Free for academic non-profit institutions. Other users need a Commercial license
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]
TNFRSF17 (TNF Receptor Superfamily Member 17) is a Protein Coding gene. Diseases associated with TNFRSF17 include Desmoplastic Small Round Cell Tumor and Macroglobulinemia. Among its related pathways are TRAF Pathway and TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions. An important paralog of this gene is TNFRSF13C.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0038023 | signaling receptor activity | TAS,IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0012505 | endomembrane system | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | TGF-Beta Pathway |
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
|
JNK Pathway
.51
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.41
|
2 | PEDF Induced Signaling |
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
|
Glucocorticoid Receptor Signaling
.43
|
3 | Akt Signaling |
Akt Signaling
.60
p38 Signaling
.60
|
Tec Kinases Signaling
.55
|
4 | RANK Signaling in Osteoclasts |
APRIL Pathway
.92
BAFF in B-Cell Signaling
.92
|
Apoptosis and survival APRIL and BAFF signaling
.39
|
5 | TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002250 | adaptive immune response | IEA | -- |
GO:0002260 | lymphocyte homeostasis | IEA | -- |
GO:0002376 | immune system process | IEA | -- |
GO:0007165 | signal transduction | TAS | 10908663 |
GO:0007275 | multicellular organism development | TAS | 8165126 |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TNFRSF17 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TNFRSF17 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TNFRSF17 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Tnfrsf17 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Tnfrsf17 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | TNFRSF17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | TNFRSF17 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
779009 | Benign: not provided | 11,967,820(+) | G/C | MISSENSE_VARIANT | |
rs11570148 | Uncertain Significance: not provided. - | 11,966,287(+) | T/Gp.Phe75Val | MISSENSE_VARIANT | |
rs371163866 | Other: Desmoplastic small round cell tumor | 11,967,816(+) | C/T | MISSENSE_VARIANT | |
rs11570146 | - | p.Ala54Val | |||
rs11570147 | - | p.Ile65Val |
Disorder | Aliases | PubMed IDs |
---|---|---|
desmoplastic small round cell tumor |
|
|
macroglobulinemia |
|
|
cryptococcal meningitis |
|
|
autoimmune disease |
|
|
granulomatous amebic encephalitis |
|
|