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Aliases for TNFRSF10B Gene

Aliases for TNFRSF10B Gene

  • TNF Receptor Superfamily Member 10b 2 3 5
  • Tumor Necrosis Factor Receptor Superfamily, Member 10b 2 3
  • TNF-Related Apoptosis-Inducing Ligand Receptor 2 3 4
  • Death Receptor 5 3 4
  • TRAIL-R2 3 4
  • TRAILR2 3 4
  • KILLER 3 4
  • TRICK2 3 4
  • ZTNFR9 3 4
  • DR5 3 4
  • P53-Regulated DNA Damage-Inducible Cell Death Receptor(Killer) 3
  • Tumor Necrosis Factor Receptor Superfamily Member 10B 3
  • Tumor Necrosis Factor Receptor-Like Protein ZTNFR9 3
  • Death Domain Containing Receptor For TRAIL/Apo-2L 3
  • Apoptosis Inducing Protein TRICK2A/2B 3
  • Apoptosis Inducing Receptor TRAIL-R2 3
  • Cytotoxic TRAIL Receptor-2 3
  • Fas-Like Protein 3
  • TRAIL Receptor 2 4
  • CD262 Antigen 4
  • KILLER/DR5 3
  • TRICK2A 3
  • TRICK2B 3
  • TRICKB 3
  • CD262 3

External Ids for TNFRSF10B Gene

Previous GeneCards Identifiers for TNFRSF10B Gene

  • GC08M022647
  • GC08M023231
  • GC08M022899
  • GC08M022933
  • GC08M021422
  • GC08M022877

Summaries for TNFRSF10B Gene

Entrez Gene Summary for TNFRSF10B Gene

  • The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]

GeneCards Summary for TNFRSF10B Gene

TNFRSF10B (TNF Receptor Superfamily Member 10b) is a Protein Coding gene. Diseases associated with TNFRSF10B include Squamous Cell Carcinoma, Head And Neck and Diffuse Infiltrative Lymphocytosis Syndrome. Among its related pathways are PEDF Induced Signaling and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include receptor activity and TRAIL binding. An important paralog of this gene is TNFRSF10A.

UniProtKB/Swiss-Prot for TNFRSF10B Gene

  • Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.

Gene Wiki entry for TNFRSF10B Gene

Additional gene information for TNFRSF10B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF10B Gene

Genomics for TNFRSF10B Gene

GeneHancer (GH) Regulatory Elements for TNFRSF10B Gene

Promoters and enhancers for TNFRSF10B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I023067 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 566.9 +0.3 282 3.6 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 IRF4 TNFRSF10B LOC286059 ENSG00000253616 PHYHIP FAM160B2 ENSG00000253200 BMP1 TNFRSF10C PEBP4 PPP3CC
GH08I023070 Enhancer 0.5 Ensembl 550.8 -1.8 -1814 0.4 ZNF282 L3MBTL2 ZBTB8A ZNF592 TNFRSF10B ENSG00000253616 LOC286059
GH08I023049 Enhancer 1.2 Ensembl ENCODE dbSUPER 19 +19.1 19127 2 HDAC1 HDGF PKNOX1 ARNT SIN3A CHAMP1 TCF12 GATA2 EGR1 ZBTB2 TNFRSF10B RHOBTB2 LOC286059 PIR57431
GH08I023159 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 6.1 -93.2 -93202 5.1 HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 TNFRSF10D ENSG00000253200 ENTPD4 C8orf58 POLR3D CCAR2 BIN3 CHMP7 LOC389641 TNFRSF10A
GH08I023017 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 6.1 +48.6 48581 6.8 HDGF PKNOX1 ARID4B SIN3A ZNF2 YY1 POLR2B ZNF766 CBX5 E2F8 LOC107986927 PIR51638 PIR53150 RHOBTB2 LOC101929237 TNFRSF10B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TNFRSF10B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TNFRSF10B gene promoter:

Genomic Locations for TNFRSF10B Gene

Genomic Locations for TNFRSF10B Gene
62,805 bases
Minus strand

Genomic View for TNFRSF10B Gene

Genes around TNFRSF10B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFRSF10B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFRSF10B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF10B Gene

Proteins for TNFRSF10B Gene

  • Protein details for TNFRSF10B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor necrosis factor receptor superfamily member 10B
    Protein Accession:
    Secondary Accessions:
    • O14720
    • O15508
    • O15517
    • O15531
    • Q6UXM8
    • Q7Z360
    • Q9BVE0

    Protein attributes for TNFRSF10B Gene

    440 amino acids
    Molecular mass:
    47878 Da
    Quaternary structure:
    • Monomer (PubMed:10549288). Can interact with TRADD and RIPK1. Interacts with HCMV protein UL141; this interaction prevents TNFRSF10B cell surface expression. Two TNFRSF10B monomers interact with a UL141 homodimer. Three TNFRSF10B molecules interact with TNFSF10 homotrimer (PubMed:10549288).

    Three dimensional structures from OCA and Proteopedia for TNFRSF10B Gene

    Alternative splice isoforms for TNFRSF10B Gene


neXtProt entry for TNFRSF10B Gene

Post-translational modifications for TNFRSF10B Gene

  • Ubiquitination at posLast=245245
  • Modification sites at PhosphoSitePlus

Other Protein References for TNFRSF10B Gene

Antibody Products

  • R&D Systems Antibodies for TNFRSF10B (TRAIL R2/TNFRSF10B)
  • Abcam antibodies for TNFRSF10B
  • Cloud-Clone Corp. Antibodies for TNFRSF10B

No data available for DME Specific Peptides for TNFRSF10B Gene

Domains & Families for TNFRSF10B Gene

Gene Families for TNFRSF10B Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Disease related genes
  • Plasma proteins
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TNFRSF10B: view

No data available for UniProtKB/Swiss-Prot for TNFRSF10B Gene

Function for TNFRSF10B Gene

Molecular function for TNFRSF10B Gene

GENATLAS Biochemistry:
tumor necrosis factor receptor superfamily,member 10B,expressed in the proliferating compartment of colonic crypt epithelia,TP53,inducible,binding APO2L,inducing a caspase-dependent apoptotic pathway,FADD dependent,inactivated in colorectal tumorigenesis (see TSG8A)
UniProtKB/Swiss-Prot Function:
Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
UniProtKB/Swiss-Prot Induction:
By ER stress. Regulated by p53/TP53.

Phenotypes From GWAS Catalog for TNFRSF10B Gene

Gene Ontology (GO) - Molecular Function for TNFRSF10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity NAS 9311998
GO:0005031 tumor necrosis factor-activated receptor activity IBA --
GO:0005515 protein binding IPI 10549288
GO:0045569 TRAIL binding NAS 9373179
genes like me logo Genes that share ontologies with TNFRSF10B: view
genes like me logo Genes that share phenotypes with TNFRSF10B: view

Human Phenotype Ontology for TNFRSF10B Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

miRNA for TNFRSF10B Gene

miRTarBase miRNAs that target TNFRSF10B

Clone Products

  • R&D Systems cDNA Clones for TNFRSF10B (TRAIL R2/TNFRSF10B)

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TNFRSF10B Gene

Localization for TNFRSF10B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF10B Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFRSF10B gene
Compartment Confidence
plasma membrane 5
cytosol 3
extracellular 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
cytoskeleton 1
lysosome 1

Gene Ontology (GO) - Cellular Components for TNFRSF10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0009986 cell surface IDA 22952982
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TNFRSF10B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TNFRSF10B Gene

Pathways & Interactions for TNFRSF10B Gene

genes like me logo Genes that share pathways with TNFRSF10B: view

SIGNOR curated interactions for TNFRSF10B Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TNFRSF10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process NAS 9430227
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process TAS --
GO:0006954 inflammatory response IBA --
GO:0006955 immune response IBA --
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with TNFRSF10B: view

Drugs & Compounds for TNFRSF10B Gene

(40) Drugs for TNFRSF10B Gene - From: DrugBank, DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
HGS-TR2J Investigational Pharma Target 0
conatumumab Investigational Pharma antibody, agonist Therapeutic Antibodies, TNF related apoptosis inducing ligand (TRAIL) receptor agonists 0
dulanermin Investigational Pharma antibody, agonist Therapeutic Antibodies, TNF related apoptosis inducing ligand (TRAIL) receptor agonists 0
TRAIL Pharma 0
apomab Pharma antibody, agonist Therapeutic Antibodies 0

(17) Additional Compounds for TNFRSF10B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TNFRSF10B: view

Transcripts for TNFRSF10B Gene

Unigene Clusters for TNFRSF10B Gene

Tumor necrosis factor receptor superfamily, member 10b:
Representative Sequences:

Clone Products

  • R&D Systems cDNA Clones for TNFRSF10B (TRAIL R2/TNFRSF10B)

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF10B Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c · 11d
SP1: - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - -
SP5: -
SP7: - - - - -
SP10: -

Relevant External Links for TNFRSF10B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNFRSF10B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNFRSF10B Gene

Protein differential expression in normal tissues from HIPED for TNFRSF10B Gene

This gene is overexpressed in Amniocyte (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TNFRSF10B Gene

Protein tissue co-expression partners for TNFRSF10B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TNFRSF10B Gene:


SOURCE GeneReport for Unigene cluster for TNFRSF10B Gene:


mRNA Expression by UniProt/SwissProt for TNFRSF10B Gene:

Tissue specificity: Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.

Evidence on tissue expression from TISSUES for TNFRSF10B Gene

  • Intestine(4.9)
  • Liver(4.5)
  • Spleen(4.4)
  • Nervous system(3.2)
  • Blood(2.9)
  • Lung(2.5)
  • Thyroid gland(2.3)
  • Kidney(2.2)
  • Lymph node(2.2)
  • Bone marrow(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFRSF10B Gene

Germ Layers:
  • ectoderm
  • integumentary
  • skin
genes like me logo Genes that share expression patterns with TNFRSF10B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TNFRSF10B Gene

Orthologs for TNFRSF10B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF10B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TNFRSF10B 33 34
  • 98.78 (n)
(Bos Taurus)
Mammalia -- 34
  • 46 (a)
-- 34
  • 41 (a)
  • 34 (a)
(Mus musculus)
Mammalia Tnfrsf10b 34
  • 32 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 29 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 27 (a)
(Gallus gallus)
Aves TNFRSF10B 33
  • 51.68 (n)
TVB 34
  • 29 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 27 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tnfrsf10b 33
  • 47.67 (n)
(Danio rerio)
Actinopterygii hdr 34
  • 19 (a)
tnfrsfa 34
  • 18 (a)
Species where no ortholog for TNFRSF10B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFRSF10B Gene

Gene Tree for TNFRSF10B (if available)
Gene Tree for TNFRSF10B (if available)

Paralogs for TNFRSF10B Gene

Paralogs for TNFRSF10B Gene

(5) SIMAP similar genes for TNFRSF10B Gene using alignment to 6 proteins: Pseudogenes for TNFRSF10B Gene

genes like me logo Genes that share paralogs with TNFRSF10B: view

Variants for TNFRSF10B Gene

Sequence variations from dbSNP and Humsavar for TNFRSF10B Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000055290 -- 23,054,801(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000057712 -- 23,045,027(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000100410 -- 23,050,308(-) TT/T genic_upstream_transcript_variant, intron_variant
rs1000114235 -- 23,038,634(-) C/T intron_variant
rs1000178770 -- 23,023,409(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF10B Gene

Variant ID Type Subtype PubMed ID
esv1764616 CNV deletion 17803354
esv2671855 CNV deletion 23128226
esv2736750 CNV deletion 23290073
esv2759604 CNV loss 17122850
nsv1015967 CNV loss 25217958
nsv1017570 CNV gain 25217958
nsv1025672 CNV gain 25217958
nsv1027718 CNV gain 25217958
nsv524231 CNV loss 19592680

Variation tolerance for TNFRSF10B Gene

Residual Variation Intolerance Score: 84.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.66; 65.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNFRSF10B Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFRSF10B Gene

Disorders for TNFRSF10B Gene

MalaCards: The human disease database

(17) MalaCards diseases for TNFRSF10B Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
squamous cell carcinoma, head and neck
  • hnscc
diffuse infiltrative lymphocytosis syndrome
malignant glioma
  • glial cell tumor
  • primary iridocyclitis
diffuse scleroderma
  • systemic scleroderma
- elite association - COSMIC cancer census association via MalaCards


  • Squamous cell carcinoma of the head and neck (HNSCC) [MIM:275355]: A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Additional Disease Information for TNFRSF10B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TNFRSF10B: view

No data available for Genatlas for TNFRSF10B Gene

Publications for TNFRSF10B Gene

  1. TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL. (PMID: 9285725) Screaton GR … Bell JI (Current biology : CB 1997) 2 3 4 22 58
  2. TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL. (PMID: 9311998) Walczak H … Rauch CT (The EMBO journal 1997) 2 3 4 22 58
  3. Genetic variation in APOJ, LPL, and TNFRSF10B affects plasma fatty acid distribution in Alaskan Eskimos. (PMID: 20410100) Voruganti VS … Comuzzie AG (The American journal of clinical nutrition 2010) 3 22 44 58
  4. Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses. (PMID: 23498957) Smith W … Benedict CA (Cell host & microbe 2013) 3 4 58
  5. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PMID: 20568250) Lee KM … Lan Q (American journal of hematology 2010) 3 44 58

Products for TNFRSF10B Gene

Sources for TNFRSF10B Gene