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Aliases for TNFAIP8 Gene

Aliases for TNFAIP8 Gene

  • TNF Alpha Induced Protein 8 2 3 5
  • Head And Neck Tumor And Metastasis-Related Protein 3 4
  • NF-Kappa-B-Inducible DED-Containing Protein 3 4
  • TNF-Induced Protein GG2-1 3 4
  • MDC-3.13 3 4
  • SCC-S2 3 4
  • NDED 3 4
  • Tumor Necrosis Factor, Alpha-Induced Protein 8 2
  • Tumor Necrosis Factor, Alpha Induced Protein 8 3
  • Tumor Necrosis Factor Alpha-Induced Protein 8 3
  • TNF Alpha-Induced Protein 8 4
  • GG2-1 3
  • SCCS2 3

External Ids for TNFAIP8 Gene

Previous GeneCards Identifiers for TNFAIP8 Gene

  • GC00U914375
  • GC05P118768
  • GC05P118719
  • GC05P118604
  • GC05P113799

Summaries for TNFAIP8 Gene

GeneCards Summary for TNFAIP8 Gene

TNFAIP8 (TNF Alpha Induced Protein 8) is a Protein Coding gene. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase inhibitor activity involved in apoptotic process. An important paralog of this gene is TNFAIP8L3.

UniProtKB/Swiss-Prot for TNFAIP8 Gene

  • Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.

Gene Wiki entry for TNFAIP8 Gene

Additional gene information for TNFAIP8 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFAIP8 Gene

Genomics for TNFAIP8 Gene

GeneHancer (GH) Regulatory Elements for TNFAIP8 Gene

Promoters and enhancers for TNFAIP8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I119267 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 574.7 +4.9 4942 12.3 HDGF PKNOX1 SMAD1 ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 TNFAIP8 DTWD2 DMXL1 GC05P119298
GH05I119317 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 608.1 +62.9 62854 27.1 FEZF1 IRF4 ZNF213 E2F8 ZNF143 MEF2D ZNF610 GLIS1 NBN NR2C1 TNFAIP8 DMXL1 LAMTOR3P2 LOC105379143 FAM170A HSD17B4 ENSG00000249426 GC05P119341 RN7SL174P GC05M119307
GH05I119352 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 563 +88.7 88660 10.6 HDGF ATF1 PKNOX1 SMAD1 SIN3A FEZF1 TCF12 ZNF213 ZNF207 RUNX3 TNFAIP8 LOC102723444 LOC105379143 DMXL1 HSD17B4 GC05P119446
GH05I119397 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 45.2 +129.8 129809 3 FOXA2 BMI1 BATF KLF5 IRF4 RAD21 ZBTB40 YY1 ZNF207 ATF7 TNFAIP8 DMXL1 DTWD2 LOC105379143 LOC102723444 GC05P119446
GH05I119410 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 44.7 +143.1 143076 2.1 PKNOX1 ATF1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF213 ARID2 ZNF143 TNFAIP8 DTWD2 ENSG00000250678 RNU6-373P HSD17B4 FAM170A DMXL1 GC05P119446 LOC102723444
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TNFAIP8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TNFAIP8 gene promoter:

Genomic Locations for TNFAIP8 Gene

Genomic Locations for TNFAIP8 Gene
chr5:119,268,692-119,399,688
(GRCh38/hg38)
Size:
130,997 bases
Orientation:
Plus strand
chr5:118,604,387-118,735,383
(GRCh37/hg19)

Genomic View for TNFAIP8 Gene

Genes around TNFAIP8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFAIP8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFAIP8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFAIP8 Gene

Proteins for TNFAIP8 Gene

  • Protein details for TNFAIP8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95379-TFIP8_HUMAN
    Recommended name:
    Tumor necrosis factor alpha-induced protein 8
    Protein Accession:
    O95379
    Secondary Accessions:
    • B3KMH1
    • B3KMI2
    • B7Z713
    • Q9P1Q1
    • Q9UER5
    • Q9UP47

    Protein attributes for TNFAIP8 Gene

    Size:
    198 amino acids
    Molecular mass:
    23003 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TNFAIP8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNFAIP8 Gene

Post-translational modifications for TNFAIP8 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TNFAIP8 Gene

Domains & Families for TNFAIP8 Gene

Gene Families for TNFAIP8 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TNFAIP8 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O95379

UniProtKB/Swiss-Prot:

TFIP8_HUMAN :
  • Belongs to the TNFAIP8 family.
Family:
  • Belongs to the TNFAIP8 family.
genes like me logo Genes that share domains with TNFAIP8: view

Function for TNFAIP8 Gene

Molecular function for TNFAIP8 Gene

UniProtKB/Swiss-Prot Function:
Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.
UniProtKB/Swiss-Prot Induction:
By nuclear factor-KB (NF-KB) and TNF. Induction by TNF depends upon activation of NF-KB.

Phenotypes From GWAS Catalog for TNFAIP8 Gene

Gene Ontology (GO) - Molecular Function for TNFAIP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP 10644768
genes like me logo Genes that share ontologies with TNFAIP8: view
genes like me logo Genes that share phenotypes with TNFAIP8: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TNFAIP8 Gene

Localization for TNFAIP8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFAIP8 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFAIP8 gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TNFAIP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 14724590
genes like me logo Genes that share ontologies with TNFAIP8: view

Pathways & Interactions for TNFAIP8 Gene

genes like me logo Genes that share pathways with TNFAIP8: view

Pathways by source for TNFAIP8 Gene

Gene Ontology (GO) - Biological Process for TNFAIP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0042981 regulation of apoptotic process IEA --
GO:0043065 positive regulation of apoptotic process IMP 10644768
GO:0043066 negative regulation of apoptotic process TAS 10644768
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA --
genes like me logo Genes that share ontologies with TNFAIP8: view

No data available for SIGNOR curated interactions for TNFAIP8 Gene

Drugs & Compounds for TNFAIP8 Gene

No Compound Related Data Available

Transcripts for TNFAIP8 Gene

Unigene Clusters for TNFAIP8 Gene

Tumor necrosis factor, alpha-induced protein 8:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFAIP8 Gene

No ASD Table

Relevant External Links for TNFAIP8 Gene

GeneLoc Exon Structure for
TNFAIP8
ECgene alternative splicing isoforms for
TNFAIP8

Expression for TNFAIP8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNFAIP8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFAIP8 Gene

This gene is overexpressed in Whole Blood (x5.4).

Protein differential expression in normal tissues from HIPED for TNFAIP8 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.7), Lymph node (10.0), and Tlymphocyte (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TNFAIP8 Gene



Protein tissue co-expression partners for TNFAIP8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TNFAIP8 Gene:

TNFAIP8

SOURCE GeneReport for Unigene cluster for TNFAIP8 Gene:

Hs.656274

mRNA Expression by UniProt/SwissProt for TNFAIP8 Gene:

O95379-TFIP8_HUMAN
Tissue specificity: Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine-activated cultured cells. Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle.

Evidence on tissue expression from TISSUES for TNFAIP8 Gene

  • Stomach(4.3)
  • Heart(4.2)
  • Nervous system(4.1)
  • Lymph node(2.6)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with TNFAIP8: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFAIP8 Gene

Orthologs for TNFAIP8 Gene

This gene was present in the common ancestor of animals.

Orthologs for TNFAIP8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNFAIP8 33 34
  • 98.89 (n)
oppossum
(Monodelphis domestica)
Mammalia TNFAIP8 34
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TNFAIP8 34
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TNFAIP8 33 34
  • 90.35 (n)
cow
(Bos Taurus)
Mammalia TNFAIP8 33 34
  • 90 (n)
rat
(Rattus norvegicus)
Mammalia Tnfaip8 33
  • 85.94 (n)
mouse
(Mus musculus)
Mammalia Tnfaip8 33 16 34
  • 83.83 (n)
chicken
(Gallus gallus)
Aves TNFAIP8 33 34
  • 82.62 (n)
lizard
(Anolis carolinensis)
Reptilia TNFAIP8 34
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tnfaip8 33
  • 77.48 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24156 33
fruit fly
(Drosophila melanogaster)
Insecta CG4091 33 34
  • 51.11 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002997 33
  • 49.56 (n)
Species where no ortholog for TNFAIP8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TNFAIP8 Gene

ENSEMBL:
Gene Tree for TNFAIP8 (if available)
TreeFam:
Gene Tree for TNFAIP8 (if available)

Paralogs for TNFAIP8 Gene

Paralogs for TNFAIP8 Gene

(3) SIMAP similar genes for TNFAIP8 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TNFAIP8: view

Variants for TNFAIP8 Gene

Sequence variations from dbSNP and Humsavar for TNFAIP8 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000021812 -- 119,300,246(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000028936 -- 119,370,072(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000042573 -- 119,291,521(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000051197 -- 119,301,559(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000061478 -- 119,369,860(+) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TNFAIP8 Gene

Variant ID Type Subtype PubMed ID
nsv950122 CNV duplication 24416366
nsv950121 CNV duplication 24416366
nsv599565 CNV gain 21841781
nsv599564 CNV gain 21841781
nsv1131910 CNV deletion 24896259
nsv1115702 CNV duplication 24896259
nsv1024648 CNV gain 25217958
nsv1016595 CNV gain 25217958
esv3606484 CNV loss 21293372
esv3606483 CNV loss 21293372
esv3606482 CNV gain 21293372
esv3606480 CNV loss 21293372
esv2759374 CNV loss 17122850
esv24760 CNV loss 19812545
dgv10045n54 CNV loss 21841781

Variation tolerance for TNFAIP8 Gene

Residual Variation Intolerance Score: 46.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.35; 7.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNFAIP8 Gene

Human Gene Mutation Database (HGMD)
TNFAIP8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNFAIP8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFAIP8 Gene

Disorders for TNFAIP8 Gene

Additional Disease Information for TNFAIP8

No disorders were found for TNFAIP8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNFAIP8 Gene

Publications for TNFAIP8 Gene

  1. Expression of SCC-S2, an antiapoptotic molecule, correlates with enhanced proliferation and tumorigenicity of MDA-MB 435 cells. (PMID: 14724590) Kumar D … Kasid U (Oncogene 2004) 3 4 22 58
  2. Identification of a novel tumor necrosis factor-alpha-inducible gene, SCC-S2, containing the consensus sequence of a death effector domain of fas-associated death domain-like interleukin- 1beta-converting enzyme-inhibitory protein. (PMID: 10644768) Kumar D … Kasid U (The Journal of biological chemistry 2000) 2 3 4 58
  3. Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes. (PMID: 10233894) Horrevoets AJ … Pannekoek H (Blood 1999) 2 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. Overexpression of TNFAIP8 is associated with tumor aggressiveness and poor prognosis in patients with invasive ductal breast carcinoma. (PMID: 28087477) Xiao M … Huang Y (Human pathology 2017) 3 58

Products for TNFAIP8 Gene

Sources for TNFAIP8 Gene

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