Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TNFRSF10A Gene

Aliases for TNFRSF10A Gene

  • TNF Receptor Superfamily Member 10a 2 3 5
  • Tumor Necrosis Factor Receptor Superfamily, Member 10a 2 3
  • TNF-Related Apoptosis-Inducing Ligand Receptor 1 3 4
  • Death Receptor 4 3 4
  • TRAIL Receptor 1 3 4
  • TRAIL-R1 3 4
  • TRAILR1 3 4
  • APO2 3 4
  • DR4 3 4
  • Tumor Necrosis Factor Receptor Superfamily Member 10a Variant 2 3
  • Tumor Necrosis Factor Receptor Superfamily Member 10A 3
  • Cytotoxic TRAIL Receptor 3
  • CD261 Antigen 4
  • TRAILR-1 3
  • CD261 3

External Ids for TNFRSF10A Gene

Previous GeneCards Identifiers for TNFRSF10A Gene

  • GC08M022787
  • GC08M023403
  • GC08M023070
  • GC08M023104
  • GC08M023048
  • GC08M021594

Summaries for TNFRSF10A Gene

Entrez Gene Summary for TNFRSF10A Gene

  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for TNFRSF10A Gene

TNFRSF10A (TNF Receptor Superfamily Member 10a) is a Protein Coding gene. Diseases associated with TNFRSF10A include Posterior Scleritis and Neuronitis. Among its related pathways are PEDF Induced Signaling and Apoptosis Modulation and Signaling. Gene Ontology (GO) annotations related to this gene include transcription factor binding and protease binding. An important paralog of this gene is TNFRSF10B.

UniProtKB/Swiss-Prot for TNFRSF10A Gene

  • Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.

Gene Wiki entry for TNFRSF10A Gene

Additional gene information for TNFRSF10A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF10A Gene

Genomics for TNFRSF10A Gene

GeneHancer (GH) Regulatory Elements for TNFRSF10A Gene

Promoters and enhancers for TNFRSF10A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I023223 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 597 +0.0 23 3.5 HDGF ATF1 ARNT ARID4B SIN3A YY1 ZNF280A GTF3C2 ZNF207 ZNF143 TNFRSF10A LOC389641 BIN3 CCAR2 ENSG00000253200 ENSG00000250714
GH08I023230 Promoter/Enhancer 1.1 Ensembl ENCODE 40.9 -5.8 -5802 1.2 FOSL1 IRF2 ATF3 STAT2 JUNB MAX MNT RUNX3 YY1 ENSG00000250714 TNFRSF10A LOC389641 CHMP7
GH08I023159 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12 +62.8 62778 5.1 HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 TNFRSF10D ENSG00000253200 ENTPD4 C8orf58 POLR3D CCAR2 BIN3 CHMP7 LOC389641 TNFRSF10A
GH08I023242 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 12.2 -20.0 -20006 5.5 ZFP64 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 ZNF610 GLIS1 NBN CHMP7 SORBS3 TNFRSF10A LOC105379326
GH08I023217 Enhancer 1.3 FANTOM5 Ensembl ENCODE 17.2 +5.6 5592 4.9 HDGF ATF1 PKNOX1 SMAD1 IRF4 TCF12 GATA2 FOS ATF7 RUNX3 CHMP7 ENSG00000253200 TNFRSF10A LOC100507071 CCAR2 C8orf58 SORBS3 LOC107986927 TNFRSF10C R3HCC1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TNFRSF10A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TNFRSF10A gene promoter:

Genomic Locations for TNFRSF10A Gene

Genomic Locations for TNFRSF10A Gene
chr8:23,190,452-23,225,167
(GRCh38/hg38)
Size:
34,716 bases
Orientation:
Minus strand
chr8:23,047,965-23,082,680
(GRCh37/hg19)

Genomic View for TNFRSF10A Gene

Genes around TNFRSF10A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFRSF10A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFRSF10A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF10A Gene

Proteins for TNFRSF10A Gene

  • Protein details for TNFRSF10A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00220-TR10A_HUMAN
    Recommended name:
    Tumor necrosis factor receptor superfamily member 10A
    Protein Accession:
    O00220
    Secondary Accessions:
    • A8K5I4
    • Q53Y72
    • Q96E62

    Protein attributes for TNFRSF10A Gene

    Size:
    468 amino acids
    Molecular mass:
    50089 Da
    Quaternary structure:
    • Monomer (PubMed:26457518). Three TNFRSF10A molecules interact with the TNFSF10 homotrimer (PubMed:26457518). Can interact with TRADD and RIPK1. Interacts with ARAP1. Interacts with HCMV protein UL141; this interaction prevents TNFRSF10A cell surface expression.

    Three dimensional structures from OCA and Proteopedia for TNFRSF10A Gene

neXtProt entry for TNFRSF10A Gene

Post-translational modifications for TNFRSF10A Gene

Other Protein References for TNFRSF10A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for TNFRSF10A (TRAIL R1/TNFRSF10A)
  • Cell Signaling Technology (CST) Antibodies for TNFRSF10A (TRAIL-R1)
  • Abcam antibodies for TNFRSF10A

No data available for DME Specific Peptides for TNFRSF10A Gene

Domains & Families for TNFRSF10A Gene

Gene Families for TNFRSF10A Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TNFRSF10A: view

No data available for UniProtKB/Swiss-Prot for TNFRSF10A Gene

Function for TNFRSF10A Gene

Molecular function for TNFRSF10A Gene

GENATLAS Biochemistry:
tumor necrosis factor receptor superfamily,member 10A,widely expressed,TNF related,widely expressed,apoptosis induced ligand (TRAIL) receptor 1,TP53 inducible,binding APO2L,inducing a caspase-dependent apoptotic pathway,FADD independent
UniProtKB/Swiss-Prot Function:
Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.

Phenotypes From GWAS Catalog for TNFRSF10A Gene

Gene Ontology (GO) - Molecular Function for TNFRSF10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 21785459
GO:0004872 receptor activity NAS 9311998
GO:0005031 tumor necrosis factor-activated receptor activity IBA --
GO:0005035 death receptor activity TAS 9082980
GO:0005515 protein binding IPI 17047155
genes like me logo Genes that share ontologies with TNFRSF10A: view
genes like me logo Genes that share phenotypes with TNFRSF10A: view

Animal Models for TNFRSF10A Gene

MGI Knock Outs for TNFRSF10A:

Animal Model Products

Clone Products

  • R&D Systems cDNA Clones for TNFRSF10A (TRAIL R1/TNFRSF10A)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNFRSF10A Gene

Localization for TNFRSF10A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF10A Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFRSF10A gene
Compartment Confidence
plasma membrane 5
nucleus 3
cytosol 3
extracellular 2
mitochondrion 2
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TNFRSF10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0009986 cell surface IDA 22952982
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TNFRSF10A: view

Pathways & Interactions for TNFRSF10A Gene

genes like me logo Genes that share pathways with TNFRSF10A: view

Pathways by source for TNFRSF10A Gene

SIGNOR curated interactions for TNFRSF10A Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for TNFRSF10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process NAS 9311998
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process TAS --
GO:0006954 inflammatory response IBA --
GO:0006955 immune response IBA --
GO:0007165 signal transduction IEA,TAS 9082980
genes like me logo Genes that share ontologies with TNFRSF10A: view

Drugs & Compounds for TNFRSF10A Gene

(31) Drugs for TNFRSF10A Gene - From: PharmGKB, DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
dulanermin Investigational Pharma antibody, agonist Therapeutic Antibodies, TNF related apoptosis inducing ligand (TRAIL) receptor agonists 0
TRAIL Pharma 0
Tumor necrosis factor alpha (TNF-alpha) inhibitors Pharma 0
mapatumumab Pharma antibody, Agonist Therapeutic Antibodies, TNF related apoptosis inducing ligand (TRAIL) receptor agonists 0

(17) Additional Compounds for TNFRSF10A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TNFRSF10A: view

Transcripts for TNFRSF10A Gene

Unigene Clusters for TNFRSF10A Gene

Tumor necrosis factor receptor superfamily, member 10a:
Representative Sequences:

Clone Products

  • R&D Systems cDNA Clones for TNFRSF10A (TRAIL R1/TNFRSF10A)

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF10A Gene

No ASD Table

Relevant External Links for TNFRSF10A Gene

GeneLoc Exon Structure for
TNFRSF10A
ECgene alternative splicing isoforms for
TNFRSF10A

Expression for TNFRSF10A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNFRSF10A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TNFRSF10A Gene

This gene is overexpressed in Liver (46.3) and Breast (17.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TNFRSF10A Gene



Protein tissue co-expression partners for TNFRSF10A Gene

NURSA nuclear receptor signaling pathways regulating expression of TNFRSF10A Gene:

TNFRSF10A

SOURCE GeneReport for Unigene cluster for TNFRSF10A Gene:

Hs.591834

mRNA Expression by UniProt/SwissProt for TNFRSF10A Gene:

O00220-TR10A_HUMAN
Tissue specificity: Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells.

Evidence on tissue expression from TISSUES for TNFRSF10A Gene

  • Blood(2.9)
  • Liver(2.4)
  • Intestine(2.3)
  • Lung(2.3)
  • Kidney(2.1)
  • Lymph node(2.1)
  • Spleen(2.1)
  • Thyroid gland(2.1)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with TNFRSF10A: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFRSF10A Gene

Orthologs for TNFRSF10A Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF10A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNFRSF10A 33 34
  • 99 (n)
cow
(Bos Taurus)
Mammalia TNFRSF10D 33 34
  • 65.45 (n)
-- 34
  • 48 (a)
ManyToMany
-- 34
  • 42 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Tnfrsf10b 33
  • 62.09 (n)
mouse
(Mus musculus)
Mammalia Tnfrsf10b 33 16 34
  • 55.84 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 31 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 24 (a)
OneToMany
chicken
(Gallus gallus)
Aves TVB 34
  • 26 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 25 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii hdr 34
  • 19 (a)
ManyToMany
tnfrsfa 34
  • 17 (a)
ManyToMany
Species where no ortholog for TNFRSF10A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFRSF10A Gene

ENSEMBL:
Gene Tree for TNFRSF10A (if available)
TreeFam:
Gene Tree for TNFRSF10A (if available)

Paralogs for TNFRSF10A Gene

Paralogs for TNFRSF10A Gene

(3) SIMAP similar genes for TNFRSF10A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TNFRSF10A: view

Variants for TNFRSF10A Gene

Sequence variations from dbSNP and Humsavar for TNFRSF10A Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs483352726 uncertain-significance, not provided 23,212,164(-) C/T coding_sequence_variant, missense_variant
rs13278062 not-provided, not provided 23,225,458(-) G/A/T upstream_transcript_variant
rs1000028712 -- 23,219,280(-) T/C intron_variant
rs1000059808 -- 23,219,074(-) C/T intron_variant
rs1000143940 -- 23,210,446(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF10A Gene

Variant ID Type Subtype PubMed ID
nsv981919 CNV duplication 23825009
nsv951114 CNV deletion 24416366
nsv610777 CNV loss 21841781
nsv1068323 OTHER inversion 25765185
nsv1027718 CNV gain 25217958
nsv1017570 CNV gain 25217958
esv3616630 CNV gain 21293372
esv2759604 CNV loss 17122850
esv2736750 CNV deletion 23290073

Variation tolerance for TNFRSF10A Gene

Residual Variation Intolerance Score: 83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.20; 62.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNFRSF10A Gene

Human Gene Mutation Database (HGMD)
TNFRSF10A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNFRSF10A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFRSF10A Gene

Disorders for TNFRSF10A Gene

MalaCards: The human disease database

(31) MalaCards diseases for TNFRSF10A Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
posterior scleritis
neuronitis
type 1 diabetes mellitus 18
  • diabetes mellitus, insulin-dependent, 18
chondromalacia
cartilage disease
  • cartilage disorder
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TNFRSF10A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TNFRSF10A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNFRSF10A Gene

Publications for TNFRSF10A Gene

  1. TRAIL-R1 polymorphisms and cancer susceptibility: an evidence-based meta-analysis. (PMID: 19643596) Chen B … Wu JQ (European journal of cancer (Oxford, England : 1990) 2009) 3 22 44 58
  2. Ala228 variant of trail receptor 1 affecting the ligand binding site is associated with chronic lymphocytic leukemia, mantle cell lymphoma, prostate cancer, head and neck squamous cell carcinoma and bladder cancer. (PMID: 16217763) Wolf S … Lichter P (International journal of cancer 2006) 3 22 44 58
  3. Death receptor 4 variants and colorectal cancer risk. (PMID: 17035413) Frank B … Burwinkel B (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2006) 3 22 44 58
  4. Association of death receptor 4 haplotype 626C-683C with an increased breast cancer risk. (PMID: 15975957) Frank B … Burwinkel B (Carcinogenesis 2005) 3 22 44 58
  5. A single nucleotide polymorphism in the extracellular domain of TRAIL receptor DR4 at nucleotide 626 in gastric cancer patients in Japan. (PMID: 16012731) Kuraoka K … Yasui W (Oncology reports 2005) 3 22 44 58

Products for TNFRSF10A Gene