- Tumor necrosis factor receptor superfamily member 1A (Q6Y4Q7_HUMAN)
- p60 (TNR1A_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P19438UniProtKB/Swiss-Prot:
TNR1A_HUMAN :- The domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE.
- Domain:
-
- The domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE.
- Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP.
Function for TNFRSF1A Gene
Molecular function for TNFRSF1A Gene
- UniProtKB/Swiss-Prot Function:
- Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
- GENATLAS Biochemistry:
- tumor necrosis factor receptor superfamily,member 1A,involved at least in two independent pathways,acidic sphingomyelinase controlling expression of multiple TNF-responsive genes,including the apoptotic pathway,neutral sphingomyelinase critical for the inflammatory and proliferative responses induced by TNF
Phenotypes From GWAS Catalog for TNFRSF1A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005031 | tumor necrosis factor-activated receptor activity | IEA,TAS | 2158863 |
| GO:0005515 | protein binding | IEA,IPI | 1087798 |
| GO:0043120 | tumor necrosis factor binding | IPI | 9435233 |
Phenotypes for TNFRSF1A Gene
- MGI mutant phenotypes for TNFRSF1A:
-
inferred from 11 alleles
- nervous system phenotype
- immune system phenotype
- respiratory system phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- liver/biliary system phenotype
- renal/urinary system phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- limbs/digits/tail phenotype
- skeleton phenotype
- hematopoietic system phenotype
- integument phenotype
- embryo phenotype
- craniofacial phenotype
- adipose tissue phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for TNFRSF1A:
-
- no effect
- Decreased viability
- Decreased vaccinia virus (VACV) infection
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased viability with MLN4924 (a NAE inhibitor)
- Mitotic spindle defects
- Lamellipodia and high actin ratio cells
- Increased TP53 protein expression ratio (wild-type / TP53 knockout cells)
Animal Models for TNFRSF1A Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TNFRSF1A - Select products 50% OFF >
- * TNFRSF1A CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TNFRSF1A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TNFRSF1A
-
Santa Cruz Biotechnology (SCBT) CRISPR for TNFRSF1A
miRNA for TNFRSF1A Gene
- miRTarBase miRNAs that target TNFRSF1A
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TNFRSF1A
- Browse OriGene Inhibitory RNA Products For TNFRSF1A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNFRSF1A
Clone Products
- Applied Biological Materials (abm): Clones for TNFRSF1A - Select products 50% OFF >
- * TNFRSF1A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for TNFRSF1A
- Addgene plasmids for TNFRSF1A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TNFRSF1A
Cell Line Products
-
Horizon Cell Lines for TNFRSF1A
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TNFRSF1A Gene
Localization for TNFRSF1A Gene
Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF1A Gene
- Cell membrane. Single-pass type I membrane protein. Golgi apparatus membrane. Single-pass type I membrane protein. Secreted. Note=A secreted form is produced through proteolytic processing.
- [Isoform 4]: Secreted. Note=Lacks a Golgi-retention motif, is not membrane bound and therefore is secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| golgi apparatus | 5 |
| mitochondrion | 4 |
| nucleus | 3 |
| endoplasmic reticulum | 3 |
| cytosol | 3 |
| cytoskeleton | 2 |
| peroxisome | 2 |
| endosome | 2 |
| lysosome | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA,IDA | 22801493 |
| GO:0002947 | tumor necrosis factor receptor superfamily complex | TAS | 24966471 |
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IDA | 13130484 |
| GO:0005739 | mitochondrion | IBA | 21873635 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for TNFRSF1A Gene
Pathways & Interactions for TNFRSF1A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | TNFR1 Pathway |
TNFR1 Pathway
.56
TNF Signaling
.55
Apoptosis and survival TNFR1 signaling pathway
.52
|
Apoptotic Pathways Triggered By HIV1
.42
Apoptosis through Death Receptors
.42
|
| 2 | TNF signaling |
.86
|
|
| 3 | Apoptosis Modulation and Signaling |
.41
|
Apoptosis and survival Apoptotic TNF-family pathways
.35
.31
|
| 4 | PEDF Induced Signaling |
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
|
Glucocorticoid Receptor Signaling
.43
|
| 5 | TGF-Beta Pathway |
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
|
JAK-STAT Pathway
.57
JNK Pathway
.51
|
Pathways by source for TNFRSF1A Gene
2 Sino Biological pathways for TNFRSF1A Gene
18 BioSystems pathways for TNFRSF1A Gene
13 Reactome pathways for TNFRSF1A Gene
31 KEGG pathways for TNFRSF1A Gene
9 GeneGo (Thomson Reuters) pathways for TNFRSF1A Gene
- Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
- Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
- Apoptosis and survival Apoptotic TNF-family pathways
- Apoptosis and survival Caspase cascade
- Apoptosis and survival TNFR1 signaling pathway
4 R&D Systems pathways for TNFRSF1A Gene
40 Qiagen pathways for TNFRSF1A Gene
- 14-3-3 and Regulation of BAD Activity
- 14-3-3 Induced Apoptosis
- 14-3-3 Induced Intracellular Signaling
- Akt Signaling
- Antioxidant Action of Vitamin-C
2 Cell Signaling Technology pathways for TNFRSF1A Gene
Interacting Proteins for TNFRSF1A Gene
Selected Interacting proteins:
P19438-TNR1A_HUMAN
ENSP00000162749
for TNFRSF1A Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for TNFRSF1A
SIGNOR curated interactions for TNFRSF1A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003176 | aortic valve development | ISS | -- |
| GO:0003177 | pulmonary valve development | ISS | -- |
| GO:0003332 | negative regulation of extracellular matrix constituent secretion | ISS | -- |
| GO:0006693 | prostaglandin metabolic process | IEA | -- |
| GO:0006915 | apoptotic process | IEA | -- |
Drugs & Compounds for TNFRSF1A Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Etanercept | Approved, Investigational | Pharma | 454 | |||
| Infliximab | Approved | Pharma | 469 | |||
| Tasonermin | Approved | Pharma | Target, agonist | 0 | ||
| Adalimumab | Approved | Pharma | 602 | |||
| 6-[3-(4-Morpholinyl)Propyl]-2-(3-Nitrophenyl)-5-Thioxo-5,6,-Dihydro-7h-Thienol[2',3':4,5]Pyrrolo[1,2-C]Imidazol-7-One | Experimental | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
-
BioLegend
- Recombinant Human sTNF-RII (TNFRSF1B) (carrier-free) (591602)
- Recombinant Human sTNF-RII (TNFRSF1B) (carrier-free) (591606)
- Recombinant Human sTNF-RI (TNFRSF1A) (carrier-free) (591504)
- Recombinant Human sTNF-RII (TNFRSF1B) (carrier-free) (591604)
- Recombinant Human sTNF-RI (TNFRSF1A) (carrier-free) (591502)
- Recombinant Human sTNF-RII (TNFRSF1B) (carrier-free) (591608)
- Recombinant Human sTNF-RI (TNFRSF1A) (carrier-free) (591508)
- Recombinant Human sTNF-RI (TNFRSF1A) (carrier-free) (591506)
Transcripts for TNFRSF1A Gene
mRNA/cDNA for TNFRSF1A Gene
- 3 REFSEQ mRNAs :
- 19 NCBI additional mRNA sequence :
- 16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000162749 2171 nts (view in UCSC)
- ENST00000366159 1339 nts (view in UCSC)
- ENST00000437813 634 nts (view in UCSC)
- ENST00000440083 1034 nts (view in UCSC)
- ENST00000534885 2069 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TNFRSF1A - Select products 50% OFF >
- * TNFRSF1A CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TNFRSF1A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TNFRSF1A
-
Santa Cruz Biotechnology (SCBT) CRISPR for TNFRSF1A
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TNFRSF1A
- Browse OriGene Inhibitory RNA Products For TNFRSF1A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNFRSF1A
Clone Products
- Applied Biological Materials (abm): Clones for TNFRSF1A - Select products 50% OFF >
- * TNFRSF1A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for TNFRSF1A
- Addgene plasmids for TNFRSF1A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TNFRSF1A
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: |
| ExUns: | 12 | ^ | 13 | ^ | 14 |
|---|---|---|---|---|---|
| SP1: | |||||
| SP2: | |||||
| SP3: | |||||
| SP4: | |||||
| SP5: | |||||
| SP6: | |||||
| SP7: | |||||
| SP8: | |||||
| SP9: | |||||
| SP10: | |||||
| SP11: | |||||
| SP12: |
Relevant External Links for TNFRSF1A Gene
- GeneLoc Exon Structure for
- TNFRSF1A
Expression for TNFRSF1A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
-
Neural Tube (Nervous System)
- Adult Oligodendrocyte Precursor Cells Cortical Sub Ventricular Zone
-
Brain (Nervous System)
- Adult Oligodendrocyte Precursor Cells Cortical Sub Ventricular Zone
- Intestine (Gastrointestinal Tract)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for TNFRSF1A Gene
This gene is overexpressed in Whole Blood (x6.3).
This gene is overexpressed in Pancreatic juice (51.7), Platelet (9.7), and Fetal heart (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TNFRSF1A Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TNFRSF1A
SOURCE GeneReport for Unigene cluster for TNFRSF1A Gene:
Hs.279594Evidence on tissue expression from TISSUES for TNFRSF1A Gene
- Nervous system(4.9)
- Blood(4.9)
- Muscle(4.6)
- Intestine(4.5)
- Lung(4.5)
- Urine(4.4)
- Spleen(4.3)
- Kidney(4.3)
- Skin(4.1)
- Liver(3.8)
- Lymph node(3.4)
- Heart(3.4)
- Bone marrow(3.3)
- Stomach(2.9)
- Adrenal gland(2.9)
- Pancreas(2.7)
- Thyroid gland(2.7)
- Gall bladder(2.5)
- Bone(2.5)
- Eye(2.4)
Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFRSF1A Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- lymphatic
- nervous
- reproductive
- respiratory
- skeletal muscle
- skeleton
- urinary
Regions:
Head and neck:
- brain
- ear
- eye
- head
Thorax:
- chest wall
- esophagus
- heart
- heart valve
Abdomen:
- intestine
- kidney
- large intestine
- liver
- small intestine
- stomach
Pelvis:
- rectum
- testicle
Limb:
- ankle
- digit
- elbow
- finger
- foot
- hand
- hip
- knee
- lower limb
- shoulder
- toe
- upper limb
- wrist
General:
- blood
- blood vessel
- lymph node
- lymph vessel
- peripheral nerve
- peripheral nervous system
- red blood cell
- skin
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for TNFRSF1A
-
OriGene qPCR primer pairs and template standards for TNFRSF1A
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt for TNFRSF1A Gene
Orthologs for TNFRSF1A Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TNFRSF1A 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | TNFRSF1A 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | TNFRSF1A 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Tnfrsf1a 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Tnfrsf1a 30 17 31 |
|
OneToOne |