Aliases for TNFRSF10D Gene
- TNF Receptor Superfamily Member 10d 2 3 5
- TRAILR4 2 3 4
- TRUNDD 2 3 4
- Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy With Truncated Death Domain 2 3
- Tumor Necrosis Factor Receptor Superfamily Member 10D 3 4
- TNF-Related Apoptosis-Inducing Ligand Receptor 4 3 4
- TRAIL Receptor With A Truncated Death Domain 3 4
- TRAIL Receptor 4 3 4
External Ids for TNFRSF10D Gene
Previous GeneCards Identifiers for TNFRSF10D Gene
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. [provided by RefSeq, Jul 2008]
GeneCards Summary for TNFRSF10D Gene
TNFRSF10D (TNF Receptor Superfamily Member 10d) is a Protein Coding gene. Diseases associated with TNFRSF10D include Osteogenic Sarcoma and Lung Cancer. Among its related pathways are Cell surface interactions at the vascular wall and TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and TRAIL binding. An important paralog of this gene is TNFRSF10B.
UniProtKB/Swiss-Prot Summary for TNFRSF10D Gene
Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway.