Aliases for TNFRSF18 Gene
External Ids for TNFRSF18 Gene
Previous GeneCards Identifiers for TNFRSF18 Gene
This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011]
GeneCards Summary for TNFRSF18 Gene
TNFRSF18 (TNF Receptor Superfamily Member 18) is a Protein Coding gene. Diseases associated with TNFRSF18 include Tropical Spastic Paraparesis and Diverticulitis. Among its related pathways are Akt Signaling and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include tumor necrosis factor-activated receptor activity. An important paralog of this gene is TNFRSF11A.
UniProtKB/Swiss-Prot Summary for TNFRSF18 Gene
Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.