The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to ... See more...

Aliases for TNFRSF10C Gene

Aliases for TNFRSF10C Gene

  • TNF Receptor Superfamily Member 10c 2 3 5
  • Tumor Necrosis Factor Receptor Superfamily, Member 10c, Decoy Without An Intracellular Domain 2 3
  • Tumor Necrosis Factor Receptor Superfamily Member 10C 3 4
  • TNF-Related Apoptosis-Inducing Ligand Receptor 3 3 4
  • Antagonist Decoy Receptor For TRAIL/Apo-2L 3 4
  • Decoy TRAIL Receptor Without Death Domain 3 4
  • Lymphocyte Inhibitor Of TRAIL 3 4
  • Decoy Receptor 1 3 4
  • TRAIL-R3 3 4
  • TRAILR3 3 4
  • DCR1 3 4
  • TRID 3 4
  • LIT 3 4
  • TRAIL Receptor Without An Intracellular Domain 4
  • Cytotoxic TRAIL Receptor-3 3
  • TRAIL Receptor 3 4
  • CD263 Antigen 4
  • DCR1-TNFR 3
  • CD263 3
  • DcR1 4

External Ids for TNFRSF10C Gene

Previous GeneCards Identifiers for TNFRSF10C Gene

  • GC08P022711
  • GC08P023296
  • GC08P022781
  • GC08P022982
  • GC08P022997
  • GC08P021504
  • GC08P023085

Summaries for TNFRSF10C Gene

Entrez Gene Summary for TNFRSF10C Gene

  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFRSF10C Gene

TNFRSF10C (TNF Receptor Superfamily Member 10c) is a Protein Coding gene. Diseases associated with TNFRSF10C include Epithelial-Stromal Tgfbi Dystrophy and Stone In Bladder Diverticulum. Among its related pathways are Direct p53 effectors and ERK Signaling. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and TRAIL binding. An important paralog of this gene is TNFRSF10D.

UniProtKB/Swiss-Prot Summary for TNFRSF10C Gene

  • Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.

Gene Wiki entry for TNFRSF10C Gene

Additional gene information for TNFRSF10C Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TNFRSF10C Gene

Genomics for TNFRSF10C Gene

GeneHancer (GH) Regulatory Elements for TNFRSF10C Gene

Promoters and enhancers for TNFRSF10C Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TNFRSF10C on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TNFRSF10C

Top Transcription factor binding sites by QIAGEN in the TNFRSF10C gene promoter:
  • ATF-2
  • c-Jun
  • CREB
  • deltaCREB
  • STAT1

Genomic Locations for TNFRSF10C Gene

Genomic Locations for TNFRSF10C Gene
chr8:23,102,590-23,117,437
(GRCh38/hg38)
Size:
14,848 bases
Orientation:
Plus strand
chr8:22,941,868-22,974,950
(GRCh37/hg19)
Size:
33,083 bases
Orientation:
Plus strand

Genomic View for TNFRSF10C Gene

Genes around TNFRSF10C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFRSF10C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFRSF10C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF10C Gene

Proteins for TNFRSF10C Gene

  • Protein details for TNFRSF10C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14798-TR10C_HUMAN
    Recommended name:
    Tumor necrosis factor receptor superfamily member 10C
    Protein Accession:
    O14798
    Secondary Accessions:
    • O14755
    • Q08AS6
    • Q6FH98
    • Q6UXM5

    Protein attributes for TNFRSF10C Gene

    Size:
    259 amino acids
    Molecular mass:
    27407 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB71413.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAC05593.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAQ88648.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

neXtProt entry for TNFRSF10C Gene

Post-translational modifications for TNFRSF10C Gene

  • N-glycosylated and O-glycosylated.
  • Glycosylation at Asn77, Asn140, and Asn156
  • Modification sites at PhosphoSitePlus

Other Protein References for TNFRSF10C Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for TNFRSF10C
  • Biorbyt antibodies for TNFRSF10C
  • Boster Bio Antibodies for TNFRSF10C
  • Santa Cruz Biotechnology (SCBT) Antibodies for TNFRSF10C

No data available for DME Specific Peptides for TNFRSF10C Gene

Domains & Families for TNFRSF10C Gene

Gene Families for TNFRSF10C Gene

Protein Domains for TNFRSF10C Gene

Blocks:
  • TNFR/CD27/30/40/95 cysteine-rich region
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TNFRSF10C Gene

GenScript: Design optimal peptide antigens:
  • TNFRSF10C protein (Q05D71_HUMAN)
  • TRAIL receptor without an intracellular domain (TR10C_HUMAN)
genes like me logo Genes that share domains with TNFRSF10C: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TNFRSF10C Gene

Function for TNFRSF10C Gene

Molecular function for TNFRSF10C Gene

UniProtKB/Swiss-Prot Function:
Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.
GENATLAS Biochemistry:
tumor necrosis factor receptor superfamily,member 10C,expressed in peripheral lymphocytes and spleen,TNF related,apoptosis induced ligand (TRAIL) receptor 3,binding APO2L

Phenotypes From GWAS Catalog for TNFRSF10C Gene

Gene Ontology (GO) - Molecular Function for TNFRSF10C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 9314565
GO:0005515 protein binding IEA --
GO:0045569 TRAIL binding IEA --
genes like me logo Genes that share ontologies with TNFRSF10C: view
genes like me logo Genes that share phenotypes with TNFRSF10C: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TNFRSF10C Gene

Localization for TNFRSF10C Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF10C Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFRSF10C gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytosol 3
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TNFRSF10C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS,IBA 9314565
GO:0009986 cell surface IBA 21873635
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with TNFRSF10C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TNFRSF10C Gene

Pathways & Interactions for TNFRSF10C Gene

PathCards logo

SuperPathways for TNFRSF10C Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
.51
.47
.43
2 Akt Signaling
.60
.60
.55
3 TGF-Beta Pathway
.60
.57
.51
4 Apoptosis Modulation and Signaling
5 TNFR1 Pathway
.42
.40
genes like me logo Genes that share pathways with TNFRSF10C: view

Pathways by source for TNFRSF10C Gene

14 Qiagen pathways for TNFRSF10C Gene
  • Akt Signaling
  • Antioxidant Action of Vitamin-C
  • Apoptosis through Death Receptors
  • Glucocorticoid Receptor Signaling
  • JAK-STAT Pathway
1 Cell Signaling Technology pathway for TNFRSF10C Gene

SIGNOR curated interactions for TNFRSF10C Gene

Inactivates:

Gene Ontology (GO) - Biological Process for TNFRSF10C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0036462 TRAIL-activated apoptotic signaling pathway IBA 21873635
GO:0042981 regulation of apoptotic process TAS --
GO:0043065 positive regulation of apoptotic process IBA 21873635
genes like me logo Genes that share ontologies with TNFRSF10C: view

Drugs & Compounds for TNFRSF10C Gene

(4) Drugs for TNFRSF10C Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(6) Additional Compounds for TNFRSF10C Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TNFRSF10C: view

Transcripts for TNFRSF10C Gene

mRNA/cDNA for TNFRSF10C Gene

1 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF10C Gene

No ASD Table

Relevant External Links for TNFRSF10C Gene

GeneLoc Exon Structure for
TNFRSF10C

Expression for TNFRSF10C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TNFRSF10C Gene

mRNA differential expression in normal tissues according to GTEx for TNFRSF10C Gene

This gene is overexpressed in Whole Blood (x48.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TNFRSF10C

SOURCE GeneReport for Unigene cluster for TNFRSF10C Gene:

Hs.655801

mRNA Expression by UniProt/SwissProt for TNFRSF10C Gene:

O14798-TR10C_HUMAN
Tissue specificity: Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart.

Evidence on tissue expression from TISSUES for TNFRSF10C Gene

  • Spleen(4.4)
  • Liver(4.3)
  • Blood(3.7)
genes like me logo Genes that share expression patterns with TNFRSF10C: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFRSF10C Gene

Orthologs for TNFRSF10C Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF10C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNFRSF10C 31 30
  • 98.5 (n)
OneToOne
cow
(Bos Taurus)
Mammalia -- 31
  • 44 (a)
ManyToMany
-- 31
  • 41 (a)
ManyToMany
TNFRSF10D 31
  • 19 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 18 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tnfrsf10b 31
  • 16 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 10 (a)
OneToMany
chicken
(Gallus gallus)
Aves TVB 31
  • 14 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 15 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii hdr 31
  • 12 (a)
ManyToMany
tnfrsfa 31
  • 11 (a)
ManyToMany
Species where no ortholog for TNFRSF10C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFRSF10C Gene

ENSEMBL:
Gene Tree for TNFRSF10C (if available)
TreeFam:
Gene Tree for TNFRSF10C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TNFRSF10C: view image

Paralogs for TNFRSF10C Gene

(3) SIMAP similar genes for TNFRSF10C Gene using alignment to 5 proteins:

  • TR10C_HUMAN
  • E5RJI1_HUMAN
  • E9PBT0_HUMAN
  • F5H6H7_HUMAN
  • Q05D71_HUMAN
genes like me logo Genes that share paralogs with TNFRSF10C: view

Variants for TNFRSF10C Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TNFRSF10C Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
709419 Benign: not provided 23,114,694(+) G/A SYNONYMOUS_VARIANT
717706 Benign: not provided 23,114,715(+) C/T SYNONYMOUS_VARIANT
732374 Likely Benign: not provided 23,103,164(+) G/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
rs12550828 - p.Thr199Asn
rs9644063 - p.Ile229Thr

Additional dbSNP identifiers (rs#s) for TNFRSF10C Gene

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF10C Gene

Variant ID Type Subtype PubMed ID
dgv12057n54 CNV loss 21841781
esv2736750 CNV deletion 23290073
esv2736752 CNV deletion 23290073
esv2759604 CNV loss 17122850
esv3616623 CNV loss 21293372
esv8868 OTHER inversion 19470904
nsv1015967 CNV loss 25217958
nsv1017570 CNV gain 25217958
nsv1025279 CNV loss 25217958
nsv1025672 CNV gain 25217958
nsv1027718 CNV gain 25217958
nsv520728 CNV loss 19592680
nsv610775 CNV loss 21841781
nsv971632 CNV duplication 23825009

Variation tolerance for TNFRSF10C Gene

Residual Variation Intolerance Score: 74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.04; 50.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNFRSF10C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNFRSF10C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFRSF10C Gene

Disorders for TNFRSF10C Gene

MalaCards: The human disease database

(35) MalaCards diseases for TNFRSF10C Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
epithelial-stromal tgfbi dystrophy
stone in bladder diverticulum
  • calculus in diverticulum of bladder
prosopagnosia
lattice corneal dystrophy
  • familial amyloid neuropathy, finnish type
suppression amblyopia
  • strabismic amblyopia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TNFRSF10C

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TNFRSF10C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNFRSF10C Gene

Publications for TNFRSF10C Gene

  1. Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. (PMID: 9325248) MacFarlane M … Alnemri ES (The Journal of biological chemistry 1997) 2 3 4 23 54
  2. Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family. (PMID: 9314565) Degli-Esposti MA … Smith CA (The Journal of experimental medicine 1997) 2 3 4 23 54
  3. An antagonist decoy receptor and a death domain-containing receptor for TRAIL. (PMID: 9242610) Pan G … Dixit VM (Science (New York, N.Y.) 1997) 3 4 23 54
  4. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. (PMID: 9242611) Sheridan JP … Ashkenazi A (Science (New York, N.Y.) 1997) 3 4 23 54
  5. Characterization of two receptors for TRAIL. (PMID: 9373179) Schneider P … Tschopp J (FEBS letters 1997) 3 4 23 54

Products for TNFRSF10C Gene

  • Boster Bio Antibodies for TNFRSF10C
  • Boster Bio ELISA Kits for TNFRSF10C
  • Biorbyt antibodies for TNFRSF10C

Sources for TNFRSF10C Gene