Aliases for TNFRSF10D Gene
- TNF Receptor Superfamily Member 10d 2 3 5
- Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy With Truncated Death Domain 2 3
- Tumor Necrosis Factor Receptor Superfamily Member 10D 3 4
- TNF-Related Apoptosis-Inducing Ligand Receptor 4 3 4
- TRAIL Receptor With A Truncated Death Domain 3 4
- Decoy Receptor 2 3 4
- TRAIL Receptor 4 3 4
External Ids for TNFRSF10D Gene
Previous GeneCards Identifiers for TNFRSF10D Gene
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. [provided by RefSeq, Jul 2008]
GeneCards Summary for TNFRSF10D Gene
TNFRSF10D (TNF Receptor Superfamily Member 10d) is a Protein Coding gene. Diseases associated with TNFRSF10D include Prostate Cancer. Among its related pathways are TP53 Regulates Transcription of Cell Death Genes and Regulation by c-FLIP. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and TRAIL binding. An important paralog of this gene is TNFRSF10B.
UniProtKB/Swiss-Prot Summary for TNFRSF10D Gene
Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway.