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Aliases for TNFAIP8L1 Gene

Aliases for TNFAIP8L1 Gene

  • TNF Alpha Induced Protein 8 Like 1 2 3 5
  • TNF Alpha-Induced Protein 8-Like Protein 1 3 4
  • Oxidative Stress-Regulated Gene-Beta 3 4
  • TNFAIP8-Like Protein 1 3 4
  • Oxy-Beta 3 4
  • TIPE1 3 4
  • Tumor Necrosis Factor, Alpha-Induced Protein 8-Like Protein 1 3
  • Tumor Necrosis Factor Alpha-Induced Protein 8-Like Protein 1 3
  • Tumor Necrosis Factor, Alpha-Induced Protein 8-Like 1 2
  • Tumor Necrosis Factor, Alpha Induced Protein 8 Like 1 3

External Ids for TNFAIP8L1 Gene

Previous GeneCards Identifiers for TNFAIP8L1 Gene

  • GC19P004591
  • GC19P004400

Summaries for TNFAIP8L1 Gene

GeneCards Summary for TNFAIP8L1 Gene

TNFAIP8L1 (TNF Alpha Induced Protein 8 Like 1) is a Protein Coding gene. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. An important paralog of this gene is TNFAIP8L2.

UniProtKB/Swiss-Prot for TNFAIP8L1 Gene

  • Acts as a negative regulator of mTOR activity.

Additional gene information for TNFAIP8L1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFAIP8L1 Gene

Genomics for TNFAIP8L1 Gene

GeneHancer (GH) Regulatory Elements for TNFAIP8L1 Gene

Promoters and enhancers for TNFAIP8L1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I004638 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.4 385 3.4 PKNOX1 ARNT ARID4B SIN3A DMAP1 IRF4 YY1 E2F8 ZNF207 ZNF143 GC19P004640 TNFAIP8L1 GC19M004643 MYDGF
GH19I004597 Enhancer 0.9 Ensembl ENCODE 6.8 -41.2 -41243 1.8 PKNOX1 TFAP4 SIN3A EBF1 ZNF335 GLIS2 POLR2A ZNF366 VEZF1 SCRT2 TNFAIP8L1 SEMA6B LOC100287614
GH19I004632 Enhancer 1.5 FANTOM5 Ensembl ENCODE 3.8 -4.5 -4482 4.2 HDGF PKNOX1 SMAD1 ARNT ARID4B FEZF1 ZBTB7B ZNF766 ZNF143 FOS TICAM1 SNRPEP4 SEMA6B CCDC94 TNFAIP8L1 ANKRD24 SH3GL1 LOC100287614
GH19I004644 Enhancer 0.9 Ensembl ENCODE 5.8 +7.4 7358 4.4 SMARCA5 BCOR CTCF ZNF362 ZBTB6 ZMYM3 EBF1 ZNF623 NR2F2 POLR2A GC19M004643 MYDGF DPP9 TNFAIP8L1 PIR47904
GH19I004624 Enhancer 0.8 ENCODE 0.4 -14.6 -14570 0.2 PKNOX1 ARID4B ZNF76 RAD21 ZNF48 ZSCAN9 THAP11 EGR2 SP5 CEBPB LOC100287614 TNFAIP8L1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TNFAIP8L1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TNFAIP8L1 gene promoter:

Genomic Locations for TNFAIP8L1 Gene

Genomic Locations for TNFAIP8L1 Gene
chr19:4,639,514-4,655,568
(GRCh38/hg38)
Size:
16,055 bases
Orientation:
Plus strand
chr19:4,639,527-4,655,580
(GRCh37/hg19)

Genomic View for TNFAIP8L1 Gene

Genes around TNFAIP8L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFAIP8L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFAIP8L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFAIP8L1 Gene

Proteins for TNFAIP8L1 Gene

  • Protein details for TNFAIP8L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVP5-TP8L1_HUMAN
    Recommended name:
    Tumor necrosis factor alpha-induced protein 8-like protein 1
    Protein Accession:
    Q8WVP5
    Secondary Accessions:
    • D6W627

    Protein attributes for TNFAIP8L1 Gene

    Size:
    186 amino acids
    Molecular mass:
    20827 Da
    Quaternary structure:
    • Interacts with FBXW5; TNFAIP8L1 competes with TSC2 to bind FBXW5 increasing TSC2 stability by preventing its ubiquitination.

neXtProt entry for TNFAIP8L1 Gene

Post-translational modifications for TNFAIP8L1 Gene

No Post-translational modifications

Other Protein References for TNFAIP8L1 Gene

No data available for DME Specific Peptides for TNFAIP8L1 Gene

Domains & Families for TNFAIP8L1 Gene

Gene Families for TNFAIP8L1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TNFAIP8L1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TNFAIP8L1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WVP5

UniProtKB/Swiss-Prot:

TP8L1_HUMAN :
  • Belongs to the TNFAIP8 family.
Family:
  • Belongs to the TNFAIP8 family.
genes like me logo Genes that share domains with TNFAIP8L1: view

Function for TNFAIP8L1 Gene

Molecular function for TNFAIP8L1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a negative regulator of mTOR activity.
UniProtKB/Swiss-Prot Induction:
Up-regulated by oxidative stress (OS) at both transcriptional and translational levels.

Gene Ontology (GO) - Molecular Function for TNFAIP8L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with TNFAIP8L1: view

Phenotypes for TNFAIP8L1 Gene

genes like me logo Genes that share phenotypes with TNFAIP8L1: view

Animal Model Products

miRNA for TNFAIP8L1 Gene

miRTarBase miRNAs that target TNFAIP8L1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TNFAIP8L1 Gene

Localization for TNFAIP8L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFAIP8L1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFAIP8L1 gene
Compartment Confidence
extracellular 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TNFAIP8L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA,ISS --
genes like me logo Genes that share ontologies with TNFAIP8L1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TNFAIP8L1 Gene

Pathways & Interactions for TNFAIP8L1 Gene

genes like me logo Genes that share pathways with TNFAIP8L1: view

Pathways by source for TNFAIP8L1 Gene

Interacting Proteins for TNFAIP8L1 Gene

Gene Ontology (GO) - Biological Process for TNFAIP8L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032007 negative regulation of TOR signaling IEA,ISS --
GO:0042981 regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with TNFAIP8L1: view

No data available for SIGNOR curated interactions for TNFAIP8L1 Gene

Drugs & Compounds for TNFAIP8L1 Gene

No Compound Related Data Available

Transcripts for TNFAIP8L1 Gene

Unigene Clusters for TNFAIP8L1 Gene

Tumor necrosis factor, alpha-induced protein 8-like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFAIP8L1 Gene

No ASD Table

Relevant External Links for TNFAIP8L1 Gene

GeneLoc Exon Structure for
TNFAIP8L1
ECgene alternative splicing isoforms for
TNFAIP8L1

Expression for TNFAIP8L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNFAIP8L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFAIP8L1 Gene

This gene is overexpressed in Colon - Sigmoid (x4.3).

Protein differential expression in normal tissues from HIPED for TNFAIP8L1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (41.0) and Bone (23.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TNFAIP8L1 Gene



Protein tissue co-expression partners for TNFAIP8L1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TNFAIP8L1 Gene:

TNFAIP8L1

SOURCE GeneReport for Unigene cluster for TNFAIP8L1 Gene:

Hs.465643

mRNA Expression by UniProt/SwissProt for TNFAIP8L1 Gene:

Q8WVP5-TP8L1_HUMAN
Tissue specificity: High expression detected in most carcinoma cell lines, especially in cells transformed with virus genomes.

Evidence on tissue expression from TISSUES for TNFAIP8L1 Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with TNFAIP8L1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFAIP8L1 Gene

Orthologs for TNFAIP8L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TNFAIP8L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNFAIP8L1 33 34
  • 100 (n)
dog
(Canis familiaris)
Mammalia TNFAIP8L1 33 34
  • 89.96 (n)
cow
(Bos Taurus)
Mammalia TNFAIP8L1 33 34
  • 87.46 (n)
mouse
(Mus musculus)
Mammalia Tnfaip8l1 33 16 34
  • 81 (n)
rat
(Rattus norvegicus)
Mammalia Tnfaip8l1 33
  • 78.67 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TNFAIP8L1 34
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TNFAIP8L1 34
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves TNFAIP8L1 33 34
  • 74.55 (n)
zebrafish
(Danio rerio)
Actinopterygii tnfaip8l1 33
  • 70.07 (n)
tnfaip8 34
  • 68 (a)
OneToOne
zgc55331 33
fruit fly
(Drosophila melanogaster)
Insecta CG4091 34
  • 30 (a)
OneToMany
Species where no ortholog for TNFAIP8L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFAIP8L1 Gene

ENSEMBL:
Gene Tree for TNFAIP8L1 (if available)
TreeFam:
Gene Tree for TNFAIP8L1 (if available)

Paralogs for TNFAIP8L1 Gene

Paralogs for TNFAIP8L1 Gene

(3) SIMAP similar genes for TNFAIP8L1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TNFAIP8L1: view

Variants for TNFAIP8L1 Gene

Sequence variations from dbSNP and Humsavar for TNFAIP8L1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000104733 -- 4,654,493(+) G/A 3_prime_UTR_variant
rs1000156642 -- 4,646,409(+) G/T intron_variant
rs1000217020 -- 4,648,893(+) C/T intron_variant
rs1000407400 -- 4,654,288(+) G/A 3_prime_UTR_variant
rs1000651111 -- 4,650,209(+) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TNFAIP8L1 Gene

Variant ID Type Subtype PubMed ID
nsv953950 CNV deletion 24416366
nsv833721 CNV loss 17160897
nsv526746 CNV loss 19592680
nsv428361 CNV loss 18775914
nsv1062709 CNV loss 25217958

Variation tolerance for TNFAIP8L1 Gene

Gene Damage Index Score: 0.28; 6.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNFAIP8L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNFAIP8L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFAIP8L1 Gene

Disorders for TNFAIP8L1 Gene

Additional Disease Information for TNFAIP8L1

No disorders were found for TNFAIP8L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNFAIP8L1 Gene

Publications for TNFAIP8L1 Gene

  1. Tnfaip8 l1/Oxi-β binds to FBXW5, increasing autophagy through activation of TSC2 in a Parkinson's disease model. (PMID: 24444419) Ha JY … Son JH (Journal of neurochemistry 2014) 3 4 58
  2. The expression of TIPE1 in murine tissues and human cell lines. (PMID: 21600655) Cui J … Liu S (Molecular immunology 2011) 3 4 58
  3. The TIPE (TNFAIP8) family in inflammation, immunity, and cancer. (PMID: 21924498) Lou Y … Liu S (Molecular immunology 2011) 2 3 58
  4. TIPE1 induces apoptosis by negatively regulating Rac1 activation in hepatocellular carcinoma cells. (PMID: 25043299) Zhang Z … Ma C (Oncogene 2015) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for TNFAIP8L1 Gene

Sources for TNFAIP8L1 Gene

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