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This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mutations in this gene underlie tumor necrosis factor receptor-associated periodic syndrome (TRAPS), characterized by fever, abdominal pain and other features. Mutations in this gene may also be associated with multiple sclerosis in human patients. [provided by RefSeq, Sep 2016]
TNFRSF1A (TNF Receptor Superfamily Member 1A) is a Protein Coding gene. Diseases associated with TNFRSF1A include Periodic Fever, Familial, Autosomal Dominant and Multiple Sclerosis 5. Among its related pathways are Apoptosis Modulation and Signaling and Signal transduction_JNK pathway. Gene Ontology (GO) annotations related to this gene include tumor necrosis factor-activated receptor activity. An important paralog of this gene is TNFRSF25.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005031 | tumor necrosis factor-activated receptor activity | IEA,TAS | 2158863 |
GO:0005515 | protein binding | IEA,IPI | 1087798 |
GO:0043120 | tumor necrosis factor binding | IPI | 9435233 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000139 | Golgi membrane | IEA,IDA | 22801493 |
GO:0002947 | tumor necrosis factor receptor superfamily complex | TAS | 24966471 |
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IDA | 13130484 |
GO:0005739 | mitochondrion | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | TNFR1 Pathway |
TNFR1 Pathway
.56
TNF Signaling
.55
Apoptosis and survival TNFR1 signaling pathway
.52
|
Apoptotic Pathways Triggered By HIV1
.42
Apoptosis through Death Receptors
.42
|
2 | TNF signaling |
.86
|
|
3 | Apoptosis Modulation and Signaling |
.41
|
Apoptosis and survival Apoptotic TNF-family pathways
.35
.31
|
4 | PEDF Induced Signaling |
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
|
Glucocorticoid Receptor Signaling
.43
|
5 | TGF-Beta Pathway |
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
|
JAK-STAT Pathway
.57
JNK Pathway
.51
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003176 | aortic valve development | ISS | -- |
GO:0003177 | pulmonary valve development | ISS | -- |
GO:0003332 | negative regulation of extracellular matrix constituent secretion | ISS | -- |
GO:0006693 | prostaglandin metabolic process | IEA | -- |
GO:0006915 | apoptotic process | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Etanercept | Approved, Investigational | Pharma | 454 | |||
Infliximab | Approved | Pharma | 469 | |||
Tasonermin | Approved | Pharma | Target, agonist | 0 | ||
Adalimumab | Approved | Pharma | 602 | |||
6-[3-(4-Morpholinyl)Propyl]-2-(3-Nitrophenyl)-5-Thioxo-5,6,-Dihydro-7h-Thienol[2',3':4,5]Pyrrolo[1,2-C]Imidazol-7-One | Experimental | Pharma | Target | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: |
ExUns: | 12 | ^ | 13 | ^ | 14 |
---|---|---|---|---|---|
SP1: | |||||
SP2: | |||||
SP3: | |||||
SP4: | |||||
SP5: | |||||
SP6: | |||||
SP7: | |||||
SP8: | |||||
SP9: | |||||
SP10: | |||||
SP11: | |||||
SP12: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TNFRSF1A 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TNFRSF1A 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TNFRSF1A 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Tnfrsf1a 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Tnfrsf1a 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | TNFRSF1A 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | TNFRSF1A 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | TNFRSF1A 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | TNFRSF1A 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tnfrsf1a 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | tnfrsf1a 30 31 |
|
OneToMany |