Aliases for TNFAIP8 Gene
External Ids for TNFAIP8 Gene
Previous GeneCards Identifiers for TNFAIP8 Gene
GeneCards Summary for TNFAIP8 Gene
TNFAIP8 (TNF Alpha Induced Protein 8) is a Protein Coding gene. Diseases associated with TNFAIP8 include Plantar Fasciitis. Among its related pathways are Glycerophospholipid biosynthesis and Metabolism. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase inhibitor activity involved in apoptotic process. An important paralog of this gene is TNFAIP8L3.
UniProtKB/Swiss-Prot for TNFAIP8 Gene
Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.