Aliases for TNFRSF12A Gene

Aliases for TNFRSF12A Gene

  • TNF Receptor Superfamily Member 12A 2 3 5
  • FN14 2 3 4
  • Fibroblast Growth Factor-Inducible Immediate-Early Response Protein 14 3 4
  • Tumor Necrosis Factor Receptor Superfamily Member 12A 3 4
  • FGF-Inducible 14 3 4
  • Tweak-Receptor 3 4
  • TweakR 2 4
  • CD266 2 3
  • Tumor Necrosis Factor Receptor Superfamily, Member 12A 2
  • Type I Transmembrane Protein Fn14 3
  • CD266 Antigen 4
  • TNFRSF12A 5
  • TWEAKR 3

External Ids for TNFRSF12A Gene

Previous GeneCards Identifiers for TNFRSF12A Gene

  • GC16P003103
  • GC16P003070
  • GC16P003010
  • GC16P003043
  • GC16P003091
  • GC16P003121
  • GC16P003141
  • GC16P003155

Summaries for TNFRSF12A Gene

GeneCards Summary for TNFRSF12A Gene

TNFRSF12A (TNF Receptor Superfamily Member 12A) is a Protein Coding gene. Diseases associated with TNFRSF12A include Ileitis and Glioblastoma. Among its related pathways are Akt Signaling and Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway.

UniProtKB/Swiss-Prot Summary for TNFRSF12A Gene

  • Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.

Gene Wiki entry for TNFRSF12A Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TNFRSF12A Gene

Genomics for TNFRSF12A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TNFRSF12A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TNFRSF12A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TNFRSF12A

Top Transcription factor binding sites by QIAGEN in the TNFRSF12A gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • COUP
  • COUP-TF
  • COUP-TF1
  • HNF-4alpha1
  • HNF-4alpha2

Genomic Locations for TNFRSF12A Gene

Latest Assembly
chr16:3,018,445-3,022,383
(GRCh38/hg38)
Size:
3,939 bases
Orientation:
Plus strand

Previous Assembly
chr16:3,070,369-3,072,384
(GRCh37/hg19 by Entrez Gene)
Size:
2,016 bases
Orientation:
Plus strand

chr16:3,068,446-3,072,384
(GRCh37/hg19 by Ensembl)
Size:
3,939 bases
Orientation:
Plus strand

Genomic View for TNFRSF12A Gene

Genes around TNFRSF12A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFRSF12A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFRSF12A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF12A Gene

Proteins for TNFRSF12A Gene

  • Protein details for TNFRSF12A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NP84-TNR12_HUMAN
    Recommended name:
    Tumor necrosis factor receptor superfamily member 12A
    Protein Accession:
    Q9NP84
    Secondary Accessions:
    • D3DUA6
    • Q9HCS0

    Protein attributes for TNFRSF12A Gene

    Size:
    129 amino acids
    Molecular mass:
    13911 Da
    Quaternary structure:
    • Associates with TRAF1 and TRAF2, and probably also with TRAF3.

    Three dimensional structures from OCA and Proteopedia for TNFRSF12A Gene

    Alternative splice isoforms for TNFRSF12A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNFRSF12A Gene

Post-translational modifications for TNFRSF12A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TNFRSF12A Gene

Antibodies for research

  • Abcam antibodies for TNFRSF12A
  • Biorbyt antibodies for TNFRSF12A
  • Santa Cruz Biotechnology (SCBT) Antibodies for TNFRSF12A

No data available for DME Specific Peptides for TNFRSF12A Gene

Domains & Families for TNFRSF12A Gene

Gene Families for TNFRSF12A Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TNFRSF12A Gene

InterPro:
Blocks:
  • TNFR/CD27/30/40/95 cysteine-rich region

Suggested Antigen Peptide Sequences for TNFRSF12A Gene

GenScript: Design optimal peptide antigens:
  • Tweak-receptor (TNR12_HUMAN)
genes like me logo Genes that share domains with TNFRSF12A: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TNFRSF12A Gene

Function for TNFRSF12A Gene

Molecular function for TNFRSF12A Gene

UniProtKB/Swiss-Prot Function:
Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.
UniProtKB/Swiss-Prot Induction:
By FGF1 and phorbol ester.

Phenotypes From GWAS Catalog for TNFRSF12A Gene

Gene Ontology (GO) - Molecular Function for TNFRSF12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 11728344
genes like me logo Genes that share ontologies with TNFRSF12A: view
genes like me logo Genes that share phenotypes with TNFRSF12A: view

Animal Models for TNFRSF12A Gene

MGI Knock Outs for TNFRSF12A:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNFRSF12A

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNFRSF12A Gene

Localization for TNFRSF12A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF12A Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFRSF12A gene
Compartment Confidence
plasma membrane 5
cytoskeleton 3
cytosol 3
extracellular 2
mitochondrion 2
nucleus 2
lysosome 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TNFRSF12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TNFRSF12A: view

Pathways & Interactions for TNFRSF12A Gene

genes like me logo Genes that share pathways with TNFRSF12A: view

Pathways by source for TNFRSF12A Gene

1 BioSystems pathway for TNFRSF12A Gene
1 KEGG pathway for TNFRSF12A Gene
1 GeneGo (Thomson Reuters) pathway for TNFRSF12A Gene
  • Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
8 Qiagen pathways for TNFRSF12A Gene
  • Akt Signaling
  • Antioxidant Action of Vitamin-C
  • Molecular Mechanisms of Cancer
  • p38 Signaling
  • STAT3 Pathway
2 Cell Signaling Technology pathways for TNFRSF12A Gene

SIGNOR curated interactions for TNFRSF12A Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TNFRSF12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0006915 apoptotic process IEA --
GO:0007155 cell adhesion IEA --
GO:0007275 multicellular organism development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with TNFRSF12A: view

Drugs & Compounds for TNFRSF12A Gene

(1) Drugs for TNFRSF12A Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
TWEAK Pharma 0

(1) Additional Compounds for TNFRSF12A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TNFRSF12A: view

Transcripts for TNFRSF12A Gene

mRNA/cDNA for TNFRSF12A Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNFRSF12A

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF12A Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5
SP1: - - - - - -
SP2: - -
SP3: -
SP4: - - -
SP5: - -

Relevant External Links for TNFRSF12A Gene

GeneLoc Exon Structure for
TNFRSF12A

Expression for TNFRSF12A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TNFRSF12A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFRSF12A Gene

This gene is overexpressed in Artery - Aorta (x4.3).

Protein differential expression in normal tissues from HIPED for TNFRSF12A Gene

This gene is overexpressed in Bone (35.8) and Urine (33.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TNFRSF12A Gene



Protein tissue co-expression partners for TNFRSF12A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TNFRSF12A

SOURCE GeneReport for Unigene cluster for TNFRSF12A Gene:

Hs.355899

mRNA Expression by UniProt/SwissProt for TNFRSF12A Gene:

Q9NP84-TNR12_HUMAN
Tissue specificity: Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas.

Evidence on tissue expression from TISSUES for TNFRSF12A Gene

  • Skin(3)
  • Muscle(2.9)
  • Heart(2.9)
  • Kidney(2.7)
  • Liver(2.6)
  • Pancreas(2.6)
  • Lung(2.5)
  • Stomach(2.5)
  • Intestine(2.4)
  • Nervous system(2.1)
  • Blood(2)
genes like me logo Genes that share expression patterns with TNFRSF12A: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFRSF12A Gene

Orthologs for TNFRSF12A Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF12A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TNFRSF12A 29 30
  • 100 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TNFRSF12A 29 30
  • 89.22 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TNFRSF12A 29 30
  • 88.24 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tnfrsf12a 29
  • 85.98 (n)
Mouse
(Mus musculus)
Mammalia Tnfrsf12a 29 16 30
  • 85.98 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TNFRSF12A 30
  • 72 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TNFRSF12A 30
  • 70 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TNFRSF12A 30
  • 48 (a)
OneToOne
Species where no ortholog for TNFRSF12A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for TNFRSF12A Gene

ENSEMBL:
Gene Tree for TNFRSF12A (if available)
TreeFam:
Gene Tree for TNFRSF12A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TNFRSF12A: view image
Alliance of Genome Resources:
Additional Orthologs for TNFRSF12A

Paralogs for TNFRSF12A Gene

No data available for Paralogs for TNFRSF12A Gene

Variants for TNFRSF12A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TNFRSF12A Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs2232799 Benign: not provided 3,021,820(+) C/A
NM_016639.3(TNFRSF12A):c.384C>A (p.Ile128=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TNFRSF12A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF12A Gene

Variant ID Type Subtype PubMed ID
esv3637645 CNV gain 21293372
nsv509588 CNV insertion 20534489
nsv510673 CNV deletion 20534489
nsv833125 CNV loss 17160897
nsv952906 CNV deletion 24416366

Variation tolerance for TNFRSF12A Gene

Residual Variation Intolerance Score: 68.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.28; 53.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNFRSF12A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNFRSF12A
Leiden Open Variation Database (LOVD)
TNFRSF12A

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFRSF12A Gene

Disorders for TNFRSF12A Gene

MalaCards: The human disease database

(5) MalaCards diseases for TNFRSF12A Gene - From: COP and GCD

Disorder Aliases PubMed IDs
ileitis
  • crohn's ileitis
glioblastoma
  • adult glioblastoma multiforme
multiple sclerosis
  • multiple sclerosis, susceptibility to
stroke, ischemic
  • cerebrovascular accident
cone-rod dystrophy 2
  • cord2
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TNFRSF12A

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TNFRSF12A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNFRSF12A Gene

Publications for TNFRSF12A Gene

  1. The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas. (PMID: 10751351) Feng SL … Winkles JA (The American journal of pathology 2000) 2 3 4 22
  2. Solution structure of the cysteine-rich domain in Fn14, a member of the tumor necrosis factor receptor superfamily. (PMID: 19241374) He F … Yokoyama S (Protein science : a publication of the Protein Society 2009) 3 4 22
  3. TWEAK/Fn14 promotes apoptosis of human endometrial cancer cells via caspase pathway. (PMID: 20189297) Wang D … Chen C (Cancer letters 2010) 3 22
  4. [The expression of TWEAKR/Fn14 in Rheumatoid arthritis fibroblast-like synoviocytes]. (PMID: 20487651) Xia LP … Xiao WG (Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 2010) 3 22
  5. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty SE … Australian Cancer Study (Ovarian Cancer) (PLoS genetics 2010) 3 40

Products for TNFRSF12A Gene

  • Biorbyt antibodies for TNFRSF12A

Sources for TNFRSF12A Gene