This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [p... See more...

Aliases for TNFRSF14 Gene

Aliases for TNFRSF14 Gene

  • TNF Receptor Superfamily Member 14 2 3 5
  • Tumor Necrosis Factor Receptor Superfamily, Member 14 (Herpesvirus Entry Mediator) 2 3
  • Tumor Necrosis Factor Receptor Superfamily Member 14 3 4
  • Herpes Virus Entry Mediator A 3 4
  • HVEA 3 4
  • HVEM 3 4
  • TR2 3 4
  • Tumor Necrosis Factor Receptor Superfamily, Member 14 2
  • Tumor Necrosis Factor Receptor-Like Gene2 3
  • Tumor Necrosis Factor Receptor-Like 2 4
  • Herpesvirus Entry Mediator A 4
  • Herpesvirus Entry Mediator 2
  • CD40-Like Protein 3
  • CD270 Antigen 4
  • LIGHTR 3
  • CD270 3
  • ATAR 3
  • HveA 4

External Ids for TNFRSF14 Gene

Previous GeneCards Identifiers for TNFRSF14 Gene

  • GC01M002044
  • GC01M002502
  • GC01M002149
  • GC01M002358
  • GC01M002521
  • GC01P002487
  • GC01P001767

Summaries for TNFRSF14 Gene

Entrez Gene Summary for TNFRSF14 Gene

  • This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for TNFRSF14 Gene

TNFRSF14 (TNF Receptor Superfamily Member 14) is a Protein Coding gene. Diseases associated with TNFRSF14 include Herpes Simplex and Primary Cutaneous Follicle Center Lymphoma. Among its related pathways are TRAF Pathway and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and tumor necrosis factor-activated receptor activity. An important paralog of this gene is LTBR.

UniProtKB/Swiss-Prot Summary for TNFRSF14 Gene

  • Receptor for four distinct ligands: The TNF superfamily members TNFSF14/LIGHT and homotrimeric LTA/lymphotoxin-alpha and the immunoglobulin superfamily members BTLA and CD160, altogether defining a complex stimulatory and inhibitory signaling network (PubMed:9462508, PubMed:10754304, PubMed:18193050, PubMed:23761635). Signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation (PubMed:19915044, PubMed:9153189, PubMed:9162022). Participates in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. In response to ligation of TNFSF14/LIGHT, delivers costimulatory signals to T cells, promoting cell proliferation and effector functions (PubMed:10754304). Interacts with CD160 on NK cells, enhancing IFNG production and anti-tumor immune response (PubMed:23761635). In the context of bacterial infection, acts as a signaling receptor on epithelial cells for CD160 from intraepithelial lymphocytes, triggering the production of antimicrobial proteins and proinflammatory cytokines (By similarity). Upon binding to CD160 on activated CD4+ T cells, downregulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (PubMed:18193050). May interact in cis (on the same cell) or in trans (on other cells) with BTLA (PubMed:19915044) (By similarity). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:19915044) (By similarity).
  • (Microbial infection) Acts as a receptor for Herpes simplex virus 1/HHV-1.
  • (Microbial infection) Acts as a receptor for Herpes simplex virus 2/HHV-2.

Gene Wiki entry for TNFRSF14 Gene

Additional gene information for TNFRSF14 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TNFRSF14 Gene

Genomics for TNFRSF14 Gene

GeneHancer (GH) Regulatory Elements for TNFRSF14 Gene

Promoters and enhancers for TNFRSF14 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TNFRSF14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TNFRSF14 gene promoter:
  • AREB6
  • E2F
  • E47
  • GATA-1
  • Nkx2-5
  • Nkx5-1
  • RP58
  • STAT3
  • Tal-1

Genomic Locations for TNFRSF14 Gene

Genomic Locations for TNFRSF14 Gene
chr1:2,555,639-2,565,622
(GRCh38/hg38)
Size:
9,984 bases
Orientation:
Plus strand
chr1:2,487,078-2,496,821
(GRCh37/hg19)
Size:
9,744 bases
Orientation:
Plus strand

Genomic View for TNFRSF14 Gene

Genes around TNFRSF14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFRSF14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFRSF14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF14 Gene

Proteins for TNFRSF14 Gene

  • Protein details for TNFRSF14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92956-TNR14_HUMAN
    Recommended name:
    Tumor necrosis factor receptor superfamily member 14
    Protein Accession:
    Q92956
    Secondary Accessions:
    • B3KW30
    • B9DI89
    • Q6IB95
    • Q8N634
    • Q8WXR1
    • Q96J31
    • Q9UM65

    Protein attributes for TNFRSF14 Gene

    Size:
    283 amino acids
    Molecular mass:
    30392 Da
    Quaternary structure:
    • Interacts with TRAF2, TRAF3 and TRAF5 (PubMed:9153189, PubMed:9162022). Interacts (via CRD1/TNFR-Cys 1) with CD160; this interaction is direct (PubMed:18193050, PubMed:23761635). Interacts with LTA and TNFSF14 (PubMed:9462508). Interacts (via CRD1/TNFR-Cys 1) in cis and trans with BTLA; the cis interactions inhibits the trans interactions (PubMed:19915044, PubMed:16169851).
    • (Microbial infection) Interacts with herpes simplex virus 1/HHV-1 envelope glycoprotein D.
    • (Microbial infection) Interacts with herpes simplex virus 2/HHV-2 envelope glycoprotein D.

    Three dimensional structures from OCA and Proteopedia for TNFRSF14 Gene

    Alternative splice isoforms for TNFRSF14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNFRSF14 Gene

Post-translational modifications for TNFRSF14 Gene

Antibody Products

  • Biorbyt antibodies for TNFRSF14

No data available for DME Specific Peptides for TNFRSF14 Gene

Domains & Families for TNFRSF14 Gene

Gene Families for TNFRSF14 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for TNFRSF14 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ42016 fis, clone SPLEN2033098, highly similar to Tumor necrosis factor receptor superfamily member 14 (B3KW30_HUMAN)
  • cDNA FLJ57170, highly similar to Tumor necrosis factor receptor superfamily member 14 (B4DU65_HUMAN)
  • Tumor necrosis factor receptor superfamily, member 14 (Herpesvirus entry mediator) (B9DI86_HUMAN)
  • Tumor necrosis factor receptor superfamily, member 14 (Herpesvirus entry mediator) (B9DI88_HUMAN)
  • TNFRSF14 protein (Q8N634_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q92956

UniProtKB/Swiss-Prot:

TNR14_HUMAN :
  • The cysteine rich domain I (CRD1/TNFR-Cys 1) is required for interaction with BY55 and BTLA.
  • Belongs to the tumor necrosis factor receptor superfamily.
Domain:
  • The cysteine rich domain I (CRD1/TNFR-Cys 1) is required for interaction with BY55 and BTLA.
Family:
  • Belongs to the tumor necrosis factor receptor superfamily.
genes like me logo Genes that share domains with TNFRSF14: view

Function for TNFRSF14 Gene

Molecular function for TNFRSF14 Gene

UniProtKB/Swiss-Prot Function:
Receptor for four distinct ligands: The TNF superfamily members TNFSF14/LIGHT and homotrimeric LTA/lymphotoxin-alpha and the immunoglobulin superfamily members BTLA and CD160, altogether defining a complex stimulatory and inhibitory signaling network (PubMed:9462508, PubMed:10754304, PubMed:18193050, PubMed:23761635). Signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation (PubMed:19915044, PubMed:9153189, PubMed:9162022). Participates in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. In response to ligation of TNFSF14/LIGHT, delivers costimulatory signals to T cells, promoting cell proliferation and effector functions (PubMed:10754304). Interacts with CD160 on NK cells, enhancing IFNG production and anti-tumor immune response (PubMed:23761635). In the context of bacterial infection, acts as a signaling receptor on epithelial cells for CD160 from intraepithelial lymphocytes, triggering the production of antimicrobial proteins and proinflammatory cytokines (By similarity). Upon binding to CD160 on activated CD4+ T cells, downregulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (PubMed:18193050). May interact in cis (on the same cell) or in trans (on other cells) with BTLA (PubMed:19915044) (By similarity). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:19915044) (By similarity).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for Herpes simplex virus 1/HHV-1.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for Herpes simplex virus 2/HHV-2.
GENATLAS Biochemistry:
tumor necrosis factor receptor superfamily,member 14,widely expressed,involved in lymphocyte activation,homolog with 4-1BB (CD137)

Phenotypes From GWAS Catalog for TNFRSF14 Gene

Gene Ontology (GO) - Molecular Function for TNFRSF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0005031 tumor necrosis factor-activated receptor activity TAS 9153189
GO:0005515 protein binding IPI 9153189
GO:0019955 cytokine binding IPI 27152329
GO:0031625 ubiquitin protein ligase binding IPI 11279055
genes like me logo Genes that share ontologies with TNFRSF14: view
genes like me logo Genes that share phenotypes with TNFRSF14: view

Animal Models for TNFRSF14 Gene

MGI Knock Outs for TNFRSF14:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TNFRSF14 Gene

Localization for TNFRSF14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF14 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFRSF14 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytosol 2
cytoskeleton 1
nucleus 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Rods & Rings (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TNFRSF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TNFRSF14: view

Pathways & Interactions for TNFRSF14 Gene

genes like me logo Genes that share pathways with TNFRSF14: view

Pathways by source for TNFRSF14 Gene

1 R&D Systems pathway for TNFRSF14 Gene
7 Qiagen pathways for TNFRSF14 Gene
  • Akt Signaling
  • Antioxidant Action of Vitamin-C
  • Molecular Mechanisms of Cancer
  • p38 Signaling
  • STAT3 Pathway

SIGNOR curated interactions for TNFRSF14 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TNFRSF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0002741 positive regulation of cytokine secretion involved in immune response IBA 21873635
GO:0006955 immune response TAS 9162022
GO:0007166 cell surface receptor signaling pathway TAS 9153189
genes like me logo Genes that share ontologies with TNFRSF14: view

Drugs & Compounds for TNFRSF14 Gene

(3) Drugs for TNFRSF14 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
B and T lymphocyte attenuator Pharma 0
LIGHT Pharma 0
LYMPHOTOXIN-Α Pharma 0

(1) Additional Compounds for TNFRSF14 Gene - From: IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
lymphotoxin-alpha
genes like me logo Genes that share compounds with TNFRSF14: view

Transcripts for TNFRSF14 Gene

mRNA/cDNA for TNFRSF14 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF14 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d ^ 11
SP1: - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - - - - - - -
SP6: - -
SP7: - - - -
SP8: -
SP9: - - -
SP10: - - - -
SP11: - -
SP12: -

Relevant External Links for TNFRSF14 Gene

GeneLoc Exon Structure for
TNFRSF14
ECgene alternative splicing isoforms for
TNFRSF14

Expression for TNFRSF14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNFRSF14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFRSF14 Gene

This gene is overexpressed in Whole Blood (x4.1).

Protein differential expression in normal tissues from HIPED for TNFRSF14 Gene

This gene is overexpressed in Adrenal (54.3) and Urine (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TNFRSF14 Gene



Protein tissue co-expression partners for TNFRSF14 Gene

NURSA nuclear receptor signaling pathways regulating expression of TNFRSF14 Gene:

TNFRSF14

SOURCE GeneReport for Unigene cluster for TNFRSF14 Gene:

Hs.512898

mRNA Expression by UniProt/SwissProt for TNFRSF14 Gene:

Q92956-TNR14_HUMAN
Tissue specificity: Widely expressed, with the highest expression in lung, spleen and thymus. Expressed in a subpopulation of B cells and monocytes (PubMed:18193050). Expressed in naive T cells (PubMed:19915044).

Evidence on tissue expression from TISSUES for TNFRSF14 Gene

  • Skin(4.7)
  • Spleen(4.6)
  • Liver(4.2)
  • Lymph node(3)
  • Blood(2.7)
  • Eye(2.3)
  • Intestine(2.3)
  • Bone marrow(2.2)
  • Kidney(2.2)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with TNFRSF14: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFRSF14 Gene

Orthologs for TNFRSF14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNFRSF14 33 32
  • 98.82 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TNFRSF14 33 32
  • 68.73 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tnfrsf14 17 33 32
  • 61.18 (n)
rat
(Rattus norvegicus)
Mammalia Tnfrsf14 32
  • 59.38 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 26 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia TNFRSF14 33
  • 27 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733953 32
  • 43.82 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-23c22.5 32
  • 45.07 (n)
TNFRSF14 (11 of 12) 33
  • 36 (a)
OneToMany
TNFRSF14 (9 of 12) 33
  • 30 (a)
OneToMany
TNFRSF14 (12 of 12) 33
  • 28 (a)
OneToMany
TNFRSF14 (7 of 12) 33
  • 27 (a)
OneToMany
TNFRSF14 (5 of 12) 33
  • 26 (a)
OneToMany
TNFRSF14 (10 of 12) 33
  • 25 (a)
OneToMany
TNFRSF14 (8 of 12) 33
  • 24 (a)
OneToMany
TNFRSF14 (2 of 12) 33
  • 24 (a)
OneToMany
TNFRSF14 (1 of 12) 33
  • 24 (a)
OneToMany
TNFRSF14 (3 of 12) 33
  • 24 (a)
OneToMany
TNFRSF14 (4 of 12) 33
  • 23 (a)
OneToMany
TNFRSF14 (6 of 12) 33
  • 19 (a)
OneToMany
Species where no ortholog for TNFRSF14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFRSF14 Gene

ENSEMBL:
Gene Tree for TNFRSF14 (if available)
TreeFam:
Gene Tree for TNFRSF14 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TNFRSF14: view image

Paralogs for TNFRSF14 Gene

Variants for TNFRSF14 Gene

Sequence variations from dbSNP and Humsavar for TNFRSF14 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs11573986 not-provided, not specified, - 2,560,684(+) G/A coding_sequence_variant, missense_variant, non_coding_transcript_variant, stop_gained
rs2234163 not-provided, not specified, - 2,559,867(+) G/A coding_sequence_variant, missense_variant, non_coding_transcript_variant, synonymous_variant
rs2234167 not-provided, not specified, - 2,562,891(+) G/A 3_prime_UTR_variant, coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs4870 not-provided, not specified, - 2,556,714(+) A/G 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, missense_variant, non_coding_transcript_variant
rs386352373 uncertain-significance, not provided 2,561,679(+) C/G coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF14 Gene

Variant ID Type Subtype PubMed ID
dgv1n47 OTHER inversion 21111241
dgv1n50 OTHER inversion 21212237
dgv5n67 CNV loss 20364138
esv1699286 OTHER inversion 17803354
esv2471749 OTHER inversion 19546169
esv3447351 OTHER inversion 20981092
nsv436691 OTHER inversion 17901297
nsv470684 CNV loss 18288195
nsv545077 CNV gain 21841781
nsv545082 CNV loss 21841781
nsv7171 OTHER inversion 18451855
nsv824364 CNV loss 20364138
nsv824475 CNV loss 20364138
nsv951557 CNV deletion 24416366
nsv951592 CNV deletion 24416366

Variation tolerance for TNFRSF14 Gene

Residual Variation Intolerance Score: 58.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.10; 38.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNFRSF14 Gene

Human Gene Mutation Database (HGMD)
TNFRSF14
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNFRSF14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFRSF14 Gene

Disorders for TNFRSF14 Gene

MalaCards: The human disease database

(6) MalaCards diseases for TNFRSF14 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
herpes simplex
  • herpesvirus hominis disease
primary cutaneous follicle center lymphoma
  • crosti's disease
cone-rod dystrophy 1
  • retinitis pigmentosa 1
nodal marginal zone lymphoma
  • mucosa-associated lymphoid tissue lymphoma
cleft lip/palate-ectodermal dysplasia syndrome
  • clped1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TNFRSF14

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TNFRSF14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNFRSF14 Gene

Publications for TNFRSF14 Gene

  1. A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation. (PMID: 9162061) Kwon BS … Young PR (The Journal of biological chemistry 1997) 2 3 4 23 56
  2. T cell intrinsic heterodimeric complexes between HVEM and BTLA determine receptivity to the surrounding microenvironment. (PMID: 19915044) Cheung TC … Ware CF (Journal of immunology (Baltimore, Md. : 1950) 2009) 3 4 23 56
  3. Search for polymorphisms in the genes for herpesvirus entry mediator, nectin-1, and nectin-2 in immune seronegative individuals. (PMID: 11756979) Struyf F … Spear PG (The Journal of infectious diseases 2002) 3 4 23 56
  4. ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5. (PMID: 9153189) Hsu H … Boyle WJ (The Journal of biological chemistry 1997) 3 4 23 56
  5. Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family. (PMID: 8898196) Montgomery RI … Spear PG (Cell 1996) 2 3 4 56

Products for TNFRSF14 Gene

  • Biorbyt antibodies for TNFRSF14

Sources for TNFRSF14 Gene