Aliases for TNFRSF10A Gene
External Ids for TNFRSF10A Gene
Previous GeneCards Identifiers for TNFRSF10A Gene
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for TNFRSF10A Gene
TNFRSF10A (TNF Receptor Superfamily Member 10a) is a Protein Coding gene. Diseases associated with TNFRSF10A include Hirata Disease and Temporal Arteritis. Among its related pathways are Apoptosis Modulation and Signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include transcription factor binding and protease binding. An important paralog of this gene is TNFRSF10B.
UniProtKB/Swiss-Prot Summary for TNFRSF10A Gene
Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (PubMed:19090789). Promotes the activation of NF-kappa-B (PubMed:9430227).