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Aliases for TNFRSF10C Gene

Aliases for TNFRSF10C Gene

  • TNF Receptor Superfamily Member 10c 2 3 5
  • Tumor Necrosis Factor Receptor Superfamily, Member 10c, Decoy Without An Intracellular Domain 2 3
  • TNF-Related Apoptosis-Inducing Ligand Receptor 3 3 4
  • Antagonist Decoy Receptor For TRAIL/Apo-2L 3 4
  • Decoy TRAIL Receptor Without Death Domain 3 4
  • Lymphocyte Inhibitor Of TRAIL 3 4
  • Decoy Receptor 1 3 4
  • TRAIL-R3 3 4
  • TRAILR3 3 4
  • DCR1 3 4
  • TRID 3 4
  • LIT 3 4
  • Tumor Necrosis Factor Receptor Superfamily Member 10C 3
  • TRAIL Receptor Without An Intracellular Domain 4
  • Cytotoxic TRAIL Receptor-3 3
  • TRAIL Receptor 3 4
  • CD263 Antigen 4
  • DCR1-TNFR 3
  • CD263 3
  • DcR1 4

External Ids for TNFRSF10C Gene

Previous GeneCards Identifiers for TNFRSF10C Gene

  • GC08P022711
  • GC08P023296
  • GC08P022781
  • GC08P022982
  • GC08P022997
  • GC08P021504
  • GC08P023085

Summaries for TNFRSF10C Gene

Entrez Gene Summary for TNFRSF10C Gene

  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFRSF10C Gene

TNFRSF10C (TNF Receptor Superfamily Member 10c) is a Protein Coding gene. Among its related pathways are Gene Expression and Akt Signaling. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and TRAIL binding. An important paralog of this gene is TNFRSF10D.

UniProtKB/Swiss-Prot for TNFRSF10C Gene

  • Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.

Gene Wiki entry for TNFRSF10C Gene

Additional gene information for TNFRSF10C Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF10C Gene

Genomics for TNFRSF10C Gene

GeneHancer (GH) Regulatory Elements for TNFRSF10C Gene

Promoters and enhancers for TNFRSF10C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J023082 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 664.4 -18.6 -18579 2.1 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 TNFRSF10C ENSG00000284956 LOC254896 ENSG00000253616 LOXL2 LOC101929237 LOC286059
GH08J023102 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 673.2 +0.7 705 1 CTCF EBF1 POLR2A IKZF1 EED ETV6 RUNX3 IKZF2 EZH2 TNFRSF10C ENSG00000284956 LOC254896 GC08P023143
GH08J023103 Promoter 0.5 EPDnew 650.7 +0.0 9 0.1 TNFRSF10C LOC254896 ENSG00000284956 GC08P023143
GH08J023525 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 32.5 +422.9 422908 0.6 CAVIN1 L3MBTL2 CEBPB JUNB EBF1 MEF2B BATF ATF2 ATF4 POLR2A TNFRSF10C ENTPD4 SLC25A37 BIN3 LOC101929315 LOC105379327
GH08J023527 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.2 +428.1 428072 6.5 PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF766 ZNF143 FOS SLC25A37 ENSG00000253200 ENTPD4 TNFRSF10C ENSG00000245025 C8orf58 LOXL2 BIN3 TNFRSF10B GC08M023551
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TNFRSF10C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TNFRSF10C gene promoter:
  • deltaCREB
  • CREB
  • STAT1
  • ATF-2
  • c-Jun

Genomic Locations for TNFRSF10C Gene

Genomic Locations for TNFRSF10C Gene
chr8:23,102,590-23,117,437
(GRCh38/hg38)
Size:
14,848 bases
Orientation:
Plus strand
chr8:22,941,868-22,974,950
(GRCh37/hg19)
Size:
33,083 bases
Orientation:
Plus strand

Genomic View for TNFRSF10C Gene

Genes around TNFRSF10C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFRSF10C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFRSF10C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF10C Gene

Proteins for TNFRSF10C Gene

  • Protein details for TNFRSF10C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14798-TR10C_HUMAN
    Recommended name:
    Tumor necrosis factor receptor superfamily member 10C
    Protein Accession:
    O14798
    Secondary Accessions:
    • O14755
    • Q08AS6
    • Q6FH98
    • Q6UXM5

    Protein attributes for TNFRSF10C Gene

    Size:
    259 amino acids
    Molecular mass:
    27407 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB71413.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAC05593.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAQ88648.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for TNFRSF10C Gene

Post-translational modifications for TNFRSF10C Gene

  • N-glycosylated and O-glycosylated.
  • Glycosylation at isoforms=156, isoforms=140, and posLast=7777
  • Modification sites at PhosphoSitePlus

Other Protein References for TNFRSF10C Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for TNFRSF10C (TRAIL R3/TNFRSF10C)
  • Boster Bio Antibodies for TNFRSF10C
  • Santa Cruz Biotechnology (SCBT) Antibodies for TNFRSF10C

No data available for DME Specific Peptides for TNFRSF10C Gene

Domains & Families for TNFRSF10C Gene

Gene Families for TNFRSF10C Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TNFRSF10C Gene

Suggested Antigen Peptide Sequences for TNFRSF10C Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TNFRSF10C: view

No data available for UniProtKB/Swiss-Prot for TNFRSF10C Gene

Function for TNFRSF10C Gene

Molecular function for TNFRSF10C Gene

UniProtKB/Swiss-Prot Function:
Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.
GENATLAS Biochemistry:
tumor necrosis factor receptor superfamily,member 10C,expressed in peripheral lymphocytes and spleen,TNF related,apoptosis induced ligand (TRAIL) receptor 3,binding APO2L

Phenotypes From GWAS Catalog for TNFRSF10C Gene

Gene Ontology (GO) - Molecular Function for TNFRSF10C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 9314565
GO:0005031 tumor necrosis factor-activated receptor activity IBA --
GO:0005515 protein binding IEA --
GO:0045569 TRAIL binding IEA --
genes like me logo Genes that share ontologies with TNFRSF10C: view
genes like me logo Genes that share phenotypes with TNFRSF10C: view

Animal Model Products

Clone Products

  • R&D Systems cDNA Clones for TNFRSF10C (TRAIL R3/TNFRSF10C)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TNFRSF10C Gene

Localization for TNFRSF10C Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF10C Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFRSF10C gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytosol 2
mitochondrion 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TNFRSF10C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9314565
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with TNFRSF10C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TNFRSF10C Gene

Pathways & Interactions for TNFRSF10C Gene

genes like me logo Genes that share pathways with TNFRSF10C: view

SIGNOR curated interactions for TNFRSF10C Gene

Inactivates:

Gene Ontology (GO) - Biological Process for TNFRSF10C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0006954 inflammatory response IBA --
GO:0006955 immune response IBA --
GO:0007165 signal transduction TAS 9314565
GO:0007275 multicellular organism development IBA --
genes like me logo Genes that share ontologies with TNFRSF10C: view

Drugs & Compounds for TNFRSF10C Gene

(4) Drugs for TNFRSF10C Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(6) Additional Compounds for TNFRSF10C Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TNFRSF10C: view

Transcripts for TNFRSF10C Gene

mRNA/cDNA for TNFRSF10C Gene

(1) REFSEQ mRNAs :
(15) Additional mRNA sequences :
(39) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TNFRSF10C Gene

Tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain:
Representative Sequences:

Clone Products

  • R&D Systems cDNA Clones for TNFRSF10C (TRAIL R3/TNFRSF10C)

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF10C Gene

No ASD Table

Relevant External Links for TNFRSF10C Gene

GeneLoc Exon Structure for
TNFRSF10C
ECgene alternative splicing isoforms for
TNFRSF10C

Expression for TNFRSF10C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNFRSF10C Gene

mRNA differential expression in normal tissues according to GTEx for TNFRSF10C Gene

This gene is overexpressed in Whole Blood (x48.0).

NURSA nuclear receptor signaling pathways regulating expression of TNFRSF10C Gene:

TNFRSF10C

SOURCE GeneReport for Unigene cluster for TNFRSF10C Gene:

Hs.655801

mRNA Expression by UniProt/SwissProt for TNFRSF10C Gene:

O14798-TR10C_HUMAN
Tissue specificity: Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart.

Evidence on tissue expression from TISSUES for TNFRSF10C Gene

  • Spleen(4.4)
  • Liver(4.3)
  • Blood(3.7)
genes like me logo Genes that share expression patterns with TNFRSF10C: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFRSF10C Gene

Orthologs for TNFRSF10C Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF10C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNFRSF10C 34 33
  • 98.5 (n)
OneToOne
cow
(Bos Taurus)
Mammalia -- 34
  • 44 (a)
ManyToMany
-- 34
  • 41 (a)
ManyToMany
TNFRSF10D 34
  • 19 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 18 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tnfrsf10b 34
  • 16 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 10 (a)
OneToMany
chicken
(Gallus gallus)
Aves TVB 34
  • 14 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 15 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii hdr 34
  • 12 (a)
ManyToMany
tnfrsfa 34
  • 11 (a)
ManyToMany
Species where no ortholog for TNFRSF10C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFRSF10C Gene

ENSEMBL:
Gene Tree for TNFRSF10C (if available)
TreeFam:
Gene Tree for TNFRSF10C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TNFRSF10C: view image

Paralogs for TNFRSF10C Gene

Paralogs for TNFRSF10C Gene

(3) SIMAP similar genes for TNFRSF10C Gene using alignment to 5 proteins:

  • TR10C_HUMAN
  • E5RJI1_HUMAN
  • E9PBT0_HUMAN
  • F5H6H7_HUMAN
  • Q05D71_HUMAN
genes like me logo Genes that share paralogs with TNFRSF10C: view

Variants for TNFRSF10C Gene

Sequence variations from dbSNP and Humsavar for TNFRSF10C Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000030867 -- 23,113,769(+) T/A intron_variant
rs1000355685 -- 23,115,969(+) G/C intron_variant
rs1000391350 -- 23,116,162(+) A/G intron_variant
rs1000615086 -- 23,117,492(+) T/C downstream_transcript_variant
rs1000680125 -- 23,103,413(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF10C Gene

Variant ID Type Subtype PubMed ID
nsv971632 CNV duplication 23825009
nsv610775 CNV loss 21841781
nsv520728 CNV loss 19592680
nsv1027718 CNV gain 25217958
nsv1025672 CNV gain 25217958
nsv1025279 CNV loss 25217958
nsv1017570 CNV gain 25217958
nsv1015967 CNV loss 25217958
esv8868 OTHER inversion 19470904
esv3616623 CNV loss 21293372
esv2759604 CNV loss 17122850
esv2736752 CNV deletion 23290073
esv2736750 CNV deletion 23290073
dgv12057n54 CNV loss 21841781

Variation tolerance for TNFRSF10C Gene

Residual Variation Intolerance Score: 74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.04; 50.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNFRSF10C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNFRSF10C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFRSF10C Gene

Disorders for TNFRSF10C Gene

Additional Disease Information for TNFRSF10C

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TNFRSF10C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNFRSF10C Gene

Publications for TNFRSF10C Gene

  1. Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. (PMID: 9325248) MacFarlane M … Alnemri ES (The Journal of biological chemistry 1997) 2 3 4 22 58
  2. Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family. (PMID: 9314565) Degli-Esposti MA … Smith CA (The Journal of experimental medicine 1997) 2 3 4 22 58
  3. An antagonist decoy receptor and a death domain-containing receptor for TRAIL. (PMID: 9242610) Pan G … Dixit VM (Science (New York, N.Y.) 1997) 3 4 22 58
  4. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. (PMID: 9242611) Sheridan JP … Ashkenazi A (Science (New York, N.Y.) 1997) 3 4 22 58
  5. Characterization of two receptors for TRAIL. (PMID: 9373179) Schneider P … Tschopp J (FEBS letters 1997) 3 4 22 58

Products for TNFRSF10C Gene

  • Boster Bio Antibodies for TNFRSF10C
  • Boster Bio ELISA Kits for TNFRSF10C

Sources for TNFRSF10C Gene

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