This locus represents naturally occurring read-through transcription between the neighboring TNFAIP8L2 (tumor necrosis factor, alpha-induced protein 8-like 2) and SCNM1 (sodium channel modifier 1) genes on chromosome 1. The protein-coding read-through transcript variant encodes a protein that shares sequence identity with the downstream gene product but its N-terminal region is... See more...

Aliases for TNFAIP8L2-SCNM1 Gene

Aliases for TNFAIP8L2-SCNM1 Gene

  • TNFAIP8L2-SCNM1 Readthrough 3
  • Sodium Channel Modifier 1 3
  • TNFAIP8L2-SCNM1 Protein 3
  • SCNM1 3

External Ids for TNFAIP8L2-SCNM1 Gene

Previous GeneCards Identifiers for TNFAIP8L2-SCNM1 Gene

  • GC01U903158

Summaries for TNFAIP8L2-SCNM1 Gene

Entrez Gene Summary for TNFAIP8L2-SCNM1 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring TNFAIP8L2 (tumor necrosis factor, alpha-induced protein 8-like 2) and SCNM1 (sodium channel modifier 1) genes on chromosome 1. The protein-coding read-through transcript variant encodes a protein that shares sequence identity with the downstream gene product but its N-terminal region is shorter due to alternate exon use relative to the downstream gene. [provided by RefSeq, Dec 2016]

GeneCards Summary for TNFAIP8L2-SCNM1 Gene

TNFAIP8L2-SCNM1 (TNFAIP8L2-SCNM1 Readthrough) is a Protein Coding gene.

Additional gene information for TNFAIP8L2-SCNM1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TNFAIP8L2-SCNM1 Gene

Genomics for TNFAIP8L2-SCNM1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TNFAIP8L2-SCNM1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J151156 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 600.7 +1.9 1933 4.9 CREB1 CTCF ZNF512 POLR2A LARP7 PRDM1 REST RAD21 IKZF2 RCOR1 SCNM1 TNFAIP8L2 TNFAIP8L2-SCNM1 SEMA6C BNIPL LYSMD1
GH01J151164 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 0.4 +9.4 9356 3.2 CEBPG SP1 CREB1 GATAD2A PRDM10 REST ZNF629 TFE3 RFX1 SIX5 LYSMD1 NONHSAG002898.2 SCNM1 PRPF3 SETDB1 ARNT PI4KB CTSK UBE2D3P3 PIP5K1A
GH01J151165 Enhancer 0.3 CraniofacialAtlas 0.4 +7.6 7576 0.2 ZSCAN4 ZNF121 LYSMD1 NONHSAG002898.2 SCNM1 TNFAIP8L2-SCNM1
GH01J151153 Enhancer 0.2 Ensembl 0.7 -2.7 -2748 0.2 lnc-SEMA6C-2 TNFAIP8L2 TNFAIP8L2-SCNM1 SEMA6C LYSMD1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TNFAIP8L2-SCNM1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TNFAIP8L2-SCNM1

Genomic Locations for TNFAIP8L2-SCNM1 Gene

Genomic Locations for TNFAIP8L2-SCNM1 Gene
chr1:151,156,649-151,170,296
(GRCh38/hg38)
Size:
13,648 bases
Orientation:
Plus strand
chr1:151,129,105-151,142,773
(GRCh37/hg19)
Size:
13,669 bases
Orientation:
Plus strand

Genomic View for TNFAIP8L2-SCNM1 Gene

Genes around TNFAIP8L2-SCNM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFAIP8L2-SCNM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFAIP8L2-SCNM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFAIP8L2-SCNM1 Gene

Proteins for TNFAIP8L2-SCNM1 Gene

Post-translational modifications for TNFAIP8L2-SCNM1 Gene

No Post-translational modifications

Other Protein References for TNFAIP8L2-SCNM1 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for TNFAIP8L2-SCNM1 Gene

Domains & Families for TNFAIP8L2-SCNM1 Gene

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TNFAIP8L2-SCNM1 Gene

Function for TNFAIP8L2-SCNM1 Gene

Phenotypes From GWAS Catalog for TNFAIP8L2-SCNM1 Gene

Phenotypes for TNFAIP8L2-SCNM1 Gene

genes like me logo Genes that share phenotypes with TNFAIP8L2-SCNM1: view

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNFAIP8L2-SCNM1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TNFAIP8L2-SCNM1 Gene

Localization for TNFAIP8L2-SCNM1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TNFAIP8L2-SCNM1 Gene

Pathways & Interactions for TNFAIP8L2-SCNM1 Gene

PathCards logo

SuperPathways for TNFAIP8L2-SCNM1 Gene

No Data Available

Interacting Proteins for TNFAIP8L2-SCNM1 Gene

Gene Ontology (GO) - Biological Process for TNFAIP8L2-SCNM1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TNFAIP8L2-SCNM1 Gene

Drugs & Compounds for TNFAIP8L2-SCNM1 Gene

No Compound Related Data Available

Transcripts for TNFAIP8L2-SCNM1 Gene

mRNA/cDNA for TNFAIP8L2-SCNM1 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNFAIP8L2-SCNM1

Alternative Splicing Database (ASD) splice patterns (SP) for TNFAIP8L2-SCNM1 Gene

No ASD Table

Relevant External Links for TNFAIP8L2-SCNM1 Gene

GeneLoc Exon Structure for
TNFAIP8L2-SCNM1

Expression for TNFAIP8L2-SCNM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TNFAIP8L2-SCNM1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TNFAIP8L2-SCNM1

genes like me logo Genes that share expression patterns with TNFAIP8L2-SCNM1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFAIP8L2-SCNM1 Gene

Orthologs for TNFAIP8L2-SCNM1 Gene

No data available for Orthologs and Evolution for TNFAIP8L2-SCNM1 Gene

Paralogs for TNFAIP8L2-SCNM1 Gene

No data available for Paralogs for TNFAIP8L2-SCNM1 Gene

Variants for TNFAIP8L2-SCNM1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TNFAIP8L2-SCNM1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
708675 Benign: not provided 151,159,105(+) G/A SYNONYMOUS_VARIANT,INTRON_VARIANT
723112 Benign: not provided 151,158,768(+) G/A MISSENSE_VARIANT,INTRON_VARIANT
775139 Benign: not provided 151,159,060(+) C/G SYNONYMOUS_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for TNFAIP8L2-SCNM1 Gene

Structural Variations from Database of Genomic Variants (DGV) for TNFAIP8L2-SCNM1 Gene

Variant ID Type Subtype PubMed ID
dgv2n68 CNV loss 17160897
esv3587520 CNV loss 21293372
nsv522840 CNV gain 19592680

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Additional Variant Information for TNFAIP8L2-SCNM1 Gene

Disorders for TNFAIP8L2-SCNM1 Gene

No disorders were found for TNFAIP8L2-SCNM1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for TNFAIP8L2-SCNM1 Gene

Publications for TNFAIP8L2-SCNM1 Gene

  1. An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders. (PMID: 29892012) Chen S … Yu H (Nature genetics 2018) 3
  2. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3

No data available for Mastermind for TNFAIP8L2-SCNM1 Gene

Products for TNFAIP8L2-SCNM1 Gene

Sources for TNFAIP8L2-SCNM1 Gene