Aliases for TNFAIP8L3 Gene

Aliases for TNFAIP8L3 Gene

  • TNF Alpha Induced Protein 8 Like 3 2 3 5
  • Tumor Necrosis Factor Alpha-Induced Protein 8-Like Protein 3 3 4
  • TNF Alpha-Induced Protein 8-Like Protein 3 3 4
  • TNFAIP8-Like Protein 3 3 4
  • TIPE3 3 4
  • Tumor Necrosis Factor, Alpha-Induced Protein 8-Like 3 2
  • Tumor Necrosis Factor, Alpha Induced Protein 8 Like 3 3
  • TNFAIP8L3 5
  • FLJ41287 2

External Ids for TNFAIP8L3 Gene

Previous GeneCards Identifiers for TNFAIP8L3 Gene

  • GC15M049137
  • GC15M051348
  • GC15M028181

Summaries for TNFAIP8L3 Gene

GeneCards Summary for TNFAIP8L3 Gene

TNFAIP8L3 (TNF Alpha Induced Protein 8 Like 3) is a Protein Coding gene. Diseases associated with TNFAIP8L3 include Astigmatism. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. An important paralog of this gene is TNFAIP8.

UniProtKB/Swiss-Prot Summary for TNFAIP8L3 Gene

  • Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling.

Additional gene information for TNFAIP8L3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TNFAIP8L3 Gene

Genomics for TNFAIP8L3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TNFAIP8L3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J051092 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 600.4 +11.3 11275 3.2 HNRNPL LARP7 ZIC2 EZH2 ZNF341 CEBPA KMT2B CEBPB ZBTB26 CHD1 lnc-AP4E1-6 TNFAIP8L3 SPPL2A AP4E1 GLDN piR-60929 MIR4713HG
GH15J051103 Enhancer 0.9 Ensembl ENCODE 600.7 +1.0 1026 1.9 ZNF629 ZNF692 ZNF10 ZXDB CEBPB FOS ATF2 NR2F2 ZNF335 PRDM4 TNFAIP8L3 ENSG00000259684 ENSG00000259715 SPPL2A TRPM7 MIR4713HG lnc-AP4E1-6 AP4E1
GH15J051105 Enhancer 0.3 Ensembl 600.7 -0.4 -425 0.2 ZNF217 KLF9 TNFAIP8L3 piR-39858-207 MIR4713HG CYP19A1
GH15J051376 Promoter/Enhancer 1.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 22.7 -271.6 -271567 1.7 FOXA1 CEBPB FOS CREB1 BHLHE40 MAFK NFE2L2 CHD1 GLDN NONHSAG016893.2 TNFAIP8L3 CYP19A1 ENSG00000259194 DMXL2
GH15J051070 Enhancer 0.5 Ensembl 11.8 +35.2 35175 0.2 DPF2 RELB IKZF1 TBX21 ATF7 MTA2 IKZF2 ENSG00000259204 TNFAIP8L3 piR-50443-130 MIR4713HG AP4E1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TNFAIP8L3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TNFAIP8L3

Top Transcription factor binding sites by QIAGEN in the TNFAIP8L3 gene promoter:
  • AREB6
  • ATF6
  • FOXC1
  • FOXD1
  • FOXI1
  • FOXJ2
  • FOXJ2 (long isoform)
  • HFH-3
  • NF-AT
  • TBP

Genomic Locations for TNFAIP8L3 Gene

Genomic Locations for TNFAIP8L3 Gene
chr15:51,056,598-51,105,276
(GRCh38/hg38)
Size:
48,679 bases
Orientation:
Minus strand
chr15:51,348,795-51,397,473
(GRCh37/hg19)
Size:
48,679 bases
Orientation:
Minus strand

Genomic View for TNFAIP8L3 Gene

Genes around TNFAIP8L3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFAIP8L3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFAIP8L3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFAIP8L3 Gene

Proteins for TNFAIP8L3 Gene

  • Protein details for TNFAIP8L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5GJ75-TP8L3_HUMAN
    Recommended name:
    Tumor necrosis factor alpha-induced protein 8-like protein 3
    Protein Accession:
    Q5GJ75
    Secondary Accessions:
    • Q6ZWD1

    Protein attributes for TNFAIP8L3 Gene

    Size:
    292 amino acids
    Molecular mass:
    32659 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI27702.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI27703.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC85572.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW77412.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TNFAIP8L3 Gene

neXtProt entry for TNFAIP8L3 Gene

Post-translational modifications for TNFAIP8L3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TNFAIP8L3 Gene

No data available for DME Specific Peptides for TNFAIP8L3 Gene

Domains & Families for TNFAIP8L3 Gene

Gene Families for TNFAIP8L3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TNFAIP8L3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TNFAIP8L3 Gene

GenScript: Design optimal peptide antigens:
  • Tumor necrosis factor alpha-induced protein 8-like protein 3 (TP8L3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5GJ75

UniProtKB/Swiss-Prot:

TP8L3_HUMAN :
  • Belongs to the TNFAIP8 family.
Family:
  • Belongs to the TNFAIP8 family.
genes like me logo Genes that share domains with TNFAIP8L3: view

Function for TNFAIP8L3 Gene

Molecular function for TNFAIP8L3 Gene

UniProtKB/Swiss-Prot Function:
Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling.

Phenotypes From GWAS Catalog for TNFAIP8L3 Gene

Gene Ontology (GO) - Molecular Function for TNFAIP8L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008526 phosphatidylinositol transporter activity IEA,ISS --
GO:0035091 phosphatidylinositol binding IEA,ISS --
genes like me logo Genes that share ontologies with TNFAIP8L3: view
genes like me logo Genes that share phenotypes with TNFAIP8L3: view

Animal Models for TNFAIP8L3 Gene

MGI Knock Outs for TNFAIP8L3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNFAIP8L3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNFAIP8L3 Gene

Localization for TNFAIP8L3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFAIP8L3 Gene

Cytoplasm. Cell membrane. Note=On PDGF activation, translocates from cytoplasm to plasma membrane. {ECO:0000250 UniProtKB:Q3TBL6}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFAIP8L3 gene
Compartment Confidence
plasma membrane 4
nucleus 4
cytosol 4
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TNFAIP8L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA,IDA 25479791
GO:0005829 cytosol IDA,TAS --
GO:0005886 plasma membrane ISS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TNFAIP8L3: view

Pathways & Interactions for TNFAIP8L3 Gene

PathCards logo

SuperPathways for TNFAIP8L3 Gene

genes like me logo Genes that share pathways with TNFAIP8L3: view

Pathways by source for TNFAIP8L3 Gene

Interacting Proteins for TNFAIP8L3 Gene

Gene Ontology (GO) - Biological Process for TNFAIP8L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0006869 lipid transport IEA --
GO:0015914 phospholipid transport IEA,ISS --
GO:0019216 regulation of lipid metabolic process IEA,ISS --
GO:0042981 regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with TNFAIP8L3: view

No data available for SIGNOR curated interactions for TNFAIP8L3 Gene

Drugs & Compounds for TNFAIP8L3 Gene

No Compound Related Data Available

Transcripts for TNFAIP8L3 Gene

mRNA/cDNA for TNFAIP8L3 Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNFAIP8L3

Alternative Splicing Database (ASD) splice patterns (SP) for TNFAIP8L3 Gene

No ASD Table

Relevant External Links for TNFAIP8L3 Gene

GeneLoc Exon Structure for
TNFAIP8L3

Expression for TNFAIP8L3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TNFAIP8L3 Gene

mRNA differential expression in normal tissues according to GTEx for TNFAIP8L3 Gene

This gene is overexpressed in Uterus (x5.7) and Fallopian Tube (x4.2).

Protein differential expression in normal tissues from HIPED for TNFAIP8L3 Gene

This gene is overexpressed in Uterus (36.5), Cervix (9.1), Ovary (6.3), and Spleen (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TNFAIP8L3 Gene



Protein tissue co-expression partners for TNFAIP8L3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TNFAIP8L3

SOURCE GeneReport for Unigene cluster for TNFAIP8L3 Gene:

Hs.306343

mRNA Expression by UniProt/SwissProt for TNFAIP8L3 Gene:

Q5GJ75-TP8L3_HUMAN
Tissue specificity: Widely expressed (at protein level) (PubMed:25479791). Highly expressed in most carcinoma cell lines (PubMed:25479791, PubMed:25242044).

Evidence on tissue expression from TISSUES for TNFAIP8L3 Gene

  • Nervous system(4.4)
  • Spleen(2)
genes like me logo Genes that share expression patterns with TNFAIP8L3: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFAIP8L3 Gene

Orthologs for TNFAIP8L3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TNFAIP8L3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TNFAIP8L3 31
  • 99 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC523131 30
  • 93.3 (n)
TNFAIP8L3 31
  • 92 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia TNFAIP8L3 30 31
  • 92.32 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TNFAIP8L3 31
  • 88 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tnfaip8l3 30
  • 87.75 (n)
Mouse
(Mus musculus)
Mammalia Tnfaip8l3 30 17 31
  • 85.95 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TNFAIP8L3 31
  • 74 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TNFAIP8L3 30 31
  • 77.12 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TNFAIP8L3 31
  • 79 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tnfaip8l3 30
  • 72.61 (n)
Zebrafish
(Danio rerio)
Actinopterygii tnfaip8l3 30 31
  • 69.8 (n)
OneToOne
zgc63960 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5318 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG4091 31
  • 37 (a)
OneToMany
Species where no ortholog for TNFAIP8L3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TNFAIP8L3 Gene

ENSEMBL:
Gene Tree for TNFAIP8L3 (if available)
TreeFam:
Gene Tree for TNFAIP8L3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TNFAIP8L3: view image

Paralogs for TNFAIP8L3 Gene

Paralogs for TNFAIP8L3 Gene

(3) SIMAP similar genes for TNFAIP8L3 Gene using alignment to 1 proteins:

  • TP8L3_HUMAN
genes like me logo Genes that share paralogs with TNFAIP8L3: view

Variants for TNFAIP8L3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TNFAIP8L3 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
719370 Likely Benign: not provided 51,105,005(-) C/G MISSENSE_VARIANT
768709 Benign: not provided 51,094,695(-) CCGGGCGGCG/C FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT
rs17647084 - p.Ala38Thr

Additional dbSNP identifiers (rs#s) for TNFAIP8L3 Gene

Structural Variations from Database of Genomic Variants (DGV) for TNFAIP8L3 Gene

Variant ID Type Subtype PubMed ID
dgv4526n54 CNV gain 21841781
esv2657157 CNV deletion 23128226
esv2760031 CNV gain 17122850
esv34532 CNV gain 17911159
esv3636459 CNV gain 21293372
esv3636460 CNV gain 21293372
esv3636461 CNV gain 21293372
nsv1038778 CNV loss 25217958
nsv1047443 CNV gain 25217958
nsv471243 CNV gain 18288195

Variation tolerance for TNFAIP8L3 Gene

Residual Variation Intolerance Score: 74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.75; 46.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNFAIP8L3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNFAIP8L3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFAIP8L3 Gene

Disorders for TNFAIP8L3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TNFAIP8L3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
astigmatism
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with TNFAIP8L3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNFAIP8L3 Gene

Publications for TNFAIP8L3 Gene

  1. Identical expression profiling of human and murine TIPE3 protein reveals links to its functions. (PMID: 25479791) Cui J … Liu S (The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2015) 3 4
  2. TIPE3 is the transfer protein of lipid second messengers that promote cancer. (PMID: 25242044) Fayngerts SA … Chen YH (Cancer cell 2014) 3 4
  3. The TIPE (TNFAIP8) family in inflammation, immunity, and cancer. (PMID: 21924498) Lou Y … Liu S (Molecular immunology 2011) 2 3
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. miR-9-5p Suppresses Malignant Biological Behaviors of Human Gastric Cancer Cells by Negative Regulation of TNFAIP8L3. (PMID: 31140050) Fan Y … Liu W (Digestive diseases and sciences 2019) 3

Products for TNFAIP8L3 Gene

  • Signalway ELISA kits for TNFAIP8L3

Sources for TNFAIP8L3 Gene