Aliases for TNFRSF1A Gene
Aliases for TNFRSF1A Gene
- TNF Receptor Superfamily Member 1A 2 3 5
- TNF-R1 3 4
- TNF-RI 3 4
- TNFR-I 3 4
- TNFR1 3 4
- TNFAR 3 4
- P55 3 4
- P60 3 4
- Tumor Necrosis Factor Receptor Superfamily, Member 1A 2
- Tumor Necrosis Factor Receptor Superfamily Member 1A 3
- Tumor Necrosis Factor Receptor 1A Isoform Beta 3
- Tumor Necrosis Factor Binding Protein 1 3
- Tumor Necrosis Factor Receptor Type 1 3
- Tumor Necrosis Factor Receptor Type I 4
External Ids for TNFRSF1A Gene
- HGNC: 11916
- Entrez Gene: 7132
- Ensembl: ENSG00000067182
- OMIM: 191190
- UniProtKB: P19438
Previous HGNC Symbols for TNFRSF1A Gene
- TNFR1
Previous GeneCards Identifiers for TNFRSF1A Gene
- GC12M006292
- GC12M006412
Summaries for TNFRSF1A Gene
-
This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mutations in this gene underlie tumor necrosis factor receptor-associated periodic syndrome (TRAPS), characterized by fever, abdominal pain and other features. Mutations in this gene may also be associated with multiple sclerosis in human patients. [provided by RefSeq, Sep 2016]
GeneCards Summary for TNFRSF1A Gene
TNFRSF1A (TNF Receptor Superfamily Member 1A) is a Protein Coding gene. Diseases associated with TNFRSF1A include Periodic Fever, Familial, Autosomal Dominant and Multiple Sclerosis 5. Among its related pathways are ERK Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include tumor necrosis factor-activated receptor activity. An important paralog of this gene is TNFRSF25.
UniProtKB/Swiss-Prot for TNFRSF1A Gene
-
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
Additional gene information for TNFRSF1A Gene
- Monarch Initiative
- Search for TNFRSF1A at DataMed
- Search for TNFRSF1A at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF1A Gene
Genomics for TNFRSF1A Gene
GeneHancer (GH) Regulatory Elements for TNFRSF1A Gene
Promoters and enhancers for TNFRSF1A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around TNFRSF1A on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the TNFRSF1A gene promoter:
-
- AP-1
- STAT3
- STAT1
- deltaCREB
- CREB
- STAT5A
- STAT1beta
- STAT1alpha
Regulatory Element Products
Genomic Locations for TNFRSF1A Gene
Genomic Locations for TNFRSF1A Gene
- chr12:6,328,757-6,342,117
- (GRCh38/hg38)
- Size:
- 13,361 bases
- Orientation:
- Minus strand
- chr12:6,437,923-6,451,283
- (GRCh37/hg19)
- Size:
- 13,361 bases
- Orientation:
- Minus strand
Genomic View for TNFRSF1A Gene
Genes around TNFRSF1A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p13.31 by Entrez Gene
- 12p13.31 by HGNC
- 12p13.31 by Ensembl
TNFRSF1A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TNFRSF1A Gene
Proteins for TNFRSF1A Gene
-
Protein details for TNFRSF1A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P19438-TNR1A_HUMAN
- Recommended name:
- Tumor necrosis factor receptor superfamily member 1A
- Protein Accession:
- P19438
- A8K4X3
- B2RDE4
- B3KPQ1
- B4DQB7
- B4E309
- B5M0B5
- D3DUR1
- Q9UCA4
Protein attributes for TNFRSF1A Gene
- Size:
- 455 amino acids
- Molecular mass:
- 50495 Da
- Quaternary structure:
-
- Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4, BABAM2, FEM1B, GRB2, SQSTM1 and TRPC4AP. Interacts directly with NOL3 (via CARD domain); inhibits TNF-signaling pathway (By similarity).
- (Microbial infection) Interacts with mumps virus protein SH; this interaction inhibits downstream NF-kappa-B pathway activation (PubMed:28659487). Interacts with HCV core protein. Interacts with human cytomegalovirus/HHV-5 protein UL138 (PubMed:21976655).
Three dimensional structures from OCA and Proteopedia for TNFRSF1A Gene
Protein Expression for TNFRSF1A Gene
Post-translational modifications for TNFRSF1A Gene
- The soluble form is produced from the membrane form by proteolytic processing.
- Glycosylation at posLast=151151, isoforms=2, 4, 5145, and isoforms=4, 554
- Modification sites at PhosphoSitePlus
Other Protein References for TNFRSF1A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for TNFRSF1A (TNF RI/TNFRSF1A)
-
Custom Antibody ServicesOriGene Antibodies for TNFRSF1A
- AM26301BT-N
- AM26301PU-N
- AM26312FC-N
- AM26312PU-N
- AM32020BT-N
- AM32020PU-N
- AP00043PU-N
- AP06465PU-N
- AP08528PU-N
- AP12726PU-N
- AP23346PU-N
- AP26365PU-N
- AP26379PU-N
- AP33326SU-N
- AP33326SU-S
- AP33393PU-N
- AP54307PU-N
- AP54311PU-N
- BM4053
- BM4053B
- BM4053X
- CL044F
- CL044PS
- CL044R
- CL044R1
- CL044RT
- PP1085B1
- PP1085B2
- PP1085P1
- PP1085P2
- R1137
- R1137P
- SM1185AF
- SM1185B
- SM1185F
- SM1185LE
- SM1185P
- SM1185R
- TA311173
- TA311833
- TA326458
- TA327070
- TA328457
- TA328458
- TA330321
- TA600021
- TA700021
- Novus Biologicals Antibodies for TNFRSF1A
-
Abcam antibodies for TNFRSF1A
- Invitrogen Antibodies for TNFRSF1A (AFLGC-TNFRSF1A)
- antibodies-online: Search results for 472 available TNFRSF1A Antibodies ranked by validation data
- Compare Top TNFRSF1A Antibodies
-
Recommended
- 249 WB Antibodies (anti-human)
- 44 FACS Antibodies (anti-human)
- 22 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 9 IP Antibodies (anti-human)
- 8 IHC Antibodies (anti-human)
- 5 Neut Antibodies (anti-human)
- 4 IHC (fro) Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 CC Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 124 WB Antibodies (anti-mouse)
- 19 FACS Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 6 IHC Antibodies (anti-mouse)
- 6 IP Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 1 CC Antibody (anti-mouse)
- 1 ICFC Antibody (anti-mouse)
- 1 Neut Antibody (anti-mouse)
- 91 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 4 IHC Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
- 249 WB Antibodies (anti-human)
- 44 FACS Antibodies (anti-human)
- 22 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 9 IP Antibodies (anti-human)
- 8 IHC Antibodies (anti-human)
- 5 Neut Antibodies (anti-human)
- 4 IHC (fro) Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 CC Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 124 WB Antibodies (anti-mouse)
- 19 FACS Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 6 IHC Antibodies (anti-mouse)
- 6 IP Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 1 CC Antibody (anti-mouse)
- 1 ICFC Antibody (anti-mouse)
- 1 Neut Antibody (anti-mouse)
- 91 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 4 IHC Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
- 249 WB Antibodies (anti-human)
- 44 FACS Antibodies (anti-human)
- 22 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 9 IP Antibodies (anti-human)
- 8 IHC Antibodies (anti-human)
- 5 Neut Antibodies (anti-human)
- 4 IHC (fro) Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 CC Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 124 WB Antibodies (anti-mouse)
- 19 FACS Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 6 IHC Antibodies (anti-mouse)
- 6 IP Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 1 CC Antibody (anti-mouse)
- 1 ICFC Antibody (anti-mouse)
- 1 Neut Antibody (anti-mouse)
- 91 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 4 IHC Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
- GeneTex TNFRSF1A Antibody for TNFRSF1A
-
Santa Cruz Biotechnology (SCBT) Antibodies for TNFRSF1A
- Sino Biological Antibodies for TNFRSF1A
Protein Products
- R&D Systems Proteins and Enzymes for TNFRSF1A (TNF RI/TNFRSF1A)
-
OriGene Purified Proteins for TNFRSF1A
- Search Origene for MassSpec and Protein Over-expression Lysates for TNFRSF1A
- Origene Custom Protein Services for TNFRSF1A
- Sino Biological Recombinant Proteins for TNFRSF1A
- Sino Biological Cell Lysates for TNFRSF1A
- ProSpec Recombinant Proteins for TNFRSF1A
- GeneTex Proteins for TNFRSF1A
-
ProSci Proteins for TNFRSF1A
- tumor necrosis factor receptor superfamily, member 1A [96-727]
- tumor necrosis factor receptor superfamily, member 1A [96-729]
- tumor necrosis factor receptor superfamily, member 1A [90-260]
- tumor necrosis factor receptor superfamily member 1A [91-574]
- tumor necrosis factor receptor superfamily, member 1a [92-179]
- tumor necrosis factor receptor superfamily member 1A [92-693]
- tumor necrosis factor receptor superfamily, member 1A [40-299]
-
Abcam proteins for TNFRSF1A
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for TNFRSF1A
- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for TNFRSF1A (TNF RI/TNFRSF1A)
- Novus Biologicals ELISA Kits for TNFRSF1A
- antibodies-online: Search results for 59 available TNFRSF1A Elisa Kits ranked by validation data
- Compare Top TNFRSF1A Elisa Kits
-
Recommended
- 2 Chicken ELISA Kits
- 3 Cow (Bovine) ELISA Kits
- 1 Guinea Pig ELISA Kit
- 20 Human ELISA Kits
- 5 Monkey ELISA Kits
- 12 Mouse (Murine) ELISA Kits
- 4 Pig (Porcine) ELISA Kits
- 1 Rabbit ELISA Kit
- 10 Rat (Rattus) ELISA Kits
- 1 Sheep (Ovine) ELISA Kit
- 2 Chicken ELISA Kits
- 3 Cow (Bovine) ELISA Kits
- 1 Guinea Pig ELISA Kit
- 20 Human ELISA Kits
- 5 Monkey ELISA Kits
- 12 Mouse (Murine) ELISA Kits
- 4 Pig (Porcine) ELISA Kits
- 1 Rabbit ELISA Kit
- 10 Rat (Rattus) ELISA Kits
- 1 Sheep (Ovine) ELISA Kit
- 2 Chicken ELISA Kits
- 3 Cow (Bovine) ELISA Kits
- 1 Guinea Pig ELISA Kit
- 20 Human ELISA Kits
- 5 Monkey ELISA Kits
- 12 Mouse (Murine) ELISA Kits
- 4 Pig (Porcine) ELISA Kits
- 1 Rabbit ELISA Kit
- 10 Rat (Rattus) ELISA Kits
- 1 Sheep (Ovine) ELISA Kit
-
Abcam assays for TNFRSF1A
- Sino Biological Assays for TNFRSF1A
No data available for DME Specific Peptides for TNFRSF1A Gene
Domains & Families for TNFRSF1A Gene
Gene Families for TNFRSF1A Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Candidate cardiovascular disease genes
- CD markers
- Disease related genes
- Plasma proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for TNFRSF1A Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TNFRSF1A Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P19438UniProtKB/Swiss-Prot:
TNR1A_HUMAN :- The domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE.
- Domain:
-
- The domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE.
- Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP.
Function for TNFRSF1A Gene
Molecular function for TNFRSF1A Gene
- UniProtKB/Swiss-Prot Function:
- Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
- GENATLAS Biochemistry:
- tumor necrosis factor receptor superfamily,member 1A,involved at least in two independent pathways,acidic sphingomyelinase controlling expression of multiple TNF-responsive genes,including the apoptotic pathway,neutral sphingomyelinase critical for the inflammatory and proliferative responses induced by TNF
Phenotypes From GWAS Catalog for TNFRSF1A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005031 | tumor necrosis factor-activated receptor activity | TAS,IEA | 2158863 |
| GO:0005515 | protein binding | IEA,IPI | 1087798 |
| GO:0042802 | identical protein binding | IPI | 7758105 |
| GO:0043120 | tumor necrosis factor binding | IBA | -- |
Phenotypes for TNFRSF1A Gene
- MGI mutant phenotypes for TNFRSF1A:
-
inferred from 10 alleles
- cardiovascular system phenotype
- respiratory system phenotype
- limbs/digits/tail phenotype
- vision/eye phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- behavior/neurological phenotype
- no phenotypic analysis
- neoplasm
- integument phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- muscle phenotype
- craniofacial phenotype
- liver/biliary system phenotype
- reproductive system phenotype
- skeleton phenotype
- embryo phenotype
- renal/urinary system phenotype
- adipose tissue phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for TNFRSF1A:
-
- Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Mitotic spindle defects
- Increased viability
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Lamellipodia cells
Animal Models for TNFRSF1A Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TNFRSF1A
-
CRISPR Products
-
OriGene CRISPR knockouts for TNFRSF1A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TNFRSF1A
- genomics-online: gRNA clones - Search results for 145 available TNFRSF1A gene related products
- Overview of 145 available TNFRSF1A gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-AC
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-XL5
- pCMV6-AC
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-XL5
- pCMV6-AC
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- Applied Biological Materials CRISPR for TNFRSF1A
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TNFRSF1A
- GenScript: Design CRISPR guide RNA sequences for TNFRSF1A
miRNA for TNFRSF1A Gene
- miRTarBase miRNAs that target TNFRSF1A
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TNFRSF1A
- Browse OriGene Inhibitory RNA Products For TNFRSF1A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNFRSF1A
- genomics-online: shRNA clones - Search results for 145 available TNFRSF1A gene related products
- Overview of 145 available TNFRSF1A gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-AC
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-XL5
- pCMV6-AC
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-XL5
- pCMV6-AC
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
Clone Products
- Sino Biological Human cDNA Clone for TNFRSF1A
- Addgene plasmids for TNFRSF1A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TNFRSF1A
- genomics-online: cdna clones - Search results for 145 available TNFRSF1A gene related products
- Overview of 145 available TNFRSF1A gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-AC
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-XL5
- pCMV6-AC
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-XL5
- pCMV6-AC
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- orf clones - Search results for 145 available TNFRSF1A gene related products
- Overview of 145 available TNFRSF1A gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-AC
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-XL5
- pCMV6-AC
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-XL5
- pCMV6-AC
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- Applied Biological Materials Clones for TNFRSF1A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for TNFRSF1A
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TNFRSF1A Gene
Localization for TNFRSF1A Gene
Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF1A Gene
- Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Secreted. Note=A secreted form is produced through proteolytic processing.
- Isoform 4: Secreted. Note=Lacks a Golgi-retention motif, is not membrane bound and therefore is secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| mitochondrion | 5 |
| golgi apparatus | 5 |
| cytosol | 3 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| cytoskeleton | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IDA | 22801493 |
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IDA | 13130484 |
| GO:0005739 | mitochondrion | IBA | -- |
| GO:0005794 | Golgi apparatus | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for TNFRSF1A Gene
Pathways & Interactions for TNFRSF1A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | TNFR1 Pathway |
.56
.55
|
|
| 2 | TNF signaling (REACTOME) |
.86
|
|
| 3 | Apoptosis Modulation and Signaling |
.41
|
.31
|
| 4 | PEDF Induced Signaling |
.47
|
|
| 5 | TGF-Beta Pathway |
.60
|
.57
.51
|
Pathways by source for TNFRSF1A Gene
3 Sino Biological pathways for TNFRSF1A Gene
18 BioSystems pathways for TNFRSF1A Gene
13 Reactome pathways for TNFRSF1A Gene
25 KEGG pathways for TNFRSF1A Gene
9 GeneGo (Thomson Reuters) pathways for TNFRSF1A Gene
2 R&D Systems pathways for TNFRSF1A Gene
40 Qiagen pathways for TNFRSF1A Gene
2 Cell Signaling Technology pathways for TNFRSF1A Gene
Interacting Proteins for TNFRSF1A Gene
Selected Interacting proteins:
P19438-TNR1A_HUMAN
ENSP00000162749
for TNFRSF1A Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for TNFRSF1A
SIGNOR curated interactions for TNFRSF1A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006693 | prostaglandin metabolic process | IEA | -- |
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0006952 | defense response | IEA | -- |
| GO:0006954 | inflammatory response | ISS,IEA | -- |
| GO:0006955 | immune response | IBA | -- |
Drugs & Compounds for TNFRSF1A Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Etanercept | Approved, Investigational | Pharma | 413 | |||
| Infliximab | Approved | Pharma | 407 | |||
| Tasonermin | Approved | Pharma | Target, agonist | 0 | ||
| Adalimumab | Approved | Pharma | 521 | |||
| 6-[3-(4-Morpholinyl)Propyl]-2-(3-Nitrophenyl)-5-Thioxo-5,6,-Dihydro-7h-Thienol[2',3':4,5]Pyrrolo[1,2-C]Imidazol-7-One | Experimental | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| lymphotoxin-alpha |
|
|
|
Drug Products
Transcripts for TNFRSF1A Gene
mRNA/cDNA for TNFRSF1A Gene
- (3) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (368) Selected AceView cDNA sequences:
- (16) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000538363 554 bps (uc058kdg.1)
- ENST00000535958 568 bps (uc058kdf.1)
- ENST00000536194 581 bps (uc058kde.1)
- ENST00000440083 1034 bps (uc058kdd.1)
- ENST00000543048 571 bps (uc058kdc.1)
Unigene Clusters for TNFRSF1A Gene
- Tumor necrosis factor receptor superfamily, member 1A:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for TNFRSF1A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TNFRSF1A
- genomics-online: gRNA clones - Search results for 145 available TNFRSF1A gene related products
- Overview of 145 available TNFRSF1A gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-AC
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-XL5
- pCMV6-AC
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-XL5
- pCMV6-AC
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- Applied Biological Materials CRISPR for TNFRSF1A
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TNFRSF1A
- GenScript: Design CRISPR guide RNA sequences for TNFRSF1A
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TNFRSF1A
- Browse OriGene Inhibitory RNA Products For TNFRSF1A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNFRSF1A
- genomics-online: shRNA clones - Search results for 145 available TNFRSF1A gene related products
- Overview of 145 available TNFRSF1A gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-AC
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-XL5
- pCMV6-AC
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-XL5
- pCMV6-AC
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
Clone Products
- Sino Biological Human cDNA Clone for TNFRSF1A
- Addgene plasmids for TNFRSF1A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TNFRSF1A
- genomics-online: cdna clones - Search results for 145 available TNFRSF1A gene related products
- Overview of 145 available TNFRSF1A gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-AC
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-XL5
- pCMV6-AC
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-XL5
- pCMV6-AC
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- orf clones - Search results for 145 available TNFRSF1A gene related products
- Overview of 145 available TNFRSF1A gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-AC
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-XL5
- pCMV6-AC
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-XL5
- pCMV6-AC
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- Applied Biological Materials Clones for TNFRSF1A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: |
| ExUns: | 12 | ^ | 13 | ^ | 14 |
|---|---|---|---|---|---|
| SP1: | |||||
| SP2: | |||||
| SP3: | |||||
| SP4: | |||||
| SP5: | |||||
| SP6: | |||||
| SP7: | |||||
| SP8: | |||||
| SP9: | |||||
| SP10: | |||||
| SP11: | |||||
| SP12: |
Expression for TNFRSF1A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
-
Neural Tube (Nervous System)
- Adult Oligodendrocyte Precursor Cells Cortical Sub Ventricular Zone
-
Brain (Nervous System)
- Adult Oligodendrocyte Precursor Cells Cortical Sub Ventricular Zone
- Intestine (Gastrointestinal Tract)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for TNFRSF1A Gene
This gene is overexpressed in Whole Blood (x6.3).
This gene is overexpressed in Pancreatic juice (51.7), Platelet (9.7), and Fetal heart (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TNFRSF1A Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of TNFRSF1A Gene:
TNFRSF1ASOURCE GeneReport for Unigene cluster for TNFRSF1A Gene:
Hs.279594Evidence on tissue expression from TISSUES for TNFRSF1A Gene
- Blood(4.9)
- Nervous system(4.9)
- Muscle(4.5)
- Lung(4.4)
- Intestine(4.3)
- Urine(4.2)
- Spleen(4.1)
- Kidney(4)
- Skin(3.8)
- Liver(3.4)
- Heart(2.9)
- Lymph node(2.9)
- Bone marrow(2.8)
- Stomach(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFRSF1A Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- lymphatic
- nervous
- reproductive
- respiratory
- skeletal muscle
- skeleton
- urinary
Regions:
Head and neck:
- brain
- ear
- eye
- head
Thorax:
- chest wall
- esophagus
- heart
- heart valve
Abdomen:
- intestine
- kidney
- large intestine
- liver
- small intestine
- stomach
Pelvis:
- rectum
- testicle
Limb:
- ankle
- digit
- elbow
- finger
- foot
- hand
- hip
- knee
- lower limb
- shoulder
- toe
- upper limb
- wrist
General:
- blood
- blood vessel
- lymph node
- lymph vessel
- peripheral nerve
- peripheral nervous system
- red blood cell
- skin
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for TNFRSF1A
-
OriGene qPCR primer pairs and template standards for TNFRSF1A
- genomics-online: primer clones - Search results for 145 available TNFRSF1A gene related products
- Overview of 145 available TNFRSF1A gene related products
-
Recommended
- pCMV6-XL5
- pCMV6-AC
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-XL5
- pCMV6-AC
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pCMV6-XL5
- pCMV6-AC
- pCMV6-Entry
- pcDNA3.1+C-(K)-DYK
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt for TNFRSF1A Gene
Orthologs for TNFRSF1A Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TNFRSF1A 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | TNFRSF1A 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | TNFRSF1A 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Tnfrsf1a 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Tnfrsf1a 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | TNFRSF1A 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | TNFRSF1A 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TNFRSF1A 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | TNFRSF1A 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tnfrsf1a 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tnfrsf1a 34 33 |
|
OneToMany | |
| TNFRSF1A (2 of 2) 34 |
|
OneToMany |
- Species where no ortholog for TNFRSF1A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for TNFRSF1A Gene
- ENSEMBL:
- Gene Tree</