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Aliases for TNFRSF12A Gene

Aliases for TNFRSF12A Gene

  • TNF Receptor Superfamily Member 12A 2 3 5
  • Fibroblast Growth Factor-Inducible Immediate-Early Response Protein 14 3 4
  • FGF-Inducible 14 3 4
  • Tweak-Receptor 3 4
  • TWEAKR 3 4
  • FN14 3 4
  • Tumor Necrosis Factor Receptor Superfamily, Member 12A 2
  • Tumor Necrosis Factor Receptor Superfamily Member 12A 3
  • Type I Transmembrane Protein Fn14 3
  • CD266 Antigen 4
  • CD266 3

External Ids for TNFRSF12A Gene

Previous GeneCards Identifiers for TNFRSF12A Gene

  • GC16P003103
  • GC16P003070
  • GC16P003010
  • GC16P003043
  • GC16P003091
  • GC16P003121
  • GC16P003141
  • GC16P003155

Summaries for TNFRSF12A Gene

GeneCards Summary for TNFRSF12A Gene

TNFRSF12A (TNF Receptor Superfamily Member 12A) is a Protein Coding gene. Among its related pathways are Cytokine Signaling in Immune system and Akt Signaling.

UniProtKB/Swiss-Prot for TNFRSF12A Gene

  • Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.

Gene Wiki entry for TNFRSF12A Gene

Additional gene information for TNFRSF12A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF12A Gene

Genomics for TNFRSF12A Gene

GeneHancer (GH) Regulatory Elements for TNFRSF12A Gene

Promoters and enhancers for TNFRSF12A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I003019 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +3.9 3858 5.2 MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 SP3 NFYC THOC6 TNFRSF12A HCFC1R1 ZNF263 ENSG00000261938 E4F1 SRRM2 TSC2 ERVK13-1 ZNF75A
GH16I003017 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 550.8 -0.5 -530 1.8 ATF1 SIN3A RAD21 ETS1 ZNF143 ATF7 CREM THAP11 SP5 REST CLDN6 TNFRSF12A BICDL2 LOC107984895 CLDN9
GH16I003020 Enhancer 0.9 ENCODE dbSUPER 550.8 +1.2 1190 0.2 SMARCE1 ZBTB21 GTF2E2 ZNF140 ZNF266 ZC3H11A ZBTB8A ZNF514 ZNF518A ZNF560 CLDN6 TNFRSF12A ENSG00000261938 ZNF263 E4F1 TSC2 ERVK13-1 SRRM2 SNORD60 CREBBP
GH16I003097 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.8 +81.7 81655 6.2 ARID4B SIN3A IRF4 YY1 ETS1 ARID2 ZNF143 RUNX3 SP3 RXRA ZSCAN10 ZNF205 ZNF213-AS1 CLDN6 TNFRSF12A ZNF205-AS1 ZNF213 ZNF263 OR1F1 ZNF597
GH16I003069 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.1 +55.9 55935 9.8 HDGF PKNOX1 YBX1 IRF4 ZNF207 ZNF143 ATF7 RUNX3 PAF1 ATF4 GC16P003518 ZNF205 LOC105371058 MMP25 IL32 FLYWCH2 BICDL2 LOC100128770 CLDN6 THOC6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TNFRSF12A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TNFRSF12A gene promoter:

Genomic Locations for TNFRSF12A Gene

Genomic Locations for TNFRSF12A Gene
chr16:3,018,445-3,022,383
(GRCh38/hg38)
Size:
3,939 bases
Orientation:
Plus strand
chr16:3,068,446-3,072,384
(GRCh37/hg19)

Genomic View for TNFRSF12A Gene

Genes around TNFRSF12A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFRSF12A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFRSF12A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF12A Gene

Proteins for TNFRSF12A Gene

  • Protein details for TNFRSF12A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NP84-TNR12_HUMAN
    Recommended name:
    Tumor necrosis factor receptor superfamily member 12A
    Protein Accession:
    Q9NP84
    Secondary Accessions:
    • D3DUA6
    • Q9HCS0

    Protein attributes for TNFRSF12A Gene

    Size:
    129 amino acids
    Molecular mass:
    13911 Da
    Quaternary structure:
    • Associates with TRAF1 and TRAF2, and probably also with TRAF3.

    Three dimensional structures from OCA and Proteopedia for TNFRSF12A Gene

    Alternative splice isoforms for TNFRSF12A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNFRSF12A Gene

Post-translational modifications for TNFRSF12A Gene

No Post-translational modifications

Other Protein References for TNFRSF12A Gene

No data available for DME Specific Peptides for TNFRSF12A Gene

Domains & Families for TNFRSF12A Gene

Gene Families for TNFRSF12A Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for TNFRSF12A Gene

Suggested Antigen Peptide Sequences for TNFRSF12A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TNFRSF12A: view

No data available for UniProtKB/Swiss-Prot for TNFRSF12A Gene

Function for TNFRSF12A Gene

Molecular function for TNFRSF12A Gene

UniProtKB/Swiss-Prot Function:
Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.
UniProtKB/Swiss-Prot Induction:
By FGF1 and phorbol ester.

Phenotypes From GWAS Catalog for TNFRSF12A Gene

Gene Ontology (GO) - Molecular Function for TNFRSF12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11728344
genes like me logo Genes that share ontologies with TNFRSF12A: view
genes like me logo Genes that share phenotypes with TNFRSF12A: view

Animal Models for TNFRSF12A Gene

MGI Knock Outs for TNFRSF12A:

Animal Model Products

Clone Products

  • R&D Systems cDNA Clones for TNFRSF12A (TWEAK R/TNFRSF12)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNFRSF12A Gene

Localization for TNFRSF12A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF12A Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFRSF12A gene
Compartment Confidence
plasma membrane 5
cytoskeleton 3
extracellular 2
cytosol 2
mitochondrion 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TNFRSF12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IEA --
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TNFRSF12A: view

Pathways & Interactions for TNFRSF12A Gene

genes like me logo Genes that share pathways with TNFRSF12A: view

Pathways by source for TNFRSF12A Gene

Gene Ontology (GO) - Biological Process for TNFRSF12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0006915 apoptotic process IEA --
GO:0006931 substrate-dependent cell migration, cell attachment to substrate IEA --
GO:0007155 cell adhesion IEA --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with TNFRSF12A: view

No data available for SIGNOR curated interactions for TNFRSF12A Gene

Drugs & Compounds for TNFRSF12A Gene

(1) Drugs for TNFRSF12A Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
TWEAK Pharma 0

(1) Additional Compounds for TNFRSF12A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TNFRSF12A: view

Transcripts for TNFRSF12A Gene

Unigene Clusters for TNFRSF12A Gene

Tumor necrosis factor receptor superfamily, member 12A:
Representative Sequences:

Clone Products

  • R&D Systems cDNA Clones for TNFRSF12A (TWEAK R/TNFRSF12)

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF12A Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5
SP1: - - - - - -
SP2: - -
SP3: -
SP4: - - -
SP5: - -

Relevant External Links for TNFRSF12A Gene

GeneLoc Exon Structure for
TNFRSF12A
ECgene alternative splicing isoforms for
TNFRSF12A

Expression for TNFRSF12A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNFRSF12A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFRSF12A Gene

This gene is overexpressed in Artery - Aorta (x4.3).

Protein differential expression in normal tissues from HIPED for TNFRSF12A Gene

This gene is overexpressed in Bone (35.8) and Urine (33.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TNFRSF12A Gene



Protein tissue co-expression partners for TNFRSF12A Gene

NURSA nuclear receptor signaling pathways regulating expression of TNFRSF12A Gene:

TNFRSF12A

SOURCE GeneReport for Unigene cluster for TNFRSF12A Gene:

Hs.355899

mRNA Expression by UniProt/SwissProt for TNFRSF12A Gene:

Q9NP84-TNR12_HUMAN
Tissue specificity: Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas.

Evidence on tissue expression from TISSUES for TNFRSF12A Gene

  • Muscle(2.7)
  • Skin(2.7)
  • Heart(2.5)
  • Kidney(2.4)
  • Liver(2.2)
  • Lung(2.2)
  • Intestine(2)
genes like me logo Genes that share expression patterns with TNFRSF12A: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFRSF12A Gene

Orthologs for TNFRSF12A Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF12A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNFRSF12A 33 34
  • 100 (n)
dog
(Canis familiaris)
Mammalia TNFRSF12A 33 34
  • 89.22 (n)
cow
(Bos Taurus)
Mammalia TNFRSF12A 33 34
  • 88.24 (n)
mouse
(Mus musculus)
Mammalia Tnfrsf12a 33 16 34
  • 85.98 (n)
rat
(Rattus norvegicus)
Mammalia Tnfrsf12a 33
  • 85.98 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TNFRSF12A 34
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TNFRSF12A 34
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TNFRSF12A 34
  • 48 (a)
OneToOne
Species where no ortholog for TNFRSF12A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TNFRSF12A Gene

ENSEMBL:
Gene Tree for TNFRSF12A (if available)
TreeFam:
Gene Tree for TNFRSF12A (if available)

Paralogs for TNFRSF12A Gene

No data available for Paralogs for TNFRSF12A Gene

Variants for TNFRSF12A Gene

Sequence variations from dbSNP and Humsavar for TNFRSF12A Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000273802 -- 3,021,354(+) C/T intron_variant
rs1000512408 -- 3,019,366(+) TTTTTTTT/TTTT/TTTTTTT upstream_transcript_variant
rs1000950947 -- 3,022,677(+) C/T downstream_transcript_variant
rs1001172979 -- 3,019,173(+) G/A upstream_transcript_variant
rs1001933083 -- 3,018,882(+) GTT/ upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF12A Gene

Variant ID Type Subtype PubMed ID
nsv952906 CNV deletion 24416366
nsv833125 CNV loss 17160897
nsv510673 CNV deletion 20534489
nsv509588 CNV insertion 20534489
esv3637645 CNV gain 21293372

Variation tolerance for TNFRSF12A Gene

Residual Variation Intolerance Score: 68.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.28; 53.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNFRSF12A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNFRSF12A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFRSF12A Gene

Disorders for TNFRSF12A Gene

Additional Disease Information for TNFRSF12A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TNFRSF12A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNFRSF12A Gene

Publications for TNFRSF12A Gene

  1. The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas. (PMID: 10751351) Feng SL … Winkles JA (The American journal of pathology 2000) 2 3 4 22 58
  2. Solution structure of the cysteine-rich domain in Fn14, a member of the tumor necrosis factor receptor superfamily. (PMID: 19241374) He F … Yokoyama S (Protein science : a publication of the Protein Society 2009) 3 4 22 58
  3. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PMID: 20568250) Lee KM … Lan Q (American journal of hematology 2010) 3 44 58
  4. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty SE … Australian Cancer Study (Ovarian Cancer) (PLoS genetics 2010) 3 44 58
  5. [The expression of TWEAKR/Fn14 in Rheumatoid arthritis fibroblast-like synoviocytes]. (PMID: 20487651) Xia LP … Xiao WG (Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 2010) 3 22 58

Products for TNFRSF12A Gene

Sources for TNFRSF12A Gene

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