Aliases for TNFAIP8L1 Gene

Aliases for TNFAIP8L1 Gene

  • TNF Alpha Induced Protein 8 Like 1 2 3 5
  • Tumor Necrosis Factor Alpha-Induced Protein 8-Like Protein 1 3 4
  • TNF Alpha-Induced Protein 8-Like Protein 1 3 4
  • Oxidative Stress-Regulated Gene-Beta 3 4
  • TNFAIP8-Like Protein 1 3 4
  • Oxy-Beta 3 4
  • TIPE1 3 4
  • Tumor Necrosis Factor, Alpha-Induced Protein 8-Like Protein 1 3
  • Tumor Necrosis Factor, Alpha-Induced Protein 8-Like 1 2
  • Tumor Necrosis Factor, Alpha Induced Protein 8 Like 1 3
  • TNFAIP8L1 5
  • MGC17791 2

External Ids for TNFAIP8L1 Gene

Previous GeneCards Identifiers for TNFAIP8L1 Gene

  • GC19P004591
  • GC19P004400

Summaries for TNFAIP8L1 Gene

GeneCards Summary for TNFAIP8L1 Gene

TNFAIP8L1 (TNF Alpha Induced Protein 8 Like 1) is a Protein Coding gene. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. An important paralog of this gene is TNFAIP8L2.

UniProtKB/Swiss-Prot Summary for TNFAIP8L1 Gene

Additional gene information for TNFAIP8L1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TNFAIP8L1 Gene

Genomics for TNFAIP8L1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TNFAIP8L1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J004632 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 603.7 -2.2 -2243 8.7 SP1 HNRNPL GATAD2A CTCF TEAD4 PRDM10 ZNF629 TFE3 ZNF512 LEF1 TNFAIP8L1 TICAM1 SNRPEP4 SEMA6B YJU2 ANKRD24 SH3GL1 HSALNG0123407 MYDGF
GH19J004641 Promoter 0.3 EPDnew 600.7 +2.2 2201 0.1 TNFAIP8L1 lnc-TNFAIP8L1-2 MYDGF
GH19J004644 Enhancer 0.9 Ensembl ENCODE 5.9 +8.3 8329 6.3 HNRNPL CTCF KDM1A RBFOX2 SP1 ZNF600 EED RELB ZNF623 NR2F2 MYDGF DPP9 TNFAIP8L1 lnc-TNFAIP8L1-2
GH19J004622 Promoter/Enhancer 1.1 Ensembl ENCODE 0.4 -17.2 -17150 1.5 CREB1 GATAD2A RCOR2 JUND PKNOX1 RXRB REST ZNF341 CEBPA SOX13 ENSG00000267408 LOC100287614 lnc-TNFAIP8L1-3 HSALNG0123407 TNFAIP8L1 SEMA6B
GH19J004624 Enhancer 1 Ensembl ENCODE 0.4 -14.5 -14527 0.8 CTCF NFKBIZ KDM1A RCOR2 PRDM1 PKNOX1 RXRB PATZ1 ZNF24 CEBPA LOC100287614 HSALNG0123407 TNFAIP8L1 SEMA6B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TNFAIP8L1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TNFAIP8L1

Top Transcription factor binding sites by QIAGEN in the TNFAIP8L1 gene promoter:
  • CBF(2)
  • CP2
  • FOXO1
  • FOXO1a
  • Ik-1
  • NF-Y
  • Sox5
  • SRY
  • USF-1
  • USF1

Genomic Locations for TNFAIP8L1 Gene

Genomic Locations for TNFAIP8L1 Gene
chr19:4,639,505-4,655,568
(GRCh38/hg38)
Size:
16,064 bases
Orientation:
Plus strand
chr19:4,639,527-4,655,580
(GRCh37/hg19)
Size:
16,054 bases
Orientation:
Plus strand

Genomic View for TNFAIP8L1 Gene

Genes around TNFAIP8L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFAIP8L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFAIP8L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFAIP8L1 Gene

Proteins for TNFAIP8L1 Gene

  • Protein details for TNFAIP8L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVP5-TP8L1_HUMAN
    Recommended name:
    Tumor necrosis factor alpha-induced protein 8-like protein 1
    Protein Accession:
    Q8WVP5
    Secondary Accessions:
    • D6W627

    Protein attributes for TNFAIP8L1 Gene

    Size:
    186 amino acids
    Molecular mass:
    20827 Da
    Quaternary structure:
    • Interacts with FBXW5; TNFAIP8L1 competes with TSC2 to bind FBXW5 increasing TSC2 stability by preventing its ubiquitination.

neXtProt entry for TNFAIP8L1 Gene

Post-translational modifications for TNFAIP8L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TNFAIP8L1 Gene

No data available for DME Specific Peptides for TNFAIP8L1 Gene

Domains & Families for TNFAIP8L1 Gene

Gene Families for TNFAIP8L1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TNFAIP8L1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TNFAIP8L1 Gene

GenScript: Design optimal peptide antigens:
  • Tumor necrosis factor alpha-induced protein 8-like protein 1 (TP8L1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8WVP5

UniProtKB/Swiss-Prot:

TP8L1_HUMAN :
  • Belongs to the TNFAIP8 family.
Family:
  • Belongs to the TNFAIP8 family.
genes like me logo Genes that share domains with TNFAIP8L1: view

Function for TNFAIP8L1 Gene

Molecular function for TNFAIP8L1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a negative regulator of mTOR activity.
UniProtKB/Swiss-Prot Induction:
Up-regulated by oxidative stress (OS) at both transcriptional and translational levels.

Phenotypes From GWAS Catalog for TNFAIP8L1 Gene

Gene Ontology (GO) - Molecular Function for TNFAIP8L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with TNFAIP8L1: view
genes like me logo Genes that share phenotypes with TNFAIP8L1: view

Animal Model Products

CRISPR Products

miRNA for TNFAIP8L1 Gene

miRTarBase miRNAs that target TNFAIP8L1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNFAIP8L1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TNFAIP8L1 Gene

Localization for TNFAIP8L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFAIP8L1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFAIP8L1 gene
Compartment Confidence
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TNFAIP8L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA,ISS --
genes like me logo Genes that share ontologies with TNFAIP8L1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TNFAIP8L1 Gene

Pathways & Interactions for TNFAIP8L1 Gene

PathCards logo

SuperPathways for TNFAIP8L1 Gene

genes like me logo Genes that share pathways with TNFAIP8L1: view

Pathways by source for TNFAIP8L1 Gene

Gene Ontology (GO) - Biological Process for TNFAIP8L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032007 negative regulation of TOR signaling IEA,ISS --
GO:0042981 regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with TNFAIP8L1: view

No data available for SIGNOR curated interactions for TNFAIP8L1 Gene

Drugs & Compounds for TNFAIP8L1 Gene

No Compound Related Data Available

Transcripts for TNFAIP8L1 Gene

mRNA/cDNA for TNFAIP8L1 Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNFAIP8L1

Alternative Splicing Database (ASD) splice patterns (SP) for TNFAIP8L1 Gene

No ASD Table

Relevant External Links for TNFAIP8L1 Gene

GeneLoc Exon Structure for
TNFAIP8L1

Expression for TNFAIP8L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TNFAIP8L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFAIP8L1 Gene

This gene is overexpressed in Colon - Sigmoid (x4.3).

Protein differential expression in normal tissues from HIPED for TNFAIP8L1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (41.0) and Bone (23.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TNFAIP8L1 Gene



Protein tissue co-expression partners for TNFAIP8L1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TNFAIP8L1

SOURCE GeneReport for Unigene cluster for TNFAIP8L1 Gene:

Hs.465643

mRNA Expression by UniProt/SwissProt for TNFAIP8L1 Gene:

Q8WVP5-TP8L1_HUMAN
Tissue specificity: High expression detected in most carcinoma cell lines, especially in cells transformed with virus genomes.

Evidence on tissue expression from TISSUES for TNFAIP8L1 Gene

  • Lung(4.3)
genes like me logo Genes that share expression patterns with TNFAIP8L1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFAIP8L1 Gene

Orthologs for TNFAIP8L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TNFAIP8L1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TNFAIP8L1 30 31
  • 100 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TNFAIP8L1 30 31
  • 89.96 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TNFAIP8L1 30 31
  • 87.46 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tnfaip8l1 30 17 31
  • 81 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tnfaip8l1 30
  • 78.67 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia TNFAIP8L1 31
  • 68 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TNFAIP8L1 31
  • 66 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TNFAIP8L1 30 31
  • 74.55 (n)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii tnfaip8l1 30
  • 70.07 (n)
tnfaip8 31
  • 68 (a)
OneToOne
zgc55331 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG4091 31
  • 30 (a)
OneToMany
Species where no ortholog for TNFAIP8L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TNFAIP8L1 Gene

ENSEMBL:
Gene Tree for TNFAIP8L1 (if available)
TreeFam:
Gene Tree for TNFAIP8L1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TNFAIP8L1: view image

Paralogs for TNFAIP8L1 Gene

Paralogs for TNFAIP8L1 Gene

(3) SIMAP similar genes for TNFAIP8L1 Gene using alignment to 1 proteins:

  • TP8L1_HUMAN
genes like me logo Genes that share paralogs with TNFAIP8L1: view

Variants for TNFAIP8L1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TNFAIP8L1 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs17851549 - p.Ala118Val

Additional dbSNP identifiers (rs#s) for TNFAIP8L1 Gene

Structural Variations from Database of Genomic Variants (DGV) for TNFAIP8L1 Gene

Variant ID Type Subtype PubMed ID
nsv1062709 CNV loss 25217958
nsv428361 CNV loss 18775914
nsv526746 CNV loss 19592680
nsv833721 CNV loss 17160897
nsv953950 CNV deletion 24416366

Variation tolerance for TNFAIP8L1 Gene

Gene Damage Index Score: 0.28; 6.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNFAIP8L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNFAIP8L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFAIP8L1 Gene

Disorders for TNFAIP8L1 Gene

No disorders were found for TNFAIP8L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNFAIP8L1 Gene

Publications for TNFAIP8L1 Gene

  1. Tnfaip8 l1/Oxi-β binds to FBXW5, increasing autophagy through activation of TSC2 in a Parkinson's disease model. (PMID: 24444419) Ha JY … Son JH (Journal of neurochemistry 2014) 3 4
  2. The expression of TIPE1 in murine tissues and human cell lines. (PMID: 21600655) Cui J … Liu S (Molecular immunology 2011) 3 4
  3. The TIPE (TNFAIP8) family in inflammation, immunity, and cancer. (PMID: 21924498) Lou Y … Liu S (Molecular immunology 2011) 2 3
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. TIPE1 suppresses osteosarcoma tumor growth by regulating macrophage infiltration. (PMID: 30062520) Chen P … Zuo Q (Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2019) 3

Products for TNFAIP8L1 Gene

  • Signalway ELISA kits for TNFAIP8L1

Sources for TNFAIP8L1 Gene