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Aliases for TNFRSF19 Gene

Aliases for TNFRSF19 Gene

  • TNF Receptor Superfamily Member 19 2 3 5
  • Toxicity And JNK Inducer 2 3 4
  • TRADE 3 4
  • TROY 3 4
  • TAJ 3 4
  • Tumor Necrosis Factor Receptor Superfamily, Member 19 2
  • Tumor Necrosis Factor Receptor Superfamily Member 19 3
  • TAJ-Alpha 3

External Ids for TNFRSF19 Gene

Previous GeneCards Identifiers for TNFRSF19 Gene

  • GC13P022133
  • GC13P018133
  • GC13P023074
  • GC13P021942
  • GC13P023042
  • GC13P024144
  • GC13P004956

Summaries for TNFRSF19 Gene

Entrez Gene Summary for TNFRSF19 Gene

  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFRSF19 Gene

TNFRSF19 (TNF Receptor Superfamily Member 19) is a Protein Coding gene. Among its related pathways are PEDF Induced Signaling and Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling. Gene Ontology (GO) annotations related to this gene include tumor necrosis factor-activated receptor activity. An important paralog of this gene is EDA2R.

UniProtKB/Swiss-Prot for TNFRSF19 Gene

  • Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death.

Gene Wiki entry for TNFRSF19 Gene

Additional gene information for TNFRSF19 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF19 Gene

Genomics for TNFRSF19 Gene

GeneHancer (GH) Regulatory Elements for TNFRSF19 Gene

Promoters and enhancers for TNFRSF19 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I023569 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.3 1285 4 PKNOX1 ATF1 FOXA2 MLX ARNT ARID4B FEZF1 SLC30A9 TCF12 GLIS2 TNFRSF19 LOC105370114
GH13I023578 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.4 +9.4 9425 2.6 HDGF PKNOX1 ATF1 FOXA2 ARID4B SIN3A GLI4 ZNF2 ZNF48 GLIS2 TNFRSF19 C1QTNF9B MIPEP PCOTH LOC105370114
GH13I023655 Enhancer 1.2 Ensembl ENCODE dbSUPER 16.1 +87.2 87163 3.2 HDAC1 FOXA2 FEZF1 BATF RARA TCF12 RCOR1 FOS ETV6 IKZF2 TNFRSF19 LOC105370114
GH13I023629 Enhancer 0.9 ENCODE 19.7 +59.6 59627 1.7 ELF3 FOXA2 NFIB MLX ARID4B FEZF1 DMAP1 RAD21 ZSCAN9 RARA TNFRSF19 LOC105370114
GH13I023669 Enhancer 1.1 Ensembl ENCODE dbSUPER 15.6 +102.8 102799 7.1 SOX13 GATAD2A STAT1 FOXA2 HLF JUNB BATF FOXA1 GATA3 JUND TNFRSF19 LOC105370114
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TNFRSF19 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TNFRSF19 gene promoter:

Genomic Locations for TNFRSF19 Gene

Genomic Locations for TNFRSF19 Gene
105,736 bases
Plus strand

Genomic View for TNFRSF19 Gene

Genes around TNFRSF19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFRSF19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFRSF19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF19 Gene

Proteins for TNFRSF19 Gene

  • Protein details for TNFRSF19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor necrosis factor receptor superfamily member 19
    Protein Accession:
    Secondary Accessions:
    • A8KA09
    • A8KA26
    • B1AM40
    • B1AM41
    • B4E2I6
    • Q9BXZ9
    • Q9BY00
    • Q9NZV2

    Protein attributes for TNFRSF19 Gene

    423 amino acids
    Molecular mass:
    46015 Da
    Quaternary structure:
    • Associates with TRAF1, TRAF2, TRAF3 and TRAF5. Interacts with LINGO1.

    Alternative splice isoforms for TNFRSF19 Gene


neXtProt entry for TNFRSF19 Gene

Post-translational modifications for TNFRSF19 Gene

Antibody Products

  • R&D Systems Antibodies for TNFRSF19 (TROY/TNFRSF19)
  • Cloud-Clone Corp. Antibodies for TNFRSF19

No data available for DME Specific Peptides for TNFRSF19 Gene

Domains & Families for TNFRSF19 Gene

Gene Families for TNFRSF19 Gene

Protein Domains for TNFRSF19 Gene

Suggested Antigen Peptide Sequences for TNFRSF19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TNFRSF19: view

No data available for UniProtKB/Swiss-Prot for TNFRSF19 Gene

Function for TNFRSF19 Gene

Molecular function for TNFRSF19 Gene

UniProtKB/Swiss-Prot Function:
Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death.

Phenotypes From GWAS Catalog for TNFRSF19 Gene

Gene Ontology (GO) - Molecular Function for TNFRSF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IBA --
GO:0005031 tumor necrosis factor-activated receptor activity NAS 10809768
genes like me logo Genes that share ontologies with TNFRSF19: view
genes like me logo Genes that share phenotypes with TNFRSF19: view

Animal Models for TNFRSF19 Gene

MGI Knock Outs for TNFRSF19:

Animal Model Products

CRISPR Products

miRNA for TNFRSF19 Gene

miRTarBase miRNAs that target TNFRSF19

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNFRSF19 Gene

Localization for TNFRSF19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF19 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFRSF19 gene
Compartment Confidence
plasma membrane 5
extracellular 3
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TNFRSF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 10809768
genes like me logo Genes that share ontologies with TNFRSF19: view

Pathways & Interactions for TNFRSF19 Gene

genes like me logo Genes that share pathways with TNFRSF19: view

Pathways by source for TNFRSF19 Gene

1 KEGG pathway for TNFRSF19 Gene
1 R&D Systems pathway for TNFRSF19 Gene
1 Qiagen pathway for TNFRSF19 Gene

Gene Ontology (GO) - Biological Process for TNFRSF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001942 hair follicle development IEA --
GO:0006915 apoptotic process NAS 10809768
GO:0007254 JNK cascade NAS 10809768
GO:0009888 tissue development IBA --
GO:0033209 tumor necrosis factor-mediated signaling pathway IEA --
genes like me logo Genes that share ontologies with TNFRSF19: view

No data available for SIGNOR curated interactions for TNFRSF19 Gene

Drugs & Compounds for TNFRSF19 Gene

No Compound Related Data Available

Transcripts for TNFRSF19 Gene

Unigene Clusters for TNFRSF19 Gene

Tumor necrosis factor receptor superfamily, member 19:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF19 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b
SP1: - - -
SP2: - - - - - - -
SP3: -
SP5: - - - - - -
SP6: -

Relevant External Links for TNFRSF19 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNFRSF19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNFRSF19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFRSF19 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x7.8), Skin - Sun Exposed (Lower leg) (x6.9), and Heart - Atrial Appendage (x4.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TNFRSF19 Gene

NURSA nuclear receptor signaling pathways regulating expression of TNFRSF19 Gene:


SOURCE GeneReport for Unigene cluster for TNFRSF19 Gene:


mRNA Expression by UniProt/SwissProt for TNFRSF19 Gene:

Tissue specificity: Highly expressed in prostate. Detected at lower levels in thymus, spleen, testis, uterus, small intestine, colon and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for TNFRSF19 Gene

  • Nervous system(4.5)
  • Spleen(4.1)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with TNFRSF19: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFRSF19 Gene

Orthologs for TNFRSF19 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF19 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TNFRSF19 33 34
  • 99.13 (n)
(Canis familiaris)
Mammalia TNFRSF19 33 34
  • 84.18 (n)
(Rattus norvegicus)
Mammalia Tnfrsf19 33
  • 77.1 (n)
(Mus musculus)
Mammalia Tnfrsf19 33 16 34
  • 76.29 (n)
(Bos Taurus)
Mammalia TNFRSF19 34
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia TNFRSF19 34
  • 66 (a)
(Monodelphis domestica)
Mammalia TNFRSF19 34
  • 65 (a)
(Gallus gallus)
Aves TNFRSF19 33 34
  • 69.74 (n)
(Anolis carolinensis)
Reptilia TNFRSF19 34
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tnfrsf19 33
  • 66.37 (n)
(Danio rerio)
Actinopterygii tnfrsf19 33 34
  • 62.4 (n)
wufa04d10 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2275 34
  • 24 (a)
Species where no ortholog for TNFRSF19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFRSF19 Gene

Gene Tree for TNFRSF19 (if available)
Gene Tree for TNFRSF19 (if available)

Paralogs for TNFRSF19 Gene

Paralogs for TNFRSF19 Gene

(1) SIMAP similar genes for TNFRSF19 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TNFRSF19: view

Variants for TNFRSF19 Gene

Sequence variations from dbSNP and Humsavar for TNFRSF19 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000073601 -- 23,589,268(+) A/G intron_variant
rs1000080530 -- 23,656,296(+) C/T intron_variant
rs1000128939 -- 23,640,978(+) T/C intron_variant
rs1000135042 -- 23,663,064(+) G/C intron_variant
rs1000160814 -- 23,573,205(+) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF19 Gene

Variant ID Type Subtype PubMed ID
nsv974235 CNV duplication 23825009
nsv962 CNV deletion 18451855
nsv832565 CNV gain 17160897
nsv561292 CNV loss 21841781
nsv525965 CNV gain 19592680
nsv455837 CNV gain 19166990
nsv1151909 OTHER inversion 26484159
nsv1140246 OTHER inversion 24896259
nsv1078303 OTHER inversion 25765185
nsv1041095 CNV loss 25217958
esv5325 OTHER complex 18987735
esv3892320 CNV loss 25118596
esv3892319 CNV gain 25118596
esv3892311 CNV gain 25118596
esv3631529 CNV gain 21293372
esv3631528 CNV loss 21293372
esv3631523 CNV gain 21293372
esv3580576 CNV loss 25503493
esv3580574 CNV loss 25503493
esv2751136 CNV loss 17911159
esv2422502 CNV duplication 17116639
dgv3084n54 CNV gain 21841781
dgv1615n100 CNV gain 25217958

Variation tolerance for TNFRSF19 Gene

Residual Variation Intolerance Score: 32.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.56; 86.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNFRSF19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFRSF19 Gene

Disorders for TNFRSF19 Gene

Additional Disease Information for TNFRSF19

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TNFRSF19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNFRSF19 Gene

Publications for TNFRSF19 Gene

  1. TROY, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles. (PMID: 10764796) Kojima T … Kitamura T (The Journal of biological chemistry 2000) 2 3 4 22 58
  2. A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors. (PMID: 15694321) Park JB … He Z (Neuron 2005) 3 4 22 58
  3. TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death. (PMID: 10809768) Eby MT … Chaudhary PM (The Journal of biological chemistry 2000) 2 3 4 58
  4. A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci. (PMID: 20512145) Bei JX … Zeng YX (Nature genetics 2010) 3 44 58
  5. Identification of single nucleotide polymorphisms in the tumor necrosis factor (TNF) and TNF receptor superfamily in the Korean population. (PMID: 15301860) Cho SM … Lee JK (Human immunology 2004) 3 44 58

Products for TNFRSF19 Gene

Sources for TNFRSF19 Gene

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