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Aliases for TNFAIP8L2 Gene

Aliases for TNFAIP8L2 Gene

  • TNF Alpha Induced Protein 8 Like 2 2 3 5
  • TNF Alpha-Induced Protein 8-Like Protein 2 3 4
  • Inflammation Factor Protein 20 3 4
  • TNFAIP8-Like Protein 2 3 4
  • TIPE2 3 4
  • Tumor Necrosis Factor, Alpha-Induced Protein 8-Like Protein 2 3
  • Tumor Necrosis Factor Alpha-Induced Protein 8-Like Protein 2 3
  • Tumor Necrosis Factor, Alpha-Induced Protein 8-Like 2 2
  • Tumor Necrosis Factor, Alpha Induced Protein 8 Like 2 3
  • Inflammation Factor 20 3

External Ids for TNFAIP8L2 Gene

Previous GeneCards Identifiers for TNFAIP8L2 Gene

  • GC01P147943
  • GC01P149395
  • GC01P122507

Summaries for TNFAIP8L2 Gene

GeneCards Summary for TNFAIP8L2 Gene

TNFAIP8L2 (TNF Alpha Induced Protein 8 Like 2) is a Protein Coding gene. Diseases associated with TNFAIP8L2 include Skin Squamous Cell Carcinoma. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. An important paralog of this gene is TNFAIP8L1.

UniProtKB/Swiss-Prot for TNFAIP8L2 Gene

  • Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis (By similarity).

Additional gene information for TNFAIP8L2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFAIP8L2 Gene

Genomics for TNFAIP8L2 Gene

GeneHancer (GH) Regulatory Elements for TNFAIP8L2 Gene

Promoters and enhancers for TNFAIP8L2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I151156 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 550.8 +2.0 1953 4.9 HDGF ARID4B RAD21 ZBTB40 RFX5 ZNF366 ZNF143 ZNF207 ETV6 IKZF2 SCNM1 TNFAIP8L2-SCNM1 TNFAIP8L2 SEMA6C BNIPL LYSMD1
GH01I150763 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.2 -391.6 -391643 3 HDAC1 PKNOX1 IRF4 GTF3C2 POLR3A ATF7 ETV6 FOS BCLAF1 IKZF2 CTSS HORMAD1 ARNT MCL1 RPRD2 POGZ LYSMD1 CDC42SE1 TNFAIP8L2 RPS27AP6
GH01I150969 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.2 -181.7 -181672 10.6 CLOCK MLX ZFP64 DMAP1 YY1 E2F8 ZNF143 SP3 SSRP1 GLIS1 CERS2 ENSG00000231073 PRPF3 SETDB1 ZNF687 HORMAD1 PIP5K1A ARNT GOLPH3L PI4KB
GH01I150156 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 5.3 -994.7 -994697 10.3 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B YBX1 IRF4 POLR2B ZNF766 LOC105371433 PLEKHO1 SV2A MTMR11 CA14 MCL1 PRPF3 MRPS21 ANP32E RPRD2
GH01I151099 Enhancer 0.7 ENCODE 11.9 -56.6 -56649 0.2 CTCF ZNF654 TRIM22 ZNF384 REST NFXL1 RAD21 RFX5 ZNF664 ARID2 TNFAIP8L2 SEMA6C GABPB2 MINDY1 PRUNE1 TMOD4 SCNM1 LYSMD1 VPS72 PIP5K1A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TNFAIP8L2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TNFAIP8L2 gene promoter:

Genomic Locations for TNFAIP8L2 Gene

Genomic Locations for TNFAIP8L2 Gene
chr1:151,156,629-151,159,749
(GRCh38/hg38)
Size:
3,121 bases
Orientation:
Plus strand
chr1:151,129,105-151,132,225
(GRCh37/hg19)

Genomic View for TNFAIP8L2 Gene

Genes around TNFAIP8L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFAIP8L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFAIP8L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFAIP8L2 Gene

Proteins for TNFAIP8L2 Gene

  • Protein details for TNFAIP8L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P589-TP8L2_HUMAN
    Recommended name:
    Tumor necrosis factor alpha-induced protein 8-like protein 2
    Protein Accession:
    Q6P589
    Secondary Accessions:
    • Q6I9Y0
    • Q9H2H7
    • Q9H5G2

    Protein attributes for TNFAIP8L2 Gene

    Size:
    184 amino acids
    Molecular mass:
    20556 Da
    Quaternary structure:
    • May interact with CASP8; however, such result is unclear since PubMed:19079267 could not reproduce the interaction with CASP8.
    SequenceCaution:
    • Sequence=AAG44785.1; Type=Frameshift; Positions=117; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TNFAIP8L2 Gene

neXtProt entry for TNFAIP8L2 Gene

Post-translational modifications for TNFAIP8L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TNFAIP8L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TNFAIP8L2 Gene

Domains & Families for TNFAIP8L2 Gene

Gene Families for TNFAIP8L2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TNFAIP8L2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TNFAIP8L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P589

UniProtKB/Swiss-Prot:

TP8L2_HUMAN :
  • The central region was initially thought to constitute a DED (death effector) domain. However, 3D-structure data reveal a previously uncharacterized fold that is different from the predicted fold of a DED (death effector) domain. It consists of a large, hydrophobic central cavity that is poised for cofactor binding.
  • Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.
Domain:
  • The central region was initially thought to constitute a DED (death effector) domain. However, 3D-structure data reveal a previously uncharacterized fold that is different from the predicted fold of a DED (death effector) domain. It consists of a large, hydrophobic central cavity that is poised for cofactor binding.
Family:
  • Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.
genes like me logo Genes that share domains with TNFAIP8L2: view

Function for TNFAIP8L2 Gene

Molecular function for TNFAIP8L2 Gene

UniProtKB/Swiss-Prot Function:
Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis (By similarity).

Phenotypes From GWAS Catalog for TNFAIP8L2 Gene

Gene Ontology (GO) - Molecular Function for TNFAIP8L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22949657
genes like me logo Genes that share ontologies with TNFAIP8L2: view
genes like me logo Genes that share phenotypes with TNFAIP8L2: view

Animal Models for TNFAIP8L2 Gene

MGI Knock Outs for TNFAIP8L2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNFAIP8L2 Gene

Localization for TNFAIP8L2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFAIP8L2 gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TNFAIP8L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA,IEA --
genes like me logo Genes that share ontologies with TNFAIP8L2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TNFAIP8L2 Gene

Pathways & Interactions for TNFAIP8L2 Gene

genes like me logo Genes that share pathways with TNFAIP8L2: view

Pathways by source for TNFAIP8L2 Gene

Gene Ontology (GO) - Biological Process for TNFAIP8L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042981 regulation of apoptotic process IEA --
GO:0045087 innate immune response IEA --
GO:0050728 negative regulation of inflammatory response IEA,IBA --
GO:0050868 negative regulation of T cell activation IBA,IEA --
genes like me logo Genes that share ontologies with TNFAIP8L2: view

No data available for SIGNOR curated interactions for TNFAIP8L2 Gene

Drugs & Compounds for TNFAIP8L2 Gene

No Compound Related Data Available

Transcripts for TNFAIP8L2 Gene

mRNA/cDNA for TNFAIP8L2 Gene

(1) REFSEQ mRNAs :
(241) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFAIP8L2 Gene

No ASD Table

Relevant External Links for TNFAIP8L2 Gene

GeneLoc Exon Structure for
TNFAIP8L2
ECgene alternative splicing isoforms for
TNFAIP8L2

Expression for TNFAIP8L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNFAIP8L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TNFAIP8L2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (28.3) and Bone marrow mesenchymal stem cell (18.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TNFAIP8L2 Gene



NURSA nuclear receptor signaling pathways regulating expression of TNFAIP8L2 Gene:

TNFAIP8L2

SOURCE GeneReport for Unigene cluster for TNFAIP8L2 Gene:

Hs.432360

Evidence on tissue expression from TISSUES for TNFAIP8L2 Gene

  • Lymph node(4.3)
  • Intestine(4.2)
  • Pancreas(4.1)
  • Blood(2)
genes like me logo Genes that share expression patterns with TNFAIP8L2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFAIP8L2 Gene

Orthologs for TNFAIP8L2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TNFAIP8L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNFAIP8L2 34 33
  • 99.28 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TNFAIP8L2 33 34
  • 89.13 (n)
cow
(Bos Taurus)
Mammalia TNFAIP8L2 33 34
  • 88.41 (n)
oppossum
(Monodelphis domestica)
Mammalia TNFAIP8L2 34
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tnfaip8l2 33
  • 86.96 (n)
mouse
(Mus musculus)
Mammalia Tnfaip8l2 16 34 33
  • 86.23 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TNFAIP8L2 34
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TNFAIP8L2 34
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tnfaip8l2 33
  • 63.59 (n)
zebrafish
(Danio rerio)
Actinopterygii tnfaip8l2b 33 34
  • 62.66 (n)
tnfaip8l2a 34
  • 59 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8642 33
fruit fly
(Drosophila melanogaster)
Insecta CG4091 34
  • 34 (a)
OneToMany
Species where no ortholog for TNFAIP8L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFAIP8L2 Gene

ENSEMBL:
Gene Tree for TNFAIP8L2 (if available)
TreeFam:
Gene Tree for TNFAIP8L2 (if available)

Paralogs for TNFAIP8L2 Gene

Paralogs for TNFAIP8L2 Gene

(3) SIMAP similar genes for TNFAIP8L2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TNFAIP8L2: view

Variants for TNFAIP8L2 Gene

Sequence variations from dbSNP and Humsavar for TNFAIP8L2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000605489 -- 151,158,487(+) A/T intron_variant
rs1002040275 -- 151,156,733(+) G/A intron_variant
rs1003724418 -- 151,154,805(+) C/T upstream_transcript_variant
rs1005317606 -- 151,156,078(+) C/A upstream_transcript_variant
rs1005410822 -- 151,155,770(+) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TNFAIP8L2 Gene

Variant ID Type Subtype PubMed ID
dgv2n68 CNV loss 17160897
nsv522840 CNV gain 19592680

Variation tolerance for TNFAIP8L2 Gene

Residual Variation Intolerance Score: 39.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.38; 27.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNFAIP8L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNFAIP8L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFAIP8L2 Gene

Disorders for TNFAIP8L2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TNFAIP8L2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
skin squamous cell carcinoma
  • epidermoid skin carcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TNFAIP8L2

genes like me logo Genes that share disorders with TNFAIP8L2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNFAIP8L2 Gene

Publications for TNFAIP8L2 Gene

  1. The TIPE (TNFAIP8) family in inflammation, immunity, and cancer. (PMID: 21924498) Lou Y … Liu S (Molecular immunology 2011) 2 3 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Adenovirus-mediated TIPE2 overexpression inhibits gastric cancer metastasis via reversal of epithelial-mesenchymal transition. (PMID: 28186089) Yin H … Xie Y (Cancer gene therapy 2017) 3 58
  4. Tumor Necrosis Factor (TNF)-α-Induced Protein 8-like-2 (TIPE2) Inhibits Proliferation and Tumorigenesis in Breast Cancer Cells. (PMID: 28081733) Wang K … He JJ (Oncology research 2017) 3 58
  5. Increased expression of TIPE2 mRNA in PBMCs of patients with ankylosing spondylitis is negatively associated with the disease severity. (PMID: 27816498) Zhao P … Li T (Human immunology 2017) 3 58

Products for TNFAIP8L2 Gene

Sources for TNFAIP8L2 Gene

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